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  1. Article: Interview with Dr. Yoshiro Kobayashi regarding Pivotal Advance: A suppressive role of nitric oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells. Interview by Helene F. Rosenberg and Joost J. Oppenheim.

    Kobayashi, Yoshiro

    Journal of leukocyte biology

    2006  Volume 80, Issue 4, Page(s) 742–743

    MeSH term(s) Animals ; Apoptosis/drug effects ; Apoptosis/immunology ; Chemokine CXCL2 ; Coculture Techniques ; Disease Models, Animal ; Humans ; Inflammation/immunology ; Macrophages/drug effects ; Macrophages/immunology ; Mice ; Monokines/biosynthesis ; Monokines/drug effects ; Nitric Oxide/pharmacology ; Nitric Oxide/physiology
    Chemical Substances Chemokine CXCL2 ; Monokines ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2006-10
    Publishing country United States
    Document type Interview ; Portraits
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.1306012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Current Trends of Neutrophil Biology.

    Kobayashi, Yoshiro

    International journal of molecular sciences

    2020  Volume 21, Issue 23

    Abstract: Neutrophils are short-lived and terminally differentiated cells, and therefore, have been considered as effector cells to phagocytose pathogens and kill them or damage tissues [ ... ]. ...

    Abstract Neutrophils are short-lived and terminally differentiated cells, and therefore, have been considered as effector cells to phagocytose pathogens and kill them or damage tissues [...].
    MeSH term(s) Animals ; Autophagy/genetics ; Extracellular Traps/metabolism ; Gout/pathology ; Humans ; Neutrophils/metabolism ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2020-11-28
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21239071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Current Trends of Neutrophil Biology

    Yoshiro Kobayashi

    International Journal of Molecular Sciences, Vol 21, Iss 9071, p

    2020  Volume 9071

    Abstract: Neutrophils are short-lived and terminally differentiated cells, and therefore, have been considered as effector cells to phagocytose pathogens and kill them or damage tissues.[.] ...

    Abstract Neutrophils are short-lived and terminally differentiated cells, and therefore, have been considered as effector cells to phagocytose pathogens and kill them or damage tissues.[.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Editorial: The Effects of Enriched Environment on NK cells and Macrophages and Their Underlying Mechanisms.

    Kobayashi, Yoshiro / Limatola, Cristina / Gan, Yu

    Frontiers in immunology

    2022  Volume 13, Page(s) 862488

    MeSH term(s) Killer Cells, Natural/physiology ; Macrophages/physiology
    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.862488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Identification of Inhibitors of the Disease-Associated Protein Phosphatase Scp1 Using Antibody Mimetic Molecules.

    Kobayashi, Tamaki / Yamazaki, Kazuki / Shinada, Junki / Mizunuma, Masataka / Furukawa, Kazuhiro / Chuman, Yoshiro

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Protein phosphorylation is a prevalent translational modification, and its dysregulation has been implicated in various diseases, including cancer. Despite its significance, there is a lack of specific inhibitors of the FCP/SCP-type Ser/Thr protein ... ...

    Abstract Protein phosphorylation is a prevalent translational modification, and its dysregulation has been implicated in various diseases, including cancer. Despite its significance, there is a lack of specific inhibitors of the FCP/SCP-type Ser/Thr protein phosphatase Scp1, characterized by high specificity and affinity. In this study, we focused on adnectin, an antibody-mimetic protein, aiming to identify Scp1-specific binding molecules with a broad binding surface that target the substrate-recognition site of Scp1. Biopanning of Scp1 was performed using an adnectin-presenting phage library with a randomized FG loop. We succeeded in identifying FG-1Adn, which showed high affinity and specificity for Scp1. Ala scanning analysis of the Scp1-binding sequence in relation to the FG-1 peptide revealed that hydrophobic residues, including aromatic amino acids, play important roles in Scp1 recognition. Furthermore, FG-1Adn was found to co-localize with Scp1 in cells, especially on the plasma membrane. In addition, Western blotting analysis showed that FG-1Adn increased the phosphorylation level of the target protein of Scp1 in cells, indicating that FG-1Adn can inhibit the function of Scp1. These results suggest that FG-1Adn can be used as a specific inhibitor of Scp1.
    MeSH term(s) Antibodies ; Phosphoprotein Phosphatases ; Amino Acids, Aromatic ; Bacteriophages ; Fibronectin Type III Domain ; Recombinant Proteins
    Chemical Substances adnectin ; Antibodies ; Phosphoprotein Phosphatases (EC 3.1.3.16) ; Amino Acids, Aromatic ; Recombinant Proteins
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073737
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  6. Article: Neutrophil biology: an update.

    Kobayashi, Yoshiro

    EXCLI journal

    2015  Volume 14, Page(s) 220–227

    Abstract: Neutrophil extracellular traps (NETs) are involved in bacterial killing as well as autoimmunity, because NETs contain proteases, bactericidal peptides, DNA and ribonucleoprotein. NETs are formed via a novel type of cell death called NETosis. NETosis is ... ...

    Abstract Neutrophil extracellular traps (NETs) are involved in bacterial killing as well as autoimmunity, because NETs contain proteases, bactericidal peptides, DNA and ribonucleoprotein. NETs are formed via a novel type of cell death called NETosis. NETosis is distinct from apoptosis, but it resembles necrosis in that both membranes are not intact so that they allow intracellular proteins to leak outside of the cells. Removal of NETs and neutrophils undergoing NETosis by phagocytes and its subsequent response are not completely clarified, as compared with the response after removal of either apoptotic or necrotic neutrophils by phagocytes. How neutrophil density in peripheral blood is kept within a certain range is important for health and disease. Although the studies on severe congenital neutropenia and benign ethnic neutropenia have provided unbiased views on it, the studies are rather limited to human neutropenia, and mice with a mutation of mouse counterpart gene often fail to exhibit neutropenia. Degranulation plays a critical role in bactericidal action. The recent studies revealed that it is also involved in immunomodulation, pain control and estrous cycle control. N1 and N2 are representative of neutrophil subpopulations. The dichotomy holds true in patients or mice with severe trauma or cancer, providing the basis of differential roles of neutrophils in diseases.
    Language English
    Publishing date 2015-02-10
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 1611-2156
    ISSN 1611-2156
    DOI 10.17179/excli2015-102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Development of Mn

    Mizunuma, Masataka / Suzuki, Mirai / Kobayashi, Tamaki / Hara, Yuki / Kaneko, Atsushi / Furukawa, Kazuhiro / Chuman, Yoshiro

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: Metal ions are used in various situations in living organisms and as a part of functional materials. Since the excessive intake of metal ions can cause health hazards and environmental pollution, the development of new molecules that can monitor metal ... ...

    Abstract Metal ions are used in various situations in living organisms and as a part of functional materials. Since the excessive intake of metal ions can cause health hazards and environmental pollution, the development of new molecules that can monitor metal ion concentrations with high sensitivity and selectivity is strongly desired. DNA can form various structures, and these structures and their properties have been used in a wide range of fields, including materials, sensors, and drugs. Guanine-rich sequences respond to metal ions and form G-quadruplex structures and G-wires, which are the self-assembling macromolecules of G-quadruplex structures. Therefore, guanine-rich DNA can be applied to a metal ion-detection sensor and functional materials. In this study, the IRDAptamer library originally designed based on G-quadruplex structures was used to screen for Mn
    MeSH term(s) DNA/chemistry ; G-Quadruplexes ; Biosensing Techniques/methods ; Ions ; Guanine/chemistry
    Chemical Substances DNA (9007-49-2) ; Ions ; Guanine (5Z93L87A1R)
    Language English
    Publishing date 2023-07-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411556
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  8. Article: [Epstein-Barr virus-associated gastritis with perigastric lymphadenopathy accompanied by infectious mononucleosis:a case report].

    Watanabe, Naoko / Yamamoto, Yoshiro / Ikegami, Ryo / Kobayashi, Kojiro / Yoshimoto, Kensuke / Nagashima, Yuji / Kanno, Jun / Yamaguchi, Kazuhisa / Igarashi, Yoshinori / Matsuda, Takahisa

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2024  Volume 121, Issue 2, Page(s) 127–133

    Abstract: A 28-year-old female patient with no particular medical history had a sore throat seven days before admission. Subsequently, she developed malaise, right abdominal pain, and a fever of 38°C and visited our hospital. A blood test revealed a mild ... ...

    Abstract A 28-year-old female patient with no particular medical history had a sore throat seven days before admission. Subsequently, she developed malaise, right abdominal pain, and a fever of 38°C and visited our hospital. A blood test revealed a mild inflammatory response and elevated liver enzymes, and she was admitted to the hospital for detailed examination and acute liver injury treatment. Various viral tests and autoantibody measurements revealed elevated Epstein-Barr virus (EBV) immunoglobulin M and negative EB nuclear antigen antibodies. Therefore, she was diagnosed with primary infectious mononucleosis-associated EB viral hepatitis. Abdominal computed tomography upon admission revealed swollen lymph nodes around the stomach;thus, esophagogastroduodenoscopy (EGD) was performed. A histopathological examination revealed severe lymphocytic infiltration, and EB encoding region in situ hybridization demonstrated that 10-20% of the lymphocytes were EBV-infected. Drip and rest treatment improved the patient's liver enzymes, and her symptoms resolved. Repeat EGD after two months revealed improved gastric erosions. Here, we report a case of EBV-associated gastritis that was discovered due to perigastric lymphadenopathy accompanied by infectious mononucleosis. This report includes a review of the literature because a few studies reported EBV-associated gastritis.
    MeSH term(s) Humans ; Female ; Adult ; Infectious Mononucleosis/complications ; Herpesvirus 4, Human ; Epstein-Barr Virus Infections/complications ; Lymphadenopathy/etiology ; Lymphadenopathy/complications ; Gastritis/etiology ; Gastritis/diagnosis ; Antibodies, Viral ; Hepatitis, Viral, Human
    Chemical Substances Antibodies, Viral
    Language Japanese
    Publishing date 2024-02-10
    Publishing country Japan
    Document type Review ; Case Reports ; English Abstract ; Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.121.127
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    Ui V Zs.34: Show issues Location:
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    Zs.MO 477: Show issues

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  9. Article ; Online: Effect of pH, NaCl concentration, and mAb concentration of feed solution on the filterability of Planova™ 20N and Planova™ BioEX.

    Hashikawa-Muto, Chie / Yokoyama, Yoshiro / Hamamoto, Ryo / Kobayashi, Kazuya / Masuda, Yumiko / Nonaka, Koichi

    Biotechnology progress

    2023  Volume 40, Issue 2, Page(s) e3420

    Abstract: Virus filtration is one of the most important steps in ensuring viral safety during the purification of monoclonal antibodies (mAbs) and other biotherapeutics derived from mammalian cell cultures. Regarding the various virus retentive filters, including ... ...

    Abstract Virus filtration is one of the most important steps in ensuring viral safety during the purification of monoclonal antibodies (mAbs) and other biotherapeutics derived from mammalian cell cultures. Regarding the various virus retentive filters, including Planova filters, a great deal of data has been reported on the virus retention capability and its mechanism. Along with the virus retention capability, filterability is a key performance indicator for designing a robust and high-throughput virus filtration step. In order to obtain higher filterability, optimization of the feed solution conditions, and filter selection is essential; however, limited data are available regarding the filtration characteristics of Planova filters. Furthermore, for Planova 20N and Planova BioEX, the virus retention characteristics were reported to differ due to their respective membrane materials and layer structures. Whether these filters differ in their filtration characteristics is an interesting question, but no comparative evaluations have been reported. In this study, the filterability of the two filters was investigated and compared using 15 feed mAb solutions of a single mAb selected by design of experiments with different combinations of pH, NaCl concentration, and mAb concentration. The filterability of Planova 20N was affected not only by the feed solution viscosity, but also by the mAb aggregate content of the feed mAb solution and mAb-membrane electrostatic interactions. In contrast, the filterability of Planova BioEX decreased under some buffer conditions. These findings and the established design spaces of these filters provide valuable insights into the process optimization of virus filtration.
    Language English
    Publishing date 2023-12-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 165657-0
    ISSN 1520-6033 ; 8756-7938
    ISSN (online) 1520-6033
    ISSN 8756-7938
    DOI 10.1002/btpr.3420
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  10. Article ; Online: The novel roles of neutrophils via opioid peptides: regulation of the estrous cycle and pain.

    Kobayashi, Yoshiro

    Archivum immunologiae et therapiae experimentalis

    2013  Volume 61, Issue 3, Page(s) 187–191

    Abstract: Neutrophils are excreted into the vaginal vault at metestrus during the estrous cycle, and this phenomenon has long been used to determine the phase of the estrous cycle. A much smaller number of neutrophils are also detected in the uterus and the ovary. ...

    Abstract Neutrophils are excreted into the vaginal vault at metestrus during the estrous cycle, and this phenomenon has long been used to determine the phase of the estrous cycle. A much smaller number of neutrophils are also detected in the uterus and the ovary. Recently, we provided several lines of evidence supporting the notion that neutrophils infiltrate into the ovary to regulate the estrous cycle by opioid peptides. Upon inflammation, on the other hand, neutrophils infiltrate into the site of infection to suppress pain by opioid peptides. Thus, opioid peptides are key molecules by which neutrophils play a novel role in regulation of the pain and estrous cycle. In both cases, opioid peptides appear to be secreted by neutrophils stimulated with chemokines, such as MIP-2 and KC in mouse, corticotropin-releasing hormone and IL-1.
    MeSH term(s) Animals ; Chemokine CXCL1/metabolism ; Chemokine CXCL2/metabolism ; Corticotropin-Releasing Hormone/metabolism ; Estrous Cycle/immunology ; Estrous Cycle/metabolism ; Humans ; Interleukin-1/metabolism ; Mice ; Neutrophil Infiltration ; Neutrophils/immunology ; Neutrophils/metabolism ; Opioid Peptides/immunology ; Opioid Peptides/metabolism ; Pain/immunology ; Pain/metabolism ; Signal Transduction
    Chemical Substances Chemokine CXCL1 ; Chemokine CXCL2 ; Cxcl1 protein, mouse ; Interleukin-1 ; Opioid Peptides ; Corticotropin-Releasing Hormone (9015-71-8)
    Language English
    Publishing date 2013-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 282209-x
    ISSN 1661-4917 ; 0004-069X
    ISSN (online) 1661-4917
    ISSN 0004-069X
    DOI 10.1007/s00005-013-0218-1
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