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Article ; Online: The emotional impact of Coronavirus 2019-nCoV (new Coronavirus disease).

Lima, Carlos Kennedy Tavares / Carvalho, Poliana Moreira de Medeiros / Lima, Igor de Araújo Araruna Silva / Nunes, José Victor Alexandre de Oliveira / Saraiva, Jeferson Steves / de Souza, Ricardo Inácio / da Silva, Claúdio Gleidiston Lima / Neto, Modesto Leite Rolim

Psychiatry research

2020 Volume 287, Page(s) 112915

Abstract: Background: A novel form of Coronavirus (2019-nCoV) in Wuhan has created a confused and rapidly evolving situation. In this situational framework, patients and front-line healthcare workers are vulnerable.: Method: Studies were identified using large- ...

Abstract	Background: A novel form of Coronavirus (2019-nCoV) in Wuhan has created a confused and rapidly evolving situation. In this situational framework, patients and front-line healthcare workers are vulnerable. Method: Studies were identified using large-circulation international journals found in two electronic databases: Scopus and Embase. Results: Populations of patients that may require tailored interventions are older adults and international migrant workers. Older adults with psychiatric conditions may be experiencing further distress. The COVID-19 epidemic has underscored potential gaps in mental health services during emergencies. Conclusions: Most health professionals working in isolation units and hospitals do not receive any training for providing mental health care. Fear seems more certainly a consequence of mass quarantine.
MeSH term(s)	Adult ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/psychology ; Emotions ; Female ; Health Personnel ; Health Services Needs and Demand ; Humans ; Mental Disorders ; Mental Health Services ; Pandemics ; Pneumonia, Viral/psychology ; SARS-CoV-2 ; Stress, Psychological
Keywords	covid19
Language	English
Publishing date	2020-03-12
Publishing country	Ireland
Document type	Letter ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2020.112915
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Article ; Online: When basic supplies are missing, what to do? Specific demands of the local street population in times of coronavirus - a concern of social psychiatry.

Neto, Modesto Leite Rolim / de Souza, Ricardo Inácio / Quezado, Rosa Magda Martins / Mendonça, Elayne Cristina Santos / de Araújo, Tallys Iury / Luz, Dayse Christina Rodrigues Pereira / de Santana, Willma José / Sampaio, Juliana Ribeiro Francelino / Carvalho, Poliana Moreira de Medeiros / Arrais, Tereza Maria Siqueira Nascimento / Landim, José Marcondes Macedo / da Silva, Claúdio Gleideston Lima

Psychiatry research

2020 Volume 288, Page(s) 112939

Abstract: Background: Homeless experts and some federal housing officials are sounding the alarm that the patchwork of government efforts to address the coronavirus outbreak risks leaving out one group of acutely vulnerable people: the homeless. In terms of ... ...

Abstract	Background: Homeless experts and some federal housing officials are sounding the alarm that the patchwork of government efforts to address the coronavirus outbreak risks leaving out one group of acutely vulnerable people: the homeless. In terms of isolation, it is too unclear what that looks like if you normally sleep on the streets. In this tough moment, when people should be turned away, not only it feels inhumane, but it is also a big public health risk, because where are they going to go? Method: The studies were identified using large-sized newspapers with international circulation RESULTS: With more cities suspecting community transmission of the novel coronavirus, people who sleep in shelters or hunker down outside already have a lower life expectancy and often have underlying health conditions that put them at greater risk if they develop COVID-19 (Global News, 2020). These people face lack of sleep, malnutrition, and "extreme stress levels just to meet their daily needs", all of which weakens the immune system. Along with mental illness or substance abuse disorders, they are "incredibly vulnerable to this virus". Conclusions: Health organizations are well aware of the risks involved in mental health. A large population of homeless people experience their pain and psychological distress intermittently. For low-income patients, the various borderline situations related to health/illness involve growing expectations regarding the basic needs. This is a serious concern when linked to the pandemic.
MeSH term(s)	Adult ; Betacoronavirus ; COVID-19 ; Community Psychiatry ; Coronavirus ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Female ; Homeless Persons/psychology ; Humans ; Mental Disorders/epidemiology ; Mental Health ; Middle Aged ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; SARS-CoV-2 ; Social Isolation ; Stress, Psychological
Keywords	covid19
Language	English
Publishing date	2020-04-13
Publishing country	Ireland
Document type	Letter
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2020.112939
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Article: The emotional impact of Coronavirus 2019-nCoV (new Coronavirus disease)

Psychiatry Res

Abstract: BACKGROUND: A novel form of Coronavirus (2019-nCoV) in Wuhan has created a confused and rapidly evolving situation. In this situational framework, patients and front-line healthcare workers are vulnerable. METHOD: Studies were identified using large- ... ...

Abstract	BACKGROUND: A novel form of Coronavirus (2019-nCoV) in Wuhan has created a confused and rapidly evolving situation. In this situational framework, patients and front-line healthcare workers are vulnerable. METHOD: Studies were identified using large-circulation international journals found in two electronic databases: Scopus and Embase. RESULTS: Populations of patients that may require tailored interventions are older adults and international migrant workers. Older adults with psychiatric conditions may be experiencing further distress. The COVID-19 epidemic has underscored potential gaps in mental health services during emergencies. CONCLUSIONS: Most health professionals working in isolation units and hospitals do not receive any training for providing mental health care. Fear seems more certainly a consequence of mass quarantine.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #8256
Database	COVID19

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Article: When basic supplies are missing, what to do? Specific demands of the local street population in times of coronavirus - a concern of social psychiatry

Psychiatry Res

Abstract: BACKGROUND: Homeless experts and some federal housing officials are sounding the alarm that the patchwork of government efforts to address the coronavirus outbreak risks leaving out one group of acutely vulnerable people: the homeless. In terms of ... ...

Abstract	BACKGROUND: Homeless experts and some federal housing officials are sounding the alarm that the patchwork of government efforts to address the coronavirus outbreak risks leaving out one group of acutely vulnerable people: the homeless. In terms of isolation, it is too unclear what that looks like if you normally sleep on the streets. In this tough moment, when people should be turned away, not only it feels inhumane, but it is also a big public health risk, because where are they going to go? METHOD: The studies were identified using large-sized newspapers with international circulation RESULTS: With more cities suspecting community transmission of the novel coronavirus, people who sleep in shelters or hunker down outside already have a lower life expectancy and often have underlying health conditions that put them at greater risk if they develop COVID-19 (Global News, 2020). These people face lack of sleep, malnutrition, and "extreme stress levels just to meet their daily needs", all of which weakens the immune system. Along with mental illness or substance abuse disorders, they are "incredibly vulnerable to this virus". CONCLUSIONS: Health organizations are well aware of the risks involved in mental health. A large population of homeless people experience their pain and psychological distress intermittently. For low-income patients, the various borderline situations related to health/illness involve growing expectations regarding the basic needs. This is a serious concern when linked to the pandemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #46479
Database	COVID19

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Article ; Online: Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis: Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress.

Fideles, Lázaro de Sousa / de Miranda, João Antônio Leal / Martins, Conceição da Silva / Barbosa, Maria Lucianny Lima / Pimenta, Helder Bindá / Pimentel, Paulo Vitor de Souza / Teixeira, Claudio Silva / Scafuri, Marina Alves Sampaio / Façanha, Samuel de Osterno / Barreto, João Erivan Façanha / Carvalho, Poliana Moreira de Medeiros / Scafuri, Ariel Gustavo / Araújo, Joabe Lima / Rocha, Jefferson Almeida / Vieira, Icaro Gusmão Pinto / Ricardo, Nágila Maria Pontes Silva / da Silva Campelo, Matheus / Ribeiro, Maria Elenir Nobre Pinho / de Castro Brito, Gerly Anne /

Cerqueira, Gilberto Santos

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 12

Abstract: Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted ... ...

Abstract	Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from
MeSH term(s)	Animals ; Fluorouracil/adverse effects ; Fluorouracil/pharmacology ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Intestinal Diseases/chemically induced ; Intestinal Diseases/drug therapy ; Intestinal Diseases/metabolism ; Intestinal Diseases/pathology ; Male ; Mice ; Mucositis/chemically induced ; Mucositis/drug therapy ; Mucositis/metabolism ; Mucositis/pathology ; Oxidative Stress/drug effects ; Rutin/pharmacology
Chemical Substances	Rutin (5G06TVY3R7) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2020-06-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25122786
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Article ; Online: Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis

Lázaro de Sousa Fideles / João Antônio Leal de Miranda / Conceição da Silva Martins / Maria Lucianny Lima Barbosa / Helder Bindá Pimenta / Paulo Vitor de Souza Pimentel / Claudio Silva Teixeira / Marina Alves Sampaio Scafuri / Samuel de Osterno Façanha / João Erivan Façanha Barreto / Poliana Moreira de Medeiros Carvalho / Ariel Gustavo Scafuri / Joabe Lima Araújo / Jefferson Almeida Rocha / Icaro Gusmão Pinto Vieira / Nágila Maria Pontes Silva Ricardo / Matheus da Silva Campelo / Maria Elenir Nobre Pinho Ribeiro / Gerly Anne de Castro Brito /

Gilberto Santos Cerqueira

Molecules, Vol 25, Iss 2786, p

Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress

2020 Volume 2786

Abstract	Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from Dimorphandra gardneriana , exhibits antioxidant, anti-inflammatory, cytoprotective, and gastroprotective properties. However, the effect of RUT on inflammatory processes in the intestine, especially on mucositis promoted by antineoplastic agents, has not yet been reported. In this study, we investigated the role of RUT on 5-FU-induced experimental intestinal mucositis. Swiss mice were randomly divided into seven groups: Saline, 5-FU, RUT-50, RUT-100, RUT-200, Celecoxib (CLX), and CLX + RUT-200 groups. The mice were weighed daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis); malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH) concentrations; mast and goblet cell counts; and cyclooxygenase-2 (COX-2) activity, as well as to perform immunohistochemical analyses. RUT treatment (200 mg/kg) prevented 5-FU-induced histopathological changes and reduced oxidative stress by decreasing MDA concentrations and increasing GSH concentrations. RUT attenuated the inflammatory response by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. These results suggest that the COX-2 pathway is one of the underlying protective mechanisms of RUT against 5-FU-induced intestinal mucositis.
Keywords	flavonoid ; inflammation ; antimetabolites ; intestine ; Organic chemistry ; QD241-441
Subject code	610
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil.

Adelino, Talita Émile Ribeiro / Giovanetti, Marta / Fonseca, Vagner / Xavier, Joilson / de Abreu, Álvaro Salgado / do Nascimento, Valdinete Alves / Demarchi, Luiz Henrique Ferraz / Oliveira, Marluce Aparecida Assunção / da Silva, Vinícius Lemes / de Mello, Arabela Leal E Silva / Cunha, Gabriel Muricy / Santos, Roselene Hans / de Oliveira, Elaine Cristina / Júnior, Jorge Antônio Chamon / de Melo Iani, Felipe Campos / de Filippis, Ana Maria Bispo / de Abreu, André Luiz / de Jesus, Ronaldo / de Albuquerque, Carlos Frederico Campelo /

Rico, Jairo Mendez / do Carmo Said, Rodrigo Fabiano / Silva, Joscélio Aguiar / de Moura, Noely Fabiana Oliveira / Leite, Priscila / Frutuoso, Lívia Carla Vinhal / Haddad, Simone Kashima / Martínez, Alexander / Barreto, Fernanda Khouri / Vazquez, Cynthia Carolina / da Cunha, Rivaldo Venâncio / Araújo, Emerson Luiz Lima / de Oliveira Tosta, Stephane Fraga / de Araújo Fabri, Allison / Chalhoub, Flávia Löwen Levy / da Silva Lemos, Poliana / de Bruycker-Nogueira, Fernanda / de Castro Lichs, Gislene Garcia / Zardin, Marina Castilhos Souza Umaki / Segovia, Fátima María Cardozo / Gonçalves, Crhistinne Cavalheiro Maymone / Grillo, Zoraida Del Carmen Fernandez / Slavov, Svetoslav Nanev / Pereira, Luiz Augusto / Mendonça, Ana Flávia / Pereira, Felicidade Mota / de Magalhães, Jurandy Júnior Ferraz / Dos Santos Júnior, Agenor de Castro Moreira / de Lima, Maricélia Maia / Nogueira, Rita Maria Ribeiro / Góes-Neto, Aristóteles / de Carvalho Azevedo, Vasco Ariston / Ramalho, Dario Brock / Oliveira, Wanderson Kleber / Macario, Eduardo Marques / de Medeiros, Arnaldo Correia / Pimentel, Victor / Holmes, Edward C / de Oliveira, Tulio / Lourenço, José / Alcantara, Luiz Carlos Junior

Nature communications

2021 Volume 12, Issue 1, Page(s) 2296

Abstract: Brazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting a continuous struggle with effective control and public health preparedness. Using Oxford Nanopore sequencing, we led field and classroom initiatives for the monitoring of DENV ...

Abstract	Brazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting a continuous struggle with effective control and public health preparedness. Using Oxford Nanopore sequencing, we led field and classroom initiatives for the monitoring of DENV in Brazil, generating 227 novel genome sequences of DENV1-2 from 85 municipalities (2015-2019). This equated to an over 50% increase in the number of DENV genomes from Brazil available in public databases. Using both phylogenetic and epidemiological models we retrospectively reconstructed the recent transmission history of DENV1-2. Phylogenetic analysis revealed complex patterns of transmission, with both lineage co-circulation and replacement. We identified two lineages within the DENV2 BR-4 clade, for which we estimated the effective reproduction number and pattern of seasonality. Overall, the surveillance outputs and training initiative described here serve as a proof-of-concept for the utility of real-time portable sequencing for research and local capacity building in the genomic surveillance of emerging viruses.
MeSH term(s)	Brazil/epidemiology ; Dengue/epidemiology ; Dengue/prevention & control ; Dengue/transmission ; Dengue/virology ; Dengue Virus/genetics ; Dengue Virus/isolation & purification ; Epidemics/prevention & control ; Epidemiological Monitoring ; Feasibility Studies ; Genetic Variation ; Genome, Viral/genetics ; Humans ; Mobile Health Units ; Molecular Epidemiology ; Molecular Typing ; Phylogeny ; Proof of Concept Study ; RNA, Viral/genetics ; RNA, Viral/isolation & purification ; Real-Time Polymerase Chain Reaction ; Retrospective Studies ; Whole Genome Sequencing
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-04-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-22607-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The psychiatric impact of the novel coronavirus outbreak.

Carvalho, Poliana Moreira de Medeiros / Moreira, Marcial Moreno / de Oliveira, Matheus Nogueira Arcanjo / Landim, José Marcondes Macedo / Neto, Modesto Leite Rolim

Psychiatry research

2020 Volume 286, Page(s) 112902

Keywords	covid19
Language	English
Publishing date	2020-02-28
Publishing country	Ireland
Document type	Letter
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2020.112902
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Article ; Online: Psychological effects caused by the COVID-19 pandemic in health professionals: A systematic review with meta-analysis.

da Silva Neto, Raimundo Monteiro / Benjamim, Cicero Jonas Rodrigues / de Medeiros Carvalho, Poliana Moreira / Neto, Modesto Leite Rolim

Progress in neuro-psychopharmacology & biological psychiatry

2020 Volume 104, Page(s) 110062

Abstract: Background: Psychological suffering by health professionals may be associated with the uncertainty of a safe workplace. Front-line professionals exposed and involved in the diagnosis and treatment of COVID-19 patients are more susceptible.: Method: ... ...

Abstract	Background: Psychological suffering by health professionals may be associated with the uncertainty of a safe workplace. Front-line professionals exposed and involved in the diagnosis and treatment of COVID-19 patients are more susceptible. Method: This review was conducted based on papers that were published at MEDLINE, BMJ, PsycINFO, and LILACS, the according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA). Results: Health professionals had a higher level of anxiety (13.0 vs. 8.5%, p < 0.01, OR = 1.6152; 95%CI 1.3283 to 1.9641; p < 0.0001) and depression 12.2 vs. 9.5%; p = 0.04; OR = 1.3246; 95%CI 1.0930 to 1.6053; p = 0.0042), besides somatizations and insomnia compared to professionals from other areas. Conclusion: Health professionals, regardless of their age, showed significant levels of mental disorders. We observed a prevalence of anxiety and depression. Insomnia was a risk factor for both.
MeSH term(s)	COVID-19 ; Coronavirus Infections ; Health Personnel/psychology ; Humans ; Mental Disorders/epidemiology ; Mental Disorders/etiology ; Mental Disorders/psychology ; Occupational Diseases/epidemiology ; Occupational Diseases/etiology ; Occupational Diseases/psychology ; Pandemics ; Pneumonia, Viral ; Prevalence ; Stress, Psychological
Keywords	covid19
Language	English
Publishing date	2020-08-06
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2020.110062
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Article: The psychiatric impact of the novel coronavirus outbreak

Carvalho, Poliana Moreira de Medeiros / Moreira, Marcial Moreno / de Oliveira, Matheus Nogueira Arcanjo / Landim, José Marcondes Macedo / Neto, Modesto Leite Rolim

Psychiatry Res

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #2749
Database	COVID19

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