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Article: Total hip arthroplasty following the failure of intertrochanteric nailing: First implant or salvage surgery?

Solarino, Giuseppe / Bizzoca, Davide / Dramisino, Pasquale / Vicenti, Giovanni / Moretti, Lorenzo / Moretti, Biagio / Piazzolla, Andrea

World journal of orthopedics

2023 Volume 14, Issue 10, Page(s) 763–770

Abstract: Background: Proximal femur fractures, including both intracapsular (femoral neck fractures) and extracapsular fractures (intertrochanteric femoral fractures, IFFs), affect around 1.5 million people per year worldwide. Mechanical failures of ... ...

Abstract	Background: Proximal femur fractures, including both intracapsular (femoral neck fractures) and extracapsular fractures (intertrochanteric femoral fractures, IFFs), affect around 1.5 million people per year worldwide. Mechanical failures of intertrochanteric nailing in IFFs could be managed with revision total hip arthroplasty (THA). Aim: To describe the surgical complexity and the procedure-related complication rates in patients with trochanteric nailing failure and treated with THA. Methods: Patients referred to our level I trauma center between April 2012 and July 2018 with failed cephalomedullary nailing following trochanteric fractures were retrospectively recruited. All patients underwent a salvage surgical procedure, Results: Seventy-four patients met the inclusion criteria (male: 29; female: 45; mean age: 73.8-years-old; range: 65-89) and were included in the current study. The average operative time was 117 min (76-192 min). The average blood loss was 585 mL (430-1720 mL). Among the 74 patients, 43 (58.1%) required transfusion of three or more blood units. Two patients died within the 4 Conclusion: The present study demonstrated that salvage options for IFF fixation failure are complex procedures with a relevant intraoperative and postoperative complication rate.
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649712-8
ISSN	2218-5836
ISSN	2218-5836
DOI	10.5312/wjo.v14.i10.763
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Article ; Online: Polydeoxyribonucleotide in the Treatment of Tendon Disorders, from Basic Science to Clinical Practice: A Systematic Review.

Bizzoca, Davide / Brunetti, Giovanni / Moretti, Lorenzo / Piazzolla, Andrea / Vicenti, Giovanni / Moretti, Francesco Luca / Solarino, Giuseppe / Moretti, Biagio

International journal of molecular sciences

2023 Volume 24, Issue 5

Abstract: Polydeoxyribonucleotide (PDRN) is a proprietary and registered drug with several beneficial effects, including tissue repairing, anti-ischemic action, and anti-inflammatory properties. The present study aims to summarize the current evidence about PRDN's ...

Abstract	Polydeoxyribonucleotide (PDRN) is a proprietary and registered drug with several beneficial effects, including tissue repairing, anti-ischemic action, and anti-inflammatory properties. The present study aims to summarize the current evidence about PRDN's clinical effectiveness in the management of tendon disorders. From January 2015 to November 2022, OVID-MEDLINE
MeSH term(s)	Humans ; Male ; Tendinopathy/therapy ; Rotator Cuff Injuries/drug therapy ; Polydeoxyribonucleotides ; Achilles Tendon ; Rotator Cuff ; Treatment Outcome ; Chronic Disease
Chemical Substances	Polydeoxyribonucleotides
Language	English
Publishing date	2023-02-26
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24054582
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Article ; Online: Subjective perception of spinal deformity after selective versus non-selective fusion of Lenke 1C curves.

Bizzoca, Davide / Piazzolla, Andrea / Solarino, Giuseppe / Moretti, Lorenzo / Moretti, Biagio

Spine deformity

2022 Volume 10, Issue 4, Page(s) 855–863

Abstract: Purpose: To assess the self-image perception and the Quality-of-Life (QoL) in female adolescents, with Lenke 1C scoliosis curves, treated with selective versus non-selective posterior spinal instrumentation and fusion (PSF).: Methods: Patients ... ...

Abstract	Purpose: To assess the self-image perception and the Quality-of-Life (QoL) in female adolescents, with Lenke 1C scoliosis curves, treated with selective versus non-selective posterior spinal instrumentation and fusion (PSF). Methods: Patients undergoing PSF for idiopathic adolescent scoliosis (AIS) were recruited and divided into two groups: patients managed with selective thoracic fusion (STF) were included in Group A, whereas patients treated with non-selective fusion (N-STF) in Group B. Each patient completed the Italian version of the Scoliosis Research Society-22R questionnaire (SRS-22R), the Quality-of-Life Profile for Spinal Deformities questionnaire (QLPSD) and the Spinal Appearance Questionnaire (SAQ), before surgery and at 24-month follow-up. Results: One hundred and fifty seven female patients (mean age 16.38) were included in this study. 80 patients underwent STF, while 77 patients received N-STF. At 24-month follow-up, patients managed with N-STF showed better SRS-22R self-image mean score (p = .012), SRS-22R satisfaction mean score (p = .033), QLPSD body image mean score (p = .005), but worse SRS-22 function mean score (p = .006) and QLPSD back flexibility mean score (p = .007), compared with patients who underwent STF. In terms of self-image perception, patients undergoing STF showed significantly worse SAQ total mean score (p = .002), SAQ appearance mean score (p = .001) and SAQ expectation (p = .001). We found a significant correlation between SAQ appearance mean score and SRS-22R self-image (R = - 0.721), SRS-22 mental health (R = - 0.8), QLPSD psychosocial functioning (R = 0.7) and QLPSD back flexibility (R = 0.8). Conclusion: Although the STF of Lenke 1C curves provides better functional outcomes, in the present study, female patients receiving STF revealed a worse perceived body image, compared with patients treated with N-STF, at 24-month follow-up. Particular attention should be addressed to the preoperative patient's mental health and body image perception, when choosing between STF and N-STF.
MeSH term(s)	Adolescent ; Body Image ; Female ; Humans ; Kyphosis/surgery ; Quality of Life/psychology ; Scoliosis/diagnostic imaging ; Scoliosis/surgery ; Spinal Fusion/adverse effects ; Spinal Fusion/methods
Language	English
Publishing date	2022-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2717704-X
ISSN	2212-1358 ; 2212-134X ; 2212-1358
ISSN (online)	2212-1358 ; 2212-134X
ISSN	2212-1358
DOI	10.1007/s43390-022-00479-8
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Article: Physiologic postoperative presepsin kinetics following primary cementless total hip arthroplasty: A prospective observational study.

Bizzoca, Davide / Piazzolla, Andrea / Moretti, Lorenzo / Vicenti, Giovanni / Moretti, Biagio / Solarino, Giuseppe

World journal of orthopedics

2023 Volume 14, Issue 7, Page(s) 547–553

Abstract: Background: Presepsin is an emerging biomarker in the diagnosis of sepsis. In the field of orthopaedics, it could be useful in diagnosing and managing periprosthetic joint infections.: Aim: To define the normal postoperative presepsin plasmatic curve, ...

Abstract	Background: Presepsin is an emerging biomarker in the diagnosis of sepsis. In the field of orthopaedics, it could be useful in diagnosing and managing periprosthetic joint infections. Aim: To define the normal postoperative presepsin plasmatic curve, in patients undergoing primary cementless total hip arthroplasty (THA). Methods: Patients undergoing primary cementless THA at our Institute were recruited. Inclusion criteria were: Primary osteoarthritis of the hip; urinary catheter time of permanence < 24 h; peripheral venous cannulation time of permanence < 24 h; no postoperative homologous blood transfusion administration and hospital stay ≤ 8 d. Exclusion criteria were: The presence of other articular prosthetic replacement or bone fixation devices; chronic inflammatory diseases; chronic kidney diseases; history of recurrent infections or malignant neoplasms; previous surgery in the preceding 12 mo; diabetes mellitus; immunosuppressive drug or corticosteroid assumption. All the patients received the same antibiotic prophylaxis. All the THA were performed by the same surgical and anaesthesia team; total operative time was defined as the time taken from skin incision to completion of skin closure. At enrollment, anthropometric data, smocking status, osteoarthritis stage according to Kellgren and Lawrence, Harris Hip Score, drugs assumption and comorbidities were recorded. All the patients underwent serial blood tests, including complete blood count, presepsin (PS) and C-reactive protein 24 h before arthroplasty and at 24, 48, 72 and 96 h postoperatively and at 3, 6 and 12-mo follow-up. Results: A total of 96 patients (51 female; 45 male; mean age = 65.74 ± 5.58) were recruited. The mean PS values were: 137.54 pg/mL at baseline, 192.08 pg/mL at 24 h post-op; 254.85 pg/mL at 48 h post-op; 259 pg/mL at 72 h post-op; 248.6 pg/mL at 96-h post-op; 140.52 pg/mL at 3-mo follow-up; 135.55 pg/mL at 6-mo follow-up and 130.11 pg/mL at 12-mo follow-up. In two patients (2.08%) a soft-tissue infection was observed; in these patients, higher levels (> 350 pg/mL) were recorded at 3-mo follow-up. Conclusion: The dosage of plasmatic PS concentration is highly recommended in patients undergoing THA before surgery to exclude the presence of an unknown infection. The PS plasmatic concentration should be also assessed at 72 h post-operatively, evaluate the maximum postoperative PS value, and at 96 h post-operatively when a decrease of presepsin should be found. The lack of a presepsin decrease at 96 h post-operatively could be a predictive factor of infection.
Language	English
Publishing date	2023-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649712-8
ISSN	2218-5836
ISSN	2218-5836
DOI	10.5312/wjo.v14.i7.547
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Article: Gender-Related Issues in the Management of Low-Back Pain: A Current Concepts Review.

Bizzoca, Davide / Solarino, Giuseppe / Pulcrano, Alessandro / Brunetti, Giovanni / Moretti, Anna Maria / Moretti, Lorenzo / Piazzolla, Andrea / Moretti, Biagio

Clinics and practice

2023 Volume 13, Issue 6, Page(s) 1360–1368

Abstract: Background: Low back pain (LBP) is an emerging disease. This review aims to investigate the role of gender-related factors in the diagnosis, clinical, and surgical management of LBP.: Methods: From January 2002 to March 2023, EMBASE, SCOPUS, OVID- ... ...

Abstract	Background: Low back pain (LBP) is an emerging disease. This review aims to investigate the role of gender-related factors in the diagnosis, clinical, and surgical management of LBP. Methods: From January 2002 to March 2023, EMBASE, SCOPUS, OVID-MEDLINE, Google Scholar, PubMed, and Web of Science were searched to identify relevant papers for further analysis. Results: Fifteen papers were included in this review. Sex- and gender-related differences were analyzed regarding the following points: (1) LBP epidemiology; (2) LBP physiopathology; (3) conservative management of LBP; (4) major vertebral surgery for LBP. The conservative treatment of LBP highlights that women claim services later in terms of poorer health status than men. In the postoperative phase, female patients show worse LBP, quality of life, and disability, but equal or greater interval change, compared with male patients complaining of lumbar degenerative disease. Conclusions: LBP epidemiology and clinical outcomes, following conservative and surgical management of patients complaining of back pain, might depend on both sex- and gender-related factors. It is mandatory to assess gender-related indicators in patients referred to LBP and address them to improve their clinical outcomes and quality of life.
Language	English
Publishing date	2023-10-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2605724-4
ISSN	2039-7283 ; 2039-7275
ISSN (online)	2039-7283
ISSN	2039-7275
DOI	10.3390/clinpract13060122
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Article ; Online: Targeting Adenosine Signalling in Knee Chondropathy: The Combined Action of Polydeoxyribonucleotide and Pulsed Electromagnetic Fields: A Current Concept Review.

Moretti, Lorenzo / Bizzoca, Davide / Geronimo, Alessandro / Abbaticchio, Andrea Michele / Moretti, Francesco Luca / Carlet, Arianna / Fischetti, Francesco / Moretti, Biagio

International journal of molecular sciences

2023 Volume 24, Issue 12

Abstract: Chondropathy of the knee is one of the most frequent degenerative cartilage pathologies with advancing age. Scientific research has, in recent years, advanced new therapies that target adenosine A2 receptors, which play a significant role in human health ...

Abstract	Chondropathy of the knee is one of the most frequent degenerative cartilage pathologies with advancing age. Scientific research has, in recent years, advanced new therapies that target adenosine A2 receptors, which play a significant role in human health against many disease states by activating different protective effects against cell sufferance and damage. Among these, it has been observed that intra-articular injections of polydeoxyribonucleotides (PDRN) and Pulsed Electromagnetic Fields (PEMF) can stimulate the adenosine signal, with significant regenerative and healing effects. This review aims to depict the role and therapeutic modulation of A2A receptors in knee chondropathy. Sixty articles aimed at providing data for our study were included in this review. The present paper highlights how intra-articular injections of PDRN create beneficial effects by reducing pain and improving functional clinical scores, thanks to their anti-inflammatory action and the important healing and regenerating power of the stimulation of cell growth, production of collagen, and the extracellular matrix. PEMF therapy is a valid option in the conservative treatment of different articular pathologies, including early OA, patellofemoral pain syndrome, spontaneous osteonecrosis of the knee (SONK), and in athletes. PEMF could also be used as a supporting therapy after an arthroscopic knee procedure total knee arthroplasty to reduce the post-operative inflammatory state. The proposal of new therapeutic approaches capable of targeting the adenosine signal, such as the intra-articular injection of PDRN and the use of PEMF, has shown excellent beneficial results compared to conventional treatments. These are presented as an extra weapon in the fight against knee chondropathy.
MeSH term(s)	Humans ; Osteoarthritis, Knee/pathology ; Adenosine/therapeutic use ; Electromagnetic Fields ; Polydeoxyribonucleotides/pharmacology ; Polydeoxyribonucleotides/therapeutic use ; Knee Joint/pathology
Chemical Substances	Adenosine (K72T3FS567) ; Polydeoxyribonucleotides
Language	English
Publishing date	2023-06-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241210090
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Article: Gender-Related Factors Influence the Subjective Perception of Deformity in Patients Undergoing Surgery for Idiopathic Scoliosis.

Bizzoca, Davide / Solarino, Giuseppe / Moretti, Anna Maria / Moretti, Lorenzo / Dramisino, Pasquale / Piazzolla, Andrea / Moretti, Biagio

Journal of personalized medicine

2023 Volume 13, Issue 11

Abstract: The present study aims to depict the importance of gender-related factors in the subjective perception of spine deformity in adolescents undergoing posterior instrumented fusion for scoliosis. Patients undergoing posterior spinal instrumentation and ... ...

Abstract	The present study aims to depict the importance of gender-related factors in the subjective perception of spine deformity in adolescents undergoing posterior instrumented fusion for scoliosis. Patients undergoing posterior spinal instrumentation and fusion (PSF) for idiopathic adolescent scoliosis (AIS) were recruited. The following data were recorded: gender, age, parents' civil status, Tegner Activity Scale (TAS), body mass index (BMI), concomitant diseases, and history of neuropsychological disorders. Each patient underwent clinical and radiological evaluations according to the protocol used at our institution. All the patients were assessed before surgery using the following Patient-Reported Outcome Measures (PROMs): the Italian version of the revised Scoliosis Research Society-22 patient questionnaire (SRS-22R), the Quality-of-Life Profile for Spinal Deformities (QLPSDs) questionnaire, and the Spinal Appearance Questionnaire (SAQ). The present study recruited 80 patients (male: 19, female: 61). A significant correlation was observed between BMI, TAS, and subjective perception scores. A worse deformity perception was observed in female patients and patients with divorced parents. Gender-related factors impact the subjective perception of spine deformity in patients undergoing PSF for AIS. Specific assessment and correction are needed to improve postoperative outcomes in these patients.
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13111585
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Article ; Online: Motion Technologies in Support of Fence Athletes

Simona Aresta / Mariapia Musci / Francesco Bottiglione / Lorenzo Moretti / Biagio Moretti / Ilaria Bortone

Applied Sciences, Vol 13, Iss 1654, p

A Systematic Review

2023 Volume 1654

Abstract: Sports biomechanics enables thorough examination of athletic movements to enhance athletic performance and/or reduce injury risk. Few studies have looked at the possibilities of cutting-edge technology in fencing, even though it presents an intriguing ... ...

Abstract	Sports biomechanics enables thorough examination of athletic movements to enhance athletic performance and/or reduce injury risk. Few studies have looked at the possibilities of cutting-edge technology in fencing, even though it presents an intriguing scenario for sports biomechanics due to the significant demands it places on the body in terms of neuromuscular coordination, strength, power, and musculoskeletal system impact. The aim of the study is to identify and summarise current evidence on the application of motion technologies in support of fence athletes and to provide a framework for the assessment and training of fencers, including performance measures and protocols. Peer-reviewed research was identified from electronic databases using a structured keyword search. Details regarding experimental design, study group characteristics, and measured outcomes were extracted from retrieved studies, summarised, and information regrouped under themes for analysis. The methodological quality of the evidence was evaluated. Thirty-five studies were included in the present review, which showed kinetic, kinematic, muscle recruitment and coordination differences among athletes as gender and athletic training differed. Findings revealed that most of the included studies investigated the lunge technique in professional athletes using Optoelectronic Systems and force platforms as preferred motion technologies. Only nine studies reported the assessment of muscle activation during task execution ( <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>25.7</mn></mrow></semantics></math> %). Less than 20% of the study recurred to Artificial Intelligence/Machine Learning (AI/ML) approaches in the analysis. The potential contribution of the user’s kinematic/kinetic data and physiological measures is still underestimated. The recommendations provided in this study could help promote and support further cross-sectional and longitudinal studies in the ...
Keywords	fence ; biomechanics ; sensors ; performance ; artificial intelligence ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	796
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Filament Transport Control for Enhancing Mechanical Properties of Parts Realised by Fused Filament Fabrication.

Rossi, Arianna / Morettini, Giulia / Moretti, Michele / Capponi, Lorenzo

Materials (Basel, Switzerland)

2022 Volume 15, Issue 10

Abstract: The fused filament fabrication (FFF) process is widely used for producing prototypes and functional parts for diverse applications. While FFF is particularly attractive due to its cost-effectiveness, on the other hand, the fabricated parts have ... ...

Abstract	The fused filament fabrication (FFF) process is widely used for producing prototypes and functional parts for diverse applications. While FFF is particularly attractive due to its cost-effectiveness, on the other hand, the fabricated parts have limitations in terms of large manufacturing time and reduced mechanical properties. The latter is strongly influenced by the fabrication process parameters, which affect the interlayer bonding and the adhesion between consecutive layers. Several works presented in the literature analysed the correlation between mechanical properties and process parameters. It was demonstrated that an increase in the fabrication feed rate causes slippage between filament and the feeding system, which leads to a decrease in the extruded material flow, and thus in part density. This work aims to investigate how the limitation of the slippage phenomenon affects the mechanical properties of parts fabricated using the FFF process. A prototype machine, equipped with a closed-loop control system on filament transport, was used to fabricate samples for tensile tests and dynamical mechanical analysis. Samples fabricated enabling the filament transport control showed an increase both in ultimate tensile strength and elongation at break for those fabricated with disabled control, whilst a decrease in stiffness was observed. In addition, the results showed that the use of a filament transport control system on a FFF machine increases the possibility of fabricating high value-added parts.
Language	English
Publishing date	2022-05-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15103530
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Article ; Online: Gender-Related Issues in the Management of Low-Back Pain

Davide Bizzoca / Giuseppe Solarino / Alessandro Pulcrano / Giovanni Brunetti / Anna Maria Moretti / Lorenzo Moretti / Andrea Piazzolla / Biagio Moretti

Clinics and Practice, Vol 13, Iss 6, Pp 1360-

A Current Concepts Review

2023 Volume 1368

Abstract: Background: Low back pain (LBP) is an emerging disease. This review aims to investigate the role of gender-related factors in the diagnosis, clinical, and surgical management of LBP. Methods: From January 2002 to March 2023, EMBASE, SCOPUS, OVID-MEDLINE, ...

Abstract	Background: Low back pain (LBP) is an emerging disease. This review aims to investigate the role of gender-related factors in the diagnosis, clinical, and surgical management of LBP. Methods: From January 2002 to March 2023, EMBASE, SCOPUS, OVID-MEDLINE, Google Scholar, PubMed, and Web of Science were searched to identify relevant papers for further analysis. Results: Fifteen papers were included in this review. Sex- and gender-related differences were analyzed regarding the following points: (1) LBP epidemiology; (2) LBP physiopathology; (3) conservative management of LBP; (4) major vertebral surgery for LBP. The conservative treatment of LBP highlights that women claim services later in terms of poorer health status than men. In the postoperative phase, female patients show worse LBP, quality of life, and disability, but equal or greater interval change, compared with male patients complaining of lumbar degenerative disease. Conclusions: LBP epidemiology and clinical outcomes, following conservative and surgical management of patients complaining of back pain, might depend on both sex- and gender-related factors. It is mandatory to assess gender-related indicators in patients referred to LBP and address them to improve their clinical outcomes and quality of life.
Keywords	low-back pain ; spine degenerative diseases ; spinal stenosis ; degenerative disc disease ; lumbar intervertebral disc herniation ; spondylolisthesis ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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