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  1. Article ; Online: A New Model of Global Reconstructive Surgery Training With Reduced Carbon Footprint of Outreach.

    Burgess, Jordan / Meyers, Natalie / Rusin-Gomez, Dora / Fox, Paige M / Chang, James

    JAMA surgery

    2024  

    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.8028
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  2. Article ; Online: The viral etiology of skin cancer.

    Meyers, Jordan M / Munger, Karl

    The Journal of investigative dermatology

    2014  Volume 134, Issue e1, Page(s) E29–32

    MeSH term(s) Animals ; Humans ; Papilloma/etiology ; Papillomaviridae/genetics ; Papillomavirus Infections/complications ; Skin Neoplasms/etiology ; Skin Neoplasms/virology
    Language English
    Publishing date 2014-10-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1038/skinbio.2014.6
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  3. Article ; Online: Advancing EBP culture and competencies through an academic-research partnership: Process and outcomes of an EBP scholar program.

    Li, Hong / Tyson, Sheryl / Meyers, Eva A / Ada, Hazel / Jordan, Michael

    Worldviews on evidence-based nursing

    2022  Volume 20, Issue 1, Page(s) 44–46

    Abstract: Background: Evidence-based practice (EBP) is increasingly being adopted in healthcare organizations to improve patient care and outcomes. Yet, barriers remain that prevent consistent implementation of EBP in clinical settings.: Aims: To increase EBP ... ...

    Abstract Background: Evidence-based practice (EBP) is increasingly being adopted in healthcare organizations to improve patient care and outcomes. Yet, barriers remain that prevent consistent implementation of EBP in clinical settings.
    Aims: To increase EBP competencies and promote practice change, a regional academic-community hospital in Los Angeles, California, jointly with a university school of nursing, developed and implemented an EBP scholar program.
    Methods: A multistep EBP process was delivered during monthly didactic workshops to ensure optimal delivery and acquisition of EBP core competencies. The Iowa Model of Evidence-Based Practice to Promote Quality Care was integrated into the curriculum to assist program scholar's efforts to systematically direct EBP implementation at the organizational level. Additional strategies were incorporated including one-to-one mentoring, institutional recognition, and protected time. The 13-item EBP Competency Scale for practicing registered professional nurses was used to measure EBP competency at baseline and post-program completion.
    Results: Five recruited scholars completed the baseline survey and three completed the postsurvey. EBP competency increased from 52.9% to 62.75%. Scholars submitted abstracts for conference poster presentation, podium presentations, and conference poster awards. One article was submitted and accepted for journal publication.
    Linking evidence to action: A multistep EBP process can enhance EBP delivery, improve EBP competency, and facilitate dissemination.
    MeSH term(s) Humans ; Evidence-Based Practice ; Quality of Health Care ; Surveys and Questionnaires ; Mentoring ; Mentors ; Evidence-Based Nursing
    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2401967-7
    ISSN 1741-6787 ; 1545-102X
    ISSN (online) 1741-6787
    ISSN 1545-102X
    DOI 10.1111/wvn.12616
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  4. Article: Inhibition of TGF-β and NOTCH Signaling by Cutaneous Papillomaviruses.

    Meyers, Jordan M / Grace, Miranda / Uberoi, Aayushi / Lambert, Paul F / Munger, Karl

    Frontiers in microbiology

    2018  Volume 9, Page(s) 389

    Abstract: Infections with cutaneous papillomaviruses have been linked to cutaneous squamous cell carcinomas that arise in patients who suffer from a rare genetic disorder, epidermodysplasia verruciformis, or those who have experienced long-term, systemic ... ...

    Abstract Infections with cutaneous papillomaviruses have been linked to cutaneous squamous cell carcinomas that arise in patients who suffer from a rare genetic disorder, epidermodysplasia verruciformis, or those who have experienced long-term, systemic immunosuppression following organ transplantation. The E6 proteins of the prototypical cutaneous human papillomavirus (HPV) 5 and HPV8 inhibit TGF-β and NOTCH signaling. The
    Language English
    Publishing date 2018-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2018.00389
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  5. Article ; Online: Hemophagocytosis-Related (Asian Variant) Intravascular Large B-Cell Lymphoma in a Hispanic Patient:  A Case Report Highlighting a Micronodular Pattern in the Spleen.

    Hall, Jordan M / Meyers, Nancy / Andrews, Jared

    American journal of clinical pathology

    2016  Volume 145, Issue 5, Page(s) 727–735

    Abstract: Objectives: We report a case of hemophagocytosis-related (Asian variant) intravascular large B-cell lymphoma (IVLBCL) in a patient of Western origin initially diagnosed by splenectomy with diffuse large B-cell lymphoma (DLBCL) with a micronodular ... ...

    Abstract Objectives: We report a case of hemophagocytosis-related (Asian variant) intravascular large B-cell lymphoma (IVLBCL) in a patient of Western origin initially diagnosed by splenectomy with diffuse large B-cell lymphoma (DLBCL) with a micronodular pattern. The clonal relationship between these two DLBCL subtypes is also investigated.
    Methods: Hemophagocytosis-related (Asian variant) IVLBCL was identified at autopsy in a 62-year-old Hispanic woman, in North America, following an antemortem diagnosis of massive splenic involvement by DLBCL with a micronodular pattern, a feature not expected of IVLBCL.
    Results: These two apparently distinct lymphoma types demonstrated similar immunophenotypic profiles and IgH gene rearrangements of identical size suggesting a clonal relationship. The 2008 WHO classification system describes IVLBCL in the spleen as having a sinusoidal pattern.
    Conclusions: Our observations provide the first molecular genetic support for a seemingly underrecognized micronodular pattern of IVLBCL in the spleen and further support the proposal of a "mixed variant" of IVLBCL with concomitant "intravascular" and "solid" phases of disease.
    MeSH term(s) Biomarkers, Tumor/analysis ; Fatal Outcome ; Female ; Flow Cytometry ; Humans ; Immunohistochemistry ; Immunophenotyping ; Lymphoma, Large B-Cell, Diffuse/pathology ; Middle Aged ; Spleen/pathology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2016-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqw027
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  6. Article: Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection.

    Vu, Michelle N / Alvarado, R Elias / Morris, Dorothea R / Lokugamage, Kumari G / Zhou, Yiyang / Morgan, Angelica L / Estes, Leah K / McLeland, Alyssa M / Schindewolf, Craig / Plante, Jessica A / Ahearn, Yani P / Meyers, William M / Murray, Jordan T / Crocquet-Valdes, Patricia A / Weaver, Scott C / Walker, David H / Russell, William K / Routh, Andrew L / Plante, Kenneth S /
    Menachery, Vineet

    bioRxiv : the preprint server for biology

    2023  

    Abstract: SARS-CoV-2 Omicron variants emerged in 2022 with >30 novel amino acid mutations in the spike protein alone. While most studies focus on receptor binding domain changes, mutations in the C-terminus of S1 (CTS1), adjacent to the furin cleavage site, have ... ...

    Abstract SARS-CoV-2 Omicron variants emerged in 2022 with >30 novel amino acid mutations in the spike protein alone. While most studies focus on receptor binding domain changes, mutations in the C-terminus of S1 (CTS1), adjacent to the furin cleavage site, have largely been ignored. In this study, we examined three Omicron mutations in CTS1: H655Y, N679K, and P681H. Generating a SARS-CoV-2 triple mutant (YKH), we found that the mutant increased spike processing, consistent with prior reports for H655Y and P681H individually. Next, we generated a single N679K mutant, finding reduced viral replication
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.17.536926
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  7. Article ; Online: Nonoperative Treatment of Fracture of the Entire Posterior Process of the Talus With Subtalar Dislocation: Case Report.

    McCoy, Jordan S / Meyers, Amy L / Marquart, Matthew

    Foot & ankle orthopaedics

    2020  Volume 5, Issue 2, Page(s) 2473011420918570

    Abstract: Level V, expert opinion. ...

    Abstract Level V, expert opinion.
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Case Reports
    ISSN 2473-0114
    ISSN (online) 2473-0114
    DOI 10.1177/2473011420918570
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  8. Article ; Online: Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation.

    Miao, Weili / Porter, Douglas F / Lopez-Pajares, Vanessa / Siprashvili, Zurab / Meyers, Robin M / Bai, Yunhao / Nguyen, Duy T / Ko, Lisa A / Zarnegar, Brian J / Ferguson, Ian D / Mills, Matthew M / Jilly-Rehak, Christie E / Wu, Cheng-Guo / Yang, Yen-Yu / Meyers, Jordan M / Hong, Audrey W / Reynolds, David L / Ramanathan, Muthukumar / Tao, Shiying /
    Jiang, Sizun / Flynn, Ryan A / Wang, Yinsheng / Nolan, Garry P / Khavari, Paul A

    Cell

    2023  Volume 186, Issue 1, Page(s) 80–97.e26

    Abstract: Glucose is a universal bioenergy source; however, its role in controlling protein interactions is unappreciated, as are its actions during differentiation-associated intracellular glucose elevation. Azido-glucose click chemistry identified glucose ... ...

    Abstract Glucose is a universal bioenergy source; however, its role in controlling protein interactions is unappreciated, as are its actions during differentiation-associated intracellular glucose elevation. Azido-glucose click chemistry identified glucose binding to a variety of RNA binding proteins (RBPs), including the DDX21 RNA helicase, which was found to be essential for epidermal differentiation. Glucose bound the ATP-binding domain of DDX21, altering protein conformation, inhibiting helicase activity, and dissociating DDX21 dimers. Glucose elevation during differentiation was associated with DDX21 re-localization from the nucleolus to the nucleoplasm where DDX21 assembled into larger protein complexes containing RNA splicing factors. DDX21 localized to specific SCUGSDGC motif in mRNA introns in a glucose-dependent manner and promoted the splicing of key pro-differentiation genes, including GRHL3, KLF4, OVOL1, and RBPJ. These findings uncover a biochemical mechanism of action for glucose in modulating the dimerization and function of an RNA helicase essential for tissue differentiation.
    MeSH term(s) Cell Nucleolus/metabolism ; Cell Nucleus/metabolism ; DEAD-box RNA Helicases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Glucose/metabolism ; Keratinocytes/cytology ; Keratinocytes/metabolism ; Humans
    Chemical Substances DEAD-box RNA Helicases (EC 3.6.4.13) ; RNA, Messenger ; Glucose (IY9XDZ35W2) ; DDX21 protein, human (EC 3.6.1.-)
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.12.004
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  9. Article ; Online: Non-surgical management of advanced hepatocellular carcinoma: A systematic review by Cancer Care Ontario.

    Meyers, Brandon M / Knox, Jennifer J / Cosby, Roxanne / Beecroft, J R / Chan, Kelvin Kw / Coburn, Natalie / Feld, Jordan J / Jonker, Derek / Mahmud, Aamer / Ringash, Jolie

    Canadian liver journal

    2021  Volume 4, Issue 3, Page(s) 257–274

    Abstract: Background: Hepatocellular carcinoma (HCC) is a global health problem, accounting for 4.7% of all new cancer cases and 8.2% of all cancer deaths worldwide in 2018. Resection and transplantation are the only modalities that offer a cure for HCC; however, ...

    Abstract Background: Hepatocellular carcinoma (HCC) is a global health problem, accounting for 4.7% of all new cancer cases and 8.2% of all cancer deaths worldwide in 2018. Resection and transplantation are the only modalities that offer a cure for HCC; however, most patients are diagnosed at an advanced stage, precluding these curative treatments. A number of local (ie, ablative therapies) and/or local-regional therapies (ie, chemo-embolization) are used and followed by systemic therapy for advanced or progressive disease. Other treatments are available, but their efficacy compared with these standards is not well known.
    Methods: Literature searches (1/2000 to 1/2020 or 1/2005 to 1/2020, depending on the specific systematic review question) were conducted, including MEDLINE, Embase and the Cochrane Database of Systematic Reviews.
    Results: Over 30,000 articles were identified. In total, 49 studies were included in the systematic review.
    Conclusions: There is no evidence to support the addition of sorafenib to any local or regional therapy. First-line systemic therapy options for unresectable or metastatic HCC include sorafenib, lenvatinib, and atezolizumab + bevacizumab. Regorafenib or cabozantinib provide survival benefits when given as second-line treatment.
    Language English
    Publishing date 2021-08-09
    Publishing country Canada
    Document type Journal Article ; Review
    ISSN 2561-4444
    ISSN (online) 2561-4444
    DOI 10.3138/canlivj-2020-0039
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  10. Article ; Online: Single-Cell and Spatial Transcriptomic Analysis of Human Skin Delineates Intercellular Communication and Pathogenic Cells.

    Thrane, Kim / Winge, Mårten C G / Wang, Hongyu / Chen, Larry / Guo, Margaret G / Andersson, Alma / Abalo, Xesús M / Yang, Xue / Kim, Daniel S / Longo, Sophia K / Soong, Brian Y / Meyers, Jordan M / Reynolds, David L / McGeever, Aaron / Demircioglu, Deniz / Hasson, Dan / Mirzazadeh, Reza / Rubin, Adam J / Bae, Gordon H /
    Karkanias, Jim / Rieger, Kerri / Lundeberg, Joakim / Ji, Andrew L

    The Journal of investigative dermatology

    2023  Volume 143, Issue 11, Page(s) 2177–2192.e13

    Abstract: Epidermal homeostasis is governed by a balance between keratinocyte proliferation and differentiation with contributions from cell-cell interactions, but conserved or divergent mechanisms governing this equilibrium across species and how an imbalance ... ...

    Abstract Epidermal homeostasis is governed by a balance between keratinocyte proliferation and differentiation with contributions from cell-cell interactions, but conserved or divergent mechanisms governing this equilibrium across species and how an imbalance contributes to skin disease are largely undefined. To address these questions, human skin single-cell RNA sequencing and spatial transcriptomics data were integrated and compared with mouse skin data. Human skin cell-type annotation was improved using matched spatial transcriptomics data, highlighting the importance of spatial context in cell-type identity, and spatial transcriptomics refined cellular communication inference. In cross-species analyses, we identified a human spinous keratinocyte subpopulation that exhibited proliferative capacity and a heavy metal processing signature, which was absent in mouse and may account for species differences in epidermal thickness. This human subpopulation was expanded in psoriasis and zinc-deficiency dermatitis, attesting to disease relevance and suggesting a paradigm of subpopulation dysfunction as a hallmark of the disease. To assess additional potential subpopulation drivers of skin diseases, we performed cell-of-origin enrichment analysis within genodermatoses, nominating pathogenic cell subpopulations and their communication pathways, which highlighted multiple potential therapeutic targets. This integrated dataset is encompassed in a publicly available web resource to aid mechanistic and translational studies of normal and diseased skin.
    MeSH term(s) Humans ; Animals ; Mice ; Transcriptome ; Skin ; Keratinocytes/metabolism ; Epidermis/pathology ; Skin Diseases/pathology ; Cell Communication
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.02.040
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