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  1. Article ; Online: Human papillomavirus vaccination uptake among 27-to-45-year-olds in the United States.

    Akpan, Idara N / Taskin, Tanjila / Wheldon, Christopher W / Rossheim, Matthew E / Thompson, Erika L

    Preventive medicine

    2024  Volume 182, Page(s) 107951

    Abstract: Objective: The human papillomavirus (HPV) vaccine prevents six types of cancer. Previously, this vaccine was only approved for 9-26-year-olds. However, in October 2018 the U.S. Food and Drug Administration approved the HPV vaccine for 27- to 45-year- ... ...

    Abstract Objective: The human papillomavirus (HPV) vaccine prevents six types of cancer. Previously, this vaccine was only approved for 9-26-year-olds. However, in October 2018 the U.S. Food and Drug Administration approved the HPV vaccine for 27- to 45-year-olds (mid-adults). The current study aimed to assess HPV vaccination among a national sample of U.S adults aged 27-45 years. This study also assessed factors associated with HPV vaccine initiation after age 26.
    Methods: Data were analyzed using the 2019 National Health Interview Survey. The study included two samples: (1) mid-adults aged 27-45 (n = 8556), and (2) mid-adults who self-reported they had initiated HPV vaccination within the 27-45 age range and those who were unvaccinated (n = 7307). The outcome variables were HPV vaccination status and HPV vaccine initiation. The independent variables represented constructs from Andersen's Behavioral Model of Health Services Use. The odds of HPV vaccination were estimated using weighted multivariable logistic regression models.
    Results: Overall, 15.6% had ever received the HPV vaccine and 13.1% initiated their first dose of the vaccine after age 26. Hispanic (aOR = 0.73; 95% CI = 0.58, 0.92) and non-Hispanic Asian persons (aOR = 0.59; 95% CI = 0.41, 0.84) had lower odds of ever receiving the vaccine than non-Hispanic White persons. Females (aOR = 2.17; 95% CI = 1.42, 3.32) had higher odds of initiating the vaccine after age 26 than males.
    Conclusions: The ACIP recommendation of shared clinical decision-making emphasizes the role of clinical interactions in HPV vaccine decision-making. Study findings highlight the need to further explore contextual factors that may influence HPV vaccine behavior among mid-adults.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184600-0
    ISSN 1096-0260 ; 0091-7435
    ISSN (online) 1096-0260
    ISSN 0091-7435
    DOI 10.1016/j.ypmed.2024.107951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 878: Show issues Location:
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  2. Book: Mathematical models in cancer research

    Wheldon, T. E.

    (Medical science series)

    1988  

    Author's details T. E. Wheldon
    Series title Medical science series
    Keywords Models, Theoretical ; Neoplasms ; Krebs ; Mathematisches Modell
    Subject Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Size XVI, 247 S. : graph. Darst.
    Publisher Hilger
    Publishing place Bristol u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003282282
    ISBN 0-85274-291-6 ; 978-0-85274-291-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1989 A 1682 order for loan Magazin

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  3. Article ; Online: Examining Mental Health and Bullying Concerns at the Intersection of Sexuality, Gender, Race, and Ethnicity Among a National Sample of Sexual and Gender Diverse Youth.

    Watson, Ryan J / Caba, Antonia E / Lawrence, Samantha E / Renley, Benton M / McCauley, Peter S / Wheldon, Christopher W / Eaton, Lisa A / Russell, Stephen T / Eisenberg, Marla E

    LGBT health

    2023  Volume 11, Issue 1, Page(s) 20–27

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Male ; Female ; Humans ; Adolescent ; Ethnicity ; Mental Health ; Gender Identity ; Sexuality ; Transgender Persons ; Bullying ; Sexual and Gender Minorities
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2727303-9
    ISSN 2325-8306 ; 2325-8292
    ISSN (online) 2325-8306
    ISSN 2325-8292
    DOI 10.1089/lgbt.2023.0072
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  4. Article ; Online: Recent advances in positron emission particle tracking: a comparative review.

    Windows-Yule, C R K / Herald, M T / Nicuşan, A L / Wiggins, C S / Pratx, G / Manger, S / Odo, A E / Leadbeater, T / Pellico, J / de Rosales, R T M / Renaud, A / Govender, I / Carasik, L B / Ruggles, A E / Kokalova-Wheldon, Tz / Seville, J P K / Parker, D J

    Reports on progress in physics. Physical Society (Great Britain)

    2022  Volume 85, Issue 1

    Abstract: Positron emission particle tracking (PEPT) is a technique which allows the high-resolution, three-dimensional imaging of particulate and multiphase systems, including systems which are large, dense, and/or optically opaque, and thus difficult to study ... ...

    Abstract Positron emission particle tracking (PEPT) is a technique which allows the high-resolution, three-dimensional imaging of particulate and multiphase systems, including systems which are large, dense, and/or optically opaque, and thus difficult to study using other methodologies. In this work, we bring together researchers from the world's foremost PEPT facilities not only to give a balanced and detailed overview and review of the technique but, for the first time, provide a rigorous, direct, quantitative assessment of the relative strengths and weaknesses of all contemporary PEPT methodologies. We provide detailed explanations of the methodologies explored, including also interactive code examples allowing the reader to actively explore, edit and apply the algorithms discussed. The suite of benchmarking tests performed and described within the document is made available in an open-source repository for future researchers.
    MeSH term(s) Algorithms ; Electrons ; Imaging, Three-Dimensional ; Positron-Emission Tomography/methods
    Language English
    Publishing date 2022-01-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 205657-4
    ISSN 1361-6633 ; 0034-4885
    ISSN (online) 1361-6633
    ISSN 0034-4885
    DOI 10.1088/1361-6633/ac3c4c
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    In stock of ZB MED Bonn / Germany

    Z 52/38: Show issues

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  5. Book: Radiation risks

    Sumner, David / Wheldon, T. E. / Watson, Walter

    1991  

    Author's details David Sumner ; Tom Wheldon ; Walter Watson
    Keywords Radiation Effects ; Radiation Injuries ; Risk Factors
    Size 236 S.
    Edition 3. ed.
    Publisher Tarragon
    Publishing place Glasgow
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT004256842
    ISBN 1-87078-104-X ; 978-1-87078-104-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1992 B 1357 order for loan Magazin

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  6. Article: Radiation physics and genetic targeting: new directions for radiotherapy. The Douglas Lea Lecture 1999.

    Wheldon, T E

    Physics in medicine and biology

    2000  Volume 45, Issue 7, Page(s) R77–95

    Abstract: Radiation as a cancer treatment modality is of high physical precision but limited biological specificity. Targeted radiotherapy, the delivery of radiation to cancer cells by radioisotopes conjugated to tumour-seeking targeting agents, is a biologically ... ...

    Abstract Radiation as a cancer treatment modality is of high physical precision but limited biological specificity. Targeted radiotherapy, the delivery of radiation to cancer cells by radioisotopes conjugated to tumour-seeking targeting agents, is a biologically attractive option but is currently effective for just a few tumour types (neuroblastoma, lymphoma) for which efficacious targeting agents are available. Radiobiological modelling and radiation microdosimetry have provided useful guidelines in choosing treatment strategies for targeted radiotherapy. These considerations generally favour the incorporation of targeted radiotherapy as one component of a multimodal treatment regimen. Very recently, gene therapy techniques have been developed which should enhance the clinical efficacy of both external beam radiation and targeted radiotherapy. Typically, non-harmful viruses are modified to incorporate therapeutic genes which cause altered cellular radiosensitivity or which facilitate the cellular uptake of targeting agents. To achieve specificity, therapeutic genes would be co-transfected with tissue-specific promoter genes causing the therapeutic genes to be expressed in cells of particular types. In laboratory models, our research group are exploring the transfection-mediated uptake of the targeting agents MIBG and sodium iodide. These approaches do not require transfection of every cell in order to cure a tumour-cells which have escaped transfection may be sterilized by radiation cross-fire from transfected neighbours. A new task for radiation microdosimetry is to quantify the cross-fire effect and to compute the efficacies of gene transfection which will be required for tumour cure. In the spirit of Douglas Lea, the analytic approach of physics can be used to illuminate and enhance developments in genetics, to the benefit of medicine.
    MeSH term(s) 3-Iodobenzylguanidine/therapeutic use ; Brain Neoplasms/therapy ; Genetic Therapy/methods ; Glioma/therapy ; Humans ; Neoplasms/radiotherapy ; Neoplasms/therapy ; Radiopharmaceuticals/therapeutic use ; Radiotherapy/methods ; Sodium Iodide/therapeutic use ; Transfection ; Tumor Cells, Cultured
    Chemical Substances Radiopharmaceuticals ; 3-Iodobenzylguanidine (35MRW7B4AD) ; Sodium Iodide (F5WR8N145C)
    Language English
    Publishing date 2000-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/0031-9155/45/7/201
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    Zs.A 199: Show issues Location:
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  7. Article ; Online: Neutron-upscattering enhancement of the triple-alpha process.

    Bishop, J / Parker, C E / Rogachev, G V / Ahn, S / Koshchiy, E / Brandenburg, K / Brune, C R / Charity, R J / Derkin, J / Dronchi, N / Hamad, G / Jones-Alberty, Y / Kokalova, Tz / Massey, T N / Meisel, Z / Ohstrom, E V / Paneru, S N / Pollacco, E C / Saxena, M /
    Singh, N / Smith, R / Sobotka, L G / Soltesz, D / Subedi, S K / Voinov, A V / Warren, J / Wheldon, C

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2151

    Abstract: The neutron inelastic scattering of carbon-12, populating the Hoyle state, is a reaction of interest for the triple-alpha process. The inverse process (neutron upscattering) can enhance the Hoyle state's decay rate to the bound states ... ...

    Abstract The neutron inelastic scattering of carbon-12, populating the Hoyle state, is a reaction of interest for the triple-alpha process. The inverse process (neutron upscattering) can enhance the Hoyle state's decay rate to the bound states of
    Language English
    Publishing date 2022-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29848-7
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  8. Article: The radiobiological basis of total body irradiation.

    Wheldon, T E

    The British journal of radiology

    1997  Volume 70, Issue 840, Page(s) 1204–1207

    Abstract: ... uniformly distributed throughout the body, as in lymphoma, non-uniform TBI is appropriate, e.g. by addition ...

    Abstract Total body irradiation (TBI) is an all-pervasive systemic treatment modality which is well suited to the sterilization of small numbers of widely dispersed radiosensitive cells. This makes it attractive for the treatment of leukaemia or lymphoma in remission. It is unlikely that hypoxia or repopulation will be a problem in TBI treatment of leukaemia, and clonal resistance to radiation occurs less readily than to drugs. Leukaemic cells are often radiosensitive with poor repair capacities but considerable variation is seen in laboratory studies and leukaemias may be highly individual. It is possible that programmed cell death (apoptosis) contributes to leukaemic cell killing and variability of apoptosis may give rise to biological individuality. Molecular methodologies may now be used to monitor leukaemic cell populations and may enable semi-quantitative predictive assays of radiosensitivity. When the malignant cell population is not uniformly distributed throughout the body, as in lymphoma, non-uniform TBI is appropriate, e.g. by addition of local boosts or by the combination of TBI with radiolabelled antibody treatment. Major side-effects mostly relate to critical organs with late-responding characteristics (low alpha/beta ratio, high sensitivity to fraction size or dose rate). The radiobiological basis of developmental effects in children is not well understood. In future, improved selectivity of TBI may come from molecular biological strategies to sensitize malignant cells and to protect normal tissues.
    MeSH term(s) Apoptosis/radiation effects ; Humans ; Leukemia/pathology ; Leukemia/radiotherapy ; Lymphoma/radiotherapy ; Radiation Tolerance ; Radiobiology ; Whole-Body Irradiation
    Language English
    Publishing date 1997-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.70.840.9505837
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  9. Article: Targeting radiation to tumours.

    Wheldon, T E

    International journal of radiation biology

    1994  Volume 65, Issue 1, Page(s) 109–116

    Abstract: Biologically targeted radiotherapy entails the preferential delivery of radiation to solid tumours or individual tumour cells by means of tumour-seeking delivery vehicles to which radionuclides can be conjugated. Variant forms of this are the binary ... ...

    Abstract Biologically targeted radiotherapy entails the preferential delivery of radiation to solid tumours or individual tumour cells by means of tumour-seeking delivery vehicles to which radionuclides can be conjugated. Variant forms of this are the binary strategies (neutron capture therapy, photodynamic therapy) in which cell killing by the targeting moiety is dependent on activation by an external radiation beam. Monoclonal antibodies have attracted attention for some years as potentially selective targeting agents, but advances in tumour and molecular biology are now providing a much wider choice of molecular species. General radiobiological principles may be derived which are applicable to most forms of targeted radiotherapy. These principles provide guidelines for the appropriate choice of radionuclide in specific treatment situations and its optimal combination with other treatment modalities. In the future, the availability of gene targeting agents will focus attention on the use of Auger electron emitters whose high potency and short range selectivity makes them attractive choices for specific killing of cancer cells whose genetic peculiarities are known.
    MeSH term(s) Boron Neutron Capture Therapy ; Humans ; Neoplasms/drug therapy ; Neoplasms/radiotherapy ; Neoplasms/therapy ; Photochemotherapy ; Radiotherapy
    Language English
    Publishing date 1994-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0955-3002 ; 0020-7616
    ISSN (online) 1362-3095
    ISSN 0955-3002 ; 0020-7616
    DOI 10.1080/09553009414550151
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  10. Article: Radionuclide therapy of cancer: particle range and therapeutic effectiveness.

    Wheldon, T E

    Nuclear medicine communications

    1993  Volume 14, Issue 6, Page(s) 408–410

    MeSH term(s) Alpha Particles ; Beta Particles ; Combined Modality Therapy ; Electrons ; Humans ; Neoplasms/diagnostic imaging ; Radionuclide Imaging
    Language English
    Publishing date 1993-06
    Publishing country England
    Document type Editorial
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/00006231-199306000-00002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1577: Show issues Location:
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