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  1. Article: Has Covid-19 permanently changed online purchasing behavior?

    Inoue, Hiroyasu / Todo, Yasuyuki

    EPJ data science

    2023  Volume 12, Issue 1, Page(s) 1

    Abstract: This study examines how the COVID-19 pandemic has affected online purchasing behavior using data from a major online shopping platform in Japan. We focus on the effect of two measures of the pandemic, i.e., the number of positive COVID-19 cases and state ...

    Abstract This study examines how the COVID-19 pandemic has affected online purchasing behavior using data from a major online shopping platform in Japan. We focus on the effect of two measures of the pandemic, i.e., the number of positive COVID-19 cases and state declarations of emergency to mitigate the pandemic. We find that both measures promoted online purchases at the beginning of the pandemic, but in later periods, their effect faded. In addition, online purchases returned to normal after states of emergency ended, and the overall time trend in online purchases excluding the effects of the two measures was stable during the first two years of the pandemic. These results suggest that the effect of the pandemic on online purchasing behavior is temporary and will not persist after the pandemic.
    Supplementary information: The online version contains supplementary material available at 10.1140/epjds/s13688-022-00375-1.
    Language English
    Publishing date 2023-01-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2705691-0
    ISSN 2193-1127
    ISSN 2193-1127
    DOI 10.1140/epjds/s13688-022-00375-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Disruption of international trade and its propagation through firm-level domestic supply chains: A case of Japan.

    Inoue, Hiroyasu / Todo, Yasuyuki

    PloS one

    2023  Volume 18, Issue 11, Page(s) e0294574

    Abstract: This study simulates how the disruption of imports from various regions affects the total production of the importer economy. We particularly incorporate the propagation of the economic effect through domestic supply chains using data on more than one ... ...

    Abstract This study simulates how the disruption of imports from various regions affects the total production of the importer economy. We particularly incorporate the propagation of the economic effect through domestic supply chains using data on more than one million firms and four million supply chain ties in Japan. Our findings are summarized as follows. First, the negative effect of the disruption of intermediate imports grows exponentially as its duration and strength increase due to downstream propagation. Second, the propagation of the economic effect is substantially affected by the network topology of importers, such as the number of importers (affected nodes) and their degree of upstreamness in supply chains, whereas the effect of their degree centrality is heterogeneous depending on their degree of upstreamness. Finally, the negative effect of import disruption can be mitigated by the reorganization of domestic supply chains, even when conducted only among network neighbors. Our findings provide important policy and managerial implications for the achievement of more robust and resilient global supply chains.
    MeSH term(s) Humans ; Commerce ; Internationality ; Japan
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0294574
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  3. Article ; Online: Disruption of international trade and its propagation through firm-level domestic supply chains

    Hiroyasu Inoue / Yasuyuki Todo

    PLoS ONE, Vol 18, Iss 11, p e

    A case of Japan.

    2023  Volume 0294574

    Abstract: This study simulates how the disruption of imports from various regions affects the total production of the importer economy. We particularly incorporate the propagation of the economic effect through domestic supply chains using data on more than one ... ...

    Abstract This study simulates how the disruption of imports from various regions affects the total production of the importer economy. We particularly incorporate the propagation of the economic effect through domestic supply chains using data on more than one million firms and four million supply chain ties in Japan. Our findings are summarized as follows. First, the negative effect of the disruption of intermediate imports grows exponentially as its duration and strength increase due to downstream propagation. Second, the propagation of the economic effect is substantially affected by the network topology of importers, such as the number of importers (affected nodes) and their degree of upstreamness in supply chains, whereas the effect of their degree centrality is heterogeneous depending on their degree of upstreamness. Finally, the negative effect of import disruption can be mitigated by the reorganization of domestic supply chains, even when conducted only among network neighbors. Our findings provide important policy and managerial implications for the achievement of more robust and resilient global supply chains.
    Keywords Medicine ; R ; Science ; Q
    Subject code 950
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Simulation of supply chain disruptions considering establishments and power outages.

    Inoue, Hiroyasu / Okumura, Yoshihiro / Torayashiki, Tetsuya / Todo, Yasuyuki

    PloS one

    2023  Volume 18, Issue 7, Page(s) e0288062

    Abstract: In this paper, we simulate the economic loss resulting from supply chain disruptions triggered by the Great East Japan Earthquake (GEJE) in 2011, applying data from firm-level supply chains and establishment-level attributes to an agent-based model. To ... ...

    Abstract In this paper, we simulate the economic loss resulting from supply chain disruptions triggered by the Great East Japan Earthquake (GEJE) in 2011, applying data from firm-level supply chains and establishment-level attributes to an agent-based model. To enhance the accuracy of the simulation, we extend data and models in previous studies in four ways. First, we identify the damage to production facilities in the disaster-hit regions more accurately by using establishment-level census and survey data and geographic information system (GIS) data on the damages caused by the GEJE and subsequent tsunami. Second, the use of establishment-level data enables us to capture supply chains between non-headquarter establishments in disaster-hit regions and establishments in other regions. Third, we incorporate the effect of power outages after the GEJE on production reduction, which exacerbated the effect of the supply chain disruption, particularly in the weeks immediately after the GEJE. Finally, our model incorporates sectoral heterogeneity by employing sector-specific parameters. Our findings indicate that the extended method can significantly improve the accuracy of predicting the domestic production after the GEJE, particularly due to the first three improvements utilizing various data sources, not because of the use of more sector-specific parameters. Our method can be applied to predict the economic effect of future disasters, such as the Nankai Trough earthquake, on each region more precisely.
    MeSH term(s) Disasters ; Earthquakes ; Tsunamis ; Computer Simulation ; Surveys and Questionnaires ; Japan
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0288062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: The Coexistence of Infection Spread Patterns in the Global Dynamics of COVID-19 Dissemination

    Inoue, Hiroyasu / Souma, Wataru / Fujiwara, Yoshi

    2024  

    Abstract: The novel coronavirus SARS-CoV-2, commonly referred to as COVID-19, triggered the global pandemic. Although the nature of the international spread of infection is an important issue, extracting diffusion networks from observations is challenging because ... ...

    Abstract The novel coronavirus SARS-CoV-2, commonly referred to as COVID-19, triggered the global pandemic. Although the nature of the international spread of infection is an important issue, extracting diffusion networks from observations is challenging because of its inherent complexity. In this paper, we investigate the process of infection worldwide, including time delays, based on global infection case data collected from January 3, 2020 to December 31, 2022. We approach the data with a complex Hilbert principal component analysis, which can consider not only the concurrent relationships between elements, but also the leading and lagging relationships. Then, we examine the interactions among countries by considering six factors: geography, population, GDP, stringency of countermeasures, vaccination rates, and government type. The results show two primary trends occurring in 2020 and in 2021-2022 and they interchange with each other. Specifically, European, highly populated, and democratic countries, i.e., countries with high mobility rates, show leading trends in 2020. In contrast, African and nondemocratic countries show leading trends in 2021-2022, followed by countries with high vaccination rates and advanced countermeasures. The results reveal that, although factors that increase infection risk lead to certain trends at the beginning of the pandemic, these trends dynamically changes over time due to socioeconomic factors, especially the introduction of countermeasures. The findings suggest that international efforts to promote countermeasures in developing countries can contribute to pandemic containment.
    Keywords Computer Science - Social and Information Networks ; Physics - Physics and Society
    Subject code 306
    Publishing date 2024-01-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Immunological Response to Subcutaneous and Intranasal Administration of SARS-CoV-2 Spike Protein in Mice.

    Kinoshita, Mao / Muranishi, Kentaro / Kawaguchi, Ken / Sudo, Kazuki / Inoue, Keita / Ishikura, Hiroyasu / Sawa, Teiji

    Vaccines

    2024  Volume 12, Issue 4

    Abstract: In novel coronavirus infection (COVID-19), the outbreak of acute lung injury due to trans-airway infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the starting point of severe disease. The COVID-19 pandemic highlights the ...

    Abstract In novel coronavirus infection (COVID-19), the outbreak of acute lung injury due to trans-airway infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the starting point of severe disease. The COVID-19 pandemic highlights the need for a vaccine that prevents not only the disease but also its infection. Currently, the SARS-CoV-2 vaccine is administered via intramuscular injection and is generally not immunogenic to the mucosa. As a result, current vaccinations fail to reduce viral shedding and transmission and ultimately do not prevent infection. We established a mouse vaccine model in which a single dose of S1 protein and aluminum oxide gel (alum) subcutaneous vaccine was followed by a booster dose of S1 protein and CpG oligodeoxynucleotide intranasal vaccine. The group that received two doses of the intranasal vaccine booster showed a significant increase in IgG and IgA antibody titers against S1 and RBD in serum and BAL, and a significant difference in neutralizing antibody titers, particularly in BAL. One intranasal vaccine booster did not induce sufficient immunity, and the vaccine strategy with two booster intranasal doses produced systemic neutralizing antibodies and mucus-neutralizing antibodies against SARS-CoV-2. It will be an important tool against the emergence of new viruses and the next pandemic.
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12040343
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  7. Article ; Online: Relationships of Radiation Dose Indices with Body Size Indices in Adult Body Computed Tomography.

    Inoue, Yusuke / Itoh, Hiroyasu / Nagahara, Kazunori / Hata, Hirofumi / Mitsui, Kohei

    Tomography (Ann Arbor, Mich.)

    2023  Volume 9, Issue 4, Page(s) 1381–1392

    Abstract: We investigated the relationships between radiation dose indices and body size indices in adult body computed tomography (CT). A total of 3200 CT scans of the thoracic, abdominal, abdominopelvic, or thoraco-abdominopelvic regions performed using one of ... ...

    Abstract We investigated the relationships between radiation dose indices and body size indices in adult body computed tomography (CT). A total of 3200 CT scans of the thoracic, abdominal, abdominopelvic, or thoraco-abdominopelvic regions performed using one of four CT scanners were analyzed. Volume CT dose index (CTDIvol) and dose length product (DLP) were compared with various body size indices derived from CT images (water-equivalent diameter, WED; effective diameter, ED) and physical measurements (weight, weight/height, body mass index, and body surface area). CTDIvol showed excellent positive linear correlations with WED and ED. CTDIvol also showed high linear correlations with physical measurement-based indices, whereas the correlation coefficients were lower than for WED and ED. Among the physical measurement-based indices, weight/height showed the strongest correlations, followed by weight. Compared to CTDIvol, the correlation coefficients with DLP tended to be lower for WED, ED, and weight/height and higher for weight. The standard CTDIvol values at 60 kg and dose increase ratios with increasing weight, estimated using the regression equations, differed among scanners. Radiation dose indices closely correlated with body size indices such as WED, ED, weight/height, and weight. The relationships between dose and body size differed among scanners, indicating the significance of dose management considering body size.
    MeSH term(s) Adult ; Humans ; Radiation Dosage ; Tomography, X-Ray Computed/methods ; Body Size ; Tomography Scanners, X-Ray Computed ; Phantoms, Imaging
    Language English
    Publishing date 2023-07-14
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography9040110
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  8. Article ; Online: Does regional quota status affect the performance of undergraduate medical students in Japan? A 10-year analysis.

    Ozeki, Satoshi / Kasamo, Sachiko / Inoue, Hiroyasu / Matsumoto, Seiji

    International journal of medical education

    2022  Volume 13, Page(s) 307–314

    Abstract: Objectives: This study aims to determine whether there is a difference in the academic performance of medical students based on admission type and examine the extent to which entrance examinations predict their performance.: Methods: This ... ...

    Abstract Objectives: This study aims to determine whether there is a difference in the academic performance of medical students based on admission type and examine the extent to which entrance examinations predict their performance.
    Methods: This observational study utilized existing data from Asahikawa Medical University. Participants were 1057 medical students who had enrolled between 2010 and 2019. Analysis of variance and Tukey's test were utilized to identify differences between admission types. The multiple linear regression explored predictors of cumulative grade point average for each type.
    Results: Analysis of variance showed significant differences in the National Center Test (F
    Conclusions: Regional quota students earned a higher cumulative grade point average than those from general admissions, despite their significantly lower scores on the National Center Test. Enhanced utilization of regional quota admissions could become an effective strategy to increase the rural physician workforce.
    MeSH term(s) Female ; Humans ; Students, Medical ; Japan ; Universities ; Physical Examination ; Physicians
    Language English
    Publishing date 2022-11-30
    Publishing country England
    Document type Observational Study ; Journal Article
    ISSN 2042-6372
    ISSN (online) 2042-6372
    DOI 10.5116/ijme.6372.1fce
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Differences in preoperative function and outcome of patients with versus without sarcopenia after total hip arthroplasty.

    Koto, Satoshi / Ikeda, Takashi / Inoue, Shunya / Inoue, Hiroyasu / Watanabe, Minoru

    Journal of physical therapy science

    2022  Volume 34, Issue 1, Page(s) 60–64

    Abstract: Purpose] Public attention regarding sarcopenia has increased in recent years. Patients with sarcopenia reportedly show worse return home rates and activities of daily living at discharge. However, no reports have described the function and outcomes of ... ...

    Abstract [Purpose] Public attention regarding sarcopenia has increased in recent years. Patients with sarcopenia reportedly show worse return home rates and activities of daily living at discharge. However, no reports have described the function and outcomes of hip osteoarthrosis patients with sarcopenia after total hip arthroplasty. This study aimed to clarify differences in preoperative physical function and outcomes of hip osteoarthrosis patients with versus without sarcopenia after total hip arthroplasty. [Participants and Methods] Twenty-five patients with hip osteoarthrosis who underwent total hip arthroplasty were included. Evaluation items were preoperative skeletal muscle mass of the extremities, isometric strength of the lower extremities (hip abduction and knee extension), grip strength, and the 10-m timed gait test results. [Results] The prevalence of sarcopenia was 8% (2/25 patients). The sarcopenic group displayed lower skeletal muscle mass index, grip strength, and 10-m timed gait test values. The sarcopenic group showed lower muscle mass in the upper and lower limbs and trunk and lower hip abductor strength than the non-sarcopenic group. [Conclusion] Eight percent of patients developed sarcopenia after total hip arthroplasty. Due to the low average age (66.0 ± 9.5 years), the prevalence was lower than that of other orthopedic diseases.
    Language English
    Publishing date 2022-01-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.34.60
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Synthesis of π-Extended Carbazole Dimers Via Oxidative Cyclization Using DDQ and Sulfonic Acid and Elucidation of the Reaction Mechanism.

    Iwanaga, Tetsuo / Oki, Tomohiro / Morioka, Yoshihiro / Inoue, Shoichiro / Sato, Hiroyasu

    The Journal of organic chemistry

    2022  Volume 87, Issue 21, Page(s) 14855–14860

    Abstract: This paper describes the synthesis of various π-extended carbazole dimers via intramolecular oxidative cyclization using a chain precursor consisting of two carbazole units bridged by a nitrogen atom. A careful selection of the reaction conditions using ... ...

    Abstract This paper describes the synthesis of various π-extended carbazole dimers via intramolecular oxidative cyclization using a chain precursor consisting of two carbazole units bridged by a nitrogen atom. A careful selection of the reaction conditions using 2,3-dichloro-5,6-dicyano-
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c01571
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