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  1. Article: [No title information]

    Meijler, F L

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

    2015  Volume 11, Issue 12, Page(s) 539

    Title translation Geachte collegae.
    Language Dutch
    Publishing date 2015-02-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2211468-3
    ISSN 1876-6250 ; 1568-5888 ; 0929-7456
    ISSN (online) 1876-6250
    ISSN 1568-5888 ; 0929-7456
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  2. Article: Archetype, adaptation and the mammalian heart.

    Meijler, F L / Meijler, T D

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

    2011  Volume 19, Issue 3, Page(s) 142–148

    Abstract: Forty years ago, we started our quest for 'The Holy Grail' of understanding ventricular rate control and rhythm in atrial fibrillation (AF). We therefore studied the morphology and function of a wide range of mammalian hearts. From mouse to whale, we ... ...

    Abstract Forty years ago, we started our quest for 'The Holy Grail' of understanding ventricular rate control and rhythm in atrial fibrillation (AF). We therefore studied the morphology and function of a wide range of mammalian hearts. From mouse to whale, we found that all hearts show similar structural and functional characteristics. This suggests that the mammalian heart remained well conserved during evolution and in this aspect it differs from other organs and parts of the mammalian body. The archetype of the mammalian heart was apparently so successful that adaptation by natural selection (evolution) caused by varying habitat demands, as occurred in other organs and many other aspects of mammalian anatomy, bypassed the heart. The structure and function of the heart of placental mammals have thus been strikingly conserved throughout evolution. The changes in the mammalian heart that did take place were mostly adjustments (scaling), to compensate for variations in body size and shape. A remarkable scaling effect is, for instance, the difference in atrioventricular (AV) conduction time, which is vital for optimal cardiac function in all mammals, small and large. Scaling of AV conduction takes place in the AV node (AVN), but its substrate is unknown. This sheds new light on the vital role of the AVN in health and disease. The AVN is master and servant of the heart at the same time and is of salient importance for our understanding of supraventricular arrhythmias in humans, especially AF. In Information Technology a software infra-structure called 'enterprise service bus' (ESB) may provide understanding of the mammalian heart's conservation during evolution. The ESB is quite unspecific (and thus general) when compared with the specialised components it has to support. For instance, one of the functions of an ESB is the routing of messages between system nodes. This routing is independent and unaware of the content of the messages. The function of the heart is likewise independent and unaware of the routing of blood (oxygen) and of the specialised components of the mammalian body it has to support. Conclusions Evolution seems to have bypassed the heart, which is in contrast to the sometimes similarly looking, but yet quite differently functioning of the other organs of the mammalian body.
    Language English
    Publishing date 2011-02-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2211468-3
    ISSN 1876-6250 ; 1568-5888 ; 0929-7456
    ISSN (online) 1876-6250
    ISSN 1568-5888 ; 0929-7456
    DOI 10.1007/s12471-011-0086-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Walter somerville.

    Meijler, F L

    British heart journal

    2008  Volume 45, Issue 1, Page(s) 11

    Language English
    Publishing date 2008-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 80073-9
    ISSN 0007-0769
    ISSN 0007-0769
    DOI 10.1136/hrt.45.1.11
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  4. Article: Cardiale sarcoïdose: betere prognose door nieuwe diagnostiek en behandeling.

    Meijler, F L

    Nederlands tijdschrift voor geneeskunde

    2005  Volume 149, Issue 32, Page(s) 1817–8; author reply 1818

    Title translation Cardiac sarcoidosis: improved prognosis through new diagnostic tests and treatment.
    MeSH term(s) Cardiomyopathies/diagnosis ; Electrocardiography/standards ; Humans ; Sarcoidosis/diagnosis
    Language Dutch
    Publishing date 2005-08-06
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  5. Article: Actieve levensbeëindiging bij pasgeborenen in nederland; analyse van alle 22 meldingen uit 1997/'04.

    Meijler, F L

    Nederlands tijdschrift voor geneeskunde

    2005  Volume 149, Issue 12, Page(s) 668; author reply 668

    Title translation Deliberate termination of life in newborns in The Netherlands; review of all 22 reported cases between 1997 and 2004.
    MeSH term(s) Decision Making ; Ethics, Medical ; Euthanasia, Active/ethics ; Humans ; Infant, Newborn ; Netherlands ; Quality of Life
    Language Dutch
    Publishing date 2005-03-19
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  6. Article: Actieve levensbeëindiging bij pasgeborenen in Nederland; analyse van alle 22 meldingen uit 1997/'04.

    Meijler, F L

    Nederlands tijdschrift voor geneeskunde

    2005  Volume 149, Issue 26, Page(s) 1484

    Title translation Deliberate termination of life in newborns in The Netherlands; review of all 22 reported cases between 1997 and 2004.
    MeSH term(s) Decision Making ; Ethics, Medical ; Euthanasia, Active/ethics ; Humans ; Infant ; Infant, Newborn ; Netherlands ; Quality of Life
    Language Dutch
    Publishing date 2005-06-25
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  7. Article: Kwaliteitsbeoordeling van medisch-wetenschappelijk onderzoek: voortaan ook op grond van maatschappelijke implicaties.

    Meijler, F L

    Nederlands tijdschrift voor geneeskunde

    2003  Volume 147, Issue 15, Page(s) 732; author reply 732–3

    Title translation Quality assessment of medical-scientific research: in the future it should also be assessed on the basis of social impact.
    MeSH term(s) Biomedical Research ; Evidence-Based Medicine ; Humans ; Netherlands ; Outcome and Process Assessment (Health Care)/trends
    Language Dutch
    Publishing date 2003-04-12
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  8. Article: Verminderd leven voelen en een sinusoïdaal patroon op het cardiotocogram: 2 alarmsignalen.

    Meijler, F L

    Nederlands tijdschrift voor geneeskunde

    2002  Volume 146, Issue 20, Page(s) 964; author reply 964

    Title translation Less feeling of life and a sinus pattern of the cardiogram: 2 alarm signals.
    MeSH term(s) Electrocardiography/methods ; Female ; Fetus ; Humans ; Monitoring, Physiologic ; Pregnancy
    Language Dutch
    Publishing date 2002-05-18
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  9. Article: Cardiovasculaire effecten van hyperthyreoïdie en de behandeling daarvan.

    Meijler, F L

    Nederlands tijdschrift voor geneeskunde

    2002  Volume 146, Issue 26, Page(s) 1254; author reply 1254–5

    Title translation Cardiovascular effects of hyperthyroidism and treatment thereof.
    MeSH term(s) Humans ; Hyperthyroidism/complications ; Myocardial Contraction/physiology ; Terminology as Topic
    Language Dutch
    Publishing date 2002-06-29
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  10. Article: Klinisch denken en beslissen in de praktijk. Koorts, purpura en krachtsverlies bij een 29-jarige vrouw.

    Meijler, F L

    Nederlands tijdschrift voor geneeskunde

    2002  Volume 146, Issue 43, Page(s) 2059; author reply 2059–60

    Title translation Clinical reasoning and decision making in practice. Fever, purpura and hemiparesis in a 29-year old female.
    MeSH term(s) Adult ; Diagnosis, Differential ; Endocarditis, Bacterial/diagnosis ; Female ; Humans ; Staphylococcal Infections/diagnosis ; Time Factors
    Language Dutch
    Publishing date 2002-10-26
    Publishing country Netherlands
    Document type Case Reports ; Comment ; Letter
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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