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  1. Article ; Online: The Uncertainty Associated with Moving Early.

    Hammond, Naomi E / Delaney, Anthony

    NEJM evidence

    2023  Volume 2, Issue 2, Page(s) EVIDe2200327

    Abstract: Some of the most common questions asked of clinicians caring for patients with critical illness are about prognosis: Will my loved one survive? If they do survive, at what cost to their quality of life? While some consolation can be provided that ... ...

    Abstract Some of the most common questions asked of clinicians caring for patients with critical illness are about prognosis: Will my loved one survive? If they do survive, at what cost to their quality of life? While some consolation can be provided that mortality rates for common conditions have fallen,
    MeSH term(s) Humans ; Uncertainty ; Quality of Life ; Hospitalization ; Patient Readmission ; Intensive Care Units
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Editorial
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDe2200327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia.

    Hills, Thomas / Delaney, Anthony / Young, Paul J

    The New England journal of medicine

    2024  Volume 390, Issue 8, Page(s) 769

    MeSH term(s) Humans ; Amikacin/therapeutic use ; Pneumonia, Ventilator-Associated/prevention & control ; Pneumonia, Ventilator-Associated/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Administration, Inhalation
    Chemical Substances Amikacin (84319SGC3C) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2400427
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  3. Article ; Online: Investigating microstructure evolution in block copolymer membranes.

    Cooper, Anthony J / Grzetic, Douglas J / Delaney, Kris T / Fredrickson, Glenn H

    The Journal of chemical physics

    2024  Volume 160, Issue 7

    Abstract: Block copolymer self-assembly in conjunction with nonsolvent-induced phase separation (SNIPS) has been increasingly leveraged to fabricate integral-asymmetric membranes. The large number of formulation and processing parameters associated with SNIPS, ... ...

    Abstract Block copolymer self-assembly in conjunction with nonsolvent-induced phase separation (SNIPS) has been increasingly leveraged to fabricate integral-asymmetric membranes. The large number of formulation and processing parameters associated with SNIPS, however, has prevented the reliable construction of high performance membranes. In this study, we apply dynamical self-consistent field theory to model the SNIPS process and investigate the effect of various parameters on the membrane morphology: solvent selectivity, nonsolvent selectivity, initial film composition, and glass transition composition. We examine how solvent selectivity and concentration of polymers in the film impact the structure of micelles that connect to form the membrane matrix. In particular, we find that preserving the order in the surface layer and forming a connection between the supporting and surface layer are nontrivial and sensitive to each parameter studied. The effect of each parameter is discussed, and suggestions are made for successfully fabricating viable block copolymer membranes.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0188196
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  4. Article: Ventilator-associated pneumonia: A problematic outcome for clinical trials.

    Young, Paul J / Delaney, Anthony / Hills, Thomas

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2023  Volume 25, Issue 4, Page(s) 159–160

    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    DOI 10.1016/j.ccrj.2023.10.005
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  5. Article ; Online: Fluid therapy in diabetic ketoacidosis.

    Ramanan, Mahesh / Delaney, Anthony / Venkatesh, Balasubramanian

    Current opinion in clinical nutrition and metabolic care

    2023  Volume 27, Issue 2, Page(s) 178–183

    Abstract: Purpose of review: To evaluate recent evidence (2021-2023) on fluid therapy in diabetic ketoacidosis. Key evidence gaps which require generation of new evidence are discussed.: Recent findings: Balanced crystalloid solutions, compared to the commonly ...

    Abstract Purpose of review: To evaluate recent evidence (2021-2023) on fluid therapy in diabetic ketoacidosis. Key evidence gaps which require generation of new evidence are discussed.
    Recent findings: Balanced crystalloid solutions, compared to the commonly recommended and used 0.9% sodium chloride solution (saline), may result in better outcomes for patients with diabetic ketoacidosis, including faster resolution of acidosis, less hyperchloremia and shorter hospital length of stay. Upcoming results from randomized trials may provide definitive evidence on the use of balanced crystalloid solutions in diabetic ketoacidosis. Evidence remains scarce or conflicting for the use of "two-bag" compared to conventional "one-bag" fluid, and rates of fluid administration, especially for adult patients. In children, concerns about cerebral oedema from faster fluid administration rates have not been demonstrated in cohort studies nor randomized trials.
    Summary: Fluid therapy is a key aspect of diabetic ketoacidosis management, with important evidence gaps persisting for several aspects of management despite recent evidence.
    MeSH term(s) Child ; Humans ; Diabetic Ketoacidosis/therapy ; Fluid Therapy/methods ; Saline Solution ; Diabetes Mellitus
    Chemical Substances Saline Solution
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0000000000001005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5586: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Protocolized Sepsis Care Is Not Helpful for Patients.

    Delaney, Anthony

    Critical care medicine

    2016  Volume 45, Issue 3, Page(s) 473–475

    MeSH term(s) Clinical Protocols ; Humans ; Patient Care Planning ; Sepsis/diagnosis ; Sepsis/mortality ; Sepsis/therapy
    Language English
    Publishing date 2016-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000001990
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    Zs.A 1261: Show issues Location:
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  7. Article ; Online: Balanced Electrolyte Solution or Saline in the Critically Ill. Reply.

    Hammond, Naomi / Delaney, Anthony / Finfer, Simon

    The New England journal of medicine

    2022  Volume 386, Issue 23, Page(s) 2249

    MeSH term(s) Adult ; Critical Illness/therapy ; Electrolytes ; Fluid Therapy ; Humans ; Saline Solution/therapeutic use
    Chemical Substances Electrolytes ; Saline Solution
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2204390
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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: Accuracy of International Classification of Disease Coding Methods to Estimate Sepsis Epidemiology: A Scoping Review.

    Kumar, Ashwani / Hammond, Naomi / Grattan, Sarah / Finfer, Simon / Delaney, Anthony

    Journal of intensive care medicine

    2023  Volume 39, Issue 1, Page(s) 3–11

    Abstract: Purpose: To provide an overview of various sepsis International Classification of Diseases (ICD) coding methods and their diagnostic accuracy.: Methods: We undertook a systematic scoping review between 1991 and 2020 (search terms: sepsis, coding, and ...

    Abstract Purpose: To provide an overview of various sepsis International Classification of Diseases (ICD) coding methods and their diagnostic accuracy.
    Methods: We undertook a systematic scoping review between 1991 and 2020 (search terms: sepsis, coding, and epidemiology) to include studies reporting the accuracy of a sepsis ICD coding method. Studies were grouped by ICD coding method, number of diagnostic accuracy parameters, ICD version, reference standard, design, country, setting, type of dataset and sepsis definition. ICD coding methods were categorised as explicit or implicit, with the explicit methods further divided into wide and narrow groups. Descriptive statistics were used to present data.
    Results: We analysed 17 studies, of which 16 (94.1%) used retrospective medical chart review as the reference standard for clinical sepsis, and eight (47.1%) used hospital administrative data to identify sepsis. There were 53 assessments of various ICD coding methods, with 32 (60.4%) of them being
    Conclusion: None of the current ICD coding methods is optimal for identifying sepsis.
    MeSH term(s) Humans ; International Classification of Diseases ; Retrospective Studies ; Sepsis/diagnosis ; Sepsis/epidemiology ; Hospitals ; Reference Standards
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/08850666231192371
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    Zs.A 2158: Show issues Location:
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  9. Article: Made to measure-Selecting outcomes in aneurysmal subarachnoid hemorrhage research.

    Andersen, Christopher R / English, Shane W / Delaney, Anthony

    Frontiers in neurology

    2022  Volume 13, Page(s) 1000454

    Abstract: There has been limited new high-level evidence generated to guide aneurysmal subarachnoid hemorrhage (aSAH) management in the past decade. The choice of outcome measures used in aSAH clinical trials may be one of the factors hindering progress. In this ... ...

    Abstract There has been limited new high-level evidence generated to guide aneurysmal subarachnoid hemorrhage (aSAH) management in the past decade. The choice of outcome measures used in aSAH clinical trials may be one of the factors hindering progress. In this narrative review we consider the current process for determining "what" to measure in aSAH and identify some of the shortcomings of these approaches. A consideration of the unique clinical course of aSAH is then discussed and how this impacts on selecting the best timepoints to assess change in the chosen constructs. We also review the how to critically appraise different measurement instruments and some of the issues with how these are applied in the context of aSAH. We conclude with current initiatives to improve outcome selection in aSAH and future directions in the research agenda.
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.1000454
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  10. Article: Fluids or vasopressors for the initial resuscitation of septic shock.

    Macdonald, Stephen / Peake, Sandra L / Corfield, Alasdair R / Delaney, Anthony

    Frontiers in medicine

    2022  Volume 9, Page(s) 1069782

    Abstract: Intravenous fluid resuscitation is recommended first-line treatment for sepsis-associated hypotension and/or hypoperfusion. The rationale is to restore circulating volume and optimize cardiac output in the setting of shock. Nonetheless, there is limited ... ...

    Abstract Intravenous fluid resuscitation is recommended first-line treatment for sepsis-associated hypotension and/or hypoperfusion. The rationale is to restore circulating volume and optimize cardiac output in the setting of shock. Nonetheless, there is limited high-level evidence to support this practice. Over the past decade emerging evidence of harm associated with large volume fluid resuscitation among patients with septic shock has led to calls for a more conservative approach. Specifically, clinical trials undertaken in Africa have found harm associated with initial fluid resuscitation in the setting of infection and hypoperfusion. While translating these findings to practice in other settings is problematic, there has been a re-appraisal of current practice with some recommending earlier use of vasopressors rather than repeated fluid boluses as an alternative to restore perfusion in septic shock. There is consequently uncertainty and variation in practice. The question of fluids or vasopressors for initial resuscitation in septic shock is the subject of international multicentre clinical trials.
    Language English
    Publishing date 2022-11-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1069782
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