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  1. Article ; Online: [Congenital Nephrotic Syndrome: Role of Podxl Gene].

    Zeni, Angela / Pecoraro, Luca / Benetti, Elisa / Brugnara, Milena

    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

    2023  Volume 40, Issue 6

    Abstract: In the last decades, our understanding of the genetic disorders of inherited podocytopathies has advanced immensely; this has been possible thanks to the development of next-generation sequencing technologies that offer the possibility to evaluate ... ...

    Abstract In the last decades, our understanding of the genetic disorders of inherited podocytopathies has advanced immensely; this has been possible thanks to the development of next-generation sequencing technologies that offer the possibility to evaluate targeted genes at a lower cost than in the past. Identifying new genetic mutations has helped to recognize the key role of the podocyte in the health of the glomerular filter and to understand the mechanisms that regulate the cell biology and pathology of the podocyte. Here we describe a patient with congenital nephrotic syndrome due to a mutation in PODXL. This gene encodes podocalyxin, a podocyte-specific surface sialomucin known to maintain the characteristic architecture of the foot processes and the patency of the filtration slits.
    MeSH term(s) Humans ; Kidney Diseases/metabolism ; Kidney Glomerulus/pathology ; Nephrotic Syndrome/genetics ; Podocytes/metabolism
    Language Italian
    Publishing date 2023-12-22
    Publishing country Italy
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 1237110-5
    ISSN 1724-5990 ; 0393-5590
    ISSN (online) 1724-5990
    ISSN 0393-5590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Children with cow milk allergy could have feeding difficulties that must not be underestimated.

    Raitano, Vincenzo / Pecoraro, Luca / Sboarina, Andrea / Brugnara, Milena / Piacentini, Giorgio / Pietrobelli, Angelo

    Minerva pediatrics

    2024  

    Language English
    Publishing date 2024-01-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062664-X
    ISSN 2724-5780
    ISSN (online) 2724-5780
    DOI 10.23736/S2724-5276.23.07454-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Role of Nutrients in Pediatric Non-Dialysis Chronic Kidney Disease: From Pathogenesis to Correct Supplementation.

    Padoan, Flavia / Guarnaroli, Matteo / Brugnara, Milena / Piacentini, Giorgio / Pietrobelli, Angelo / Pecoraro, Luca

    Biomedicines

    2024  Volume 12, Issue 4

    Abstract: Nutrition management is fundamental for children with chronic kidney disease (CKD). Fluid balance and low-protein and low-sodium diets are the more stressed fields from a nutritional point of view. At the same time, the role of micronutrients is often ... ...

    Abstract Nutrition management is fundamental for children with chronic kidney disease (CKD). Fluid balance and low-protein and low-sodium diets are the more stressed fields from a nutritional point of view. At the same time, the role of micronutrients is often underestimated. Starting from the causes that could lead to potential micronutrient deficiencies in these patients, this review considers all micronutrients that could be administered in CKD to improve the prognosis of this disease.
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12040911
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  4. Article: The Evolution of Scientific Knowledge in Childhood Asthma over Time: A Surprising History.

    Venditto, Laura / Morano, Sonia / Ferrante, Giuliana / Piazza, Michele / Tenero, Laura / Piacentini, Giorgio / Pecoraro, Luca

    Children (Basel, Switzerland)

    2024  Volume 11, Issue 2

    Abstract: Asthma is a disease that has been described since the times of Hammurabi. However, it is only since the 1960s that effective therapeutic strategies have been available. Pathogenic mechanisms underlying the disease have been deeply studied, contributing ... ...

    Abstract Asthma is a disease that has been described since the times of Hammurabi. However, it is only since the 1960s that effective therapeutic strategies have been available. Pathogenic mechanisms underlying the disease have been deeply studied, contributing to creating a "patient-specific asthma" definition. Biological drugs have been approved over the last twenty years, improving disease management in patients with severe asthma via a "precision medicine-driven approach". This article aims to describe the evolution of scientific knowledge in childhood asthma, focusing on the most recent biological therapies and their indications for patients with severe asthma.
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children11020262
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  5. Article: Bathing in Atopic Dermatitis in Pediatric Age: Why, How and When.

    Pagliaro, Margherita / Pecoraro, Luca / Stefani, Camilla / Pieropan, Sara / Piacentini, Giorgio / Pietrobelli, Angelo

    Pediatric reports

    2024  Volume 16, Issue 1, Page(s) 57–68

    Abstract: Atopic dermatitis is a chronic inflammatory skin disease. The treatment plays an important role in influencing the patients' quality of life. The basic management consists of appropriate skin cleansing, including bathing and eventually using bathing ... ...

    Abstract Atopic dermatitis is a chronic inflammatory skin disease. The treatment plays an important role in influencing the patients' quality of life. The basic management consists of appropriate skin cleansing, including bathing and eventually using bathing additives. Recommendations regarding frequency and duration of bathing, water temperature and usefulness of bathing additives are widely different, often leading to confusion among patients. This review aims to give insights into the best bathing practices and the use of bathing additives in atopic dermatitis in children. Several bathing additives, including bleach baths, commercial baby cleansers, bath baby oils and bath salt, appear to be promising adjunctive therapies for atopic dermatitis due to their anti-inflammatory, anti-bacterial, anti-pruritus and skin barrier repair properties through different mechanisms of action. However, their efficacy and safety are not fully understood in some cases. The usefulness of other bath additives, such as acidic and more natural substances (green tea extracts, pine tar, sodium bicarbonate), is still under investigation. Further studies are needed to determine their optimal use to achieve clinical benefit safely.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2036-749X
    ISSN 2036-749X
    DOI 10.3390/pediatric16010006
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  6. Article: The Future for the Children of Tomorrow: Avoiding Salt in the First 1000 Days.

    Mazzuca, Giorgia / Artusa, Silvia / Pietrobelli, Angelo / Di Cara, Giuseppe / Piacentini, Giorgio / Pecoraro, Luca

    Children (Basel, Switzerland)

    2024  Volume 11, Issue 1

    Abstract: It is widely known that optimal nutrition in the first 1000 days of life positively impacts the child's development throughout adulthood. In this setting, salt should not be added to complementary feeding. In developed countries, salt intake is generally ...

    Abstract It is widely known that optimal nutrition in the first 1000 days of life positively impacts the child's development throughout adulthood. In this setting, salt should not be added to complementary feeding. In developed countries, salt intake is generally higher than recommended for children. Excessive salt intake is the major determinant of hypertension and is associated with several cardiovascular outcomes. Therefore, pediatricians have a key role in raising awareness among parents to avoid salt consumption in the first 1000 days of life to ensure better health for their children. Starting from a review of the literature published in PubMed/MedLine regarding the short- and long-term consequences of salt consumption during the first 1000 days of life, our comprehensive review aims to analyze the beneficial effects of avoiding salt at such a vulnerable stage of life as the first 1000 days. Obesity, hypertension, increased salt sensitivity, high sweet drink consumption, increased mortality, and morbidity persisting in adult age represent the principal consequences of a higher salt intake during the first 1000 days of life.
    Language English
    Publishing date 2024-01-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children11010098
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  7. Article: Lipid Profile, Eating Habit, and Physical Activity in Children with Down Syndrome: A Prospective Study.

    Pecoraro, Luca / Zadra, Melissa / Cavallin, Francesco / Lauriola, Silvana / Piacentini, Giorgio / Pietrobelli, Angelo

    Diseases (Basel, Switzerland)

    2024  Volume 12, Issue 4

    Abstract: Children with Down Syndrome (DS) frequently undergo health challenges, including a higher prevalence of overweight and obesity. We aimed to evaluate the impact of dietary and physical advice provided by a specialized pediatrician over two years. In this ... ...

    Abstract Children with Down Syndrome (DS) frequently undergo health challenges, including a higher prevalence of overweight and obesity. We aimed to evaluate the impact of dietary and physical advice provided by a specialized pediatrician over two years. In this prospective study, 44 children with DS, aged 2 to 17, underwent outpatient follow-up visits every six months between December 2020 and May 2023. Dietary habits, physical activities, anthropometric data, and laboratory results were recorded at baseline and 2-year follow-up. Adherence to the Mediterranean diet and physical activity were investigated using the 'KIDMED' and 'Godin-Shepard Leisure-Time' questionnaires, respectively, completed by the parents of the children. Venous blood samples were taken to determine the lipid profile. A significant reduction in BMI z-scores (
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases12040068
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  8. Article ; Online: Gastroesophageal reflux in the breastfed infant less than 4 months old: is this really an issue?

    Pecoraro, Luca / Chiaffoni, Giovanni / Dalle Carbonare, Luca / Salvottini, Chiara / Piacentini, Giorgio / Pietrobelli, Angelo

    Minerva pediatrics

    2022  Volume 75, Issue 3, Page(s) 437–439

    MeSH term(s) Female ; Humans ; Infant ; Breast Feeding ; Gastroesophageal Reflux/etiology ; Esophagitis, Peptic
    Language English
    Publishing date 2022-05-27
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062664-X
    ISSN 2724-5780
    ISSN (online) 2724-5780
    DOI 10.23736/S2724-5276.22.06837-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The need of an updated culture of "occupational" atopic hand dermatitis in children at the time of COVID-19.

    Pecoraro, Luca / Chiaffoni, Giovanni / Piacentini, Giorgio / Pietrobelli, Angelo

    Acta bio-medica : Atenei Parmensis

    2022  Volume 93, Issue 6, Page(s) e2022324

    Abstract: During the COVID-19 outbreak, handwashing emerged as an essential tool to prevent the spread of SARS-CoV-2 virus. It can put into practice using warm water and soap or, if not available, alcohol-based hand sanitizers (ABHS). Anyway, the use of warm water ...

    Abstract During the COVID-19 outbreak, handwashing emerged as an essential tool to prevent the spread of SARS-CoV-2 virus. It can put into practice using warm water and soap or, if not available, alcohol-based hand sanitizers (ABHS). Anyway, the use of warm water and soap is not always possible. On the contrary, ABHS are frequently used for their versatility, but can represent a risk factor for atopic dermatitis exacerbations in the pediatric age. At the same time, the Italian Ministry of Health established a school regulation, asking the students to periodically disinfect hands with sanitizing gel, or soap and water, especially before entering classrooms and laboratories, immediately after contact with everyday objects, after using the toilet, after throwing away the handkerchief and before and after eating. No rules have been personalized in this statement for children affected by atopic dermatitis attending the school. Based on this observation, we reported two case reports, involving children with a known diagnosis of atopic dermatitis, who attended our Pediatric Allergy Unit in Mantua, Italy. They experienced a worsening of symptoms related to AD on their hands in the last year for an intensive handwashing with ABHS before entering all classrooms and laboratories every day at school. Avoiding ABHS at school and washing their hands with a non-alcohol and additives soap and water solved their problem and brought their atopic dermatitis back to good control. So, it seems appropriate to consider ABHS as a "school trigger" and the low-controlled atopic dermatitis of these two patients as an "occupational dermatitis". An adequate pediatric culture of atopic dermatitis at the time of COVID 19 is needed.
    MeSH term(s) Humans ; Child ; Dermatitis, Atopic/etiology ; Dermatitis, Atopic/prevention & control ; Dermatitis, Atopic/epidemiology ; Soaps ; COVID-19 ; SARS-CoV-2 ; Ethanol ; Water
    Chemical Substances Soaps ; Ethanol (3K9958V90M) ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-12-16
    Publishing country Italy
    Document type Case Reports ; Letter
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v93i6.13135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Parental perception of SIDS prevention measures: where are we at?

    Pecoraro, Luca / Panzeri, Carolà / Nisi, Fulvio / Lauriola, Silvana / Piacentini, Giorgio / Pietrobelli, Angelo

    Minerva pediatrics

    2023  Volume 75, Issue 3, Page(s) 433–435

    MeSH term(s) Humans ; Parents ; Sudden Infant Death/prevention & control ; Perception
    Language English
    Publishing date 2023-02-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062664-X
    ISSN 2724-5780
    ISSN (online) 2724-5780
    DOI 10.23736/S2724-5276.23.07182-3
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