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  1. Article ; Online: Long-term survival in patients with incurable breast cancer. An analysis of 93 cases.

    Rhomberg, Walter / Rhomberg, Thomas

    Anticancer research

    2014  Volume 34, Issue 10, Page(s) 5637–5642

    Abstract: Background/aim: The aim of this study was to elucidate why some patients with incurable breast cancer may survive far beyond our expectation.: Patients and methods: The analysis is based on two cohorts of patients with unresectable locoregional ... ...

    Abstract Background/aim: The aim of this study was to elucidate why some patients with incurable breast cancer may survive far beyond our expectation.
    Patients and methods: The analysis is based on two cohorts of patients with unresectable locoregional recurrences or distant metastases. Survival time, tumor characteristics, disease-free interval, metastasis type, coexistent diseases and a family history for breast cancer were recorded.
    Results: Among 553 patients, 93 patients were found to have survived >4 years. The following favourable prognostic factors were identified: a disease-free interval of 5.5 years and a high frequency of locoregional and skeletal metastasis. In addition, the patients showed several coexistent disorders and a higher incidence of familial breast cancer. The more coexistent disorders are found in a patient, the longer seems to be the survival.
    Conclusion: Survival in metastatic breast cancer may not only be determined by known prognostic factors but also by a variety of hormonal and complex genetic influences, and possibly by non-cytotoxic drugs.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Cohort Studies ; Comorbidity ; Female ; Humans ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Risk Factors
    Language English
    Publishing date 2014-10
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The radiation response of sarcomas by histologic subtypes: a review with special emphasis given to results achieved with razoxane.

    Rhomberg, Walter

    Sarcoma

    2006  Volume 2006, Issue 1, Page(s) 87367

    Abstract: Purpose. Relatively few results are available in the literature about the radiation response of unresectable sarcomas in relation to their histology. Therefore, an attempt was made to summarize the present situation. Materials and methods. This report is ...

    Abstract Purpose. Relatively few results are available in the literature about the radiation response of unresectable sarcomas in relation to their histology. Therefore, an attempt was made to summarize the present situation. Materials and methods. This report is based on a review of the literature and the author's own experience. Adult-type soft tissue sarcomas, chondrosarcomas, and chordomas were analyzed. Radioresponse was mainly associated with the degree of tumor shrinkage, that is, objective responses. Histopathologic responses, that is, the degree of necrosis, are only discussed in relation to radiation treatment reports of soft tissue sarcomas as a group. Results. Radiation therapy alone leads to major responses in about 50% of lipo-, fibro-, leiomyo-, or chondrosarcomas. The response rate is less than 50% in malignant fibrous histiocytomas, synovial, neurogenic, and other rare soft tissue sarcomas. The response rates may increase up to 75% through the addition of radiosensitizers such as halogenated pyrimidines or razoxane, or by the use of high-LET irradiation. Angiosarcomas become clearly more responsive if biologicals, angiomodulating, and/or tubulin affinic substances are given together with radiation therapy. Razoxane is able to increase the duration and quality of responses even in difficult-to-treat tumors like chondrosarcomas or chordomas. Conclusions. The available data demonstrate that the radioresponsiveness of sarcomas is very variable and dependent on histology, kind of radiation, and various concomitantly given drugs. The rate of complete sustained remissions by radiation therapy alone or in combination with drugs is still far from satisfactory although progress has been made through the use of sensitizing agents.
    Language English
    Publishing date 2006-10-13
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1338527-6
    ISSN 1357-714X
    ISSN 1357-714X
    DOI 10.1155/SRCM/2006/87367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Premature calcifications of costal cartilages: a new perspective.

    Rhomberg, Walter / Schuster, Antonius

    Radiology research and practice

    2014  Volume 2014, Page(s) 523405

    Abstract: Background. Calcifications of the costal cartilages occur, as a rule, not until the age of 30 years. The knowledge of the clinical significance of early and extensive calcifications is still incomplete. Materials and Methods. A search was made to find ... ...

    Abstract Background. Calcifications of the costal cartilages occur, as a rule, not until the age of 30 years. The knowledge of the clinical significance of early and extensive calcifications is still incomplete. Materials and Methods. A search was made to find patients below the age of 30 years who showed distinct calcifications of their lower costal cartilages by viewing 360 random samples of intravenous pyelograms and abdominal plain films. The histories, and clinical and laboratory findings of these patients were analyzed. Results. Nineteen patients fulfilled the criteria of premature calcifications of costal cartilages (CCCs). The patients had in common that they were frequently referred to a hospital and were treated by several medical disciplines. Nevertheless many complaints of the patients remained unsolved. Premature CCCs were often associated with rare endocrine disorders, inborn errors of metabolism, and abnormal hematologic findings. Among the metabolic disorders there were 2 proven porphyrias and 7 patients with a suspected porphyria but with inconclusive laboratory findings. Conclusion. Premature CCCs are unlikely to be a normal variant in skeletal radiology. The findings in this small group of patients call for more intensive studies, especially in regard to the putative role of a porphyria.
    Language English
    Publishing date 2014-12-23
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2594649-3
    ISSN 2090-195X ; 2090-1941
    ISSN (online) 2090-195X
    ISSN 2090-1941
    DOI 10.1155/2014/523405
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  4. Article ; Online: The Radiation Response of Sarcomas by Histologic Subtypes

    Walter Rhomberg

    Sarcoma, Vol

    A Review With Special Emphasis Given to Results Achieved With Razoxane

    2006  Volume 2006

    Keywords Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2006-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Impfung: Gebärmutterhalskrebs

    Rhomberg, Walter

    Medizin und Ideologie

    2007  Volume 29, Issue 4, Page(s) 24

    Language German
    Document type Article
    ZDB-ID 570613-0
    Database Current Contents Medicine

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  6. Article ; Online: Premature Calcifications of Costal Cartilages

    Walter Rhomberg / Antonius Schuster

    Radiology Research and Practice, Vol

    A New Perspective

    2014  Volume 2014

    Keywords Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Medicine (General) ; R5-920 ; Medicine ; R
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Premature Calcifications of Costal Cartilages

    Walter Rhomberg / Antonius Schuster

    Radiology Research and Practice, Vol

    A New Perspective

    2014  Volume 2014

    Abstract: Background. Calcifications of the costal cartilages occur, as a rule, not until the age of 30 years. The knowledge of the clinical significance of early and extensive calcifications is still incomplete. Materials and Methods. A search was made to find ... ...

    Abstract Background. Calcifications of the costal cartilages occur, as a rule, not until the age of 30 years. The knowledge of the clinical significance of early and extensive calcifications is still incomplete. Materials and Methods. A search was made to find patients below the age of 30 years who showed distinct calcifications of their lower costal cartilages by viewing 360 random samples of intravenous pyelograms and abdominal plain films. The histories, and clinical and laboratory findings of these patients were analyzed. Results. Nineteen patients fulfilled the criteria of premature calcifications of costal cartilages (CCCs). The patients had in common that they were frequently referred to a hospital and were treated by several medical disciplines. Nevertheless many complaints of the patients remained unsolved. Premature CCCs were often associated with rare endocrine disorders, inborn errors of metabolism, and abnormal hematologic findings. Among the metabolic disorders there were 2 proven porphyrias and 7 patients with a suspected porphyria but with inconclusive laboratory findings. Conclusion. Premature CCCs are unlikely to be a normal variant in skeletal radiology. The findings in this small group of patients call for more intensive studies, especially in regard to the putative role of a porphyria.
    Keywords Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 616 ; 610
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book: Razoxane and dexrazoxane

    Hellmann, K / Rhomberg, Walter

    two multifunctional agents : experimental and clinical results

    2010  

    Author's details Kurt Hellmann, Walter Rhomberg, editors
    MeSH term(s) Razoxane/pharmacology ; Antineoplastic Agents/pharmacology ; Neoplasms/drug therapy
    Language English
    Size xiii, 243 p. :, ill. ;, 25 cm.
    Publisher Springer
    Publishing place Dordrecht ; New York
    Document type Book
    ISBN 9789048191673 ; 904819167X ; 9789048191680 ; 9048191688
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article: Porphyrie und Radiotherapie: doch eine Risikokonstellation?

    Rhomberg, Walter / Offner, Felix Albert

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2005  Volume 181, Issue 6, Page(s) 401–404

    Abstract: Background: Little is known concerning the relation of porphyrias to radiation treatment for cancer. The recent literature does not report negative outcomes at least in single cases of breast cancer, bladder cancer or in a patient with lymphoma. ... ...

    Title translation Porphyria and radiotherapy: yet a constellation of risk?.
    Abstract Background: Little is known concerning the relation of porphyrias to radiation treatment for cancer. The recent literature does not report negative outcomes at least in single cases of breast cancer, bladder cancer or in a patient with lymphoma. Theoretically, there is a risk for radiation treatment in cases of porphyrias.
    Case report: Two patients with porphyria are described who underwent radiotherapy for glioblastoma multiforme. Case histories, radiation treatment data and the proof of porphyria are given in detail. The patients received a concomitant radiochemotherapy with infusions of ACNU [1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-(2-chloroethyl)-3-nitrosourea] every 6 weeks. The total radiation doses at the ICRU point were 60 and 38 Gy, respectively, given in single daily fractions of 2 Gy.
    Results: Both patients responded well as far as objective tumor regression is concerned but died early after 7 and 1.5 months following diagnosis. The first patient experienced a large brain necrosis and deterioration of her porphyria. The second patient died of cardiopulmonary insufficiency still during radiotherapy with persistent or even increased signs of porphyria. The tumor showed extensive necrosis already after 38 Gy.
    Conclusion: In view of annotations in the literature and this case report, caution is advised as for irradiation of brain or nervous tissues in case of porphyrias. Molecular biology data seems to support this warning to some extent.
    MeSH term(s) Aged ; Brain Neoplasms/radiotherapy ; Female ; Glioblastoma/radiotherapy ; Humans ; Male ; Middle Aged ; Necrosis ; Porphyrias/epidemiology ; Porphyrias/etiology ; Porphyrias/pathology ; Radiotherapy/adverse effects ; Risk Assessment ; Treatment Outcome
    Language German
    Publishing date 2005-06
    Publishing country Germany
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-005-1311-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Razoxane and Dexrazoxane - Two Multifunctional Agents

    Hellmann, Kurt / Rhomberg, Walter

    Experimental and Clinical Results

    2010  

    Abstract: Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through ... ...

    Author's details edited by Kurt Hellmann, Walter Rhomberg
    Abstract Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms. They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc. The protection of normal tissues is nowhere more important than that of brain, and there are indications that the proteins thought to be responsible for the ravages of Alzheimer¿s disease could be stabilized by one or both these drugs. TOC:PREFACE, 1. INTRODUCTION, 2. RAZOXANE, 3. DEXRAZOXANE, 4. SUMMARY and OUTLOOK
    MeSH term(s) Dexrazoxane ; Razoxane
    Keywords Cardiology ; Internal medicine ; Medicine ; Neurosciences ; Oncology ; Radiotherapy ; Medizin / Gesundheit # Biochemie / Labormedizin ; Medizin / Gesundheit # Innere Medizin ; Medizin / Gesundheit # Onkologie ; Medizin / Gesundheit # Radiologie ; Medizin / Gesundheit # Sonstiges
    Language English
    Size Online-Ressource, v.: digital
    Publisher Springer Science+Business Media B.V
    Publishing place Dordrecht
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9789048191673 ; 9789048191680 ; 904819167X ; 9048191688
    DOI 10.1007/978-90-481-9168-0
    Database Former special subject collection: coastal and deep sea fishing

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