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  1. Book: Hepatitis B virus and immune response

    Fiorino, Sirio

    2008  

    Author's details S. Fiorino
    Keywords Hepatitis B virus / immunology ; Hepatitis B Antibodies / immunology ; Immunity, Cellular
    Language English
    Size VI, 99 S. : Ill.
    Publisher Nova Science Publ
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT015776327
    ISBN 978-1-60456-450-1 ; 1-60456-450-4
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: A comparison of interpretable XGBoost and artificial neural network model for the prediction of severe acute pancreatitis.

    Lu, Yajing / Qiu, Minhao / Pan, Shuang / Basharat, Zarrin / Zippi, Maddalena / Fiorino, Sirio / Hong, Wandong

    Polish archives of internal medicine

    2024  

    Abstract: Introduction: Acute pancreatitis (AP) that progresses to persistent organ failure is defined as severe acute pancreatitis (SAP) which has a relatively high mortality. Early establishment of a prediction model is crucial for the improvement of disease ... ...

    Abstract Introduction: Acute pancreatitis (AP) that progresses to persistent organ failure is defined as severe acute pancreatitis (SAP) which has a relatively high mortality. Early establishment of a prediction model is crucial for the improvement of disease prognosis.
    Objectives: The aim of this study was to evaluate the accuracy of Extreme Gradient Boosting (XGBoost) and artificial neural network model (ANN) for predicting SAP.
    Patients and methods: A total of 648 patients with AP were enrolled. XGBoost and ANN models were developed and valuated in the training set (519 patients) and test set (129 patients), respectively. The accuracy and results of XGBoost and ANN models were evaluated both by area under the receiver operating characteristic curves (AUC) and the area under precision recall curve.
    Results: 15 variables were selected for model construction through univariable analysis. The AUCs of XGBoost model and ANN model in five-fold cross-validation of the training set were 0.92 (95%CI, 0.87-0.97) and 0.86 (95%CI, 0.78-0.92), respectively. AUCs of XGBoost model and ANN model for the test set were 0.93 (95%CI, 0.85-1.00) and 0.87 (95%CI, 0.79-0.96). XGBoost outperformed ANN in terms of both diagnostic accuracy and the area under the precision recall curve. Individualized prediction by XGBoost model was explained by local interpretable model-agnostic explanations (LIME) plot.
    Conclusions: An interpretable XGBoost model showed higher discriminatory efficiency in predicting SAP compared to ANN.
    Language English
    Publishing date 2024-03-15
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: An Unexpected Gastric Subepithelial Mass.

    Zippi, Maddalena / Fiorino, Sirio / Bertoldi, Innocenzo / Hong, Wandong / Occhigrossi, Giuseppe

    Oman medical journal

    2021  Volume 36, Issue 2, Page(s) e252

    Language English
    Publishing date 2021-03-31
    Publishing country Oman
    Document type Journal Article
    ZDB-ID 2571431-4
    ISSN 2070-5204 ; 1999-768X
    ISSN (online) 2070-5204
    ISSN 1999-768X
    DOI 10.5001/omj.2021.36
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Long COVID-19 gastrointestinal related disorders and traditional Chinese medicine: A network target-based approach.

    Mattioli, Laura Beatrice / Frosini, Maria / Corazza, Ivan / Fiorino, Sirio / Zippi, Maddalena / Micucci, Matteo / Budriesi, Roberta

    Phytotherapy research : PTR

    2024  

    Abstract: The significant number of individuals impacted by the pandemic makes prolonged symptoms after COVID-19 a matter of considerable concern. These are numerous and affect multiple organ systems. According to the World Health Organization (WHO), prolonged ... ...

    Abstract The significant number of individuals impacted by the pandemic makes prolonged symptoms after COVID-19 a matter of considerable concern. These are numerous and affect multiple organ systems. According to the World Health Organization (WHO), prolonged gastrointestinal issues are a crucial part of post-COVID-19 syndrome. The resulting disruption of homeostasis underscores the need for a therapeutic approach based on compounds that can simultaneously affect more than one target/node. The present review aimed to check for nutraceuticals possessing multiple molecular mechanisms helpful in relieving Long COVID-19-specific gastrointestinal symptoms. Specific plants used in Keywords Chinese Medicine (TCM) expected to be included in the WHO Global Medical Compendium were selected based on the following criteria: (1) they are widely used in the Western world as natural remedies and complementary medicine adjuvants; (2) their import and trade are regulated by specific laws that ensure quality and safety (3) have the potential to be beneficial in alleviating intestinal issues associated with Long COVID-19. Searches were performed in PubMed, Elsevier, Google Scholar, Scopus, Science Direct, and ResearchGate up to 2023. Cinnamomum cassia, Glycyrrhiza uralensis, Magnolia officinalis, Poria cocos, Salvia miltiorrhiza, Scutellaria baicalensis, and Zingiber officinalis were identified as the most promising for their potential impact on inflammation and oxidative stress. Based on the molecular mechanisms of the phytocomplexes and isolated compounds of the considered plants, their clinical use may lead to benefits in gastrointestinal diseases associated with Long COVID-19, thanks to a multiorgan and multitarget approach.
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.8163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: HBV and HCV infection and pancreatic ductal adenocarcinoma.

    Fiorino, Sirio

    Hepatobiliary & pancreatic diseases international : HBPD INT

    2013  Volume 12, Issue 6, Page(s) 570–574

    MeSH term(s) Female ; Hepatitis B, Chronic/complications ; Hepatitis C, Chronic/complications ; Humans ; Male ; Pancreatic Neoplasms/epidemiology
    Language English
    Publishing date 2013-12-01
    Publishing country Singapore
    Document type Editorial ; Comment
    ZDB-ID 2241386-8
    ISSN 1499-3872
    ISSN 1499-3872
    DOI 10.1016/s1499-3872(13)60090-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Figurative aspects suggestive of infectious diseases in the ceramic pots of the pre-Columbian Moche culture. Analysis of the ceramics collection in the Larco Museum of Lima, Peru.

    Sabbatani, Sergio / Fiorino, Sirio / Manfredi, Roberto

    Le infezioni in medicina

    2021  Volume 29, Issue 4, Page(s) 633–642

    Abstract: The historical-medical and anthropological studies, regarding Mesoamerica and South America, have been mainly focused on the great empires (Inca, Atzec, Maya), while other civilizations have been less investigated and only recently are gaining interest. ... ...

    Abstract The historical-medical and anthropological studies, regarding Mesoamerica and South America, have been mainly focused on the great empires (Inca, Atzec, Maya), while other civilizations have been less investigated and only recently are gaining interest. In general, the paleopathological research provides interesting data to know the type of nutrition and the general environmental conditions as well as to point out some ritual mutilation practices, which were relatively frequent in the pre-Columbian cultures. A lot of civilizations flourished in the South America before the arrival of the Spanish Conquistadores in the new world. In the last years it is progressively increasing the interest for the study of the Moche culture as well as for a deeper knowledge of pathocenosis of infectious diseases in the Moche society. Human infectious diseases are known to have a frequent animal origin, in particular from domesticated species, although the species domesticated in the pre-Columbian era were a small number. The purpose of our paper has been to examine the archeological findings suggestive of infectious diseases in artistic ceramic pots, dating back to the Moche period. We examined the iconography of ceramic pots belonging to the collection of the Larco Museum in Lima and reproducing body signs suggestive of infectious diseases. We identified 8 handworks with very interesting features by a medical point of view. In these handworks there are signs and lesions possibly associated with infectious diseases: risus sardonicus, orbital edema, facial nerve palsy, dorsal kyphosis, face and skin lesions. These features are compatible with some infectious diseases, including: syphilis, Bartonella bacilliformis, leishmaniasis, Pott's disease and Chagas disease. A wide discussion about these handworks is provided.
    Language English
    Publishing date 2021-12-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2041081-5
    ISSN 2532-8689 ; 1124-9390
    ISSN (online) 2532-8689
    ISSN 1124-9390
    DOI 10.53854/liim-2904-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The plague which hit the city of Bologna in the year 1630.

    Sabbatani, Sergio / Fiorino, Sirio / Manfredi, Roberto

    Le infezioni in medicina

    2021  Volume 29, Issue 1, Page(s) 145–156

    Abstract: In the year 1630, similarly to other cities of Northern Italy, Bologna was affected by a plague epidemic. It occurred after the arrival of Lansquenet troops, engaged by the Emperor Frederick II in the siege of Mantua city. The human losses have been ... ...

    Abstract In the year 1630, similarly to other cities of Northern Italy, Bologna was affected by a plague epidemic. It occurred after the arrival of Lansquenet troops, engaged by the Emperor Frederick II in the siege of Mantua city. The human losses have been calculated by the historian demographer Bellettini in the terms of around 15,000 people, so that the number of inhabitants in Bologna declined from 62,000 to 47,000 units in the time span of 7-8 months. Initially, during the winter and the early spring, although the plague epidemic had been known after that it involved many cities close to Bologna (i.e. Turin, Milan, Venice, Genoa and Verona), the population tried to keep the epidemic hidden, being afraid that commerce exchanges could be affected by this event. Later, starting from the month of May, under the guidance of cardinal Bernardino Spada, cooperating with the numerous religious orders and in particular with the one of the Camillians, the city reacted, launching an organization effort which significantly aided in the containment of the plague epidemic. A number of Lazarettos were organized outside of the city walls and relevant sums supported the clean operation of over 3,000 houses. The city Senate sustained the poor population with a sum of 700,000 lire and grain donations. Even if the loss of human lives was high, it resulted not so dramatic, compared with that paid by other Italian cities. From a cultural point of view, according to the belief of the scientific knowledge of that time, the miasmatic theories were still considered satisfactory, although in the common practice the people who could leave the city escaped from Bologna, in order to avoid the contagion. We can argue that the impact of the epidemic was reduced by means of the organizational approach with strict isolation measures for sick persons, the closing of the city walls in the urban areas more affected by the plague, and finally a sanctionatory and punitive approach for individuals, who disregarded the applied rules.
    MeSH term(s) Cities ; Epidemics ; History, 17th Century ; Humans ; Italy ; Plague/epidemiology ; Seasons
    Language English
    Publishing date 2021-03-05
    Publishing country Italy
    Document type Historical Article ; Journal Article
    ZDB-ID 2041081-5
    ISSN 1124-9390
    ISSN 1124-9390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Hypertransaminasemia in the course of infection with SARS-CoV-2: Incidence and pathogenetic hypothesis.

    Zippi, Maddalena / Fiorino, Sirio / Occhigrossi, Giuseppe / Hong, Wandong

    World journal of clinical cases

    2020  Volume 8, Issue 8, Page(s) 1385–1390

    Abstract: In patients infected with severe acute respiratory syndrome coronavirus 2, the respiratory symptoms, such as fever, cough and dyspnea, are the most frequent clinical manifestations. These patients may also present with less well-defined symptoms like ... ...

    Abstract In patients infected with severe acute respiratory syndrome coronavirus 2, the respiratory symptoms, such as fever, cough and dyspnea, are the most frequent clinical manifestations. These patients may also present with less well-defined symptoms like diarrhea, nausea, vomiting and/or abdominal discomfort both at the time of diagnosis and during the clinical course. In a few cases, these symptoms may also present before the appearance of respiratory symptoms. To penetrate the body, Severe acute respiratory syndrome coronavirus 2 uses ACE2 receptors, which are present not only in respiratory epithelium but also in gastrointestinal mucosa and liver cholangiocytes. In several cases, viral RNA is detectable in the stool of patients with coronavirus disease 2019 (COVID-19). The liver damage seems to show a multifactorial origin. About 2%-11% of patients with COVID-19 have known underlying hepatic pathologies. In 14%-53% of COVID-19 cases, there is an alteration of the indices of liver cytolysis and is more frequently observed in severe forms of COVID-19, especially during hospitalization.
    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v8.i8.1385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An Unexpected Gastric Subepithelial Mass

    Maddalena Zippi / Sirio Fiorino / Innocenzo Bertoldi / Wandong Hong / Giuseppe Occhigrossi

    Oman Medical Journal, Vol 36, Iss 2, Pp e252-e

    2021  Volume 252

    Abstract: A 63-year-old man came to our observation complaining of symptoms referable to gastroesophageal reflux disease. No epigastric pain, postprandial fullness, or vomiting were present during clinical examination. His history did not show noteworthy ... ...

    Abstract A 63-year-old man came to our observation complaining of symptoms referable to gastroesophageal reflux disease. No epigastric pain, postprandial fullness, or vomiting were present during clinical examination. His history did not show noteworthy pathologies. The patient did not follow any pharmacological therapy, and there was no family history for neoplasia of the digestive system.
    Keywords cysts ; subepithelial lesions ; Medicine ; R
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Oman Medical Specialty Board
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: The plague in Bologna in the year 1527.

    Sabbatani, Sergio / Fiorino, Sirio / Manfredi, Roberto

    Le infezioni in medicina

    2020  Volume 28, Issue 2, Page(s) 278–287

    Abstract: In the year 1527, following the invasion of Italy by Landsknechts, who were headed by Georg von Frundsberg, the bubonic plague appeared in the country. These soldiers were part of an army that Charles V sent to invade Italy in order to subjugate the ... ...

    Abstract In the year 1527, following the invasion of Italy by Landsknechts, who were headed by Georg von Frundsberg, the bubonic plague appeared in the country. These soldiers were part of an army that Charles V sent to invade Italy in order to subjugate the Italian states which had adhered to the League of Cognac. In Bologna during the year 1527 believers held a procession from the Sanctuary of the Madonna del Soccorso, through the city, as far as the Church of San Rocco. The reason for this practice was linked with the plague epidemic. After some cases of plague observed in the Borgo di San Pietro district the miracle of the interruption of the epidemics, thanks to the intervention of Our Lady, was narrated by the faithfuls. Later, after several decades, it was reported by several authors from Bologna, who were not witnesses to the facts, that the epidemic had involved 12,000 out of a total population of around 60,000 inhabitants at that time. We re-evaluated this situation starting from the demographic data concerning the citizens in Bologna during the 15th, 16th and 17th centuries. Furthermore, we performed a search in the State Archives in the city of Bologna in order to find any public notices from the city authorities in the year 1527 aiming to counteract a plague epidemic. Our investigation found no elements to support the outbreak of this disease. Throughout the 16th century, until 1590, the population grew significantly, and no public notices were issued or specific laws enacted to deal with the plague until the year 1557. However, it remains possible that in the area in question, some episodes of plague occurred, but it was fortunately a micro-epidemic, which involved a very poor area of the city. Then this disease was self-limited. However, in our opinion, this episode proved very important, since in this district of Bologna, and around a wooden image of the Madonna del Soccorso, a confraternity took place, and its activities continued until the year 1798. This group of citizens also played a major role in many charitable activities to aid the inhabitants of Bologna, during a difficult historical period, namely the Protestant Reformation, and contributed to strengthen the faith of Catholic believers.
    MeSH term(s) Epidemics/history ; History, 16th Century ; Humans ; Italy/epidemiology ; Plague/history
    Language English
    Publishing date 2020-05-30
    Publishing country Italy
    Document type Historical Article ; Journal Article
    ZDB-ID 2041081-5
    ISSN 1124-9390
    ISSN 1124-9390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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