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  1. Article ; Online: Foreword.

    Baumeister, Wolfgang

    Biochemical and biophysical research communications

    2022  Volume 633, Page(s) 2

    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2022.10.025
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
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  2. Article ; Online: Cryo-electron tomography: The power of seeing the whole picture.

    Baumeister, Wolfgang

    Biochemical and biophysical research communications

    2022  Volume 633, Page(s) 26–28

    Abstract: Cryo-electron tomography allows to visualize the molecular architecture of pristinely preserved cellular landscapes in three dimensions. In favorable scenarios, macromolecular and supramolecular structures can be determined in situ with near-atomic ... ...

    Abstract Cryo-electron tomography allows to visualize the molecular architecture of pristinely preserved cellular landscapes in three dimensions. In favorable scenarios, macromolecular and supramolecular structures can be determined in situ with near-atomic resolution. The aim of visual proteomics is the parallel identification and annotation of all densities in the tomograms allowing for a comprehensive description of the molecular sociology of cells.
    MeSH term(s) Electron Microscope Tomography/methods ; Cryoelectron Microscopy/methods ; Macromolecular Substances/chemistry
    Chemical Substances Macromolecular Substances
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2022.08.078
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  3. Article ; Online: Cryo-electron tomography: A long journey to the inner space of cells.

    Baumeister, Wolfgang

    Cell

    2022  Volume 185, Issue 15, Page(s) 2649–2652

    Abstract: Cryogenic electron tomography (cryo-ET) is the application of tomographic principles of data acquisition and reconstruction to frozen-hydrated biological specimens. It combines a close-to-life preservation of cellular structures with the power of high- ... ...

    Abstract Cryogenic electron tomography (cryo-ET) is the application of tomographic principles of data acquisition and reconstruction to frozen-hydrated biological specimens. It combines a close-to-life preservation of cellular structures with the power of high-resolution three-dimensional imaging, which allows us to study the molecular architecture of cells, or their molecular sociology, in unprecedented detail.
    MeSH term(s) Cryoelectron Microscopy/methods ; Electron Microscope Tomography/methods ; Imaging, Three-Dimensional/methods
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.06.034
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  4. Article ; Online: Obituary Luis Bachmann: An early pioneer of cryo-electron microscopy.

    Plattner, Helmut / Baumeister, Wolfgang

    Journal of structural biology

    2024  Volume 216, Issue 2, Page(s) 108069

    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032718-6
    ISSN 1095-8657 ; 1047-8477
    ISSN (online) 1095-8657
    ISSN 1047-8477
    DOI 10.1016/j.jsb.2024.108069
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  5. Article: Cryo-electron tomography: A long journey to the inner space of cells

    Baumeister, Wolfgang

    Cell. 2022 July 21, v. 185, no. 15

    2022  

    Abstract: Cryogenic electron tomography (cryo-ET) is the application of tomographic principles of data acquisition and reconstruction to frozen-hydrated biological specimens. It combines a close-to-life preservation of cellular structures with the power of high- ... ...

    Abstract Cryogenic electron tomography (cryo-ET) is the application of tomographic principles of data acquisition and reconstruction to frozen-hydrated biological specimens. It combines a close-to-life preservation of cellular structures with the power of high-resolution three-dimensional imaging, which allows us to study the molecular architecture of cells, or their molecular sociology, in unprecedented detail.
    Keywords data collection ; sociology ; tomography
    Language English
    Dates of publication 2022-0721
    Size p. 2649-2652.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.06.034
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: The persuasive power of Ernesto Carafoli.

    Baumeister, Wolfgang

    Biochemical and biophysical research communications

    2019  Volume 520, Issue 4, Page(s) 657–658

    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2019.10.171
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  7. Article ; Online: Atomic structures of ribosomes at work captured by in situ cryo-electron tomography.

    Guo, Qiang / Baumeister, Wolfgang / Gao, Ning

    Science bulletin

    2023  Volume 68, Issue 22, Page(s) 2671–2673

    MeSH term(s) Electron Microscope Tomography/methods ; Ribosomes/chemistry ; Models, Molecular
    Language English
    Publishing date 2023-09-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.09.035
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  8. Article ; Online: Towards Visual Proteomics at High Resolution.

    Bäuerlein, Felix J B / Baumeister, Wolfgang

    Journal of molecular biology

    2021  Volume 433, Issue 20, Page(s) 167187

    Abstract: Traditionally, structural biologists approach the complexity of cellular proteomes in a reductionist manner. Proteomes are fractionated, their molecular components purified and studied one-by-one using the experimental methods for structure determination ...

    Abstract Traditionally, structural biologists approach the complexity of cellular proteomes in a reductionist manner. Proteomes are fractionated, their molecular components purified and studied one-by-one using the experimental methods for structure determination at their disposal. Visual proteomics aims at obtaining a holistic picture of cellular proteomes by studying them in situ, ideally in unperturbed cellular environments. The method that enables doing this at highest resolution is cryo-electron tomography. It allows to visualize cellular landscapes with molecular resolution generating maps or atlases revealing the interaction networks which underlie cellular functions in health and in disease states. Current implementations of cryo ET do not yet realize the full potential of the method in terms of resolution and interpretability. To this end, further improvements in technology and methodology are needed. This review describes the state of the art as well as measures which we expect will help overcoming current limitations.
    MeSH term(s) Animals ; Cryoelectron Microscopy/methods ; Humans ; Machine Learning ; Models, Molecular ; Protein Conformation ; Proteins/chemistry ; Proteins/ultrastructure ; Proteomics/methods
    Chemical Substances Proteins
    Language English
    Publishing date 2021-08-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2021.167187
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    Zs.A 867: Show issues Location:
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  9. Article ; Online: Cooperation in the Time of COVID.

    Butterworth, Jade / Smerdon, David / Baumeister, Roy / von Hippel, William

    Perspectives on psychological science : a journal of the Association for Psychological Science

    2023  , Page(s) 17456916231178719

    Abstract: Humans evolved to be hyper-cooperative, particularly when among people who are well known to them, when relationships involve reciprocal helping opportunities, and when the costs to the helper are substantially less than the benefits to the recipient. ... ...

    Abstract Humans evolved to be hyper-cooperative, particularly when among people who are well known to them, when relationships involve reciprocal helping opportunities, and when the costs to the helper are substantially less than the benefits to the recipient. Because humans' cooperative nature evolved over many millennia when they lived exclusively in small groups, factors that cause cooperation to break down tend to be those associated with life in large, impersonal, modern societies: when people are not identifiable, when interactions are one-off, when self-interest is not tied to the interests of others, and when people are concerned that others might free ride. From this perspective, it becomes clear that policies for managing pandemics will be most effective when they highlight superordinate goals and connect people or institutions to one another over multiple identifiable interactions. When forging such connections is not possible, policies should mimic critical components of ancestral conditions by providing reputational markers for cooperators and reducing the systemic damage caused by free riding. In this article, we review policies implemented during the pandemic, highlighting spontaneous community efforts that leveraged these aspects of people's evolved psychology, and consider implications for future decision makers.
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2224911-4
    ISSN 1745-6924 ; 1745-6916
    ISSN (online) 1745-6924
    ISSN 1745-6916
    DOI 10.1177/17456916231178719
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  10. Article ; Online: Statistical spatial analysis for cryo-electron tomography.

    Martinez-Sanchez, Antonio / Baumeister, Wolfgang / Lučić, Vladan

    Computer methods and programs in biomedicine

    2022  Volume 218, Page(s) 106693

    Abstract: Cryo-electron tomography (cryo-ET) is uniquely suited to precisely localize macromolecular complexes in situ, that is in a close-to-native state within their cellular compartments, in three-dimensions at high resolution. Point pattern analysis (PPA) ... ...

    Abstract Cryo-electron tomography (cryo-ET) is uniquely suited to precisely localize macromolecular complexes in situ, that is in a close-to-native state within their cellular compartments, in three-dimensions at high resolution. Point pattern analysis (PPA) allows quantitative characterization of the spatial organization of particles. However, current implementations of PPA functions are not suitable for applications to cryo-ET data because they do not consider the real, typically irregular 3D shape of cellular compartments and molecular complexes. Here, we designed and implemented first and the second-order, uni- and bivariate PPA functions in a Python package for statistical spatial analysis of particles located in three dimensional regions of arbitrary shape, such as those encountered in cellular cryo-ET imaging (PyOrg). To validate the implemented functions, we applied them to specially designed synthetic datasets. This allowed us to find the algorithmic solutions that provide the best accuracy and computational performance, and to evaluate the precision of the implemented functions. Applications to experimental data showed that despite the higher computational demand, the use of the second-order functions is advantageous to the first-order ones, because they allow characterization of the particle organization and statistical inference over a range of distance scales, as well as the comparative analysis between experimental groups comprising multiple tomograms. Altogether, PyOrg is a versatile, precise, and efficient open-source software for reliable quantitative characterization of macromolecular organization within cellular compartments imaged in situ by cryo-ET, as well as to other 3D imaging systems where real-size particles are located within regions possessing complex geometry.
    MeSH term(s) Cryoelectron Microscopy/methods ; Electron Microscope Tomography/methods ; Image Processing, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods ; Macromolecular Substances ; Spatial Analysis
    Chemical Substances Macromolecular Substances
    Language English
    Publishing date 2022-02-15
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2022.106693
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