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  1. Book ; Online ; E-Book: Nanotechnology Principles in Drug Targeting and Diagnosis

    Rai, Mahendra / Khan, Shagufta / Belgamwar, Aarti

    (Micro and Nano Technologies Series)

    2023  

    Author's details Mahendra Rai, Shagufta Khan, and Aarti Belgamwar, editors
    Series title Micro and Nano Technologies Series
    MeSH term(s) Drug Delivery Systems. ; Nanoparticle Drug Delivery System. ; Nanotechnology ; Nanoparticles. ; Neoplasms/therapy.
    Keywords Drug targeting
    Subject code 615.6
    Language English
    Size 1 online resource (470 pages)
    Edition First edition.
    Publisher Elsevier
    Publishing place Cambridge, MA
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-98348-0 ; 9780323917636 ; 978-0-323-98348-8 ; 0323917631
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Terpenes and Terpenoids

    Perveen, Shagufta / Mohammad Al-Taweel, Areej

    Recent Advances

    (Biochemistry ; 21)

    2021  

    Series title Biochemistry ; 21
    Keywords Organic chemistry ; cancer, antioxidant, toxicity, chemotherapy, essential oils, carotenoids
    Language English
    Size 1 electronic resource (142 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030644790
    ISBN 9781838819187 ; 1838819185
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Pharmacognosy

    Perveen, Shagufta / Al-Taweel, Areej

    Medicinal Plants

    2019  

    Keywords Pharmacology ; cancer, antioxidant, drug discovery, secondary metabolites, polyphenols, traditional medicine
    Language English
    Size 1 electronic resource (320 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030646035
    ISBN 9781838808747 ; 1838808744
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: Terpenes and Terpenoids

    Perveen, Shagufta / Al-Taweel, Areej

    2018  

    Keywords Biochemistry ; biosynthesis, malaria, plasmodium falciparum, biological activities, mechanisms
    Language English
    Size 1 electronic resource (152 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030647783
    ISBN 9781838815295 ; 1838815295
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Therapeutic significance of molecular hybrids for breast cancer research and treatment.

    Shagufta / Ahmad, Irshad

    RSC medicinal chemistry

    2022  Volume 14, Issue 2, Page(s) 218–238

    Abstract: Worldwide, breast cancer is still a leading cause of cancer death in women. Indeed, over the years, several anti-breast cancer drugs have been developed; however, the complex heterogeneous nature of breast cancer disease reduces the applicability of ... ...

    Abstract Worldwide, breast cancer is still a leading cause of cancer death in women. Indeed, over the years, several anti-breast cancer drugs have been developed; however, the complex heterogeneous nature of breast cancer disease reduces the applicability of conventional targeted therapies with the upsurge in side effects and multi-drug resistance. Molecular hybrids generated by a combination of two or more active pharmacophores emerged as a promising approach in recent years for the design and synthesis of anti-breast cancer drugs. The hybrid anti-breast cancer molecules are well known for their several advantages compared to the parent moiety. These hybrid forms of anti-breast cancer molecules demonstrated remarkable effects in blocking different pathways contributing to the pathogenies of breast cancer and improved specificity. In addition, these hybrids are patient compliant with reduced side effects and multi-drug resistance. The literature revealed that molecular hybrids are applied to discover and develop novel hybrids for various complex diseases. This review article highlights the recent progress (∼2018-2022) in developing molecular hybrids, including linked, merged, and fused hybrids, as promising anti-breast cancer agents. Furthermore, their design principles, biological potential, and future perspective are discussed. The provided information will lead to the development of novel anti-breast cancer hybrids with excellent pharmacological profiles in the future.
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d2md00356b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Unexpected Cola-Colored Urine in a Neonate.

    Dipak, Niraj Kumar / Shagufta, Nadia

    NeoReviews

    2023  Volume 24, Issue 11, Page(s) e737–e740

    MeSH term(s) Humans ; Infant, Newborn ; Urine
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1526-9906
    ISSN (online) 1526-9906
    DOI 10.1542/neo.24-11-e737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: An Update on Pharmacological Relevance and Chemical Synthesis of Natural Products and Derivatives with Anti SARS-CoV-2 Activity.

    Shagufta / Ahmad, Irshad

    ChemistrySelect

    2021  Volume 6, Issue 42, Page(s) 11502–11527

    Abstract: Natural products recognized traditionally as a vital source of active constituents in pharmacotherapy. The COVID-19 infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible, pathogenic, and considered an ... ...

    Abstract Natural products recognized traditionally as a vital source of active constituents in pharmacotherapy. The COVID-19 infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible, pathogenic, and considered an ongoing global health emergency. The emergence of COVID-19 globally and the lack of adequate treatment brought attention towards herbal medicines, and scientists across the globe instigated the search for novel drugs from medicinal plants and natural products to tackle this deadly virus. The natural products rich in scaffold diversity and structural complexity are an excellent source for antiviral drug discovery. Recently the investigation of several natural products and their synthetic derivatives resulted in the identification of promising anti SARS-CoV-2 agents. This review article will highlight the pharmacological relevance and chemical synthesis of the recently discovered natural product and their synthetic analogs as SARS-CoV-2 inhibitors. The summarized information will pave the path for the natural product-based drug discovery of safe and potent antiviral agents, particularly against SARS-CoV-2.
    Language English
    Publishing date 2021-11-08
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2365-6549
    ISSN 2365-6549
    DOI 10.1002/slct.202103301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2.

    Shagufta / Ahmad, Irshad

    European journal of medicinal chemistry

    2021  Volume 213, Page(s) 113157

    Abstract: The unforeseen emergence of coronavirus disease 2019 (COVID-19), a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the Wuhan province of China in December 2019, subsequently its abrupt spread across the world has severely affected human ... ...

    Abstract The unforeseen emergence of coronavirus disease 2019 (COVID-19), a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the Wuhan province of China in December 2019, subsequently its abrupt spread across the world has severely affected human life. In a short span of time, COVID-19 has sacked more than one million human lives and marked as a severe global pandemic, which is drastically accountable for the adverse effect directly to the human society, particularly the health care system and the economy. The unavailability of approved and effective drugs or vaccines against COVID-19 further created conditions more adverse and terrifying. To win the war against this pandemic within time there is a desperate need for the most adequate therapeutic treatment, which can be achieved by the collaborative research work among scientists worldwide. In continuation of our efforts to support the scientific community, a review has been presented which discusses the structure and the activity of numerous molecules exhibiting promising SARS-CoV-2 and other CoVs inhibition activities. Furthermore, this review offers an overview of the structure, a plausible mechanism of action of SARS-CoV-2, and crucial structural features substantial to inhibit the primary virus-based and host-based targets involved in SARS-CoV-2 treatment. We anticipate optimistically that this perspective will provide the reader and researcher's better understanding regarding COVID-19 and pave the path in the direction of COVID-19 drug discovery and development paradigm.
    MeSH term(s) Animals ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; COVID-19/epidemiology ; Drug Discovery ; Humans ; Pandemics ; Protease Inhibitors/chemistry ; Protease Inhibitors/therapeutic use ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Protease Inhibitors ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-01-12
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2021.113157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 784: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: The Conundrum of Medical Writing

    Shagufta Saeed Sial

    Journal of Rawalpindi Medical College, Vol 26, Iss

    2022  Volume 1

    Abstract: Writing is an art. Medical writing is an amalgamation of art with science. Not all medical writers have the inherent capability to pen down their work. For some it is a source of contentment, happiness, and authorization whereas it’s a hard nut to crack ... ...

    Abstract Writing is an art. Medical writing is an amalgamation of art with science. Not all medical writers have the inherent capability to pen down their work. For some it is a source of contentment, happiness, and authorization whereas it’s a hard nut to crack for others, requiring additional efforts to accomplish this uphill task. Future medical writers confront many challenges before they embark upon this worthwhile endeavour. Some may not realize its importance; others simply enter into the world of bewilderment as to how to start. Yet others are well versed with the subject but just cannot pen it down and the majority cannot squeeze their time in because of their hectic daily routines. In order to counter these challenges, one has to overcome the conundrum of medical writing. Why to Write? Medical writing is an essential feature of evidence-based medicine and is mandatory for progress in the medical profession. Apart from religious, international, national, institutional, and professional gains, the honor, regard, and respect a medical writer earns in the scientific world is priceless. High research scores, h-indices, portfolios, citations, and references quoted by other researchers and writers elevate you to unfathomable heights. Your work creates an opportunity for others to get benefit from the work done and the medical knowledge grows in a stepladder fashion. Ultimately the main aim i.e. Benefit humanity also fulfilling the divine requirement for a Muslim medical writer. This qualm of writers' hesitancy can have devastating effects on the professional career of a writer. Age limit constraints, fear of losing an opportunity to appear in examinations on time, poor prospects for gaining senior posts and promotions, etc. can be detrimental to the psychosocial well-being too. This initiates the unfortunate vicious circle causing further delay or even abandonment of work. This state of affairs could be demoralizing for a doctor who is otherwise humane, hardworking, conscientious, and has been courteous to patients. ...
    Keywords Medical Writing ; Medicine ; R
    Subject code 100
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Rawalpindi Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Seaweed as natural raw material for industrial applications; extraction, physio-chemical characterization and antioxidant potential of alginate based biofilm.

    Iqra Rasheed, - / Shagufta Riaz, - / Seema Shafique, -

    Pakistan journal of pharmaceutical sciences

    2023  Volume 36, Issue 4, Page(s) 1241–1248

    Abstract: Brown seaweed Jolyna laminarioides was collected during low tide from coastal area of Karachi and was used as renewable source for production of sodium alginate. Starch was mixed with alginate as secondary polymer along with high (30%) and low (15%) ... ...

    Abstract Brown seaweed Jolyna laminarioides was collected during low tide from coastal area of Karachi and was used as renewable source for production of sodium alginate. Starch was mixed with alginate as secondary polymer along with high (30%) and low (15%) concentration of bio-plasticizer (sorbitol and glycerol) to produce an eco-friendly biofilm by casting technique. Thickness, moisture content, solubility, bio-degradation test, density, scanning electron microscopy (SEM), Fourier transform infra-red spectroscopy (FTIR) and DPPH (2,2-diphenyl picrylhydrazyl) assay was performed for each blend of biofilm. The obtained results showed the affinity of sorbitol and glycerol with alginate-starch matrix with significant moisture content, thickness and biodegradation properties. The antioxidative potential of alginate based biofilms make it suitable for pharmaceutical and cosmeceutical applications like bio-packaging and manufacturing of eco-friendly production.
    MeSH term(s) Antioxidants/pharmacology ; Glycerol ; Alginates ; Biofilms ; Seaweed ; Sorbitol
    Chemical Substances Antioxidants ; Glycerol (PDC6A3C0OX) ; Alginates ; Sorbitol (506T60A25R)
    Language English
    Publishing date 2023-08-21
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6588: Show issues Location:
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