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  1. Article ; Online: Enhanced biomimetic catalysis via self-cascade photocatalytic hydrogen peroxide production over modified carbon nitride nanozymes for total antioxidant capacity evaluation.

    Li, Shengzhen / Chu, Shushu / Xia, Mingyuan / Wei, Hengya / Lu, Yizhong

    Journal of colloid and interface science

    2024  Volume 660, Page(s) 771–779

    Abstract: The peroxidase mimics usually requires the addition of exogenous hydrogen peroxide ( ... ...

    Abstract The peroxidase mimics usually requires the addition of exogenous hydrogen peroxide (H
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.01.132
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  2. Article ; Online: Influence of intergenerational support on the mental health of older people in China.

    Jiang, Zicheng / Liu, Huan / Deng, Jing / Ye, Yizhong / Li, Dexun

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0299986

    Abstract: Today, population aging is the main trend of population development. Home-based care is mainly adopted in Chinese society, and scholars have paid ample attention to the effect of intergenerational support on the mental health of older people. However, ... ...

    Abstract Today, population aging is the main trend of population development. Home-based care is mainly adopted in Chinese society, and scholars have paid ample attention to the effect of intergenerational support on the mental health of older people. However, research conclusions differ. This study uses data from the 2018 China Health and Pension Tracking Survey (CHARLS), which we analyzed with STATA software to construct least squares regression and two-stage least squares regression models. The regression model included 6,647 respondents to investigate the mental health status of older people based on depression status. Intergenerational support was defined as economic support, emotional support, and daily care provided by the children of older people. We studied the impact of three aspects of intergenerational support on the mental health of the elderly. We performed a robustness test using the variable replacement and propensity score matching methods, and analyzed age, gender, and urban-rural heterogeneity. The results showed that economic support had no significant impact on the mental health of older people, while emotional support and daily care had a positive effect. The heterogeneity results indicated that the relationship between intergenerational support and mental health of older people differed significantly based on age, gender, and urban and rural areas. Therefore, children should raise their awareness of supporting their parents, pay attention to their parents' mental health, and provide emotional support and daily care. Furthermore, community work improves family relations, creates a good social environment, and encourages young people to respect and be filial to older people. The government should improve the medical security system and old-age service system, and provide policy support to help the mental health of older people.
    MeSH term(s) Child ; Humans ; Aged ; Adolescent ; Mental Health ; Intergenerational Relations ; China/epidemiology ; Aging ; Family Relations
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299986
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  3. Article ; Online: A Crossrate-Based Approach for Reliability-Based Multidisciplinary Dynamic System Design Optimization

    Li Lu / Yizhong Wu / Qi Zhang / Ping Qiao

    Applied Sciences, Vol 13, Iss 1600, p

    2023  Volume 1600

    Abstract: In practical applications, the multidisciplinary dynamic system design optimization (MDSDO)-based solution is limited by uncertainty, which causes random variation in the physical design variable in the static discipline and the equation of state in the ... ...

    Abstract In practical applications, the multidisciplinary dynamic system design optimization (MDSDO)-based solution is limited by uncertainty, which causes random variation in the physical design variable in the static discipline and the equation of state in the dynamic discipline. To address the lack of reliability of the MDSDO solution, a crossrate-based MDSDO approach (C-MDSDO), consisting of the MDSDO stage and a reliability assessment stage, is proposed in this paper. In the reliability assessment stage, a sub-optimization problem based on the crossrate of the objective reliability index sample trajectory is designed to obtain the shifting vector, which is employed to obtain a sufficiently reliable solution. In addition, the proposed approach adopts a sequential problem-solving framework that avoids nested optimization and a reliability assessment. One numerical case and two engineering cases were employed to validate the effectiveness of the proposed method. The results show that the reliability of the proposed solutions significantly improved.
    Keywords multidisciplinary dynamic system design optimization ; sequential approach ; reliability assessment ; shifting vector ; crossrate ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 670
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: ZNF143 facilitates the growth and migration of glioma cells by regulating KPNA2-mediated Hippo signalling

    Yan Chen / Jitao Li / Jiangchun Ma / Yizhong Bao

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 12

    Abstract: Abstract The disordered expression of ZNF143 is closely related to the malignant progression of tumours. However, the basic control mechanism of ZNF143 in glioma has not yet been clarified. Therefore, we tried to find a new pathway to illustrate the ... ...

    Abstract Abstract The disordered expression of ZNF143 is closely related to the malignant progression of tumours. However, the basic control mechanism of ZNF143 in glioma has not yet been clarified. Therefore, we tried to find a new pathway to illustrate the function of ZNF143 in glioma. To explore the function of KPNA2 in the development of glioma, we used survival analysis by the Kaplan‒Meier method to assess the overall survival (OS) of patients with low and high KPNA2 expression in the TCGA and CGGA cohorts. Western blotting assays and RT‒PCR assays were utilized to determine the expression level of KPNA2 in glioma cells. The interaction between ZNF143 and KPNA2 was confirmed by ChIP assays. Proliferation was assessed by CCK-8 assays, and migration was evaluated by wound healing and Transwell assays. Apoptosis was determined by flow cytometry, and the expression level of YAP/TAZ was visualized using an immunofluorescence assay. The expression levels of LATS1, LATS2, YAP1, and p-YAP1 were determined. Patients with low KPNA2 expression showed a better prognosis than those with high KPNA2 expression. KPNA2 was found to be upregulated in human glioma cells. ZNF143 can bind to the promoter region of KPNA2. Downregulation of ZNF143 and KPNA2 can activate the Hippo signalling pathway and reduce YAP/TAZ expression in human glioma cells, thus inducing apoptosis of human glioma cells and weakening their proliferation, migration and invasion. In conclusion, ZNF143 mediates the Hippo/YAP signalling pathway and inhibits the growth and migration of glioma cells by regulating KPNA2.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A weighted two-stage sequence alignment framework to identify motifs from ChIP-exo data.

    Li, Yang / Wang, Yizhong / Wang, Cankun / Ma, Anjun / Ma, Qin / Liu, Bingqiang

    Patterns (New York, N.Y.)

    2024  Volume 5, Issue 3, Page(s) 100927

    Abstract: In this study, we introduce TESA (weighted two-stage alignment), an innovative motif prediction tool that refines the identification of DNA-binding protein motifs, essential for deciphering transcriptional regulatory mechanisms. Unlike traditional ... ...

    Abstract In this study, we introduce TESA (weighted two-stage alignment), an innovative motif prediction tool that refines the identification of DNA-binding protein motifs, essential for deciphering transcriptional regulatory mechanisms. Unlike traditional algorithms that rely solely on sequence data, TESA integrates the high-resolution chromatin immunoprecipitation (ChIP) signal, specifically from ChIP-exonuclease (ChIP-exo), by assigning weights to sequence positions, thereby enhancing motif discovery. TESA employs a nuanced approach combining a binomial distribution model with a graph model, further supported by a "bookend" model, to improve the accuracy of predicting motifs of varying lengths. Our evaluation, utilizing an extensive compilation of 90 prokaryotic ChIP-exo datasets from proChIPdb and 167
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3899
    ISSN (online) 2666-3899
    DOI 10.1016/j.patter.2024.100927
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  6. Article: Antimicrobial Resistance of

    Li, Xiaolu / Wang, Yizhong / Cao, Rong / Xiao, Fangfei / Wang, Xufei / Ye, Lin / Xiao, Yongmei / Li, Dan / Zhang, Ting

    Infection and drug resistance

    2024  Volume 17, Page(s) 329–339

    Abstract: Background: Our previous study reported a high rate of recurrence in children with : Methods: Antimicrobial susceptibility testing (AST) using the agar dilution method according to the Clinical and Laboratory Standard Institute (CLSI) were performed ... ...

    Abstract Background: Our previous study reported a high rate of recurrence in children with
    Methods: Antimicrobial susceptibility testing (AST) using the agar dilution method according to the Clinical and Laboratory Standard Institute (CLSI) were performed on
    Results: A total of 50
    Conclusion: C. difficile
    Language English
    Publishing date 2024-01-26
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S441312
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  7. Article ; Online: Correction to: Magnetic activated carbon from spent coffee grounds: iron-catalyzed CO

    Li, Zhili / Jiang, Tianxiang / Huo, Hanxin / Zhang, Yizhong / Wang, Xunliang / Guo, Jian / Ma, Yuhui

    Environmental science and pollution research international

    2023  Volume 31, Issue 6, Page(s) 9867

    Language English
    Publishing date 2023-12-30
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-31780-2
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  8. Article ; Online: Natural Enzyme-Inspired Design of the Single-Atom Cu Nanozyme as Dual-Enzyme Mimics for Distinguishing Total Antioxidant Capacity and the Ascorbic Acid Level.

    Tao, Chenyu / Jiang, Yuanyuan / Chu, Shushu / Miao, Yanrong / Zhang, Jiqing / Lu, Yizhong / Niu, Li

    Analytical chemistry

    2024  

    Abstract: Although various oxidase mimetic or peroxidase (POD) mimetic nanozymes have been extensively studied, their poor substrate selectivity significantly inhibits their practical applications. Nanozymes with specific biomolecules as substrates, especially ... ...

    Abstract Although various oxidase mimetic or peroxidase (POD) mimetic nanozymes have been extensively studied, their poor substrate selectivity significantly inhibits their practical applications. Nanozymes with specific biomolecules as substrates, especially ascorbic acid oxidase (AAO) mimetic nanozymes with ascorbic acid (AA) as a substrate, have scarcely been studied. Herein, inspired by the multi-Cu atom sites and the redox electron transfer pathway of Cu
    Language English
    Publishing date 2024-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c05245
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    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: How do natural resources and economic growth impact load capacity factor in selected Next-11 countries? Assessing the role of digitalization and government stability.

    Li, Xiaobin / Sun, Yizhong / Dai, Jiapeng / Mehmood, Usman

    Environmental science and pollution research international

    2023  Volume 30, Issue 36, Page(s) 85670–85684

    Abstract: With growing  environmental concerns, everyone's attention has shifted to how we use our limited materials supplies. Rapid economic expansion is dependent on heavy resource use, decreasing biodiversity and raising the ecological footprints (EF), ... ...

    Abstract With growing  environmental concerns, everyone's attention has shifted to how we use our limited materials supplies. Rapid economic expansion is dependent on heavy resource use, decreasing biodiversity and raising the ecological footprints (EF), resulting in a reduction in the load capacity factor (LCF). Because of this, scholars and policymakers are actively looking for approaches to improve the LCF without hindering economic growth (GDP). For similar reasons, this research aims at how the selected next eleven economies improved their LCF from 1990 to 2018 by analyzing the effect of digitalization (DIG), natural resources (NAT), GDP, globalization, and governance. To account for dependence across sections and slope variation, the cross-sectional augmented ARDL model is used in this research. The long-term findings indicate that LCF was diminished by dependence on NAT, globalization, and economic growth and was bolstered by DIG and sound governance. The work recommends that financial and policy support is needed for initiatives such as zero-emission vehicle production and energy-efficient building construction. By offering a line of credit at low interest rates, renewable energy projects can attract domestic and private investors.
    MeSH term(s) Economic Development ; Cross-Sectional Studies ; Carbon Dioxide ; Natural Resources ; Renewable Energy ; Internationality ; Government
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-07-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-28414-y
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  10. Article ; Online: ZNF143 facilitates the growth and migration of glioma cells by regulating KPNA2-mediated Hippo signalling.

    Chen, Yan / Li, Jitao / Ma, Jiangchun / Bao, Yizhong

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11097

    Abstract: The disordered expression of ZNF143 is closely related to the malignant progression of tumours. However, the basic control mechanism of ZNF143 in glioma has not yet been clarified. Therefore, we tried to find a new pathway to illustrate the function of ... ...

    Abstract The disordered expression of ZNF143 is closely related to the malignant progression of tumours. However, the basic control mechanism of ZNF143 in glioma has not yet been clarified. Therefore, we tried to find a new pathway to illustrate the function of ZNF143 in glioma. To explore the function of KPNA2 in the development of glioma, we used survival analysis by the Kaplan‒Meier method to assess the overall survival (OS) of patients with low and high KPNA2 expression in the TCGA and CGGA cohorts. Western blotting assays and RT‒PCR assays were utilized to determine the expression level of KPNA2 in glioma cells. The interaction between ZNF143 and KPNA2 was confirmed by ChIP assays. Proliferation was assessed by CCK-8 assays, and migration was evaluated by wound healing and Transwell assays. Apoptosis was determined by flow cytometry, and the expression level of YAP/TAZ was visualized using an immunofluorescence assay. The expression levels of LATS1, LATS2, YAP1, and p-YAP1 were determined. Patients with low KPNA2 expression showed a better prognosis than those with high KPNA2 expression. KPNA2 was found to be upregulated in human glioma cells. ZNF143 can bind to the promoter region of KPNA2. Downregulation of ZNF143 and KPNA2 can activate the Hippo signalling pathway and reduce YAP/TAZ expression in human glioma cells, thus inducing apoptosis of human glioma cells and weakening their proliferation, migration and invasion. In conclusion, ZNF143 mediates the Hippo/YAP signalling pathway and inhibits the growth and migration of glioma cells by regulating KPNA2.
    MeSH term(s) Humans ; Cell Proliferation ; Cell Movement/genetics ; Hippo Signaling Pathway ; Glioma/genetics ; Cell Line, Tumor ; Trans-Activators ; Protein Serine-Threonine Kinases/genetics ; Tumor Suppressor Proteins ; alpha Karyopherins/genetics
    Chemical Substances ZNF143 protein, human ; Trans-Activators ; LATS2 protein, human (EC 2.7.1.11) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Tumor Suppressor Proteins ; KPNA2 protein, human ; alpha Karyopherins
    Language English
    Publishing date 2023-07-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38158-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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