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  1. Article ; Online: Neuroscience Research presents NSR paper awards.

    Kamiguchi, Hiroyuki

    Neuroscience research

    2021  Volume 169, Page(s) 1

    MeSH term(s) Awards and Prizes
    Language English
    Publishing date 2021-06-17
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2021.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1993: Show issues Location:
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  2. Article ; Online: Achievements of Japan neuroscience award winners.

    Kamiguchi, Hiroyuki

    Neuroscience research

    2018  Volume 129, Page(s) 1

    MeSH term(s) Awards and Prizes ; Humans ; Japan ; Neurosciences ; Research ; Research Personnel
    Language English
    Publishing date 2018-03-07
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2018.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Molecular machinery regulating organelle dynamics during axon growth and guidance.

    Shirane, Michiko / Kamiguchi, Hiroyuki

    Seminars in cell & developmental biology

    2022  Volume 133, Page(s) 3–9

    Abstract: Axon growth and guidance in the developing nervous system rely on intracellular membrane dynamics that involve endosome maturation and transport, as well as its regulated tethering to the endoplasmic reticulum (ER). Recent studies have identified several ...

    Abstract Axon growth and guidance in the developing nervous system rely on intracellular membrane dynamics that involve endosome maturation and transport, as well as its regulated tethering to the endoplasmic reticulum (ER). Recent studies have identified several key molecules, such as protrudin, which plays a dynamic role at membrane contact sites between the ER and endosomes/lysosomes, and myosin Va, which acts as a sensor for ER-derived Ca
    MeSH term(s) Endoplasmic Reticulum ; Endosomes ; Lysosomes ; Mitochondrial Membranes ; Axons
    Language English
    Publishing date 2022-02-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2022.02.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2918: Show issues Location:
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  4. Article ; Online: Editorial announcement - Welcome to the new journey of Neuroscience Research.

    Kamiguchi, Hiroyuki

    Neuroscience research

    2017  Volume 114, Page(s) 1–2

    MeSH term(s) Humans ; Journalism/trends ; Neurosciences ; Research
    Language English
    Publishing date 2017-01
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2017.01.001
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  5. Article ; Online: Lipids as new players in axon guidance and circuit development.

    Guy, Adam T / Kamiguchi, Hiroyuki

    Current opinion in neurobiology

    2020  Volume 66, Page(s) 22–29

    Abstract: The formation of functional neuronal circuitry depends on axon guidance, in which extracellular chemotropic cues provide directional instructions to developing axons in the embryonic nervous system. Recently lipids, in particular lysolipids, are being ... ...

    Abstract The formation of functional neuronal circuitry depends on axon guidance, in which extracellular chemotropic cues provide directional instructions to developing axons in the embryonic nervous system. Recently lipids, in particular lysolipids, are being appraised as a new class of axon guidance cues. Most lysolipids are formed by enzymatic hydrolysis of membrane phospholipids, and signal via a wide variety of mechanisms including specific G protein-coupled receptors. For example, lysophosphatidylglucoside released from a specific type of glia activates neuronal GPR55 to regulate axon tract patterning. However, demonstrating the in vivo mechanisms of lysolipid axon guidance is often challenging and complex. Here we will review in detail lysolipids that have been identified or proposed as axon guidance cues in the developing nervous system.
    MeSH term(s) Axon Guidance ; Axons ; Lipids ; Neurons ; Signal Transduction
    Chemical Substances Lipids
    Language English
    Publishing date 2020-10-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2020.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3260: Show issues Location:
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  6. Article ; Online: Protecting-group-free glycosylation of phosphatidic acid in aqueous media.

    Kano, Koki / Ishii, Nozomi / Miyagawa, Atsushi / Takeda, Hiroaki / Hirabayashi, Yoshio / Kamiguchi, Hiroyuki / Greimel, Peter / Matsuo, Ichiro

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 10, Page(s) 2138–2142

    Abstract: The glycosylation of unprotected carbohydrates has emerged as an area of significant interest because it obviates the need for long reaction sequences involving protecting-group manipulations. Herein, we report the one-pot synthesis of anomeric glycosyl ... ...

    Abstract The glycosylation of unprotected carbohydrates has emerged as an area of significant interest because it obviates the need for long reaction sequences involving protecting-group manipulations. Herein, we report the one-pot synthesis of anomeric glycosyl phosphates through the condensation of unprotected carbohydrates with phospholipid derivatives while retaining high stereo- and regioselective control. The anomeric center was activated using 2-chloro-1,3-dimethylimidazolinium chloride to facilitate condensation with glycerol-3-phosphate derivatives in an aqueous solution. A water/propionitrile mixture provided superior stereoselectivity while maintaining good yields. Under these optimized conditions, the condensation of stable isotope-labeled glucose with phosphatidic acid provided efficient access to labeled glycophospholipids as an internal standard for mass spectrometry.
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob02173k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Transcriptome analysis of human neural cells derived from isogenic embryonic stem cells with 16p11.2 deletion.

    Nomura, Yoshiko / Nomura, Jun / Kamiguchi, Hiroyuki / Nishikawa, Toru / Takumi, Toru

    Neuroscience research

    2021  Volume 171, Page(s) 114–123

    Abstract: 16p11.2 deletion is one of the most influential copy number variations (CNVs) associated with autism spectrum disorder (ASD). Previous studies have investigated the pathophysiology of 16p11.2 deletion both in vitro and in vivo, and have identified ... ...

    Abstract 16p11.2 deletion is one of the most influential copy number variations (CNVs) associated with autism spectrum disorder (ASD). Previous studies have investigated the pathophysiology of 16p11.2 deletion both in vitro and in vivo, and have identified features such as NMDAR dysfunction, excitation-inhibition imbalance, transcriptional dysregulation, and impaired cortical development. However, little is known about the transcriptional profiles of human neural cells. Here, we constructed an isogenic human embryonic stem (hES) cell model with 16p11.2 deletion using a CRISPR/Cas9 system and performed transcriptome analyses of hES-derived 2-dimensional neural cells. We identified several characteristics which may correlate with the neuropathology of 16p11.2 deletion: predisposition to differentiate into neural lineages, enhanced neurogenesis, and dysregulation of G protein-coupled receptor signaling and RAF/MAPK pathway. We also found upregulation of fragile X mental retardation protein (FMRP) target genes including GRM5, which is implicated as a common trait between 16p11.2 deletion and fragile X syndrome. Extending our knowledge into other ASD models would help us to understand the molecular pathology of this disorder.
    MeSH term(s) Autism Spectrum Disorder/genetics ; Chromosome Deletion ; DNA Copy Number Variations ; Embryonic Stem Cells ; Gene Expression Profiling ; Humans
    Language English
    Publishing date 2021-03-27
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2021.03.005
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  8. Article ; Online: Spatially restricted long-term transgene expression in the developing skin used for studying the interaction of epidermal development and sensory innervation.

    Chan, Carmen / Kamiguchi, Hiroyuki / Shimogori, Tomomi

    Development, growth & differentiation

    2019  Volume 61, Issue 4, Page(s) 276–282

    Abstract: Skin development is tightly temporally coordinated with its sensory innervation, which consists of the peripheral branches of the dorsal root ganglion (DRG) axons. Various studies suggest that the skin produces a long-range attractant for the sensory ... ...

    Abstract Skin development is tightly temporally coordinated with its sensory innervation, which consists of the peripheral branches of the dorsal root ganglion (DRG) axons. Various studies suggest that the skin produces a long-range attractant for the sensory axons. However, the exact identity of the guidance cue(s) remains unclear. To reveal the detailed molecular mechanism that controls DRG axon guidance and targeting, manipulation of specific skin layers at specific time points are required. To test a variety of attractants that can be expressed in specific skin layers at specific timepoints, we combined in utero electroporation with the Tol2 transposon system to induce long-term transgene expression in the developing mouse skin, including in the highly proliferative epidermal stem cells (basal layer) and their descendants (spinous and granular layer cells). The plasmid solution was injected as close to the hindpaw plantar surface as possible. Immediately, electric pulses were passed through the embryo to transduce the plasmid DNA into hindpaw skin cells. Balancing outcome measurements including: embryo survival, transfection efficiency, and the efficiency of transgene integration into host cells, we found that IUE was best performed on E13.5, and using an electroporation voltage of 34V. After immunostaining embryonic and early postnatal skin tissue sections for keratinocyte and sensory axon markers, we observe the growth of axons into skin epidermal layers including areas expressing EGFP. Therefore, this method is useful for studying the interaction between axon growth and epidermal cell division/differentiation.
    MeSH term(s) Animals ; Axons/metabolism ; Epidermal Cells/cytology ; Epidermal Cells/metabolism ; Epidermis/embryology ; Epidermis/growth & development ; Epidermis/innervation ; Epidermis/metabolism ; Female ; Mice ; Mice, Inbred C57BL ; Neurons/cytology ; Neurons/metabolism ; Pregnancy ; Skin/embryology ; Skin/growth & development ; Skin/innervation ; Skin/metabolism ; Transgenes/genetics
    Language English
    Publishing date 2019-04-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280433-5
    ISSN 1440-169X ; 0012-1592
    ISSN (online) 1440-169X
    ISSN 0012-1592
    DOI 10.1111/dgd.12603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 194: Show issues Location:
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  9. Article ; Online: Introduction: Second messengers in neural development.

    Kamiguchi, Hiroyuki / Borodinsky, Laura N

    Developmental neurobiology

    2015  Volume 75, Issue 4, Page(s) 335–336

    MeSH term(s) Animals ; Higher Nervous Activity/physiology ; Humans ; Neurogenesis/physiology ; Second Messenger Systems/physiology
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Introduction to glyco-neuroscience.

    Kamiguchi, Hiroyuki / Kadomatsu, Kenji

    Experimental neurology

    2015  Volume 274, Issue Pt B, Page(s) 89

    MeSH term(s) Animals ; Extracellular Matrix/metabolism ; Glycoproteins/chemistry ; Glycoproteins/metabolism ; Glycoside Hydrolases ; Humans ; Nervous System/metabolism ; Neurosciences
    Chemical Substances Glycoproteins ; Glycoside Hydrolases (EC 3.2.1.-) ; carbohydrase (EC 3.2.1.-)
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2015.11.008
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