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  1. Article: Das Gespräch: Maria Michalk, neue gesundheitspolitische Sprecherin der CDU/CSU-Fraktion im Bundestag, über ihre Ziele

    Beerheide, Rebecca / Michalk, Maria / Maibach-Nagel, Egbert

    Deutsches Ärzteblatt : Ausgabe A, Praxis-Ausgabe : niedergelassene Ärzte

    2015  Volume 112, Issue 38, Page(s) 1502

    Language German
    Document type Article
    ZDB-ID 1453475-7
    ISSN 0012-1207
    Database Current Contents Medicine

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  2. Article ; Conference proceedings: Aktuelle Ergebnisse der EGFR-Mutationsanalysen beim fortgeschrittenen nichtkleinzelligen Bronchialkarzinom des Lungenkrebszentrums des Krankenhauses Martha-Maria Halle-Dölau

    Haak, G / Nagel, S / Schütte, W / Steinert, M / Böhnke, A / Hauptmann, S

    Pneumologie

    2010  

    Abstract: Einleitung: Seit November 2009 erfolgt die systematische Untersuchung und Erfassung des Mutationsstatus des endothelial growth factors in allen in unserer Einrichtung neu diagnostizierten fortgeschrittenen nichtkleinzelligen Bronchialkarzinome. Dies ... ...

    Event/congress 12. Herbsttagung der Mitteldeutschen Gesellschaft für Pneumologie, Zeulenroda, 2010
    Abstract Einleitung: Seit November 2009 erfolgt die systematische Untersuchung und Erfassung des Mutationsstatus des endothelial growth factors in allen in unserer Einrichtung neu diagnostizierten fortgeschrittenen nichtkleinzelligen Bronchialkarzinome. Dies geschieht vorrangig im Rahmen der durch AstraZeneca deutschlandweit initiierten nicht-interventionellen REASON-Studie. Ziel ist die epidemiologische Erfassung und wissenschaftliche Auswertung des EGFR-Mutationsstatus bei neu diagnostizierten lokal fortgeschrittenen oder metastasierten nichtkleinzelligen Bronchialkarzinomen des klinischen Stadiums IIIb oder IV von Patienten kaukasischen Ursprungs. Dieser Mutationsstatus spielt nach derzeitigem Kenntnisstand eine wesentliche Rolle beim Therapieerfolg der malignen Erkrankung mit Tyrosinkinaseinhibitoren. Voraussetzung für eine Therapie mit Gefitinib (IRESSA®) in der Erstlinie ist der Nachweis einer aktivierenden Mutation in den entsprechenden Exonen 18, 19, 20 oder 21 des für die Tyrosinkinase des EGF-Rezeptor kodierenden Abschnitts des Chromosoms 7p12.
    Methoden: Die entsprechend notwendigen PCR-Analysen führt die molekularpathologische Abteilung des Intituts für Pathologie der MLU Halle durch. In unserer pneumologischen Ambulanz erfolgt die Erfassung und Aufarbeitung der erhaltenen Befunde.
    Ergebnisse: Zum Zeitpunkt der Erarbeitung des Abstracts hat unsere Klinik 40 Analysen erfasst. In diesem Patientengut wurden 6 Mutationen erfasst.
    Diskussion: In unserem Patientengut detektierten wir derzeit einen 15%igen Anteil an aktivierenden Mutationen der Tyrosinkinase des EGF-Rezeptors. Dieser Anteil entspricht den Literaturangaben. Aktuelle Daten werden auf der 12. Herbsttagung der MDGP demonstriert.
    Language German
    Publishing date 2010-11-10
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-2010-1268885
    Database Thieme publisher's database

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  3. Book: Gesprächsführung in der Altenpflege

    Langfeldt-Nagel, Maria

    Lehrbuch

    (Reinhardts Gerontologische Reihe ; 32)

    2017  

    Author's details Maria Langfeldt-Nagel
    Series title Reinhardts Gerontologische Reihe ; 32
    Reinhardts gerontologische Reihe
    Collection Reinhardts gerontologische Reihe
    Keywords Alltagsbegleiter und BetreuungsassistentInnen in Alteneinrichtungen, regionale Betreuungsgruppen, soziale Dienste in Wohn- und Hausgemeinschaften, Ambulante Pflegedienste u. Tagespflegeeinrichtungen, pflegende Angehörige etc. ; altenpflege ; gerontologie ; gesprächsführung ; kommunikation ; Gerontologie & Pflege ; Altenpflege ; Kommunikation ; Gesprächsführung
    Subject Alter ; Altenpflegekonzept ; Altenkrankenpflege ; Geriatrische Altenpflege ; Gesprächstechnik ; Kommunikationsprozess ; Informationsprozess
    Language German
    Size 252 Seiten, 20 Illustrationen
    Edition 3., überarbeitete Auflage
    Publisher Ernst Reinhardt Verlag
    Publishing place München
    Publishing country Germany
    Document type Book
    HBZ-ID HT019210979
    ISBN 978-3-497-02697-5 ; 3-497-02697-2 ; 9783497603930 ; 3497603937
    Database Catalogue ZB MED Medicine, Health

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    2017 A 521 available for loan (reading room) Lesesaal EG

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  4. Book: Gesprächsführung in der Altenpflege

    Langfeldt-Nagel, Maria

    Lehrbuch ; mit 7 Tabellen

    (Reinhardts gerontologische Reihe ; 32)

    2011  

    Author's details Maria Langfeldt-Nagel
    Series title Reinhardts gerontologische Reihe ; 32
    Collection
    Keywords Altenpflege ; Kommunikation ; Gesprächsführung
    Subject Gesprächstechnik ; Kommunikationsprozess ; Informationsprozess ; Alter ; Altenpflegekonzept ; Altenkrankenpflege ; Geriatrische Altenpflege
    Subject code 362.61014
    Language German
    Size 256 S. : Ill., 22 cm
    Edition 2., aktualisierte Aufl.
    Publisher Reinhardt
    Publishing place München u.a.l
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT016882888
    ISBN 978-3-497-02232-8 ; 3-497-02232-2
    Database Catalogue ZB MED Medicine, Health

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    2011 A 2893 order for loan Magazin

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  5. Article ; Online: Herpes Zoster, a Rash of Cerebrovascular Events.

    Nagel, Maria A / Bubak, Andrew N

    Mayo Clinic proceedings

    2019  Volume 94, Issue 5, Page(s) 742–744

    MeSH term(s) Exanthema ; Herpes Zoster ; Herpesvirus 3, Human ; Humans
    Language English
    Publishing date 2019-04-13
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2019.03.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: What have we learned from the real-world efficacy of FFA in DS and LGS? A post-marketing study in clinical practice.

    Valls Carbó, Adrián / Beltrán, Álvaro / Sánchez-Miranda Román, Irene / Cabal, Borja / Gómez-Porro, Pablo / Aledo-Serrano, Ángel / López Sobrino, Gloria / Ayuga, Fernando / Gómez Eguilaz, María / Gil-Nagel, Antonio

    Epilepsy & behavior : E&B

    2024  Volume 151, Page(s) 109620

    Abstract: Objective: To evaluate the effectiveness and tolerability of fenfluramine (FFA) in routine clinical practice treating real-world populations with Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS).: Methods: This was a retrospective analysis of ... ...

    Abstract Objective: To evaluate the effectiveness and tolerability of fenfluramine (FFA) in routine clinical practice treating real-world populations with Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS).
    Methods: This was a retrospective analysis of patients with DS or LGS who initiated FFA treatment from 2018 to 2022 at a single center. Patient demographics, medical history, seizure characteristics, and treatment outcomes were collected from electronic medical records. Duration of FFA treatment, dosage regimens, seizure frequency, seizure severity, improvements in cognitive, social, and motor outcomes, and adverse events were extracted and analyzed. Effectiveness was assessed using ≥50 % sustained reduction in monthly seizure frequency vs baseline for ≥2 consecutive months at 12 months; seizure freedom was a secondary measure.
    Results: Seizure frequency data was available for 56 of 68 patients included in the study. At 12 months, 50 patients (89.3 %) remained on FFA treatment; 58 % of these patients achieved a ≥50 % sustained response and 10 % experienced seizure freedom. Cognitive, motor, and social improvement were noted in 70.7 %, 36.2 %, and 27.6 % of patients, respectively. The total number of concomitant antiseizure medications was reduced by ≥1 in 29.4 % of patients. No differences were found between DS and LGS patients in these outcomes; age at start of FFA and age at the 12-month timepoint did not have an effect. At least one AE was experienced by 59.7% of patients; in 86.5% of the cases, AEs were plausibly related to treatment. While 70.3% of AEs were self-resolving and 81.8% of the remaining patients experienced mild AEs, 1 patient experienced a serious AE unrelated to FFA which resulted in the patient's death. There were no cases of pulmonary arterial hypertension or ventricular heart disease.
    Significance: The effectiveness and tolerability of FFA treatment in patients with DS or LGS in this retrospective analysis of real-world data were consistent with those seen in randomized clinical trials.
    MeSH term(s) Humans ; Lennox Gastaut Syndrome/drug therapy ; Anticonvulsants/adverse effects ; Retrospective Studies ; Fenfluramine/therapeutic use ; Epilepsies, Myoclonic/drug therapy ; Seizures
    Chemical Substances Anticonvulsants ; Fenfluramine (2DS058H2CF)
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2024.109620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Varicella Zoster Virus Vasculopathy.

    Nagel, Maria A / Bubak, Andrew N

    The Journal of infectious diseases

    2018  Volume 218, Issue suppl_2, Page(s) S107–S112

    Abstract: Varicella zoster virus (VZV) is a ubiquitous, exclusively human alphaherpesvirus that produces varicella then becomes latent in ganglionic neurons. In elderly and immunocompromised individuals, VZV reactivates and typically produces herpes zoster. ... ...

    Abstract Varicella zoster virus (VZV) is a ubiquitous, exclusively human alphaherpesvirus that produces varicella then becomes latent in ganglionic neurons. In elderly and immunocompromised individuals, VZV reactivates and typically produces herpes zoster. Studies of patients with VZV vasculopathy have identified key clinical, imaging, and laboratory features to assist in diagnosis and treatment. Complementary studies have further expanded the spectrum of VZV vasculopathy to include the extracranial circulation and identified mechanisms contributing to its pathogenesis. Given our increasing aging population and recognition that VZV reactivation manifesting as zoster is a risk factor for stroke and myocardial infarction, recognition of VZV as a potential cause of vascular disease with or without associated zoster rash is essential to decrease associated morbidity and mortality because VZV vasculopathy can be treated with antiviral therapy.
    MeSH term(s) Antiviral Agents/therapeutic use ; Aortic Diseases/virology ; Arteritis/virology ; Herpes Zoster/complications ; Herpes Zoster/drug therapy ; Herpes Zoster/pathology ; Herpesvirus 3, Human ; Humans ; Risk Factors ; Stroke/etiology ; Stroke/virology
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2018-09-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiy425
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  8. Article ; Online: Correction: Frequency of varicella zoster virus DNA in human adrenal glands.

    Badani, Hussain / White, Teresa / Schulick, Nicole / Raeburn, Christopher D / Topkaya, Ibrahim Halil / Gilden, Don / Nagel, Maria A

    Journal of neurovirology

    2023  Volume 29, Issue 4, Page(s) 376

    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1283265-0
    ISSN 1538-2443 ; 1355-0284
    ISSN (online) 1538-2443
    ISSN 1355-0284
    DOI 10.1007/s13365-023-01159-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: Central nervous system infections produced by varicella zoster virus.

    Nagel, Maria A / Niemeyer, Christy S / Bubak, Andrew N

    Current opinion in infectious diseases

    2020  Volume 33, Issue 3, Page(s) 273–278

    Abstract: Purpose of review: Varicella zoster virus (VZV) causes varicella, establishes latency, then reactivates to produce herpes zoster. VZV reactivation can also cause central nervous system (CNS) disease with or without rash. Herein, we review these CNS ... ...

    Abstract Purpose of review: Varicella zoster virus (VZV) causes varicella, establishes latency, then reactivates to produce herpes zoster. VZV reactivation can also cause central nervous system (CNS) disease with or without rash. Herein, we review these CNS diseases, pathogenesis, diagnosis, and treatment.
    Recent findings: The most common CNS manifestation of VZV infection is vasculopathy that presents as headache, cognitive decline, and/or focal neurological deficits. VZV vasculopathy has also been associated with cerebral amyloid angiopathy and moyamoya syndrome. Rarely, VZV will produce a meningitis, encephalitis, cerebellitis, and myelopathy. Pathogenic mechanisms include direct VZV infection of affected tissue, persistent inflammation, and/or virus-induced hypercoagulability. Diagnosis is confirmed by the temporal association of rash to disease onset, intrathecal synthesis of anti-VZV antibodies, and/or the presence of VZV DNA in CSF. Most cases respond to intravenous acyclovir with corticosteroids.
    Summary: VZV produces a wide spectrum of CNS disorders that may be missed as some cases do not have an associated rash or a CSF pleocytosis. Clinicians must be vigilant in including VZV in their differential diagnosis of CNS infections as VZV is a ubiquitous pathogen; importantly, VZV CNS infections are treatable with intravenous acyclovir therapy and corticosteroids.
    MeSH term(s) Acyclovir/therapeutic use ; Adrenal Cortex Hormones/therapeutic use ; Antibodies, Viral/immunology ; Antiviral Agents/therapeutic use ; Central Nervous System Infections/diagnosis ; Central Nervous System Infections/drug therapy ; Central Nervous System Infections/virology ; Herpes Zoster/diagnosis ; Herpes Zoster/drug therapy ; Herpes Zoster/virology ; Herpesvirus 3, Human/immunology ; Herpesvirus 3, Human/pathogenicity ; Humans ; Meningitis/diagnosis ; Meningitis/drug therapy ; Meningitis/virology
    Chemical Substances Adrenal Cortex Hormones ; Antibodies, Viral ; Antiviral Agents ; Acyclovir (X4HES1O11F)
    Language English
    Publishing date 2020-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Functional Characterization of a Spectrum of Novel Romano-Ward Syndrome

    Rinné, Susanne / Oertli, Annemarie / Nagel, Claudia / Tomsits, Philipp / Jenewein, Tina / Kääb, Stefan / Kauferstein, Silke / Loewe, Axel / Beckmann, Britt Maria / Decher, Niels

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: ... ...

    Abstract The
    MeSH term(s) Humans ; Romano-Ward Syndrome/genetics ; KCNQ1 Potassium Channel/genetics ; Jervell-Lange Nielsen Syndrome/genetics ; Phenotype ; Electrocardiography ; Mutation ; KCNQ Potassium Channels/genetics
    Chemical Substances KCNQ1 Potassium Channel ; KCNQ Potassium Channels ; KCNQ1 protein, human
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021350
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