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  1. Article ; Online: Epidemiology of Antiphospholipid Syndrome in the General Population.

    Dabit, Jesse Y / Valenzuela-Almada, Maria O / Vallejo-Ramos, Sebastian / Duarte-García, Alí

    Current rheumatology reports

    2022  Volume 23, Issue 12, Page(s) 85

    Abstract: Purpose of review: The epidemiology of antiphospholipid syndrome (APS) is poorly understood. Here, we review the current understanding of the epidemiology of antiphospholipid syndrome in the general population and the frequency of antiphospholipid ... ...

    Abstract Purpose of review: The epidemiology of antiphospholipid syndrome (APS) is poorly understood. Here, we review the current understanding of the epidemiology of antiphospholipid syndrome in the general population and the frequency of antiphospholipid antibodies in the general population in patients with obstetric morbidity, arterial events, and venous thromboembolism.
    Recent findings: There have been few population-based studies that estimated the prevalence and incidence of APS. The estimated incidence and prevalence among most these studies ranged between 1 and 2 cases per 100,000 and 40 and 50 cases per 100,000 respectively. The prevalence of antiphospholipid antibodies in patients with obstetric morbidity was 6-9%, while in arterial events and venous thromboembolism is 9-10%. However, this data remains limited. Mortality of patients with APS is 50-80% higher than the general population. The epidemiology of APS has been difficult to elucidate. Population-based studies patients with diverse age, racial, and ethnic backgrounds are needed.
    MeSH term(s) Antibodies, Antiphospholipid ; Antiphospholipid Syndrome/epidemiology ; Female ; Humans ; Incidence ; Pregnancy ; Prevalence
    Chemical Substances Antibodies, Antiphospholipid
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-021-01038-2
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    Zs.A 5531: Show issues Location:
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  2. Article ; Online: The protective effect of rheumatic disease agents in COVID-19.

    Valenzuela-Almada, María O / Putman, Michael S / Duarte-García, Alí

    Best practice & research. Clinical rheumatology

    2021  Volume 35, Issue 1, Page(s) 101659

    Abstract: Several immunosuppressive therapies have been investigated as potential treatments for patients with severe and critical coronavirus disease 2019 (COVID-19). Notable examples include corticosteroids, interleukin 6 (IL-6), interleukin 1 (IL-1), Janus ... ...

    Abstract Several immunosuppressive therapies have been investigated as potential treatments for patients with severe and critical coronavirus disease 2019 (COVID-19). Notable examples include corticosteroids, interleukin 6 (IL-6), interleukin 1 (IL-1), Janus kinase (JAK), and tumor necrosis factor alpha (TNF-α) inhibitors. The aim of this narrative review is to analyze the mechanistic rationale and available evidence for these selected anti-rheumatic drugs for the treatment of COVID-19. Currently, only corticosteroids have consistently proven to be effective in decreasing mortality and are recommended in clinical guidelines for the treatment of severe and critical COVID-19. Multiple randomized controlled trials (RCTs) are ongoing to determine the role of other immunosuppressants.
    MeSH term(s) Antirheumatic Agents/therapeutic use ; COVID-19 ; Humans ; Immunosuppressive Agents/therapeutic use ; Rheumatic Diseases/drug therapy ; SARS-CoV-2
    Chemical Substances Antirheumatic Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2021-01-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2021.101659
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  3. Article ; Online: Incidence, Prevalence, and Mortality of Lupus Nephritis: A Population-Based Study Over Four Decades Using the Lupus Midwest Network.

    Hocaoǧlu, Mehmet / Valenzuela-Almada, Maria O / Dabit, Jesse Y / Osei-Onomah, Shirley-Ann / Chevet, Baptiste / Giblon, Rachel E / Zand, Ladan / Fervenza, Fernando C / Helmick, Charles G / Crowson, Cynthia S / Duarte-García, Alí

    Arthritis & rheumatology (Hoboken, N.J.)

    2023  Volume 75, Issue 4, Page(s) 567–573

    Abstract: Objective: There is a paucity of population-based studies investigating the epidemiology of lupus nephritis (LN) in the US and long-term secular trends of the disease and its outcomes. We aimed to examine the epidemiology of LN in a well-defined 8- ... ...

    Abstract Objective: There is a paucity of population-based studies investigating the epidemiology of lupus nephritis (LN) in the US and long-term secular trends of the disease and its outcomes. We aimed to examine the epidemiology of LN in a well-defined 8-county region in the US.
    Methods: Patients with incident LN between 1976 and 2018 in Olmsted County, Minnesota (1976-2009) and an 8-county region in southeast Minnesota (2010-2018) were identified. Age- and sex-specific incidence rates and point prevalence over 4 decades, adjusted to the projected 2000 US population, were determined. Standardized mortality ratios (SMRs), survival rates, and time to end-stage renal disease (ESRD) were estimated.
    Results: There were 72 patients with incident LN between 1976 and 2018, of whom 76% were female and 69% were non-Hispanic White. Mean ± SD age at diagnosis was 38.4 ± 16.24 years. Average annual LN incidence per 100,000 population between 1976 and 2018 was 1.0 (95% CI 0.8-1.3) and was highest in patients ages 30-39 years. Between the 1976-1989 and 2000-2018 time periods, overall incidence of LN increased from 0.7 to 1.3 per 100,000, but this was not statistically significant. Estimated LN prevalence increased from 16.8 per 100,000 in 1985 to 21.2 per 100,000 in 2015. Patients with LN had an SMR of 6.33 (95% CI 3.81-9.89), with no improvement in the mortality gap in the last 4 decades. At 10 years, survival was 70%, and 13% of LN patients had ESRD.
    Conclusion: The incidence and prevalence of LN in this area increased in the last 4 decades. LN patients have poor outcomes, with high rates of ESRD and mortality rates 6 times that of the general population.
    MeSH term(s) Male ; Humans ; Female ; Adult ; Young Adult ; Middle Aged ; Lupus Nephritis ; Incidence ; Prevalence ; Kidney Failure, Chronic/etiology ; Minnesota/epidemiology
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42375
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    Zs.A 24: Show issues Location:
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  4. Article ; Online: Epidemiology of Cutaneous Lupus Erythematosus Among Adults Over Four Decades (1976-2018): A Lupus Midwest Network (LUMEN) Study.

    Hocaoğlu, Mehmet / Davis, Mark Denis P / Osei-Onomah, Shirley-Ann / Valenzuela-Almada, Maria O / Dabit, Jesse Y / Duong, Stephanie Q / Yang, Jeffrey X / Helmick, Charles G / Crowson, Cynthia / Duarte-García, Alí

    Mayo Clinic proceedings

    2022  Volume 97, Issue 12, Page(s) 2282–2290

    Abstract: Objective: To characterize the epidemiological trends and mortality of cutaneous lupus erythematosus (CLE) between 1976 and 2018 in Olmsted County, Minnesota.: Patients and methods: In this retrospective population-based cohort study, all incident ... ...

    Abstract Objective: To characterize the epidemiological trends and mortality of cutaneous lupus erythematosus (CLE) between 1976 and 2018 in Olmsted County, Minnesota.
    Patients and methods: In this retrospective population-based cohort study, all incident and prevalent CLE cases among adult residents in Olmsted County, Minnesota, between January 1, 1976, and December 31, 2018, were identified and categorized by subtype through medical record review using the resources of the Rochester Epidemiology Project.
    Results: The overall incidence rate of CLE between 1976 and 2018 was 3.9 (95% CI, 3.4 to 4.5) per 100,000. The incidence of CLE was relatively stable, with no major trend across sexes or age groups. The age- and sex-adjusted prevalence of CLE was 108.9 per 100,000 on January 1, 2015. Mortality in CLE patients was similar to that of the general population, with a standardized mortality ratio of 1.23 (95% CI, 0.88 to 1.66) with no observed trends in mortality over time.
    Conclusion: In the past 4 decades, the incidence of CLE remained stable. Patients with CLE have mortality comparable to that of the general population.
    MeSH term(s) Adult ; Humans ; Cohort Studies ; Retrospective Studies ; Lupus Erythematosus, Cutaneous/epidemiology ; Incidence ; Prevalence ; Minnesota/epidemiology
    Language English
    Publishing date 2022-11-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2022.06.022
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  5. Article ; Online: Epidemiology of Childhood-Onset Systemic Lupus Erythematosus: A Population-Based Study.

    Valenzuela-Almada, Maria O / Hocaoglu, Mehmet / Dabit, Jesse Y / Osei-Onomah, Shirley-Ann / Basiaga, Matthew L / Orandi, Amir B / Giblon, Rachel E / Barbour, Kamil E / Crowson, Cynthia S / Duarte-García, Alí

    Arthritis care & research

    2022  Volume 74, Issue 5, Page(s) 728–732

    Abstract: Objective: To characterize the incidence and prevalence of childhood-onset systemic lupus erythematosus (SLE), and to estimate the proportion of patients who are diagnosed with SLE during childhood.: Methods: A cohort of patients with incident ... ...

    Abstract Objective: To characterize the incidence and prevalence of childhood-onset systemic lupus erythematosus (SLE), and to estimate the proportion of patients who are diagnosed with SLE during childhood.
    Methods: A cohort of patients with incident childhood-onset SLE from 1976 to 2018 from an 8-county region in the US were identified based on comprehensive medical record review. All patients met the European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) classification criteria for SLE or the ACR SLE classification criteria from 1997 at or before age 18 years. Incidence rates were estimated using Poisson methods. We estimated the childhood-onset SLE point prevalence for January 1, 2015. Results were sex and age adjusted to the US 2000 population. Among all the SLE patients living in the 8-county region on January 1, 2015, the proportion of patients diagnosed at ≤18 years was estimated.
    Results: A total of 13 children were diagnosed with childhood-onset SLE during the study period (using the EULAR/ACR definition; mean age at diagnosis 15.1 years, 85% female, 69% White). Childhood-onset SLE overall adjusted incidence rate was 0.7 (95% confidence interval [95% CI] 0.2-1.1) per 100,000 children. The incidence rate in girls was 1.2 (95% CI 0.5-1.9) per 100,000 children, while in boys it was 0.2 (95% CI 0.0-0.5) per 100,000. The adjusted prevalence of childhood-onset SLE was 1.1 (95% CI 0.0-3.1) per 100,000 children. The proportion of patients with SLE diagnosed as children was 9% (95% CI 6-13%).
    Conclusion: In this population-based study, both the incidence and prevalence rates of childhood-onset SLE were ~1 per 100,000 children. One in 10 adults with SLE was diagnosed in childhood. More studies are needed to further characterize the epidemiology of childhood-onset SLE in minorities.
    MeSH term(s) Adolescent ; Adult ; Child ; Female ; Humans ; Incidence ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/epidemiology ; Male ; Prevalence ; Rheumatology ; White People
    Language English
    Publishing date 2022-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.24827
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    Zs.A 2446: Show issues Location:
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  6. Article ; Online: Long-Term Opioid Therapy Among Patients With Systemic Lupus Erythematosus in the Community: A Lupus Midwest Network (LUMEN) Study.

    Figueroa-Parra, Gabriel / Jeffery, Molly M / Dabit, Jesse Y / Chevet, Baptiste / Valenzuela-Almada, Maria O / Hocaoglu, Mehmet / Osei-Onomah, Shirley-Ann / Kurani, Shaheen / Vallejo, Sebastian / Achenbach, Sara J / Hooten, W Michael / Barbour, Kamil E / Crowson, Cynthia S / Duarte-García, Alí

    The Journal of rheumatology

    2022  Volume 50, Issue 4, Page(s) 504–511

    Abstract: Objective: There is little information about the epidemiology and factors associated with opioid therapy in systemic lupus erythematosus (SLE). We aimed to assess the prevalence of opioid therapy and explore factors associated with long-term opioid ... ...

    Abstract Objective: There is little information about the epidemiology and factors associated with opioid therapy in systemic lupus erythematosus (SLE). We aimed to assess the prevalence of opioid therapy and explore factors associated with long-term opioid therapy (LTOT) in patients with SLE.
    Methods: Patients with SLE were matched with controls without SLE in a population-based cohort on January 1, 2015. We captured demographics, manifestations of SLE, comorbidities (ie, fibromyalgia, mood disorders, osteoarthritis, chronic low back pain [CLBP], chronic kidney disease (CKD), avascular necrosis, osteoporosis, fragility fractures, and cancer), and the Area Deprivation Index (ADI). Opioid prescription data were used to assess the prevalence of LTOT, defined as contiguous prescriptions (gaps of < 30 days between prescriptions) and receiving opioid therapy for ≥ 90 days or ≥ 10 prescriptions before the index date.
    Results: A total of 465 patients with SLE and 465 controls without SLE were included. In total, 13% of patients with SLE and 3% of controls without SLE were receiving opioid therapy (
    Conclusion: Patients with SLE are more likely to receive LTOT than controls. Among patients with SLE, LTOT was associated with pericarditis and several comorbidities. However, LTOT was not associated with CKD despite the limited pain control options among these patients.
    MeSH term(s) Humans ; Analgesics, Opioid/therapeutic use ; Retrospective Studies ; Fibromyalgia/drug therapy ; Fibromyalgia/epidemiology ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/epidemiology ; Pericarditis ; Fractures, Bone
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2022-11-15
    Publishing country Canada
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.220822
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    Zs.A 1168: Show issues Location:
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  7. Article ; Online: Health Care Utilization in Systemic Lupus Erythematosus in the Community: The Lupus Midwest Network.

    Chevet, Baptiste / Figueroa-Parra, Gabriel / Valenzuela-Almada, Maria O / Hocaoglu, Mehmet / Vallejo, Sebastian / Osei-Onomah, Shirley-Ann / Giblon, Rachel E / Dabit, Jesse Y / Chamberlain, Alanna M / Cornec, Divi / Greenlund, Kurt J / Barbour, Kamil E / Crowson, Cynthia S / Duarte-García, Alí

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2022  Volume 29, Issue 1, Page(s) 29–35

    Abstract: Objective: The aim of this study was to determine inpatient health care utilization in an incident cohort of patients with systemic lupus erythematosus (SLE) compared with the general population.: Methods: This was a population-based cohort study in ... ...

    Abstract Objective: The aim of this study was to determine inpatient health care utilization in an incident cohort of patients with systemic lupus erythematosus (SLE) compared with the general population.
    Methods: This was a population-based cohort study in the upper Midwest, United States. We included patients fulfilling the European League Against Rheumatism/American College of Rheumatology SLE classification criteria between 1995 and 2018. They were 1:1 age-, sex-, county-matched with individuals without SLE. All hospital admissions and emergency department (ED) visits were electronically retrieved for 1995-2020. Rates for hospital admission, length of stay, readmission, ED visits, and discharge destination were compared between groups.
    Results: Three hundred forty-one patients with SLE and 341 comparators without SLE were included (mean age, 48.6 years at diagnosis; 79.2% female). Rates of hospitalization for patients with SLE and comparators were 29.8 and 9.9 per 100 person-years, respectively. These differences were present across sexes and age groups. Hospitalization rates were higher in patients with SLE after diagnosis and remained higher than comparators for the first 15 years of the disease. Patients with SLE were more likely than comparators to visit the ED (hazard ratio, 2.71; 95% confidence interval, 2.05-3.59). Readmission rates (32% vs. 21%, p = 0.017) were higher in patients with SLE. Length of stay and discharge destination were similar between both groups.
    Conclusion: Patients with SLE were more likely to be hospitalized and to visit the ED than individuals without SLE, highlighting important inpatient care needs. Increased hospitalization rates were observed in both male and female patients and all age groups.
    MeSH term(s) Humans ; Male ; Female ; United States/epidemiology ; Middle Aged ; Cohort Studies ; Retrospective Studies ; Hospitalization ; Patient Acceptance of Health Care ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/therapy
    Language English
    Publishing date 2022-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001899
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    Zs.A 4815: Show issues Location:
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  8. Article ; Online: Industry involvement in rheumatology consensus-based recommendations: a systematic review.

    Feterman Jimenez, Dominique / Duron, Garret / Hendin, Joshua / Mantovani Cardoso, Eduardo / Valenzuela-Almada, Maria O / Vallejo, Sebastian / Duarte-Garcia, Ali / Sufka, Paul / Whittle, Samuel L / Robinson, Philip C / Prokop, Larry J / Putman, Michael S

    The Lancet. Rheumatology

    2021  Volume 4, Issue 2, Page(s) e145–e152

    Abstract: Consensus-based recommendations guide standards of care for clinical practice. Pharmaceutical industry involvement in producing such recommendations might undermine their objectivity. We did a systematic review of rheumatology consensus-based ... ...

    Abstract Consensus-based recommendations guide standards of care for clinical practice. Pharmaceutical industry involvement in producing such recommendations might undermine their objectivity. We did a systematic review of rheumatology consensus-based recommendations that were published in English from 2000 to 2020. We compared those that were endorsed by major professional societies to those that were sponsored by industry using the validated Appraisal of Guidelines for Research & Evaluation (AGREE) II instrument. Of 234 consensus-based recommendation projects, 51 (22%) were endorsed by major societies and 74 (32%) were sponsored by the pharmaceutical industry. Among industry-sponsored projects, the sponsor was involved in the consensus-based process in 21 (28%), provided a medical writer in 12 (16%), offered honoraria for participation in five (7%), and was allowed to approve the final draft of one project. When compared with projects endorsed by major societies, industry-sponsored projects were less likely to have a high quality assessment on the AGREE II instrument. These results suggest that industry sponsorship of consensus-based recommendations is common in projects that do not receive endorsement by major societies. Such projects are often of lower quality than guidelines endorsed by major professional societies. Medical journals should consider steps to encourage greater rigour of development and to limit undue influence by industry sponsors.
    Language English
    Publishing date 2021-12-17
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(21)00332-5
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  9. Article ; Online: Risk of severe COVID-19 outcomes associated with rheumatoid arthritis and phenotypic subgroups: a retrospective, comparative, multicentre cohort study.

    Figueroa-Parra, Gabriel / Gilbert, Emily L / Valenzuela-Almada, Maria O / Vallejo, Sebastian / Neville, Matthew R / Patel, Naomi J / Cook, Claire / Fu, Xiaoqing / Hagi, Ramla / McDermott, Gregory C / Dilorio, Michael A / Masto, Lucy / Vanni, Kathleen M M / Kowalski, Emily / Qian, Grace / Zhang, Yuqing / Wallace, Zachary S / Duarte-García, Alí / Sparks, Jeffrey A

    The Lancet. Rheumatology

    2022  Volume 4, Issue 11, Page(s) e765–e774

    Abstract: Background: Rheumatoid arthritis has been associated with severe COVID-19, but few studies have investigated how phenotypes of rheumatoid arthritis affect these associations. We aimed to investigate the associations between rheumatoid arthritis and ... ...

    Abstract Background: Rheumatoid arthritis has been associated with severe COVID-19, but few studies have investigated how phenotypes of rheumatoid arthritis affect these associations. We aimed to investigate the associations between rheumatoid arthritis and phenotypes of interstitial lung disease, serostatus, and bone erosions with COVID-19 severity.
    Methods: We did a retrospective, comparative, multicentre cohort study at two large health-care systems (Mayo Clinic [19 hospitals and affiliated outpatient centres] and Mass General Brigham [14 hospitals and affiliated outpatient centres]) in the USA. Consecutive patients with rheumatoid arthritis meeting the 2010 American College of Rheumatology/European League Against Rheumatism classification criteria and who had COVID-19 between March 1, 2020, and June 6, 2021, were matched 1:5 on age, sex, and calendar date with patients without rheumatoid arthritis (comparators). Data were received from electronic health records from Mayo Clinic and Mass General Brigham. We examined subgroups of patients with rheumatoid arthritis by phenotypic features: rheumatoid arthritis-associated interstitial lung disease, seropositivity (for anti-cyclic citrullinated peptide, rheumatoid factor, or both), and bone erosions. Severe COVID-19 was a composite of hospitalisation or death. We used Cox regression to estimate hazard ratios (HR) for severe COVID-19, comparing rheumatoid arthritis and subgroups to the comparator group.
    Findings: We identified 582 patients with rheumatoid arthritis and 2875 matched comparators, all of whom had COVID-19 within the study dates. The mean age of those with rheumatoid arthritis was 62 [SD 14] years, 421 (72%) of 582 were women and 161 (28%) were men, 457 (79%) were White, 65 (11%) were Hispanic or Latino, and 41 (7%) were Black. Among patients with rheumatoid arthritis, 50 (9%) of 582 had interstitial lung disease, 388 (68%) of 568 were seropositive, and 159 (27%) of 582 had bone erosions. Severe COVID-19 occurred in 126 (22%) of 582 patients with rheumatoid arthritis versus 363 (13%) 2875 in the comparator group. Patients with rheumatoid arthritis had an HR of 1·75 (95% CI 1·45-2·10) for severe COVID-19 versus the comparator group. Patients with rheumatoid arthritis-associated interstitial lung disease had an HR of 2·50 (1·66-3·77) versus the comparator group for severe COVID-19. The risk for severe COVID-19 was also higher in patients with rheumatoid arthritis who were seropositive (HR 1·97 [95% CI 1·58-2·46]) or had erosive disease (1·93 [1·41-2·63]) than for those in the comparator group.
    Interpretation: Patients with rheumatoid arthritis have an increased risk of severe COVID-19 across phenotypic subgroups, especially among patients with interstitial lung disease. These findings suggest that rheumatoid arthritis with interstitial lung disease, or its treatment, might be a substantial contributor to severe COVID-19 outcomes for patients with rheumatoid arthritis.
    Funding: None.
    Language English
    Publishing date 2022-09-13
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(22)00227-2
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  10. Article ; Online: Association Between Race/Ethnicity and COVID-19 Outcomes in Systemic Lupus Erythematosus Patients From the United States: Data From the COVID-19 Global Rheumatology Alliance.

    Ugarte-Gil, Manuel F / Alarcón, Graciela S / Seet, Andrea M / Izadi, Zara / Montgomery, Anna D / Duarte-García, Alí / Gilbert, Emily L / Valenzuela-Almada, Maria O / Wise, Leanna / Sparks, Jeffrey A / Hsu, Tiffany Y-T / D'Silva, Kristin M / Patel, Naomi J / Sirotich, Emily / Liew, Jean W / Hausmann, Jonathan S / Sufka, Paul / Grainger, Rebecca / Bhana, Suleman /
    Wallace, Zachary / Jacobsohn, Lindsay / Strangfeld, Anja / Mateus, Elsa F / Hyrich, Kimme L / Gossec, Laure / Carmona, Loreto / Lawson-Tovey, Saskia / Kearsley-Fleet, Lianne / Schaefer, Martin / Machado, Pedro M / Robinson, Philip C / Gianfrancesco, Milena / Yazdany, Jinoos

    Arthritis care & research

    2022  Volume 75, Issue 1, Page(s) 53–60

    Abstract: Objective: To determine the association between race/ethnicity and COVID-19 outcomes in individuals with systemic lupus erythematosus (SLE).: Methods: Individuals with SLE from the US with data entered into the COVID-19 Global Rheumatology Alliance ... ...

    Abstract Objective: To determine the association between race/ethnicity and COVID-19 outcomes in individuals with systemic lupus erythematosus (SLE).
    Methods: Individuals with SLE from the US with data entered into the COVID-19 Global Rheumatology Alliance registry between March 24, 2020 and August 27, 2021 were included. Variables included age, sex, race, and ethnicity (White, Black, Hispanic, other), comorbidities, disease activity, pandemic time period, glucocorticoid dose, antimalarials, and immunosuppressive drug use. The ordinal outcome categories were: not hospitalized, hospitalized with no oxygenation, hospitalized with any ventilation or oxygenation, and death. We constructed ordinal logistic regression models evaluating the relationship between race/ethnicity and COVID-19 severity, adjusting for possible confounders.
    Results: We included 523 patients; 473 (90.4%) were female and the mean ± SD age was 46.6 ± 14.0 years. A total of 358 patients (74.6%) were not hospitalized; 40 patients (8.3%) were hospitalized without oxygen, 64 patients (13.3%) were hospitalized with any oxygenation, and 18 (3.8%) died. In a multivariable model, Black (odds ratio [OR] 2.73 [95% confidence interval (95% CI) 1.36-5.53]) and Hispanic (OR 2.76 [95% CI 1.34-5.69]) individuals had higher odds of more severe outcomes than White individuals.
    Conclusion: Black and Hispanic individuals with SLE experienced more severe COVID-19 outcomes, which is consistent with findings in the US general population. These results likely reflect socioeconomic and health disparities and suggest that more aggressive efforts are needed to prevent and treat infection in this population.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Middle Aged ; COVID-19 ; Ethnicity ; Hispanic or Latino ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/epidemiology ; Rheumatology ; United States/epidemiology ; White ; Black or African American
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.25039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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