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Book ; Conference proceedings: MARC conversion manual--authorities (series)

Gillespie, Veronica M / Stubbs, Linda

content designation conventions and online procedures

1985

Institution	Library of Congress. / MARC Editorial Division. Library of Congress. / Name Authority Conversion Section
Author's details	[prepared by Veronica M. Gillespie, with the special assistance of Linda Stubbs, and with the assistance of the Name Authority Conversion Section, MARC Editorial Division, Processing Services, Library of Congress]. --
Keywords	Authority files (Cataloging)/Handbooks, manuals, etc. ; MARC formats ; Machine-readable bibliographic data/Handbooks, manuals, etc. ; Cataloging/Data processing/Handbooks, manuals, etc.
Language	English
Dates of publication	1985-9999
Size	1 v. (loose-leaf) :, ill., forms ;, 22 x 28 cm.
Edition	2nd ed. --
Publisher	The Division
Publishing place	Washington, D.C.
Document type	Book ; Conference proceedings
Note	Cover title: MARC conversion manual, series authorities. ; Includes index.
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Neuroinflammation after SCI: Current Insights and Therapeutic Potential of Intravenous Immunoglobulin.

Gillespie, Ellen R / Ruitenberg, Marc J

Journal of neurotrauma

2020 Volume 39, Issue 3-4, Page(s) 320–332

Abstract: Traumatic spinal cord injury (SCI) elicits a complex cascade of cellular and molecular inflammatory events. Although certain aspects of the inflammatory response are essential to wound healing and repair, post-SCI inflammation is, on balance, thought to ... ...

Abstract	Traumatic spinal cord injury (SCI) elicits a complex cascade of cellular and molecular inflammatory events. Although certain aspects of the inflammatory response are essential to wound healing and repair, post-SCI inflammation is, on balance, thought to be detrimental to recovery by causing "bystander damage" and the spread of pathology into spared but vulnerable regions of the spinal cord. Much of the research to date has therefore focused on understanding the inflammatory drivers of secondary tissue loss after SCI, to define therapeutic targets and positively modulate this response. Numerous experimental studies have demonstrated that modulation of the inflammatory response to SCI can indeed lead to significant neuroprotection and improved recovery. However, it is now also recognized that broadscale immunosuppression is not necessarily beneficial and may even carry the risk of contributing to the development of serious adverse events. Immune modulation rather than suppression is therefore now considered a more promising approach to target harmful post-traumatic inflammation following a major neurotraumatic event such as SCI. One promising immunomodulatory agent is intravenous immunoglobulin (IVIG), a plasma product that contains mostly immunoglobulin G (IgG) from thousands of healthy donors. IVIG is currently already widely used to treat a range of autoimmune diseases, but recent studies have found that it also holds great promise for treating acute neurological conditions, including SCI. This review provides an overview of the inflammatory response to SCI, immunomodulatory approaches that are currently in clinical trials, proposed mechanisms of action for IVIG therapy, and the putative relevance of these in the context of neurotraumatic events.
MeSH term(s)	Cytokines ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Factors/therapeutic use ; Inflammation/physiopathology ; Spinal Cord/drug effects ; Spinal Cord Injuries/physiopathology ; Spinal Cord Injuries/therapy
Chemical Substances	Cytokines ; Immunoglobulins, Intravenous ; Immunologic Factors
Language	English
Publishing date	2020-08-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2019.6952
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Article ; Online: Scaffolding the Transition to Residency: A Qualitative Study of Coach and Resident Perspectives.

Park, Agnes / Gillespie, Colleen / Triola, Marc / Buckvar-Keltz, Lynn / Greene, Richard E / Winkel, Abigail Ford

Academic medicine : journal of the Association of American Medical Colleges

2023 Volume 99, Issue 1, Page(s) 91–97

Abstract: Purpose: This study explores coaching during transition from medical school to residency through the perspectives of residents and faculty coaches participating in a coaching program from residency match through the first year of residency.: Method: ... ...

Abstract	Purpose: This study explores coaching during transition from medical school to residency through the perspectives of residents and faculty coaches participating in a coaching program from residency match through the first year of residency. Method: From January to September 2020, 15 faculty coaches in internal medicine, obstetrics and gynecology, emergency medicine, orthopedics, and pathology participated in a synchronous, in-person coaching training course. All 94 postgraduate year 1 residents in these 5 training programs participated. Between November 2021 and March 2022, focus groups were held with interns from all residency programs participating in the program. Interviews were conducted with faculty coaches in February 2022. Faculty and residents discussed their experiences with and perceptions of coaching. De-identified transcripts were coded, and researchers organized these codes into broader categories, generated cross-cutting themes from the concepts described in both cohorts, and proposed a model for the potential of coaching to support the transition to residency. Descriptive themes were constructed and analytic themes developed by identifying concepts that crossed the data sets. Results: Seven focus groups were held with 39 residents (42%). Residents discussed the goals of a coaching program, coach attributes, program factors, resident attributes, and the role of the coach. Coaches focused on productivity of coaching, coaching skills and approach, professional development, and scaffolding the coaching experience. Three analytic themes were created: (1) coaching as creating an explicit curriculum for growth through the transition to residency, (2) factors contributing to successful coaching, and (3) ways in which these factors confront graduate medical education norms. Conclusions: Learner and faculty perspectives on coaching through the transition to residency reveal the potential for coaching to make an explicit and modifiable curriculum for professional growth and development. Creating structures for coaching in graduate medical education may allow for individualized professional development, improved mindset, self-awareness, and self-directed learning.
MeSH term(s)	Humans ; Internship and Residency ; Clinical Competence ; Education, Medical, Graduate ; Qualitative Research ; Gynecology ; Mentoring
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000005446
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Article ; Online: SMARTer Goalsetting: A Pilot Innovation for Coaches During the Transition to Residency.

Winkel, Abigail Ford / Chang, Lucy Y / McGlone, Pauline / Gillespie, Colleen / Triola, Marc

Academic medicine : journal of the Association of American Medical Colleges

2023 Volume 98, Issue 5, Page(s) 585–589

Abstract: Problem: Ability to set goals and work with coaches can support individualized, self-directed learning. Understanding the focus and quality of graduating medical student and first-year resident goals and the influence of coaching on goal-setting can ... ...

Abstract	Problem: Ability to set goals and work with coaches can support individualized, self-directed learning. Understanding the focus and quality of graduating medical student and first-year resident goals and the influence of coaching on goal-setting can inform efforts to support learners through the transition from medical school to residency. Approach: This observational study examined goal-setting among graduating medical students and first-year residents from April 2021 to March 2022. The medical students set goals while participating in a Transition to Residency elective. The residents in internal medicine, obstetrics and gynecology, emergency medicine, orthopedics, and pathology set goals through meeting 1:1 with coaches. Raters assessed goals using a 3-point rubric on domains of specific, measurable, attainable, relevant, and timely (i.e., SMART goal framework) and analyzed descriptive statistics, Mann-Whitney U tests, and linear regressions. Outcomes: Among 48 medical students, 30 (62.5%) set 108 goals for early residency. Among 134 residents, 62 (46.3%) entered goals. Residents met with coaches 2.8 times on average (range 0-8 meetings, median = 3). Goal quality was higher in residents than medical students (average score for S: 2.71 vs 2.06, P < .001; M: 2.38 vs 1.66, P < .001; A: 2.92 vs 2.64, P < .001; R: 2.94 vs 2.86, P = .002; T: 1.71 vs 1.31, P < .001). The number of coaching meetings was associated with more specific, measurable goals (specific: F [1, 1.02] = 6.56, P = .01, R2 = .10; measurable: F [1, 1.49] = 4.74, P = .03, R2 = .07). Next steps: Learners set realistic, attainable goals through the transition to residency, but the goals could be more specific, measurable, and timely. The residents set SMARTer goals, with coaching improving goal quality. Understanding how best to scaffold coaching and support goal-setting through this transition may improve trainees' self-directed learning and well-being.
MeSH term(s)	Female ; Pregnancy ; Humans ; Internship and Residency ; Gynecology/education ; Obstetrics/education ; Learning ; Mentoring ; Clinical Competence
Language	English
Publishing date	2023-01-16
Publishing country	United States
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000005153
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Article ; Online: Artificial Intelligence Screening of Medical School Applications: Development and Validation of a Machine-Learning Algorithm.

Triola, Marc M / Reinstein, Ilan / Marin, Marina / Gillespie, Colleen / Abramson, Steven / Grossman, Robert I / Rivera, Rafael

Academic medicine : journal of the Association of American Medical Colleges

2023 Volume 98, Issue 9, Page(s) 1036–1043

Abstract: Purpose: To explore whether a machine-learning algorithm could accurately perform the initial screening of medical school applications.: Method: Using application data and faculty screening outcomes from the 2013 to 2017 application cycles (n = 14, ... ...

Abstract	Purpose: To explore whether a machine-learning algorithm could accurately perform the initial screening of medical school applications. Method: Using application data and faculty screening outcomes from the 2013 to 2017 application cycles (n = 14,555 applications), the authors created a virtual faculty screener algorithm. A retrospective validation using 2,910 applications from the 2013 to 2017 cycles and a prospective validation using 2,715 applications during the 2018 application cycle were performed. To test the validated algorithm, a randomized trial was performed in the 2019 cycle, with 1,827 eligible applications being reviewed by faculty and 1,873 by algorithm. Results: The retrospective validation yielded area under the receiver operating characteristic (AUROC) values of 0.83, 0.64, and 0.83 and area under the precision-recall curve (AUPRC) values of 0.61, 0.54, and 0.65 for the invite for interview, hold for review, and reject groups, respectively. The prospective validation yielded AUROC values of 0.83, 0.62, and 0.82 and AUPRC values of 0.66, 0.47, and 0.65 for the invite for interview, hold for review, and reject groups, respectively. The randomized trial found no significant differences in overall interview recommendation rates according to faculty or algorithm and among female or underrepresented in medicine applicants. In underrepresented in medicine applicants, there were no significant differences in the rates at which the admissions committee offered an interview (70 of 71 in the faculty reviewer arm and 61 of 65 in the algorithm arm; P = .14). No difference in the rate of the committee agreeing with the recommended interview was found among female applicants (224 of 229 in the faculty reviewer arm and 220 of 227 in the algorithm arm; P = .55). Conclusions: The virtual faculty screener algorithm successfully replicated faculty screening of medical school applications and may aid in the consistent and reliable review of medical school applicants.
MeSH term(s)	Humans ; Female ; Artificial Intelligence ; Retrospective Studies ; Schools, Medical ; Algorithms ; Machine Learning
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000005202
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Article ; Online: Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems.

Gillespie, Ellen R / Grice, Laura F / Courtney, Isabel G / Lao, Hong Wa / Jung, Woncheol / Ramkomuth, Sonny / Xie, Jacky / Brown, David A / Walsham, James / Radford, Kristen J / Nguyen, Quan H / Ruitenberg, Marc J

Journal of neuroinflammation

2024 Volume 21, Issue 1, Page(s) 63

Abstract: Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology. Here we used NSG-SGM3 mice engrafted with human umbilical cord haematopoietic stem cells to investigate ... ...

Abstract	Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology. Here we used NSG-SGM3 mice engrafted with human umbilical cord haematopoietic stem cells to investigate how human immune cells respond to and/or are changed by traumatic spinal cord injury (SCI). We hypothesised that the use of such mice could help advance our understanding of spinal cord injury-induced immune depression syndrome (SCI-IDS), and also how human leukocytes change as they migrate from the circulation into the lesion site. Our scRNAseq experiments, supplemented by flow cytometry, demonstrate the existence of up to 11 human immune cell (sub-) types and/or states across the blood and injured spinal cord (7 days post-SCI) of humanised NSG-SGM3 mice. Further comparisons of human immune cell transcriptomes between naïve, sham-operated and SCI mice identified a total of 579 differentially expressed genes, 190 of which were 'SCI-specific' (that is, genes regulated only in response to SCI but not sham surgery). Gene ontology analysis showed a prominent downregulation of immune cell function under SCI conditions, including for T cell receptor signalling and antigen presentation, confirming the presence of SCI-IDS and the transcriptional signature of human leukocytes in association with this phenomenon. We also highlight the activating influence of the local spinal cord lesion microenvironment by comparing the transcriptomes of circulating versus infiltrated human immune cells; those isolated from the lesion site were enriched for genes relating to both immune cell activity and function (e.g., oxidative phosphorylation, T cell proliferation and antigen presentation). We lastly applied an integrated bioinformatics approach to determine where immune responses in humanised NSG-SGM3 mice appear congruent to the native responses of human SCI patients, and where they diverge. Collectively, our study provides a valuable resource and methodological framework for the use of these mice in translational research.
MeSH term(s)	Mice ; Humans ; Animals ; Spinal Cord Injuries/metabolism ; Leukocytes/pathology ; Gene Expression ; Spinal Cord Diseases ; Sequence Analysis, RNA
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-024-03048-0
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Article ; Online: Bridging the Gap from Student to Doctor

Abigail Ford Winkel / Colleen Gillespie / Agnes Park / Jeremy Branzetti / Patrick Cocks / Richard E. Greene / Sondra Zabar / Marc Triola

Medical Education Online, Vol 28, Iss

Developing Coaches for the Transition to Residency

2023 Volume 1

Abstract: Background A lack of educational continuity creates disorienting friction at the onset of residency. Few programs have harnessed the benefits of coaching, which can facilitate self-directed learning, competency development, and professional identity ... ...

Abstract	Background A lack of educational continuity creates disorienting friction at the onset of residency. Few programs have harnessed the benefits of coaching, which can facilitate self-directed learning, competency development, and professional identity formation, to help ease this transition.Objective To describe the process of training faculty Bridge Coaches for the Transition to Residency Advantage (TRA) program for interns.Methods Nineteen graduate faculty educators participated in a coaching training course with formative skills assessment as part of a faculty development program starting in January 2020. Surveys (n = 15; 79%) and a focus group (n = 7; 37%) were conducted to explore the perceived impact of the training course on coaching skills, perceptions of coaching, and further program needs during the pilot year of the TRA program.Results Faculty had strong skills around establishing trust, authentic listening, and supporting goal-setting. They required more practice around guiding self-discovery and following a coachee-led agenda. Faculty found the training course to be helpful for developing coaching skills. Faculty embraced their new roles as coaches and appreciated having a community of practice with other coaches. Suggestions for improvement included more opportunities to practice and receive feedback on skills and additional structures to further support TRA program encounters with coaches.Conclusions The faculty development program was feasible and had good acceptance among participants. Faculty were well-suited to serve as coaches and valued the coaching mindset. Adequate skills reinforcement and program structure were identified as needs to facilitate a coaching program in graduate medical education.
Keywords	Coaching ; transition to residency ; faculty development ; graduate medical education ; master adaptive learner ; Special aspects of education ; LC8-6691 ; Medicine (General) ; R5-920
Subject code	910 ; 370
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intravenous immunoglobulin (IVIG) promotes brain repair and improves cognitive outcomes after traumatic brain injury in a FcγRIIB receptor-dependent manner.

Willis, Emily F / Gillespie, Ellen R / Guse, Kirsten / Zuercher, Adrian W / Käsermann, Fabian / Ruitenberg, Marc J / Vukovic, Jana

Brain, behavior, and immunity

2022 Volume 109, Page(s) 37–50

Abstract: Intravenous immunoglobulin (IVIG) is a promising immune-modulatory therapy for limiting harmful inflammation and associated secondary tissue loss in neurotrauma. Here, we show that IVIG therapy attenuates spatial learning and memory deficits following a ... ...

Abstract	Intravenous immunoglobulin (IVIG) is a promising immune-modulatory therapy for limiting harmful inflammation and associated secondary tissue loss in neurotrauma. Here, we show that IVIG therapy attenuates spatial learning and memory deficits following a controlled cortical impact mouse model of traumatic brain injury (TBI). These improvements in cognitive outcomes were associated with increased neuronal survival, an overall reduction in brain tissue loss, and a greater preservation of neural connectivity. Furthermore, we demonstrate that the presence of the main inhibitory FcγRIIB receptor is required for the beneficial effects of IVIG treatment in TBI, with our results simultaneously highlighting the role of this receptor in reducing secondary damage arising from brain injury.
MeSH term(s)	Mice ; Animals ; Immunoglobulins, Intravenous/pharmacology ; Immunoglobulins, Intravenous/therapeutic use ; Brain ; Brain Injuries, Traumatic/complications ; Brain Injuries/complications ; Cognition
Chemical Substances	Immunoglobulins, Intravenous
Language	English
Publishing date	2022-12-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2022.12.018
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Article ; Online: Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury.

Yates, Abi G / Jogia, Trisha / Gillespie, Ellen R / Couch, Yvonne / Ruitenberg, Marc J / Anthony, Daniel C

Journal of neuroinflammation

2021 Volume 18, Issue 1, Page(s) 15

Abstract: ... student's t-test, as appropriate.: Results: SCI induced a robust APR, hallmarked by elevated hepatic ...

Abstract	Background: The acute phase response (APR) to CNS insults contributes to the overall magnitude and nature of the systemic inflammatory response. Aspects of this response are thought to drive secondary inflammatory pathology at the lesion site, and suppression of the APR can therefore afford some neuroprotection. In this study, we examined the APR in a mouse model of traumatic spinal cord injury (SCI), along with its relationship to neutrophil recruitment during the immediate aftermath of the insult. We specifically investigated the effect of IL-1 receptor antagonist (IL-1RA) administration on the APR and leukocyte recruitment to the injured spinal cord. Methods: Adult female C57BL/6 mice underwent either a 70kD contusive SCI, or sham surgery, and tissue was collected at 2, 6, 12, and 24 hours post-operation. For IL-1RA experiments, SCI mice received two intraperitoneal injections of human IL-1RA (100mg/kg), or saline as control, immediately following, and 5 hours after impact, and animals were sacrificed 6 hours later. Blood, spleen, liver and spinal cord were collected to study markers of central and peripheral inflammation by flow cytometry, immunohistochemistry and qPCR. Results were analysed by two-way ANOVA or student's t-test, as appropriate. Results: SCI induced a robust APR, hallmarked by elevated hepatic expression of pro-inflammatory marker genes and a significantly increased neutrophil presence in the blood, liver and spleen of these animals, as early as 2 hours after injury. This peripheral response preceded significant neutrophil infiltration of the spinal cord, which peaked 24 hours post-SCI. Although expression of IL-1RA was also induced in the liver following SCI, its response was delayed compared to IL-1β. Exogenous administration of IL-1RA during this putative therapeutic window was able to suppress the hepatic APR, as evidenced by a reduction in CXCL1 and SAA-2 expression as well as a significant decrease in neutrophil infiltration in both the liver and the injured spinal cord itself. Conclusions: Our data indicate that peripheral administration of IL-1RA can attenuate the APR which in turn reduces immune cell infiltration at the spinal cord lesion site. We propose IL-1RA treatment as a viable therapeutic strategy to minimise the harmful effects of SCI-induced inflammation.
MeSH term(s)	Acute-Phase Reaction/immunology ; Acute-Phase Reaction/metabolism ; Acute-Phase Reaction/prevention & control ; Animals ; Female ; Humans ; Immunity, Cellular/drug effects ; Immunity, Cellular/physiology ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/prevention & control ; Injections, Intraperitoneal ; Interleukin 1 Receptor Antagonist Protein/administration & dosage ; Mice ; Mice, Inbred C57BL ; Spinal Cord Injuries/drug therapy ; Spinal Cord Injuries/immunology ; Spinal Cord Injuries/metabolism ; Thoracic Vertebrae/injuries ; Treatment Outcome
Chemical Substances	Interleukin 1 Receptor Antagonist Protein
Language	English
Publishing date	2021-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-020-02050-6
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Article ; Online: Diaries as Technologies for Sense-making and Self-transformation in Times of Vulnerability.

Bernal Marcos, Marcos José / Zittoun, Tania / Gillespie, Alex

Integrative psychological & behavioral science

2023 Volume 58, Issue 2, Page(s) 563–588

Abstract: Diaries have been generally understood as "windows" on sense-making processes when studying life ruptures. In this article, we draw on Michel Foucault's conceptualization of self-writing as a "technology of the self" and on sociocultural psychology to ... ...

Abstract	Diaries have been generally understood as "windows" on sense-making processes when studying life ruptures. In this article, we draw on Michel Foucault's conceptualization of self-writing as a "technology of the self" and on sociocultural psychology to propose that diaries are not "windows" but technologies that aid in the sense-making. Concretely, we analyzed three non-exhaustive and non-exclusive uses of diary writing in times of vulnerability: (1) imagination of the future and preparation to encounter difficulties; (2) distancing from one's own experience; and (3) creating personal commitments. Our longitudinal data comprised three public online diaries written over more than twenty years, belonging to three anonymous individuals selected from a database of more than 400 diaries. We analyzed these three diaries by iterating between qualitative and quantitative analysis. We conclude that: (1) beyond their expressive dimension, diaries are technologies that support the sense-making process, but not without difficulties; (2) diaries form a self-generated space for dialogue with oneself in which the diarist also becomes aware of the social nature of her life story; (3) diaries are not only technologies for the Socratic "know thyself" but also technologies to work on oneself, especially in terms of the personal perspective on the past or the future; and (4) the practice of diary writing goes beyond sense-making towards personal development and the desire to transform one's life trajectory.
MeSH term(s)	Humans ; Diaries as Topic ; Adult ; Female ; Longitudinal Studies ; Imagination ; Writing ; Male ; Self Concept
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2396310-4
ISSN	1936-3567 ; 1932-4502
ISSN (online)	1936-3567
ISSN	1932-4502
DOI	10.1007/s12124-023-09765-0
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