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  1. Article: The psychology behind response of people in wake of the COVID-19 pandemic in India.

    Roy, Pritha

    Indian journal of psychiatry

    2020  Volume 62, Issue 3, Page(s) 330–331

    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/psychiatry.IndianJPsychiatry_308_20
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    Zs.B 2038: Show issues Location:
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  3. Article ; Online: The psychology behind response of people in wake of the COVID-19 pandemic in India

    Roy, Pritha

    Indian Journal of Psychiatry

    2020  Volume 62, Issue 3, Page(s) 330

    Keywords Psychiatry and Mental health ; covid19
    Language English
    Publisher Medknow
    Publishing country in
    Document type Article ; Online
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/psychiatry.indianjpsychiatry_308_20
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Elucidation of the structural dynamics of mutations in PHB2 protein associated with growth suppression and cancer progression.

    Khatua, Susmita / Roy, Alankar / Sen, Pritha / Ray, Sujay

    Gene

    2023  Volume 890, Page(s) 147820

    Abstract: Prohibitin is a multifunctional protein that plays an important role in numerous cellular processes. Membrane-associated mitochondrial prohibitin complex is made up of two subunits, PHB1 and PHB2 which are ubiquitously expressed and analogous to each ... ...

    Abstract Prohibitin is a multifunctional protein that plays an important role in numerous cellular processes. Membrane-associated mitochondrial prohibitin complex is made up of two subunits, PHB1 and PHB2 which are ubiquitously expressed and analogous to each other. High levels of prohibitin expression have consequently been found in esophageal cancer, endometrial adenocarcinoma, gastric cancer, hepatocellular carcinoma, breast cancer and bladder cancer. The aim of this study is to analyse two-point mutation PHB2_MT1(I → A) and PHB2_MT2(I → P), their effect on PHB2 protein and its effect on formation of mitochondrial complex. It is a residual level study, based on current experimental validation. To establish the effects of the two-point mutations, computational approaches such as molecular modelling, molecular docking, normal mode simulation, molecular dynamics simulations and MM/GBSA were used. An analysis of the energy dynamics of both unbound and complex proteins was conducted to elucidate how mutations impact the energy distribution of PHB2. Our study confirmed that the two mutations decreased the overall stability of PHB2. This was evidenced by heightened atomic fluctuations within the mutated region, accompanied by elevated deviations observed in RMSD and R
    Language English
    Publishing date 2023-09-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2023.147820
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
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  5. Article ; Online: Incidence and clinical profile of brain metastasis treated with whole brain radiotherapy in a tertiary hospital in eastern India: A retrospective audit.

    Sammaddar, Debdeep / Basu, Abhishek / Roy, Pritha / Chowdhury, Hambir

    Indian journal of cancer

    2023  Volume 60, Issue 3, Page(s) 337–344

    Abstract: Introduction: Management of brain metastases (BM) is witnessing marked advancement worldwide and modern technologies with better outcomes are gradually being adopted in developing countries. However, data regarding current practice in this field is ... ...

    Abstract Introduction: Management of brain metastases (BM) is witnessing marked advancement worldwide and modern technologies with better outcomes are gradually being adopted in developing countries. However, data regarding current practice in this field is lacking from the Indian subcontinent prompting us to plan the current study.
    Materials and methods: A retrospective, single institutional audit was performed on 112 patients with solid tumors metastasizing to the brain treated over the last 4 years at a tertiary care center in eastern India, of which 79 were ultimately evaluable. Demography, patterns of incidence, and overall survival (OS) were determined.
    Results: The prevalence of BM was 5.65% among all patients with solid tumors. The median age was 55 years with a slight male preponderance. Lung followed by breast were the most common primary subsites. Multiple BM (54%), left-sided (61%), and frontal lobe lesions (54%) were the more common. Metachronous BM was found in 76% of patients. All patients received whole brain radiation therapy (WBRT). The median OS for the entire cohort was 7 months (95% confidence interval [CI]: 4 - 19 months). The median OS for lung and breast primaries were 6.5 and 8 months and for recursive partitioning analysis (RPA) classes I, II, and III the OS were 11.5, 7, and 3 months, respectively. Median OS did not differ by number of or other sites of metastases.
    Conclusions: The outcomes from our series about BM from solid tumors in patients from eastern Indian are in congruence to those available in the literature. Patients with BM are still largely treated with WBRT in resource-limited settings.
    MeSH term(s) Humans ; Male ; Middle Aged ; Prognosis ; Tertiary Care Centers ; Retrospective Studies ; Incidence ; Cranial Irradiation ; Brain Neoplasms/epidemiology ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/pathology ; Brain/pathology ; Radiosurgery ; Treatment Outcome
    Language English
    Publishing date 2023-03-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 410194-7
    ISSN 1998-4774 ; 0019-509X
    ISSN (online) 1998-4774
    ISSN 0019-509X
    DOI 10.4103/ijc.IJC_1211_20
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    Zs.B 581: Show issues Location:
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  6. Article ; Online: Impact of maternal substance use on offspring's cardiovascular health.

    Janardhan, Nitya / Roy, Pritha Ghosh / Vyas, Arpita Kalla

    Toxicology and applied pharmacology

    2022  Volume 450, Page(s) 116164

    Abstract: Substance use (SU) during pregnancy is on the rise, posing significant risks to the developing fetus. The adverse impact of maternal alcohol and nicotine use during the perinatal period on offspring health has been well established, including their ... ...

    Abstract Substance use (SU) during pregnancy is on the rise, posing significant risks to the developing fetus. The adverse impact of maternal alcohol and nicotine use during the perinatal period on offspring health has been well established, including their associations with adverse cardiovascular health in offspring. However, limited studies examine the impact of other well-known SU utilized during pregnancy on offspring's cardiovascular health. This review summarizes the proposed mechanism of action of four commonly utilized substances: cocaine, marijuana, methamphetamine, and opioids, and their cardiovascular impact. Furthermore, we will review the current understanding of the adverse impact of substance use during pregnancy on offspring's cardiovascular system based on existing studies. This review will also highlight possible molecular mechanisms underlying the in-utero adverse programming of offspring's cardiovascular system secondary to SU in pregnancy and address the gaps in current understanding of how SU adversely impacts the developing cardiovascular system of offspring in utero.
    MeSH term(s) Female ; Heart ; Humans ; Pregnancy ; Prenatal Exposure Delayed Effects ; Substance-Related Disorders/epidemiology
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2022.116164
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    Zs.B 14: Show issues Location:
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  7. Article ; Online: Noncovalent Association and Partitioning of Some Perfume Components at Infinite Dilution with Myelin Basic Protein Pseudophase in Normal Saline.

    Tahir, Ume / Hussam, Abul / Roy, Pritha / Hashmi, Irina

    Langmuir : the ACS journal of surfaces and colloids

    2021  Volume 37, Issue 16, Page(s) 4793–4801

    Abstract: Myelin basic protein (MBP), one of the major protein constituents of the myelin sheath, possesses unique ligand-binding features. We present a novel equilibrium headspace gas chromatographic technique to examine the thermodynamics of noncovalent ... ...

    Abstract Myelin basic protein (MBP), one of the major protein constituents of the myelin sheath, possesses unique ligand-binding features. We present a novel equilibrium headspace gas chromatographic technique to examine the thermodynamics of noncovalent interactions between common perfume components: Lilial, Hedione, Hexylcinnamic aldehyde, and Versalide with MBP monomers and its hexameric MBP-pseudophase. A general theoretical model is used to calculate the critical aggregation concentration (cac) of MBP, perfume component binding constants with monomeric MBP,
    MeSH term(s) Myelin Basic Protein ; Myelin Sheath ; Perfume ; Saline Solution ; Thermodynamics
    Chemical Substances Myelin Basic Protein ; Perfume ; Saline Solution
    Language English
    Publishing date 2021-04-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.0c03475
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  8. Article ; Online: Nanoapatite-Loaded κ-Carrageenan/Poly(vinyl alcohol)-Based Injectable Cryogel for Hemostasis and Wound Healing.

    Kumar, Nikhil / Bose, Pritha / Kumar, Subodh / Daksh, Shivani / Verma, Yogesh Kumar / Roy, Bal G / Som, Swati / Singh, Jai Deo / Datta, Anupama

    Biomacromolecules

    2024  Volume 25, Issue 2, Page(s) 1228–1245

    Abstract: Immediate control of excessive bleeding and prevention of infections are of utmost importance in the management of wounds. Cryogels have emerged as promising materials for the rapid release of medication and achieving hemostasis. However, their quick ... ...

    Abstract Immediate control of excessive bleeding and prevention of infections are of utmost importance in the management of wounds. Cryogels have emerged as promising materials for the rapid release of medication and achieving hemostasis. However, their quick release properties pose the challenge of exposing patients to high concentrations of drugs. In this study, hybrid nanocomposites were developed to address this issue by combining poly(vinyl alcohol) and κ-carrageenan with whitlockite nanoapatite (WNA) particles and ciprofloxacin, aiming to achieve rapid hemostasis and sustained antibacterial effects. A physically cross-linked cryogel was obtained by subjecting a blend of poly(vinyl alcohol) and κ-carrageenan to successive freezing-thawing cycles, followed by the addition of WNA. Furthermore, ciprofloxacin was introduced into the cryogel matrix for subsequent evaluation of its wound healing properties. The resulting gel system exhibited a 3D microporous structure and demonstrated excellent swelling, low cytotoxicity, and outstanding mechanical properties. These characteristics were evaluated through analytical and rheological experiments. The nanocomposite cryogel with 4% whitlockite showed extended drug release of 71.21 ± 3.5% over 21 days and antibacterial activity with a considerable growth inhibition zone (4.19 ± 3.55 cm). Experiments on a rat model demonstrated a rapid hemostasis property of cryogels within an average of 83 ± 4 s and accelerated the process of wound healing with 96.34% contraction compared to the standard, which exhibited only ∼78% after 14 days. The histopathological analysis revealed that the process of epidermal re-epithelialization took around 14 days following the skin incision. The cryogel loaded with WNAs and ciprofloxacin holds great potential for strategic utilization in wound management applications as an effective material for hemostasis and anti-infection purposes.
    MeSH term(s) Humans ; Rats ; Animals ; Cryogels/chemistry ; Polyvinyl Alcohol/pharmacology ; Carrageenan/chemistry ; Wound Healing ; Ciprofloxacin ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Hemostasis ; Ethanol ; Calcium Phosphates
    Chemical Substances Cryogels ; whitlockite (14358-97-5) ; Polyvinyl Alcohol (9002-89-5) ; Carrageenan (9000-07-1) ; Ciprofloxacin (5E8K9I0O4U) ; Anti-Bacterial Agents ; Ethanol (3K9958V90M) ; Calcium Phosphates
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c01180
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  9. Article ; Online: Enhanced adaptation to salinity stress in lentil seedlings through the use of trehalose-functionalized silica nanoparticles (TSiNPs): Exploring silica-sugar absorption and oxidative balance.

    Sarkar, Mahima Misti / Rudra, Pritha / Paul, Paramita / Dua, Tarun Kumar / Roy, Swarnendu

    Plant physiology and biochemistry : PPB

    2023  Volume 206, Page(s) 108309

    Abstract: Silica nanoparticles (SiNPs) confer better growth and development of plants under salinity stress. Moreover, the surface-functionalization of SiNPs with bioactive molecules is expected to enhance its efficacy. The present study thus aimed to modify the ... ...

    Abstract Silica nanoparticles (SiNPs) confer better growth and development of plants under salinity stress. Moreover, the surface-functionalization of SiNPs with bioactive molecules is expected to enhance its efficacy. The present study thus aimed to modify the surface of SiNPs, by attaching a bioactive molecule (trehalose) to obtain TSiNPs. The successful surface functionalization was confirmed using FTIR, XRD, and EDS. The spherical shape and amorphous nature of the nanoparticles were confirmed using SEM. The TEM image analysis revealed that the size of SiNPs and TSiNPs ranged between 20-50 nm and 200-250 nm, respectively. A novel bioassay experiment designed to study the release of silica and trehalose from nanoparticles elucidated that the TSiNPs improved the release and uptake of silica. Also, trehalose uptake significantly improved after 72 h of application due to enhanced release of trehalose from TSiNPs. Further, this study also aimed to investigate the potential benefits of SiNPs and TSiNPs in promoting the growth and development of plants under salinity stress. In this context, the nanoparticles were applied to the saline-stressed (0, 200, 300 mM) lentil seedlings for the in-planta experiments. The results revealed that both SiNPs and TSiNPs improved the growth of seedlings (shoot, and root length), ionic balance (K
    MeSH term(s) Seedlings/metabolism ; Trehalose ; Lens Plant/metabolism ; Sugars ; Silicon Dioxide ; Hydrogen Peroxide ; Antioxidants/metabolism ; Salt Stress ; Nanoparticles ; Oxidative Stress ; Salinity
    Chemical Substances Trehalose (B8WCK70T7I) ; Sugars ; Silicon Dioxide (7631-86-9) ; Hydrogen Peroxide (BBX060AN9V) ; Antioxidants
    Language English
    Publishing date 2023-12-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 742978-2
    ISSN 1873-2690 ; 0981-9428
    ISSN (online) 1873-2690
    ISSN 0981-9428
    DOI 10.1016/j.plaphy.2023.108309
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    Z 2696: Show issues
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  10. Article: An Unusual Cause of Abdominal Pain.

    Roy, Pritha / Mukherjee, Ramanuj / Parik, Madhav

    Oman medical journal

    2018  Volume 34, Issue 3, Page(s) 266–267

    Language English
    Publishing date 2018-04-18
    Publishing country Oman
    Document type Journal Article
    ZDB-ID 2571431-4
    ISSN 2070-5204 ; 1999-768X
    ISSN (online) 2070-5204
    ISSN 1999-768X
    DOI 10.5001/omj.2019.51
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