LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 541

Search options

  1. Article ; Online: Epithelial barrier regulation, antigen sampling, and food allergy.

    Cook-Mills, Joan M / Emmerson, Lauren N

    The Journal of allergy and clinical immunology

    2022  Volume 150, Issue 3, Page(s) 493–502

    Abstract: Food allergy is often associated with development of atopic dermatitis. Atopic dermatitis is a chronic inflammatory skin condition with a strong association with skin barrier gene mutations. Loss-of-function mutations in skin barrier genes increase ... ...

    Abstract Food allergy is often associated with development of atopic dermatitis. Atopic dermatitis is a chronic inflammatory skin condition with a strong association with skin barrier gene mutations. Loss-of-function mutations in skin barrier genes increase transepidermal water loss. Also, reduction of the skin barrier can be mediated by environmental exposures. In preclinical studies of mice with skin barrier disruption, exposure to allergens on the skin induces food allergy. Exposure to food allergens on the skin with coexposure of the skin to other environmental factors induces signals in the skin for activation of food allergy, allergen-specific IgE, and oral food-induced anaphylaxis. In contrast, oral food allergen consumption before skin exposure to food allergen induces tolerance to the food allergen. However, this induction of tolerance may be blocked if skin is exposed to environmental allergens at the time of initial oral food allergen consumption. Further studies are needed to address the mechanisms of induction of food allergy by coexposure of the skin to food allergens, aeroallergens, and other environmental factors. Furthermore, clinical studies are needed to determine the effects of food allergen on skin before skin development of atopic dermatitis.
    MeSH term(s) Allergens ; Anaphylaxis ; Animals ; Dermatitis, Atopic ; Food Hypersensitivity ; Immunoglobulin E ; Mice
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2022-08-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.06.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.92: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Understanding Survival Analysis in Clinical Trials.

    Emmerson, J / Brown, J M

    Clinical oncology (Royal College of Radiologists (Great Britain))

    2020  Volume 33, Issue 1, Page(s) 12–14

    Language English
    Publishing date 2020-08-09
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1036844-9
    ISSN 1433-2981 ; 0936-6555
    ISSN (online) 1433-2981
    ISSN 0936-6555
    DOI 10.1016/j.clon.2020.07.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2774: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: From hormone replacement therapy to regenerative scaffolds: A review of current and novel primary hypothyroidism therapeutics.

    Heim, Maria / Nixon, Ian J / Emmerson, Elaine / Callanan, Anthony

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 997288

    Abstract: Primary hypothyroidism severely impacts the quality of life of patients through a decrease in the production of the thyroid hormones T3 and T4, leading to symptoms affecting cardiovascular, neurological, cognitive, and metabolic function. The incidence ... ...

    Abstract Primary hypothyroidism severely impacts the quality of life of patients through a decrease in the production of the thyroid hormones T3 and T4, leading to symptoms affecting cardiovascular, neurological, cognitive, and metabolic function. The incidence rate of primary hypothyroidism is expected to increase in the near future, partially due to increasing survival of patients that have undergone radiotherapy for head and neck cancer, which induces this disease in over half of those treated. The current standard of care encompasses thyroid hormone replacement therapy, traditionally in the form of synthetic T4. However, there is mounting evidence that this is unable to restore thyroid hormone signaling in all tissues due to often persistent symptoms. Additional complications are also present in the form of dosage difficulties, extensive drug interactions and poor patience compliance. The alternative therapeutic approach employed in the past is combination therapy, which consists of administration of both T3 and T4, either synthetic or in the form of desiccated thyroid extract. Here, issues are present regarding the lack of regulation concerning formulation and lack of data regarding safety and efficacy of these treatment methods. Tissue engineering and regenerative medicine have been applied in conjunction with each other to restore function of various tissues. Recently, these techniques have been adapted for thyroid tissue, primarily through the fabrication of regenerative scaffolds. Those currently under investigation are composed of either biopolymers or native decellularized extracellular matrix (dECM) in conjunction with either primary thyrocytes or stem cells which have undergone directed thyroid differentiation. Multiple of these scaffolds have successfully restored an athyroid phenotype
    MeSH term(s) Humans ; Thyroxine/therapeutic use ; Hypothyroidism/drug therapy ; Hypothyroidism/diagnosis ; Thyroid (USP)/therapeutic use ; Quality of Life ; Hormone Replacement Therapy/methods ; Thyroid Hormones/therapeutic use
    Chemical Substances Thyroxine (Q51BO43MG4) ; Thyroid (USP) ; Thyroid Hormones
    Language English
    Publishing date 2022-10-05
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.997288
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Recommendations for designing and analysing multi-arm non-inferiority trials: a review of methodology and current practice.

    Emmerson, Jake / Todd, Susan / Brown, Julia M

    Trials

    2021  Volume 22, Issue 1, Page(s) 417

    Abstract: Background and purpose: Multi-arm non-inferiority (MANI) trials, here defined as non-inferiority trials with multiple experimental treatment arms, can be useful in situations where several viable treatments exist for a disease area or for testing ... ...

    Abstract Background and purpose: Multi-arm non-inferiority (MANI) trials, here defined as non-inferiority trials with multiple experimental treatment arms, can be useful in situations where several viable treatments exist for a disease area or for testing different dose schedules. To maintain the statistical integrity of such trials, issues regarding both design and analysis must be considered, from both the multi-arm and the non-inferiority perspectives. Little guidance currently exists on exactly how these aspects should be addressed and it is the aim of this paper to provide recommendations to aid the design of future MANI trials.
    Methods: A comprehensive literature review covering four databases was conducted to identify publications associated with MANI trials. Literature was split into methodological and trial publications in order to investigate the required design and analysis considerations for MANI trials and whether they were being addressed in practice.
    Results: A number of issues were identified that if not properly addressed, could lead to issues with the FWER, power or bias. These ranged from the structuring of trial hypotheses at the design stage to the consideration of potential heterogeneous treatment variances at the analysis stage. One key issue of interest was adjustment for multiple testing at the analysis stage. There was little consensus concerning whether more powerful p value adjustment methods were preferred to approximate adjusted CIs when presenting and interpreting the results of MANI trials. We found 65 examples of previous MANI trials, of which 31 adjusted for multiple testing out of the 39 that were adjudged to require it. Trials generally preferred to utilise simple, well-known methods for study design and analysis and while some awareness was shown concerning FWER inflation and choice of power, many trials seemed not to consider the issues and did not provide sufficient definition of their chosen design and analysis approaches.
    Conclusions: While MANI trials to date have shown some awareness of the issues raised within this paper, very few have satisfied the criteria of the outlined recommendations. Going forward, trials should consider the recommendations in this paper and ensure they clearly define and reason their choices of trial design and analysis techniques.
    MeSH term(s) Bias ; Data Interpretation, Statistical ; Research Design
    Language English
    Publishing date 2021-06-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1468-6708
    ISSN (online) 1745-6215 ; 1468-6694
    ISSN 1468-6708
    DOI 10.1186/s13063-021-05364-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book: Principles and practice of clinical bacteriology

    Emmerson, Alfred M.

    1997  

    Author's details ed. by A. M. Emmerson
    Keywords Bacteriological Techniques ; Bakteriologie
    Subject Bakterienkunde
    Language English
    Size XIV, 802 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Chichester u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes index
    HBZ-ID HT007828288
    ISBN 0-471-93617-0 ; 978-0-471-93617-6
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 7740 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book: Surveillance of nosocomial infections

    Emmerson, Alfred M.

    (Baillière's clinical infectious diseases ; 3,2)

    1996  

    Author's details A. M. Emmerson ..., guest ed
    Series title Baillière's clinical infectious diseases ; 3,2
    Collection
    Keywords Cross Infection / epidemiology ; Cross Infection / prevention & control ; Incidence ; Data Collection ; Hospitalismus
    Subject Infektiöser Hospitalismus ; Krankenhausinfektion ; Nosokomiale Infektion
    Language English
    Size XI, 306 S. : graph. Darst.
    Publisher Baillière Tindall
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007258047
    ISBN 0-7020-2102-4 ; 978-0-7020-2102-2
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1384 -3,2- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Salivary gland stem cells: A review of development, regeneration and cancer.

    Emmerson, Elaine / Knox, Sarah M

    Genesis (New York, N.Y. : 2000)

    2018  Volume 56, Issue 5, Page(s) e23211

    Abstract: Salivary glands are responsible for maintaining the health of the oral cavity and are routinely damaged by therapeutic radiation for head and neck cancer as well as by autoimmune diseases such as Sjögren's syndrome. Regenerative approaches based on the ... ...

    Abstract Salivary glands are responsible for maintaining the health of the oral cavity and are routinely damaged by therapeutic radiation for head and neck cancer as well as by autoimmune diseases such as Sjögren's syndrome. Regenerative approaches based on the reactivation of endogenous stem cells or the transplant of exogenous stem cells hold substantial promise in restoring the structure and function of these organs to improve patient quality of life. However, these approaches have been hampered by a lack of knowledge on the identity of salivary stem cell populations and their regulators. In this review we discuss our current knowledge on salivary stem cells and their regulators during organ development, homeostasis and regeneration. As increasing evidence in other systems suggests that progenitor cells may be a source of cancer, we also review whether these same salivary stem cells may also be cancer initiating cells.
    MeSH term(s) Adult Stem Cells/physiology ; Animals ; Cell Differentiation/physiology ; Humans ; Neoplasms/metabolism ; Neoplasms/therapy ; Regeneration/physiology ; Salivary Glands/cytology ; Salivary Glands/metabolism
    Language English
    Publishing date 2018-05-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2004544-X
    ISSN 1526-968X ; 1526-954X
    ISSN (online) 1526-968X
    ISSN 1526-954X
    DOI 10.1002/dvg.23211
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2772: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book: The clinical efficacy of ticarcillin clavulanic acid

    Emmerson, Alfred M.

    (International clinical practice series ; 5)

    1993  

    Title variant ticarcillin-clavulanic
    Author's details ed. by A. M. Emmerson
    Series title International clinical practice series ; 5
    Collection
    Keywords Respiratory Tract Infections / drug therapy ; Septicemia / drug therapy ; Antibiotics, Combined / therapeutic use ; Beta-Lactamases / antagonists & inhibitors ; Clavulanic Acids / therapeutic use ; Ticarcillin / therapeutic use
    Language English
    Size 41 S. : graph. Darst.
    Publisher Wells Medical
    Publishing place Royal Tunbridge Wells
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007225958
    ISBN 1-86996-993-6 ; 978-1-86996-993-6
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 3577 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Agri-environment schemes are associated with greater terrestrial invertebrate abundance and richness in upland grasslands

    Arnott, Amy / Riddell, Gillian / Emmerson, Mark / Reid, Neil

    Agronomy for sustainable development. 2022 Feb., v. 42, no. 1

    2022  

    Abstract: ... Area) grassland (> 150 m above sea level) where productivity is poor. This study used a factorial ...

    Abstract Agri-environment schemes are a key mechanism by which agricultural sustainability is encouraged by subsidising farmers to adopt environmentally friendly management (e.g. reduction of inputs) to maintain and enhance the delivery of biodiversity-associated ecosystem services. Studies testing the efficacy of agri-environment schemes have yielded varying results, and few have focused on upland (marginal or Less Favoured Area) grassland (> 150 m above sea level) where productivity is poor. This study used a factorial field experiment to examine patterns in plant communities and terrestrial invertebrates between agri-environment scheme and conventionally managed semi-improved and improved upland grasslands, using 90 spatially paired fields. Total plant species richness and rare plant species richness (those with < 10% occurrence) were unaffected by agri-environment scheme management, but were significantly higher on semi-improved than improved grasslands. Total and rare invertebrate abundance and family-level richness were unrelated to grassland type (semi-improved or improved). Total and rare invertebrate abundances were 4% and 218% higher, and total and rare invertebrate family-level richness were 17% and 14% higher in agri-environment scheme than conventionally managed fields, respectively. Here, we show that agri-environment scheme management of marginal or Less Favoured Area upland grassland was associated with higher multi-taxa invertebrate abundance and richness associated with swards indicative of wetter conditions with lower dominance of perennial ryegrass (Lolium perenne) and greater coverage of other native grass species compared to conventional management. This suggests that agri-environment schemes may maintain, enhance or offset declines in terrestrial invertebrates and their associated ecosystem service delivery by maintaining more diverse swards, and suggests that they make a positive contribution to biodiversity conservation.
    Keywords Lolium perenne ; agri-environmental policy ; agronomy ; biodiversity conservation ; ecosystem services ; ecosystems ; field experimentation ; grasslands ; highlands ; indigenous species ; invertebrates ; rare species ; species richness ; sustainable agriculture
    Language English
    Dates of publication 2022-02
    Size p. 6.
    Publishing place Springer Paris
    Document type Article
    ISSN 1774-0746
    DOI 10.1007/s13593-021-00738-4
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Microbial Inactivation: Gaseous or Aqueous Ozonation?

    Epelle, Emmanuel I / Emmerson, Amy / Nekrasova, Marija / Macfarlane, Andrew / Cusack, Michael / Burns, Anthony / Mackay, William / Yaseen, Mohammed

    Industrial & engineering chemistry research

    2022  Volume 61, Issue 27, Page(s) 9600–9610

    Abstract: For decades, ozone has been known to have antimicrobial properties when dissolved or generated in water and when utilized in its gaseous form on different substrates. This property (the ability to be used in air and water) makes it versatile and ... ...

    Abstract For decades, ozone has been known to have antimicrobial properties when dissolved or generated in water and when utilized in its gaseous form on different substrates. This property (the ability to be used in air and water) makes it versatile and applicable to different industries. Although the medium of ozonation depends on the specific process requirements, some industries have the inherent flexibility of medium selection. Thus, it is important to evaluate the antimicrobial efficacy in both media at similar concentrations, an endeavor hardly reported in the literature. This study provides insights into ozone's efficacy in air and water using two Gram-negative bacteria (
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484436-9
    ISSN 1520-5045 ; 0888-5885
    ISSN (online) 1520-5045
    ISSN 0888-5885
    DOI 10.1021/acs.iecr.2c01551
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top