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  1. Book: Tissue engineering of the peripheral nerve

    Geuna, Stefano

    biomaterials and physical therapy

    (International review of neurobiology ; 109)

    2013  

    Author's details ed. by Stefano Geuna
    Series title International review of neurobiology ; 109
    Collection
    Language English
    Size XII, 237 S. : Ill.
    Edition 1. ed.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018105955
    ISBN 978-0-12-420045-6 ; 0-12-420045-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui II Zs 180 -109- verfügbar in Königswinter Königswinter

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  2. Book: Tissue engineering of the peripheral nerve

    Geuna, Stefano

    stem cells and regeneration promoting factors

    (International review of neurobiology ; 108)

    2013  

    Author's details ed. by Stefano Geuna
    Series title International review of neurobiology ; 108
    Collection
    Language English
    Size XIV, 323 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018094260
    ISBN 978-0-12-410499-0 ; 0-12-410499-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui II Zs 180 -108- verfügbar in Königswinter Königswinter

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  3. Book: Essays on peripheral nerve repair and regeneration

    Geuna, Stefano

    (International review of neurobiology ; 87)

    2009  

    Author's details ed. by Stefano Geuna
    Series title International review of neurobiology ; 87
    Collection
    Language English
    Size XXII, 572 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016082820
    ISBN 978-0-12-375084-6 ; 0-12-375084-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui II Zs 180 -87- verfügbar in Königswinter Königswinter

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Can we promote neural regeneration through microbiota-targeted strategies? Introducing the new concept of neurobiotics.

    Herrera-Rincon, Celia / Murciano-Brea, Julia / Geuna, Stefano

    Neural regeneration research

    2022  Volume 17, Issue 9, Page(s) 1965–1966

    Language English
    Publishing date 2022-02-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.335149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Peripheral nerve regeneration research: Why is it getting so "cool"?

    Geuna, Stefano

    Neural regeneration research

    2014  Volume 7, Issue 29, Page(s) 2245–2246

    Language English
    Publishing date 2014-12-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.3969/j.issn.1673-5374.2012.29.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The sciatic nerve injury model in pre-clinical research.

    Geuna, Stefano

    Journal of neuroscience methods

    2015  Volume 243, Page(s) 39–46

    Abstract: In the pre-clinical view, the study of peripheral nerve repair and regeneration still needs to be carried out in animal models due to the structural complexity of this organ which can be only partly simulated in vitro. The far most used experimental ... ...

    Abstract In the pre-clinical view, the study of peripheral nerve repair and regeneration still needs to be carried out in animal models due to the structural complexity of this organ which can be only partly simulated in vitro. The far most used experimental model is based on the injury of the sciatic nerve, the largest nerve trunk in mammals. In this paper, the potential application of the sciatic nerve injury model in pre-clinical research is critically reviewed. This paper is aimed at helping researchers in properly employing this in vivo model for the study of nerve repair and regeneration as well as interpreting the results in a clinical translation perspective.
    MeSH term(s) Animals ; Disease Models, Animal ; Nerve Regeneration/physiology ; Sciatic Nerve/injuries ; Sciatic Nerve/pathology ; Sciatic Nerve/physiopathology ; Sciatic Neuropathy/pathology ; Sciatic Neuropathy/physiopathology
    Language English
    Publishing date 2015-03-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 282721-9
    ISSN 1872-678X ; 0165-0270
    ISSN (online) 1872-678X
    ISSN 0165-0270
    DOI 10.1016/j.jneumeth.2015.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1486: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The Impact of the Molecular Weight of Degradation Products with Silicon from Porous Chitosan-Siloxane Hybrids on Neuronal Cell Behavior.

    Shirosaki, Yuki / Fregnan, Federica / Muratori, Luisa / Yasutomi, Saki / Geuna, Stefano / Raimondo, Stefania

    Polymers

    2023  Volume 15, Issue 15

    Abstract: Silicon (Si) is an essential trace element in the human body and it exists in connective tissue as aqueous orthosilicic acid. Porous chitosan-3-glycidoxypropyltrimethoxysilane (GPTMS) hybrids can regenerate nerve tissue and recover sensor and motor ... ...

    Abstract Silicon (Si) is an essential trace element in the human body and it exists in connective tissue as aqueous orthosilicic acid. Porous chitosan-3-glycidoxypropyltrimethoxysilane (GPTMS) hybrids can regenerate nerve tissue and recover sensor and motor functions. However, the structures and roles of the degradation products with Si extracted from the hybrids in nerve regeneration are not clear. In this study, we prepared porous chitosan-GPTMS hybrids with different amounts of GPTMS to amino groups of chitosan (chitosan:GPTMS = 1:0.5 and 1:1 molar ratios). The structures of the degradation products with Si from the hybrids were examined using time-of-flight mass spectrometry, and biological assessments were conducted in order to evaluate their potential use in the preparation of devices for nerve repair. Glial and motor cell lines and ex vivo explants of dorsal root ganglia were used in this study for evaluating their behavior in the presence of the different degradation products with Si. The structure of the degradation products with Si depended on the starting composition. The results showed that glial cell proliferation was lower in the medium with the higher-molecular-weight degradation products with Si. Moreover, motor cell line differentiation and the neurite outgrowth of dorsal root ganglion explants were improved with the lower-molecular-weight degradation products with Si. The results obtained could be useful for designing a new nerve regeneration scaffold including silicon components.
    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15153272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Chapter Effect of Local Delivery of GDNF Conjugated Iron Oxide Nanoparticles on Nerve Regeneration along Long Chitosan Nerve Guide

    Michael, Tolmasov / Almog, Mara / Ziv-Polat, Ofra / Mandelbaum-Livnat, Mira M. / Geuna, Stefano / Bitan, Yifat / Morano, Michela / Biran, Tali / Rochkind, Shimon / Fregnan, Federica / Reider, Evgeniy / Shahar, Abraham / Nissan, Moshe

    2017  

    Keywords Neurosciences ; GDNF conjugated iron oxide nanoparticles, chitosan tube, peripheral nerve regeneration
    Size 1 Online-Ressource
    Publisher InTechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021047208
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Book ; Online: Chapter Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits

    Ronchi, Giulia / Shahar, Abraham / Rochkind, Shimon / Reider, Evgeniy / Bitan, Yifat / Geuna, Stefano / Viano, Nicoletta / Koren, Akiva / Mandelbaum-Livnat, Mira M. / Morano, Michela / Ziv-Polat, Ofra / Biron, Tali

    2017  

    Keywords Biomedical engineering ; peripheral nerve injury, chitosan guidance conduit, conduit acetylation, hyaluronic acid gel, magnetic fibrin hydrogel
    Size 1 Online-Ressource
    Publisher InTechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021047544
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Potential Effects of Stem Cells Derived from the Peripheral Nerve and Adipose Tissue after the Nerve Crush Injury in Control and Obese Rats.

    Kayhan Kustepe, Elif / Altunkaynak, Berrin Zuhal / Alkan, Işınsu / Kivrak, Elfide Gizem / Yildiran, Alişan / Geuna, Stefano

    Journal of investigative surgery : the official journal of the Academy of Surgical Research

    2022  Volume 35, Issue 5, Page(s) 1021–1033

    Abstract: Aim of this study is to investigate effects of stem cells derived from the peripheral nerve and adipose tissues following the nerve crush injury in control and obese rats. For this aim, 41 Wistar Albino female rats were separated into eight equal groups; ...

    Abstract Aim of this study is to investigate effects of stem cells derived from the peripheral nerve and adipose tissues following the nerve crush injury in control and obese rats. For this aim, 41 Wistar Albino female rats were separated into eight equal groups; non-obese control (NOC) obese control (OC), non-obese injury (NOH), obese injury (OH), non-obese adipose (NOY), obese adipose (OY), non-obese nerve (NOPS), obese nerve (OPS). At the end of 8 weeks, all experimental animals without control groups were subjected to nerve crush procedure and sciatic nerve or fat stem cell homogenates were injected on the treatment group rats, and then, recovery process has been observed and histopathological, stereological, electrophysiological analyses and bioinformatic evaluation were made on removed sciatic nerves. Stereological results showed that adipose homogenate gave more successful results than peripheral nerve homogenates in the NOY group in comparison to the NOPS group in terms of myelinated axon number. Peripheral nerve homogenate has shown more successful results in the OPS group in comparison to the OY group. The number of unmyelinated axons was increased following treatment with adipose tissue homogenate in NOY and OY groups. In terms of myelin sheath thickness; we detected that treatments by peripheral nerve and especially adipose tissue homogenates lead to increase in the thickness of the axons of the peripheral nerves belong to the control and obese injury groups. All results showed that mesenchymal stem cell treatment by fresh tissue homogenates is successful in peripheral nerve regeneration and fat tissue is a considerable source of the stem cells for clinical applications.
    MeSH term(s) Adipose Tissue ; Animals ; Crush Injuries/drug therapy ; Crush Injuries/pathology ; Nerve Crush ; Nerve Regeneration ; Obesity/complications ; Obesity/therapy ; Peripheral Nerve Injuries/drug therapy ; Rats ; Rats, Wistar ; Sciatic Nerve/injuries ; Stem Cells
    Language English
    Publishing date 2022-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639444-9
    ISSN 1521-0553 ; 0894-1939
    ISSN (online) 1521-0553
    ISSN 0894-1939
    DOI 10.1080/08941939.2021.1991530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2364: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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