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  1. Book ; Online: Pulmonary Fibrosis

    Tzouvelekis, Argyrios / Eickelberg, Oliver / Kaminski, Naftali / Bouros, Demosthenes / Aidinis, Vassilis

    2019  

    Keywords Medicine ; Lung pathophysiology ; interstitial lung diseases ; idiopathic pulmonary fibrosis
    Size 1 electronic resource (136 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230236
    ISBN 9782889631957 ; 2889631958
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Listen to the WNT; It Talks: WNT7A Drives Epithelial-Mesenchymal Cross-Talk within the Fibrotic Niche in Idiopathic Pulmonary Fibrosis.

    Königshoff, Melanie / Eickelberg, Oliver

    American journal of respiratory cell and molecular biology

    2022  Volume 68, Issue 3, Page(s) 239–240

    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis ; Fibrosis ; Wnt Proteins
    Chemical Substances WNT7A protein, human ; Wnt Proteins
    Language English
    Publishing date 2022-12-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2022-0479ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; Thesis: Discovery of new cinnamic acid amides as novel antifibrotic drugs

    Gerckens, Michael Wolfgang [Verfasser] / Eickelberg, Oliver [Akademischer Betreuer]

    2023  

    Author's details Michael Wolfgang Gerckens ; Betreuer: Oliver Eickelberg
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: Watching an Evolution in Progress, Cutting-Edge Research Transforming Outcomes in Interstitial Lung Disease: Introduction to an

    Maher, Toby M / Podolanczuk, Anna J / Drake, Wonder P / Sime, Patricia J / Eickelberg, Oliver / DeMeo, Dawn L / Richeldi, Luca

    American journal of respiratory and critical care medicine

    2024  Volume 209, Issue 9, Page(s) 1049–1050

    MeSH term(s) Humans ; Lung Diseases, Interstitial/therapy ; Lung Diseases, Interstitial/physiopathology ; Biomedical Research
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Introductory Journal Article ; Editorial
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202404-0675ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Three Is Better than One: An Improved Multiple-Hit Model of Primary Graft Dysfunction.

    Smirnova, Natalia F / Eickelberg, Oliver

    American journal of respiratory cell and molecular biology

    2019  Volume 61, Issue 2, Page(s) 141–142

    MeSH term(s) Cell Death ; Cold Ischemia ; Humans ; Lung Transplantation ; Primary Graft Dysfunction ; Reperfusion Injury
    Language English
    Publishing date 2019-03-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2019-0082ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Defining the Cell Types That Drive Idiopathic Pulmonary Fibrosis Using Single-Cell RNA Sequencing.

    Poczobutt, Joanna M / Eickelberg, Oliver

    American journal of respiratory and critical care medicine

    2019  Volume 199, Issue 12, Page(s) 1454–1456

    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis/genetics ; Lung ; Sequence Analysis, RNA ; Transcriptome
    Language English
    Publishing date 2019-02-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201901-0197ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sex-Specific Alterations of the Lung Transcriptome at Birth in Mouse Offspring Prenatally Exposed to Vanilla-Flavored E-Cigarette Aerosols and Enhanced Susceptibility to Asthma.

    Noël, Alexandra / Yilmaz, Sultan / Farrow, Tori / Schexnayder, Matthew / Eickelberg, Oliver / Jelesijevic, Tomislav

    International journal of environmental research and public health

    2023  Volume 20, Issue 4

    Abstract: Currently, approximately 8 million adult Americans use electronic cigarettes (e-cigs) daily, including women of childbearing age. It is known that more than 10% of women smoke during their pregnancy, and recent surveys show that rates of maternal vaping ... ...

    Abstract Currently, approximately 8 million adult Americans use electronic cigarettes (e-cigs) daily, including women of childbearing age. It is known that more than 10% of women smoke during their pregnancy, and recent surveys show that rates of maternal vaping are similar to rates of maternal cigarette smoking. However, the effects of inhaling e-cig aerosol on the health of fetuses remain unknown. The objective of the present study was to increase our understanding of the molecular effects caused by in utero exposures to e-cig aerosols on developing mouse lungs and, later in life, on the offspring's susceptibility to developing asthma.
    Methods: Pregnant mice were exposed throughout gestation to either filtered air or vanilla-flavored e-cig aerosols containing 18 mg/mL of nicotine. Male and female exposed mouse offspring were sacrificed at birth, and then the lung transcriptome was evaluated. Additionally, once sub-groups of male offspring mice reached 4 weeks of age, they were challenged with house dust mites (HDMs) for 3 weeks to assess asthmatic responses.
    Results: The lung transcriptomic responses of the mouse offspring at birth showed that in utero vanilla-flavored e-cig aerosol exposure significantly regulated 88 genes in males (62 genes were up-regulated and 26 genes were down-regulated), and 65 genes were significantly regulated in females (17 genes were up-regulated and 48 genes were down-regulated). Gene network analyses revealed that in utero e-cig aerosol exposure affected canonical pathways associated with CD28 signaling in T helper cells, the role of NFAT in the regulation of immune responses, and phospholipase C signaling in males, whereas the dysregulated genes in the female offspring were associated with NRF2-mediated oxidative stress responses. Moreover, we found that in utero exposures to vanilla-flavored e-cig aerosol exacerbated HDM-induced asthma in 7-week-old male mouse offspring compared to respective in utero air + HDM controls.
    Conclusions: Overall, these data demonstrate that in utero e-cig aerosol exposure alters the developing mouse lung transcriptome at birth in a sex-specific manner and provide evidence that the inhalation of e-cig aerosols is detrimental to the respiratory health of offspring by increasing the offspring' susceptibility to developing lung diseases later in life.
    MeSH term(s) Pregnancy ; Animals ; Female ; Male ; Mice ; Electronic Nicotine Delivery Systems ; Transcriptome ; Vanilla ; Respiratory Aerosols and Droplets ; Lung ; Asthma/metabolism
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20043710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Decellularized Human Lung Scaffolds as Complex Three-Dimensional Tissue Culture Models to Study Functional Behavior of Fibroblasts.

    Burgstaller, Gerald / Gerckens, Michael / Eickelberg, Oliver / Königshoff, Melanie

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2299, Page(s) 447–456

    Abstract: In vitro culturing of cells in two-dimensional (2D) environments is a widespread used methodology in biomedical research. Most commonly, cells are cultured on artificial plastic dish surfaces, which lead to abnormal functional behaviors, as plastic does ... ...

    Abstract In vitro culturing of cells in two-dimensional (2D) environments is a widespread used methodology in biomedical research. Most commonly, cells are cultured on artificial plastic dish surfaces, which lead to abnormal functional behaviors, as plastic does not reflect the native microenvironment found in vivo or in situ. Therefore, a multitude of three-dimensional (3D) cell culture systems were developed in the past years, which aim to bridge the gap between 2D cell culture dishes and the in vivo situation. One of the more recent development in the field, the generation of viable precision-cut tissue slices from various organs emerged as an exciting approach to study complex interactions and biological processes ex vivo in 3D. Decellularization of such tissue slices leads to the removal of all functional cells, and leaves behind a scaffold of extracellular matrix (ECM), which closely recapitulates the molecular composition, mechanical properties, topology, and microarchitecture of native ECM. Subsequently, decellularized precision-cut lung slices (PCLS), also called 3D lung tissue culture (3D-LTCs), can be successfully reseeded with a variety of cell types, including fibroblasts, which attach to and engraft into the matrix. Here, we describe the generation of PCLS from resected human lung tissue and their decellularization and recellularization with primary human fibroblasts. This novel 3D tissue culture model allows for various functional studies of fibroblast behavior on native ECM composition and topology.
    MeSH term(s) Cells, Cultured ; Extracellular Matrix/metabolism ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Humans ; Lung/cytology ; Lung/metabolism ; Tissue Culture Techniques/methods ; Tissue Engineering ; Tissue Scaffolds
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1382-5_30
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Two sides of the same coin? A review of the similarities and differences between idiopathic pulmonary fibrosis and rheumatoid arthritis-associated interstitial lung disease.

    Matson, Scott / Lee, Joyce / Eickelberg, Oliver

    The European respiratory journal

    2021  Volume 57, Issue 5

    Abstract: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) and idiopathic pulmonary fibrosis (IPF) are distinct diseases; however, they share several clinical, radiographic and genetic features. For instance, usual interstitial pneumonia (UIP), ... ...

    Abstract Rheumatoid arthritis associated interstitial lung disease (RA-ILD) and idiopathic pulmonary fibrosis (IPF) are distinct diseases; however, they share several clinical, radiographic and genetic features. For instance, usual interstitial pneumonia (UIP), which is an ILD pattern required for a diagnosis of IPF, is also the most common ILD pattern in RA-ILD. The presence of UIP in RA-ILD is a poor prognostic sign with outcomes similar to those seen in IPF. The recent finding of a shared genetic susceptibility between IPF and RA-ILD has sparked additional interest in this relationship. This review outlines these similarities and differences in clinical presentation, appearance and outcomes in RA-ILD and IPF.In addition, this review highlights previous research in molecular biomarkers in both conditions, exploring areas of overlap and distinction. This focus on biomarkers in IPF and RA-ILD aims to highlight potential areas of discovery and clues to a potential shared pathobiology through investigation of novel molecular markers or the repurposing of biomarkers from one condition to the other.The drive to better understand RA-ILD by leveraging our knowledge of IPF is underscored by our divergent treatment paradigms for these conditions and the concern for potential harm. As a result of advancing our understanding of the links between IPF and RA-ILD, current strategies for diagnosis, screening and treatment of ILD may fundamentally change in the coming years. Until then, clinicians face difficult clinical questions regarding the co-management of the articular disease and the ILD in RA.
    MeSH term(s) Arthritis, Rheumatoid ; Biomarkers ; Humans ; Idiopathic Pulmonary Fibrosis ; Lung Diseases, Interstitial ; Prognosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-05-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02533-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reproducible Single-Cell Genomic Research in Pulmonary and Critical Care Medicine.

    Eickelberg, Oliver / Misharin, Alexander V / Sime, Patricia J

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 11, Page(s) 1495–1497

    MeSH term(s) Critical Care ; Genomics ; Humans ; Idiopathic Pulmonary Fibrosis ; Lung ; Medicine ; Research
    Language English
    Publishing date 2020-09-10
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202008-3073ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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