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Article ; Conference proceedings: Multimodal Anatomy of the Human Forniceal Commissure

Akeret, Kevin / Forkel, Stephanie J. / Buzzi, Raphael M. / Vasella, Flavio / Amrein, Irmgard / Colacicco, Giovanni / Regli, Luca / Serra, Carlo / Krayenbühl, Niklaus

Journal of Neurological Surgery Part B: Skull Base

2024 Volume 85, Issue S 01

Event/congress	33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0044-1779840
Database	Thieme publisher's database

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Article: Impact of the COVID-19 Pandemic on Corneal Transplantation: A Report From the Italian Association of Eye Banks.

Mencucci, Rita / Cennamo, Michela / Ponzin, Diego / Genzano Besso, Federico / Pocobelli, Giulio / Buzzi, Matilde / Nucci, Carlo / Aiello, Francesco

Frontiers in medicine

2022 Volume 9, Page(s) 844601

Abstract: Purpose: To analyze the impact of COVID-19 on Italian corneal transplantation from March-2020 to February 2021 compared to the same timeframe of the 2 previous years, in order to identify potential consequences of a global pandemic on corneal ... ...

Abstract	Purpose: To analyze the impact of COVID-19 on Italian corneal transplantation from March-2020 to February 2021 compared to the same timeframe of the 2 previous years, in order to identify potential consequences of a global pandemic on corneal procurement and transplantation services during this time. Methods: This national, multicentric, retrospective cohort study evaluated data collected from 12 (100%) Italian eye banks from March 2020 to February 2021 (Group A). The number of tissues collected, distributed and discarded were compared with the same time-frame of the 2 previous years: 2019 and 2018 (group B and C, respectively). The different type of transplants performed were reported. Data were analyzed using a non-parametric Friedman test. Results: Corneal procurement and the percentage of distributed tissues reduced in 2020 by more than 30 and 15%, respectively, compared to the 2 previous years. During the pandemic corneal transplant surgery showed only a modest drop: the number of the penetrating keratoplasties (PKs) and the anterior lamellar keratoplasties (ALKs) decreased by about 30 and 20% in comparison with groups B and C, respectively; between the Endothelial Keratoplasties (EKs), the Descemet membrane endothelial keratoplasty (DMEK) increased slightly from March 2020 to February 2021. Conclusions: Italy was one of the first countries most affected by the outbreak of COVID-19, and the Italian government adopted severe measures to limit viral transmission. The pandemic generated several implications in corneal transplant activity during the first lockdown. Then an efficacious reaction with constant, vigorous work led to a resumption of transplant surgery to a near-normal standard. The increase of EKs, despite the pandemic, is a sign that the advance in corneal transplantation has gone ahead and it continues to evolve.
Language	English
Publishing date	2022-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.844601
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Article ; Online: Vascular access for hemodialysis in Italy: What a national survey reveals.

Napoli, Marcello / Guzzi, Francesco / Morale, Walter / Lomonte, Carlo / Galli, Franco / Lodi, Massimo / Bonforte, Giuseppe / Bonucchi, Decenzio / Brunori, Giuliano / Buzzi, Laura / Forneris, Giacomo / Gallieni, Maurizio / Meola, Mario / Pirozzi, Nicola / Sessa, Concetto / Spina, Monica / Tazza, Luigi

The journal of vascular access

2024 , Page(s) 11297298231217318

Abstract: Background: Since in Italy there are no official data on vascular access (VA) for hemodialysis the Vascular Access Project Group (VAPG) of the Italian Society of Nephrology (SIN) designed a national survey.: Methods: A 35-question survey was designed ...

Abstract	Background: Since in Italy there are no official data on vascular access (VA) for hemodialysis the Vascular Access Project Group (VAPG) of the Italian Society of Nephrology (SIN) designed a national survey. Methods: A 35-question survey was designed and sent it to the Italian facilities through the SIN website. The basic questions were the prevalence, the location, and the surveillance of VA, the bedside use of ultrasound, the use of fluoroscopy for central venous catheter (CVC) placement, and of buttonhole technique, the role of nephrologist in the access creation. Result: The questionnaire was completed in June 2022 by 161 facilities. The survey registered 15,499 patients, approximately one-third of the Italian dialysis population. The prevalence of arteriovenous fistula (AVF), arteriovenous Graft (AVG), and CVC were 61.8%, 3.7%, and 34.5% respectively. The AVF location was 50% in distal forearm, 20% in meanproximal forearm, 30% in upper arm. For AVF creation, nephrologists were involved in 72% of facilities while for CVC placement in 62%. As regards VA monitoring, 21% of the facilities did not have a surveillance protocol; 60% did not register AVF thrombosis and 53% did not register CVC infections. Most of facilities use the fluoroscope during CVC placement, 37% when needed, and 22% never. Ultrasound-guided puncture of complex AVFs was used by 80% of facilities. Buttonhole puncture was used in 5% of patients. Conclusions: Some considerations emerge from the survey data: (1) The increasing CVC prevalence compared to DOPPS 5 study. (2) The low rate of AVG prevalence. (3) The nephrologist is the operator in many VA procedures. (4) The fluoroscopy for CVC placement and the US-guide puncture of the complex AVF are widely used in most facilities. (5) The practice of the buttonhole is not widespread. (6) When the operator is the nephrologist more distal fistulas are performed.
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2252820-9
ISSN	1724-6032 ; 1129-7298
ISSN (online)	1724-6032
ISSN	1129-7298
DOI	10.1177/11297298231217318
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Article ; Online: Multimodal anatomy of the human forniceal commissure.

Akeret, Kevin / Forkel, Stephanie J / Buzzi, Raphael M / Vasella, Flavio / Amrein, Irmgard / Colacicco, Giovanni / Serra, Carlo / Krayenbühl, Niklaus

Communications biology

2022 Volume 5, Issue 1, Page(s) 742

Abstract: Ambiguity surrounds the existence and morphology of the human forniceal commissure. We combine advanced in-vivo tractography, multidirectional ex-vivo fiber dissection, and multiplanar histological analysis to characterize this structure's anatomy. ... ...

Abstract	Ambiguity surrounds the existence and morphology of the human forniceal commissure. We combine advanced in-vivo tractography, multidirectional ex-vivo fiber dissection, and multiplanar histological analysis to characterize this structure's anatomy. Across all 178 subjects, in-vivo fiber dissection based on the Human Connectome Project 7 T MRI data identifies no interhemispheric connections between the crura fornicis. Multidirectional ex-vivo fiber dissection under the operating microscope demonstrates the psalterium as a thin soft-tissue membrane spanning between the right and left crus fornicis, but exposes no commissural fibers. Multiplanar histological analysis with myelin and Bielchowsky silver staining, however, visualizes delicate cruciform fibers extending between the crura fornicis, enclosed by connective tissue, the psalterium. The human forniceal commissure is therefore much more delicate than previously described and presented in anatomical textbooks. This finding is consistent with the observed phylogenetic trend of a reduction of the forniceal commissure in non-human primates compared to non-primate eutherian mammals.
MeSH term(s)	Animals ; Connectome ; Humans ; Magnetic Resonance Imaging ; Mammals ; Myelin Sheath ; Phylogeny
Language	English
Publishing date	2022-07-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-03692-3
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Article ; Online: Multimodal anatomy of the human forniceal commissure

Kevin Akeret / Stephanie J. Forkel / Raphael M. Buzzi / Flavio Vasella / Irmgard Amrein / Giovanni Colacicco / Carlo Serra / Niklaus Krayenbühl

Communications Biology, Vol 5, Iss 1, Pp 1-

2022 Volume 11

Abstract: Anatomical dissection and tractography elucidate the delicate nature of the human forniceal commissure, an interhemispheric white matter circuit. ...

Abstract	Anatomical dissection and tractography elucidate the delicate nature of the human forniceal commissure, an interhemispheric white matter circuit.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of the COVID-19 Pandemic on Corneal Transplantation

Rita Mencucci / Michela Cennamo / Diego Ponzin / Federico Genzano Besso / Giulio Pocobelli / Matilde Buzzi / Carlo Nucci / Francesco Aiello

Frontiers in Medicine, Vol

A Report From the Italian Association of Eye Banks

2022 Volume 9

Abstract: PurposeTo analyze the impact of COVID-19 on Italian corneal transplantation from March-2020 to February 2021 compared to the same timeframe of the 2 previous years, in order to identify potential consequences of a global pandemic on corneal procurement ... ...

Abstract	PurposeTo analyze the impact of COVID-19 on Italian corneal transplantation from March-2020 to February 2021 compared to the same timeframe of the 2 previous years, in order to identify potential consequences of a global pandemic on corneal procurement and transplantation services during this time.MethodsThis national, multicentric, retrospective cohort study evaluated data collected from 12 (100%) Italian eye banks from March 2020 to February 2021 (Group A). The number of tissues collected, distributed and discarded were compared with the same time-frame of the 2 previous years: 2019 and 2018 (group B and C, respectively). The different type of transplants performed were reported. Data were analyzed using a non-parametric Friedman test.ResultsCorneal procurement and the percentage of distributed tissues reduced in 2020 by more than 30 and 15%, respectively, compared to the 2 previous years. During the pandemic corneal transplant surgery showed only a modest drop: the number of the penetrating keratoplasties (PKs) and the anterior lamellar keratoplasties (ALKs) decreased by about 30 and 20% in comparison with groups B and C, respectively; between the Endothelial Keratoplasties (EKs), the Descemet membrane endothelial keratoplasty (DMEK) increased slightly from March 2020 to February 2021.ConclusionsItaly was one of the first countries most affected by the outbreak of COVID-19, and the Italian government adopted severe measures to limit viral transmission. The pandemic generated several implications in corneal transplant activity during the first lockdown. Then an efficacious reaction with constant, vigorous work led to a resumption of transplant surgery to a near-normal standard. The increase of EKs, despite the pandemic, is a sign that the advance in corneal transplantation has gone ahead and it continues to evolve.
Keywords	SARS-CoV-2 ; eye bank guidelines ; corneal transplant ; eye donor screening ; endokeratoplasty ; Medicine (General) ; R5-920
Subject code	940
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The psycho-social effects of COVID-19 on Italian adolescents' attitudes and behaviors.

Buzzi, Carlo / Tucci, Maurizio / Ciprandi, Riccardo / Brambilla, Ilaria / Caimmi, Silvia / Ciprandi, Giorgio / Marseglia, Gian Luigi

Italian journal of pediatrics

2020 Volume 46, Issue 1, Page(s) 69

Abstract: Background: COVID-19 is an emerging issue that has significant consequences on psycho-social well-being.: Methods: In this regard, a survey was conducted on a large group of adolescents in Italy. The survey investigated four items: concerns and fears, ...

Abstract	Background: COVID-19 is an emerging issue that has significant consequences on psycho-social well-being. Methods: In this regard, a survey was conducted on a large group of adolescents in Italy. The survey investigated four items: concerns and fears, information on the pandemic, provisions of public authorities (e.g., lockdown), and impact on everyday life. Results: Adolescents actively participated in the survey. COVID-19 affected emotions and lifestyle. COVID-19 influenced relationships with peers and parents. There were regional differences. Conclusions: The current research highlighted the remarkable, healthy, and certainly unexpected, emotional balance of the new generations in the face of a sudden, unpredictable phenomenon capable of jeopardizing life itself. While understanding the gravity of the phenomenon and willingly adapting to all the necessary precautions, the adolescents still seemed to express an excellent ability to manage situations of insecurity and to deal with unfavorable and adverse conditions by adapting to the new routine and finding alternative and innovative means of meeting their social and psychological needs.
MeSH term(s)	Adolescent ; Adolescent Behavior/psychology ; Attitude ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Cross-Sectional Studies ; Emotions/physiology ; Female ; Humans ; Italy/epidemiology ; Life Style ; Male ; Pandemics ; Parents/psychology ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; SARS-CoV-2 ; Surveys and Questionnaires
Keywords	covid19
Language	English
Publishing date	2020-05-24
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-020-00833-4
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Article ; Online: The value-based healthcare approach to haemophilia: Development of outcome measures for the evaluation of care of people with haemophilia.

Cortesi, Paolo Angelo / Fornari, Carla / Conti, Sara / Pollio, Berardino / Boccalandro, Elena / Buzzi, Andrea / Carulli, Christian / Coppola, Antonio / De Cristofaro, Raimondo / Di Minno, Matteo Nicola Dario / Dolan, Gerard / Ferri Grazzi, Enrico / Fornari, Arianna / Gualtierotti, Roberta / Hermans, Cedric / Jiménez-Juste, Victor / Kenet, Gili / Lupi, Angelo / Martinoli, Carlo /

Mansueto, Maria Francesca / Nicolò, Gabriella / Tagliaferri, Annarita / Gringeri, Alessandro / Molinari, Angelo Claudio / Mantovani, Lorenzo Giovanni / Castaman, Giancarlo

Haemophilia : the official journal of the World Federation of Hemophilia

2024 Volume 30, Issue 2, Page(s) 437–448

Abstract: Introduction: Considering the advances in haemophilia management and treatment observed in the last decades, a new set of value-based outcome indicators is needed to assess the quality of care and the impact of these medical innovations.: Aim: The ... ...

Abstract	Introduction: Considering the advances in haemophilia management and treatment observed in the last decades, a new set of value-based outcome indicators is needed to assess the quality of care and the impact of these medical innovations. Aim: The Value-Based Healthcare in Haemophilia project aimed to define a set of clinical outcome indicators (COIs) and patient-reported outcome indicators (PROIs) to assess quality of care in haemophilia in high-income countries with a value-based approach to inform and guide the decision-making process. Methods: A Value-based healthcare approach based on the available literature, current guidelines and the involvement of a multidisciplinary group of experts was applied to generate a set of indicators to assess the quality of care of haemophilia. Results: A final list of three COIs and five PROIs was created and validated. The identified COIs focus on two domains: musculoskeletal health and function, and safety. The identified PROIs cover five domains: bleeding frequency, pain, mobility and physical activities, Health-Related Quality of Life and satisfaction. Finally, two composite outcomes, one based on COIs, and one based on PROIs, were proposed as synthetic outcome indicators of quality of care. Conclusion: The presented standard set of health outcome indicators provides the basis for harmonised longitudinal and cross-sectional monitoring and comparison. The implementation of this value-based approach would enable a more robust assessment of quality of care in haemophilia, within a framework of continuous treatment improvements with potential added value for patients. Moreover, proposed COIs and PROIs should be reviewed and updated routinely.
MeSH term(s)	Humans ; Hemophilia A/drug therapy ; Quality of Life ; Cross-Sectional Studies ; Value-Based Health Care ; Outcome Assessment, Health Care
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1229713-6
ISSN	1365-2516 ; 1351-8216 ; 1355-0691
ISSN (online)	1365-2516
ISSN	1351-8216 ; 1355-0691
DOI	10.1111/hae.14943
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Article ; Online: The psycho-social effects of COVID-19 on Italian adolescents’ attitudes and behaviors

Carlo Buzzi / Maurizio Tucci / Riccardo Ciprandi / Ilaria Brambilla / Silvia Caimmi / Giorgio Ciprandi / Gian Luigi Marseglia

Italian Journal of Pediatrics, Vol 46, Iss 1, Pp 1-

2020 Volume 7

Abstract: Abstract Background COVID-19 is an emerging issue that has significant consequences on psycho-social well-being. Methods In this regard, a survey was conducted on a large group of adolescents in Italy. The survey investigated four items: concerns and ... ...

Abstract	Abstract Background COVID-19 is an emerging issue that has significant consequences on psycho-social well-being. Methods In this regard, a survey was conducted on a large group of adolescents in Italy. The survey investigated four items: concerns and fears, information on the pandemic, provisions of public authorities (e.g., lockdown), and impact on everyday life. Results Adolescents actively participated in the survey. COVID-19 affected emotions and lifestyle. COVID-19 influenced relationships with peers and parents. There were regional differences. Conclusions The current research highlighted the remarkable, healthy, and certainly unexpected, emotional balance of the new generations in the face of a sudden, unpredictable phenomenon capable of jeopardizing life itself. While understanding the gravity of the phenomenon and willingly adapting to all the necessary precautions, the adolescents still seemed to express an excellent ability to manage situations of insecurity and to deal with unfavorable and adverse conditions by adapting to the new routine and finding alternative and innovative means of meeting their social and psychological needs.
Keywords	COVID-19 ; Adolescents ; Survey ; Psycho-social issues ; Italy ; Pediatrics ; RJ1-570 ; covid19
Subject code	300
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The role of cone beam CT in the study of symptomatic total knee arthroplasty (TKA): a 20 cases report.

Nardi, Cosimo / Buzzi, Roberto / Molteni, Roberto / Cossi, Carlo / Lorini, Chiara / Calistri, Linda / Colagrande, Stefano

The British journal of radiology

2017 Volume 90, Issue 1074, Page(s) 20160925

Abstract: Objective: The aims of this study were to evaluate the efficacy of cone beam CT (CBCT) in the study of the patellar tilt angle and rotational alignment of the femoral/tibial component after total knee arthroplasty and to estimate how metallic artefacts ... ...

Abstract	Objective: The aims of this study were to evaluate the efficacy of cone beam CT (CBCT) in the study of the patellar tilt angle and rotational alignment of the femoral/tibial component after total knee arthroplasty and to estimate how metallic artefacts impaired detection of periprosthetic bone structures and bordering tendon-muscle structures. Methods: 20 symptomatic total knee arthroplasties were examined using CBCT by three independent observers. The patellar tilt angle and rotational alignment of femoral and tibial components were measured in relation to the femoral flange, transepicondylar axis and tibial tuberosity, respectively. A four-score scale, ranging from "many metallic artefacts" (the structure cannot be identified) to "no metallic artefacts" (the structure can be perfectly identified), was used to judge every structure. Results: The patellar tilt angle and rotational alignment of the prosthetic components showed very high intra- and interobserver agreements (intraclass correlation coefficient values 0.895-0.975 and 0.891-0.948, respectively). Bone and tendon-muscle structures cannot be identified in the distal part of the femoral component, whereas they can be well identified in the proximal part of the femoral component and in the proximal/middle third of the tibial stem. Conclusion: CBCT was an effective tool, providing reproducible measurements of the patellar tilt angle and the rotational alignment of the femoral/tibial component. Furthermore, it allowed bone and tendon-muscle structures analysis with little impediments from metal artefacts. Advances in knowledge: CBCT allows easy and accurate measurements on the rotational axial plane, unburdened by image quality impairment due to metal artefacts.
MeSH term(s)	Aged ; Arthroplasty, Replacement, Knee ; Cone-Beam Computed Tomography/methods ; Female ; Humans ; Male ; Postoperative Complications/diagnostic imaging
Language	English
Publishing date	2017-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20160925
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