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  1. Article: Effect of Shi-Zhen-An-Shen herbal formula granule in the treatment of young people at ultra-high risk for psychosis: a pilot study.

    Zhu, Hong / Ning, Yanzhe / Zheng, Sisi / Feng, Sitong / Dong, Linrui / Jia, Hongxiao

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1160452

    Abstract: ... from the outpatient department. They were randomly assigned to receive either Shi-Zhen-An-Shen herbal formula granule ...

    Abstract Introduction: To date, there is no conclusive evidence for early interventions on ultra-high risk (UHR) for psychosis. The Chinese herbal medicine is confirmed to be beneficial in improving psychiatric symptoms and cognitive impairments for schizophrenia patients. However, the effect of Chinese herbal medicine on treating UHR patients remains unknown.
    Methods: Eighty UHR patients were recruited from the outpatient department. They were randomly assigned to receive either Shi-Zhen-An-Shen herbal formula granule (SZAS-HFG) combined with aripiprazole placebo or aripiprazole combined with SZAS-HFG placebo for a 12-week treatment. The psychiatric symptoms were assessed using the Structured Interview for Prodromal Syndromes (SIPS). The Trail Making Test part A (TMT-A), Brief Visuospatial Memory Test (BVMT), Hopkins Verbal Learning Test (HVLT), and Continuous Performance Test (CPT) were used to assess cognitive functions. we also employed the Global Assessment of Functioning (GAF) to evaluate social functioning. The linear mixed-effects models were performed to detect the difference in effectiveness between the two groups.
    Results: After 12-week treatment, both groups showed significant effects of time on SIPS, TMT-A, HVLT, BVMT, and GAF. There was a significant effect of group only on CPT. Moreover, we also found a significant interaction effect on GAF.
    Conclusion: SZAS-HFG can effectively alleviate psychosis symptoms, and improve cognitive impairments and overall functioning as well as aripiprazole.
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1160452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of Shi-Zhen-An-Shen herbal formula granule in the treatment of young people at ultra-high risk for psychosis

    Hong Zhu / Yanzhe Ning / Sisi Zheng / Sitong Feng / Linrui Dong / Hongxiao Jia

    Frontiers in Psychiatry, Vol

    a pilot study

    2023  Volume 14

    Abstract: ... from the outpatient department. They were randomly assigned to receive either Shi-Zhen-An-Shen herbal formula granule ...

    Abstract IntroductionTo date, there is no conclusive evidence for early interventions on ultra-high risk (UHR) for psychosis. The Chinese herbal medicine is confirmed to be beneficial in improving psychiatric symptoms and cognitive impairments for schizophrenia patients. However, the effect of Chinese herbal medicine on treating UHR patients remains unknown.MethodsEighty UHR patients were recruited from the outpatient department. They were randomly assigned to receive either Shi-Zhen-An-Shen herbal formula granule (SZAS-HFG) combined with aripiprazole placebo or aripiprazole combined with SZAS-HFG placebo for a 12-week treatment. The psychiatric symptoms were assessed using the Structured Interview for Prodromal Syndromes (SIPS). The Trail Making Test part A (TMT-A), Brief Visuospatial Memory Test (BVMT), Hopkins Verbal Learning Test (HVLT), and Continuous Performance Test (CPT) were used to assess cognitive functions. we also employed the Global Assessment of Functioning (GAF) to evaluate social functioning. The linear mixed-effects models were performed to detect the difference in effectiveness between the two groups.ResultsAfter 12-week treatment, both groups showed significant effects of time on SIPS, TMT-A, HVLT, BVMT, and GAF. There was a significant effect of group only on CPT. Moreover, we also found a significant interaction effect on GAF.ConclusionSZAS-HFG can effectively alleviate psychosis symptoms, and improve cognitive impairments and overall functioning as well as aripiprazole.Clinical trial registration: Chinese Clinical Trial Registry, ChiCTR-IOR-17013513.
    Keywords ultra-high risk ; Chinese herbal medicine ; cognitive impairment ; social functioning ; schizophrenia ; Psychiatry ; RC435-571
    Subject code 150
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine.

    Shao, Heng / Gan, Quan / Chen, Zhuangfei / Zhu, Shasha / Zhu, Yanqing

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 7761852

    Abstract: ... a pharmacological network on genetic targets and pathways between Jiu Wei Zhen Xin Formula (JWZXF) and GAD ...

    Abstract Currently, there are many effective pharmacological treatments for generalized anxiety disorder (GAD), formulated herbal granule is also an alternative way. Our research intends to construct a pharmacological network on genetic targets and pathways between Jiu Wei Zhen Xin Formula (JWZXF) and GAD. Through the TCMSP database, we collected the active ingredients of JWZXF and potential targets of the active ingredients. The GAD-related proteins collected from GeneCards database and DisGeNET database were combined. Component-target protein networks were constructed and visualized using Cytoscape 3.8.2 software to comprehensively clarify the relationships between ingredients, components, and targets. The intersection targets were imported into the STRING database, and the protein-protein interaction (PPI) network was constructed. We constructed and analyzed the visualized "drug-target-disease" network. Gene Ontology (GO) enrichment together with Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis were conducted on the common target through R language. Forty-one effective components and 106 potential targets of JWZXF were found. There were top ten hub genes and multiple important signaling pathways involved in the treatment of GAD with the JWZXF. This study expounded the pharmacological actions and molecular mechanisms of the JWZXF in treating GAD from a holistic perspective. The potential pharmacological effects of the JWZXF are closely related to regulation because not only does it comprehensively analyze the possible mechanism of JWZXF treatment of GAD but it can also facilitate further in-depth research and provide a theoretical basis for the clinical expansion of its application.
    Language English
    Publishing date 2022-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/7761852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine

    Heng Shao / Quan Gan / Zhuangfei Chen / Shasha Zhu / Yanqing Zhu

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Volume 2022

    Abstract: ... a pharmacological network on genetic targets and pathways between Jiu Wei Zhen Xin Formula (JWZXF) and GAD ...

    Abstract Currently, there are many effective pharmacological treatments for generalized anxiety disorder (GAD), formulated herbal granule is also an alternative way. Our research intends to construct a pharmacological network on genetic targets and pathways between Jiu Wei Zhen Xin Formula (JWZXF) and GAD. Through the TCMSP database, we collected the active ingredients of JWZXF and potential targets of the active ingredients. The GAD-related proteins collected from GeneCards database and DisGeNET database were combined. Component-target protein networks were constructed and visualized using Cytoscape 3.8.2 software to comprehensively clarify the relationships between ingredients, components, and targets. The intersection targets were imported into the STRING database, and the protein-protein interaction (PPI) network was constructed. We constructed and analyzed the visualized “drug-target-disease” network. Gene Ontology (GO) enrichment together with Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis were conducted on the common target through R language. Forty-one effective components and 106 potential targets of JWZXF were found. There were top ten hub genes and multiple important signaling pathways involved in the treatment of GAD with the JWZXF. This study expounded the pharmacological actions and molecular mechanisms of the JWZXF in treating GAD from a holistic perspective. The potential pharmacological effects of the JWZXF are closely related to regulation because not only does it comprehensively analyze the possible mechanism of JWZXF treatment of GAD but it can also facilitate further in-depth research and provide a theoretical basis for the clinical expansion of its application.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 570
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book: Han Ying, Ying Han zhen duan xue ci hui

    Yang, Zhiyin / Zhu, Lifang

    Chinese-English & English-Chinese diagnostic vocabulary

    2015  

    Title variant Chinese-English & English-Chinese diagnostic vocabulary
    Author's details zhu bian Yang Zhiyin, Zhu Lifang
    MeSH term(s) Diagnosis
    Language Chinese ; English
    Size 5, 650 pages
    Edition Di 1 ban.
    Document type Book
    ISBN 9787117170444 ; 7117170441
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article ; Online: Zhi Zhen Fang formula reverses Hedgehog pathway mediated multidrug resistance in colorectal cancer.

    Sui, Hua / Duan, Peiwen / Guo, Piaoting / Hao, Lishuang / Liu, Xuan / Zhang, Jinhua / Zhu, Huirong / Zhao, Miaomiao / Wang, Hao / Li, Qi / Wang, Songpo

    Oncology reports

    2017  Volume 38, Issue 4, Page(s) 2087–2095

    Abstract: Zhi-Zhen-Fang (ZZR), a Traditional Chinese Medicine (TCM) formula, has been clinically used ...

    Abstract Zhi-Zhen-Fang (ZZR), a Traditional Chinese Medicine (TCM) formula, has been clinically used in China to treat drug-resistant colorectal cancer (CRC) patients as an adjuvant. In this study, the efficacy of ZZR in suppressing multidrug resistance (MDR) on CRC was evaluated in vitro and in vivo. We observed that ZZR enhanced the sensitivity of chemotherapeutic drugs and induced apoptosis in a dose- and time-dependent mannner in CRC MDR cells. Interestingly, signaling of Hedgehog pathway, particularly Gli1, was also inhibited by ZZR. This effect of ZZR in reversing drug resistance and suppressing Gli1 was attenuated by a Hedgehog activator (SAG). Furthermore, ZZR inhibited MDR CRC tumor growth in a xenograft mouse model as well as downregulated Gli1 levels. This study provided the first direct evidence demonstrating ZZR can attenuate MDR by repressing Hedgehog signaling in human CRC.
    Language English
    Publishing date 2017-10
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.2017.5917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4213: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Suzhou Shi Zuduan Zhen hu xue xi chong bing liu xing fang zhi shi

    Zhu, Zhenqiu

    2015  

    Author's details Zhu Zhenqiu zhu bian
    MeSH term(s) Schistosomiasis/prevention & control ; Schistosomiasis/history ; History, 20th Century
    Keywords China
    Language Chinese
    Size 227 pages, 44 pages of plates :, illustrations (some color), color maps ;, 26 cm
    Edition Di 1 ban.
    Document type Book
    ISBN 9787567212794 ; 756721279X
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article: [Optimization of the matrix formulation of compound Die Da Zhen Tong cataplasm by uniform design].

    Zhang, Ji-xing / Wang, Jian-ping / Zhu, Feng / Deng, Zi-jie / Zhao, Cui-wei

    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

    2011  Volume 34, Issue 6, Page(s) 971–974

    Abstract: Objective: To optimize the matrix formulation of compound Die Da Zhen Tong cataplasm.: Methods ... ratio of the matrix formulation component part in compound Die Da Zhen Tong cataplasm,and the viscosity ... The percentage of the matrix formulation component part in compound Die Da Zhen Tong cataplasm was, NP-700 ...

    Abstract Objective: To optimize the matrix formulation of compound Die Da Zhen Tong cataplasm.
    Methods: The optimal preparation was selected by U17 (17(16)) uniform design, independent variables were the percentage ratio of the matrix formulation component part in compound Die Da Zhen Tong cataplasm,and the viscosity, continued viscosity and overall desirability used as indexes were dependent variables.
    Results: The percentage of the matrix formulation component part in compound Die Da Zhen Tong cataplasm was, NP-700: carbomer 980: PVP K-90: dihydroxy aluminum: tartaric: kaolinite: sorbitol: glycerin = 5: 1. 2: 2.5: 0.25: 0.15:4: 12: 5.
    Conclusion: The optimized cataplasm has good viscosity, continued viscosity and high overall desirability.
    MeSH term(s) Adhesiveness ; Administration, Cutaneous ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Biocompatible Materials/administration & dosage ; Biocompatible Materials/chemistry ; Chemistry, Pharmaceutical/methods ; Drug Combinations ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Hydrogen-Ion Concentration ; Plants, Medicinal/chemistry ; Polypropylenes/administration & dosage ; Polypropylenes/chemistry ; Povidone/administration & dosage ; Povidone/chemistry ; Regression Analysis ; Tartrates/administration & dosage ; Tartrates/chemistry ; Viscosity
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Biocompatible Materials ; Drug Combinations ; Drugs, Chinese Herbal ; Polypropylenes ; Tartrates ; Povidone (FZ989GH94E)
    Language Chinese
    Publishing date 2011-06
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1001-4454
    ISSN 1001-4454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Zhong yi wang zhen yu yong yao

    Zhu, Yiguo

    (Zhong yi zhen fa yu yong yao xi lie cong shu)

    2007  

    Author's details zhu bian Yiguo Zhu, Weiping Xu
    Series title Zhong yi zhen fa yu yong yao xi lie cong shu
    MeSH term(s) Medicine, Chinese Traditional ; Physical Examination ; Drug Therapy
    Language Chinese
    Size 1, 2, 7, 371 p. :, ill. ;, 21 cm.
    Edition Di 1 ban.
    Publisher Shanxi ke xue ji shu chu ban she
    Publishing place Taiyuan Shi
    Document type Book
    ISBN 9787537729604 ; 7537729603
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book: Zhen dao lin chuang zhen duan yu zhi liao

    Zhu, Hanzhang

    1999  

    Title translation Clinical diagnosis and therapy with needle knife.
    Author's details Zhu Hanzhang, Liu Baizhi zhu
    MeSH term(s) Muscles/injuries ; Wounds and Injuries/surgery ; Surgical Instruments
    Language Chinese
    Size 6, 315 p. :, ill.
    Edition Di 1 ban.
    Publisher Ren min wei sheng chu ban she
    Publishing place Beijing Shi
    Document type Book
    ISBN 9787117033497 ; 7117033495
    Database Catalogue of the US National Library of Medicine (NLM)

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