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  1. Book: Cilia

    Satir, Peter / Christensen, Søren T.

    methods and protocols

    (Methods in molecular biology ; 1454 ; Springer protocols)

    2016  

    Author's details edited by Peter Satir, Søren Tvorup Christensen
    Series title Methods in molecular biology ; 1454
    Springer protocols
    Collection
    Keywords Drosophila ; Xenopus ; cell organelle ; ciliates ; flagellate algae ; motile cilia ; nematodes ; planaria ; sensory cilia ; zebrafish
    Language English
    Size XIV, 259 Seiten, Illustrationen, Diagramme, 25.4 cm x 17.8 cm, 0 g
    Publisher Humana Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT019075297
    ISBN 978-1-4939-3787-5 ; 1-4939-3787-1 ; 9781493937899 ; 1493937898
    Database Catalogue ZB MED Medicine, Health

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    Zs A 7042 -1454- verfügbar in Königswinter Königswinter

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  2. Article ; Online: The conserved ancestral signaling pathway from cilium to nucleus.

    Satir, Peter / Satir, Birgit H

    Journal of cell science

    2019  Volume 132, Issue 15

    Abstract: Many signaling molecules are localized to both the primary cilium and nucleus. Localization of specific transmembrane receptors and their signaling scaffold molecules in the cilium is necessary for correct physiological function. After a specific ... ...

    Abstract Many signaling molecules are localized to both the primary cilium and nucleus. Localization of specific transmembrane receptors and their signaling scaffold molecules in the cilium is necessary for correct physiological function. After a specific signaling event, signaling molecules leave the cilium, usually in the form of an endocytic vesicle scaffold, and move to the nucleus, where they dissociate from the scaffold and enter the nucleus to affect gene expression. This ancient pathway probably arose very early in eukaryotic evolution as the nucleus and cilium co-evolved. Because there are similarities in molecular composition of the nuclear and ciliary pores the entry and exit of proteins in both organelles rely on similar mechanisms. In this Hypothesis, we propose that the pathway is a dynamic universal cilia-based signaling pathway with some variations from protists to man. Everywhere the cilium functions as an important organelle for molecular storage of certain key receptors and selection and concentration of their associated signaling molecules that move from cilium to nucleus. This could also have important implications for human diseases such as Huntington disease.
    MeSH term(s) Animals ; Cell Nucleus/metabolism ; Cell Nucleus/pathology ; Cilia/metabolism ; Cilia/pathology ; Humans ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Models, Biological ; Signal Transduction
    Language English
    Publishing date 2019-08-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.230441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: CILIA: before and after.

    Satir, Peter

    Cilia

    2017  Volume 6, Page(s) 1

    Abstract: This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beginning of the new millennium, although ... ...

    Abstract This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beginning of the new millennium, although sensory and primary cilia were well described, research was largely focused on motile cilia, their structure, movement, and biogenesis. After IFT and the link to PKD, although work on motile cilia has continued to progress, research on primary cilia has exploded, leading to new insights into the role of cilia in cell signaling and development. Genomics, proteomics, and new imaging techniques have unified the field and pointed out the critical role of cilia as a restricted cell organellar compartment, functionally integrated with other cell organelles including the autophagosome and the nucleus.
    Language English
    Publishing date 2017-03-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2689513-4
    ISSN 2046-2530
    ISSN 2046-2530
    DOI 10.1186/s13630-017-0046-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chirality of the cytoskeleton in the origins of cellular asymmetry.

    Satir, Peter

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2016  Volume 371, Issue 1710

    Abstract: Self-assembly of two important components of the cytoskeleton of eukaryotic cells, actin microfilaments and microtubules (MTs) results in polar filaments of one chirality. As is true for bacterial flagella, in actin microfilaments, screw direction is ... ...

    Abstract Self-assembly of two important components of the cytoskeleton of eukaryotic cells, actin microfilaments and microtubules (MTs) results in polar filaments of one chirality. As is true for bacterial flagella, in actin microfilaments, screw direction is important for assembly processes and motility. For MTs, polar orientation within the cell is paramount. The alignment of these elements in the cell cytoplasm gives rise to emergent properties, including the potential for cell differentiation and specialization. Complex MTs with a characteristic chirality are found in basal bodies and centrioles; this chirality is preserved in cilia. In motile cilia, it is reflected in the direction of the effective stroke. The positioning of the basal body or cilia on the cell surface depends on polarity proteins. In evolution, survival depends on global polarity information relayed to the cell in part by orientation of the MT and actin filament cytoskeletons and the chirality of the basal body to determine left and right coordinates within a defined anterior-posterior cell and tissue axis.This article is part of the themed issue 'Provocative questions in left-right asymmetry'.
    MeSH term(s) Actin Cytoskeleton/metabolism ; Biological Evolution ; Cytoskeleton/metabolism ; Eukaryotic Cells/cytology ; Microtubules/metabolism
    Language English
    Publishing date 2016--19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2015.0408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  5. Article ; Online: Onward from the cradle.

    Satir, Peter

    Molecular biology of the cell

    2014  Volume 25, Issue 21, Page(s) 3277–3279

    Abstract: This essay records a voyage of discovery from the "cradle of cell biology" to the present, focused on the biology of the oldest known cell organelle, the cilium. In the "romper room" of cilia and microtubule (MT) biology, the sliding MT hypothesis of ... ...

    Abstract This essay records a voyage of discovery from the "cradle of cell biology" to the present, focused on the biology of the oldest known cell organelle, the cilium. In the "romper room" of cilia and microtubule (MT) biology, the sliding MT hypothesis of ciliary motility was born. From the "summer of love," students and colleagues joined the journey to test switch-point mechanisms of motility. In the new century, interest in nonmotile (primary) cilia, never lost from the cradle, was rekindled, leading to discoveries relating ciliogenesis to autophagy and hypotheses of how molecules cross ciliary necklace barriers for cell signaling.
    MeSH term(s) Cell Biology/history ; Chlamydomonas/cytology ; Chlamydomonas/metabolism ; Cilia/ultrastructure ; History, 20th Century ; History, 21st Century ; Humans
    Language English
    Publishing date 2014-10-29
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E14-05-1014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 410: Show issues

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  6. Article ; Online ; Conference proceedings: The new biology of cilia: review and annotation of a symposium.

    Satir, Peter

    Developmental dynamics : an official publication of the American Association of Anatomists

    2012  Volume 241, Issue 2, Page(s) 426–430

    MeSH term(s) Animals ; Cell Biology/history ; Cell Biology/trends ; Cilia/physiology ; Cilia/ultrastructure ; History, 20th Century ; History, 21st Century
    Language English
    Publishing date 2012-02
    Publishing country United States
    Document type Congresses ; Historical Article
    ZDB-ID 1102541-4
    ISSN 1097-0177 ; 1058-8388
    ISSN (online) 1097-0177
    ISSN 1058-8388
    DOI 10.1002/dvdy.23713
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  7. Article ; Online: Coiled-coils and motile cilia.

    Satir, Peter

    Nature genetics

    2011  Volume 43, Issue 1, Page(s) 10–11

    MeSH term(s) Animals ; Cilia/metabolism ; Cilia/ultrastructure ; Humans ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism
    Chemical Substances Microtubule-Associated Proteins
    Language English
    Publishing date 2011-01-07
    Publishing country United States
    Document type Comment ; News
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/ng0111-10
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  8. Book ; Conference proceedings: Signal transduction in cytoplasmic organization and cell motility

    Satir, Peter

    proceedings of a UCLA symposium held in Lake Tahoe, Calif., Febr. 15 - 21, 1987

    (UCLA Symposia on Molecular and Cellular Biology ; N.S.,77)

    1988  

    Institution University of California Los Angeles
    Event/congress Symposium on Signal Transduction in Cytoplasmic Organization and Cell Motility (1987, TahoeCityCalif.)
    Author's details [UCLA Symposium on Signal Transduction in Cytoplasmic Organization and Cell Motility]. Ed.: Peter Satir
    Series title UCLA Symposia on Molecular and Cellular Biology ; N.S.,77
    Collection
    Keywords Cell Movement / congresses ; Cytoplasm / metabolism / congresses ; Signal Transduction / congresses ; Cytoplasma ; Erregungsleitung ; Zellkommunikation
    Subject Zelle ; Interzelluläre Kommunikation ; Zell-Zell-Interaktion ; Zellinteraktion ; Cell-to-Cell Interaction ; Cell-to-Cell communication ; Reizleitung ; Nervenleitung ; Zellplasma ; Zytoplasma
    Size XVIII, 386 S. : Ill., graph. Darst.
    Publisher Liss
    Publishing place New York
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003248624
    ISBN 0-8451-2676-8 ; 978-0-8451-2676-9
    Database Catalogue ZB MED Medicine, Health

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    1989 A 650 order for loan Magazin

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  9. Article: Oxidized Regenerated Cellulose can be a Cause of False Tumor Recurrence on PET/CT in Patients with Lung Cancer Treated Surgically.

    Sayan, Muhammet / Çelik, Ali / Şatır Türk, Merve / Özkan, Dilvin / Akarsu, Irmak / Yazıcı, Ozan / Aydos, Uğuray / Yılmaz Demirci, Nilgün / Akyol, Gülen / Kurul, İsmail Cüneyt / Taştepe, Abdullah İrfan

    Molecular imaging and radionuclide therapy

    2023  Volume 32, Issue 1, Page(s) 8–12

    Abstract: ... computed tomography (CT) and, if necessary, positron emission tomography (PET)/CT. Sometimes, inflammatory ... ORC) used intraoperatively may cause false tumor recurrence on PET/CT.: Methods: The records ... criteria were the presence of local recurrence of cancer on PET/CT, specification of using ORC ...

    Abstract Objectives: Regular follow-up of patients with lung cancer treated surgically is crucial to detect local recurrence or distant metastasis of the tumor. Postoperative follow-ups are performed with thorax computed tomography (CT) and, if necessary, positron emission tomography (PET)/CT. Sometimes, inflammatory tissue reactions due to the materials used during the surgery for hemostasis may cause the appearance of tumor recurrence in imaging modalities. In this study, we presented that oxidized regenerated cellulose (ORC) used intraoperatively may cause false tumor recurrence on PET/CT.
    Methods: The records of patients who had local tumor recurrence after lung cancer surgery was reviewed retrospectively. Inclusion criteria were the presence of local recurrence of cancer on PET/CT, specification of using ORC in the surgical notes, and histopathological diagnosis of the recurrence site of tumor was reported as a foreign body reaction. Data of patients were collected according to age, gender, surgery performed, adjuvant therapy status, resolution status and time ORC, and standard uptake value of
    Results: Eleven patients (1 female, 10 males) who met the criteria were included in the study. The median age was 64. Histopathological results of all patients were reported as foreign body reactions. The median detection time of PET/CT positivity after surgery was 139 days (range: 52-208 days). False tumor recurrence was resolved in 8 patients (72.7%) in their control radiological examinations and median resolution time was 334 days (range: 222-762 days). The median maximum standard uptake value of the lesions was 6.2 (1.7-11) on the PET/CT.
    Conclusion: ORC used intraoperatively in patients undergoing surgery for lung cancer may cause false tumor recurrence in imaging modalities in postsurgical follow-ups. When tumor recurrence is suspected in the follow-up of these patients, histopathological confirmation is necessary to prevent unnecessary operations and treatments.
    Language English
    Publishing date 2023-02-11
    Publishing country Turkey
    Document type Journal Article
    ISSN 2146-1414
    ISSN 2146-1414
    DOI 10.4274/mirt.galenos.2022.20082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Controlling the direction of division.

    Satir, Peter

    Stem cell research & therapy

    2010  Volume 1, Issue 3, Page(s) 21

    Abstract: Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing ... ...

    Abstract Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia?
    MeSH term(s) Adenomatous Polyposis Coli Protein/genetics ; Animals ; Cell Division ; Cell Polarity/genetics ; Cilia/metabolism ; Gastrointestinal Tract/cytology ; Gastrointestinal Tract/growth & development ; Humans ; Kidney Tubules/cytology ; Kidney Tubules/growth & development ; Mice ; Spindle Apparatus/metabolism ; Stem Cells/metabolism ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Wnt Signaling Pathway/genetics
    Chemical Substances APC protein, human ; Adenomatous Polyposis Coli Protein ; Wnt Proteins
    Language English
    Publishing date 2010-07-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/scrt21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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