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Article ; Online: Examination of the periaqueductal gray as a site for controlling arterial pressure in the conscious spontaneously hypertensive rat.

O'Callaghan, E L / McBryde, F D / Patel, N K / Paton, J F R

Autonomic neuroscience : basic & clinical

2022 Volume 240, Page(s) 102984

Abstract: Our understanding of central nervous system regulation of the set-point of arterial pressure remains incomplete, especially in conditions of hypertension. The ventrolateral periaqueductal gray (vlPAG) is of particular interest given that its acute ... ...

Abstract	Our understanding of central nervous system regulation of the set-point of arterial pressure remains incomplete, especially in conditions of hypertension. The ventrolateral periaqueductal gray (vlPAG) is of particular interest given that its acute activation induces hypotension and sympatho-inhibition in anaesthetised, normotensive animals, and recent preliminary studies have shown that vlPAG stimulation can reduce blood pressure in refractory hypertensive patients. To assist our mechanistic understanding, we investigated whether electrical stimulation of the vlPAG had depressor actions in a model of neurogenic hypertension, the spontaneously hypertensive (SH) rat. We found that electrical stimulation of the lateral and vlPAG (2-6 V, 20-40 Hz, 0.18-0.2 ms pulse width) decreased arterial pressure (-19 ± 4 mm Hg, n = 8) and heart rate (median - 18 bpm) in anaesthetised SH rats. In contrast, in conscious freely-moving SH rats fitted with blood pressure telemetry, stimulation of this same region produced failed to evoked a hypotensive response (n = 13; either no change, n = 9; or an increase in arterial pressure of 23 ± 4 mm Hg, n = 4). The hypotensive action of the vlPAG observed in anaesthetised animals has been attributed to inhibition of pre-sympathetic neurones originating in the rostral ventrolateral medulla. We therefore used an un-anaesthetised, decerebrate SH rat preparation to investigate whether activation of vlPAG neurons produced sympatho-inhibition that might be below the threshold at which a peripheral vascular response could be observed. Only sympatho-excitatory responses to electrical and excitatory amino acid microinjections were observed, and these were evoked from both the dorsal and ventral PAG; no responses were evoked from the vlPAG. We conclude that the vlPAG is not a reliable antihypertensive locus in the awake SH rat. We discuss the potential importance of the state-dependency of the hypotensive response that can be evoked from the vlPAG, which has important implications for translating to humans.
MeSH term(s)	Animals ; Arterial Pressure ; Blood Pressure/physiology ; Humans ; Hypertension/metabolism ; Hypotension ; Microinjections ; Periaqueductal Gray/physiology ; Rats ; Rats, Inbred SHR ; Rats, Sprague-Dawley
Language	English
Publishing date	2022-04-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020105-9
ISSN	1872-7484 ; 1566-0702
ISSN (online)	1872-7484
ISSN	1566-0702
DOI	10.1016/j.autneu.2022.102984
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Article ; Online: Raman spectroscopy: A rapid method to assess the effects of pasture feeding on the nutritional quality of butter.

Gómez-Mascaraque, L G / Kilcawley, K / Hennessy, D / Tobin, J T / O'Callaghan, T F

Journal of dairy science

2020 Volume 103, Issue 10, Page(s) 8721–8731

Abstract: The animal diet is a critical variable affecting the composition and functionality of dairy products. As "Grass-Fed" labeling becomes more prominent on the market, rapid and label-free methods for verification of feeding systems are required. This work ... ...

Abstract	The animal diet is a critical variable affecting the composition and functionality of dairy products. As "Grass-Fed" labeling becomes more prominent on the market, rapid and label-free methods for verification of feeding systems are required. This work proposes the use of Raman spectroscopy to study the effects of 3 different experimental cow feeding systems-perennial ryegrass pasture, perennial ryegrass with white clover pasture, and an indoor total mixed ration diet (TMR)-on the nutritional quality of sweet cream butter. The results demonstrate that Raman spectroscopy coupled with multivariate analysis is a promising approach to distinguish butter derived from pasture or conventional TMR feeding systems. A Pearson correlation analysis confirmed high positive correlations between the spectral bin at 1,657 cm
MeSH term(s)	Animal Feed/analysis ; Animals ; Butter/analysis ; Cattle ; Fatty Acids/analysis ; Female ; Herbivory ; Lactation ; Lolium ; Milk/chemistry ; Nutritive Value ; Pilot Projects ; Poaceae ; Spectrum Analysis, Raman ; Trifolium
Chemical Substances	Fatty Acids ; Butter (8029-34-3)
Language	English
Publishing date	2020-08-06
Publishing country	United States
Document type	Clinical Trial, Veterinary ; Journal Article
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2020-18716
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Article ; Online: Impact of feeding regimes and lactation stage on sensory attributes of Cheddar cheese.

McGuinness, Lauren / Timlin, Mark / Murphy, John P / Hennessy, Deirdre / Fitzpatrick, Ellen / McCarthy, Kieran / O'Donovan, Michael / O'Callaghan, Tom F / Kilcawley, Kieran N / Dolores O'Riordan, E / Brodkorb, Andre / Sheehan, Jeremiah J / Feeney, Emma L

Food research international (Ottawa, Ont.)

2024 Volume 180, Page(s) 114046

Abstract: This study investigated the effects of diet and stage of lactation (SOL) on sensory profiles, texture, volatile profiles, and colour of Cheddar cheese. Cheddar cheese was manufactured from early-, mid-, and late-lactation milk obtained from seasonally ... ...

Abstract	This study investigated the effects of diet and stage of lactation (SOL) on sensory profiles, texture, volatile profiles, and colour of Cheddar cheese. Cheddar cheese was manufactured from early-, mid-, and late-lactation milk obtained from seasonally calved cows (n = 54). Cows were assigned a diet; group 1: perennial ryegrass (GRS), group 2: total mixed ration (TMR), and group 3: partial mixed ration (PMR). Instrumental analysis was performed at 270 days (mature Cheddar). Sensory evaluation took place after 548 days (extra mature Cheddar). Toluene was the only volatile compound that was significantly influenced by diet. The trained panel rated early-lactation cheese as stronger than mid- and late- for cowy/barny flavour and late-lactation cheese as sweeter than early- and mid-lactation cheese. Mid-lactation cheese was liked least overall. Early-lactation cheeses were rated higher for 'crumbly' texture than mid- and late. Diet affected consumer ratings, with GRS and PMR cheese rated as more intense than TMR for flavour, aftertaste, and saltiness. Consumers reported that TMR cheese was lighter in colour compared to GRS cheese, which was supported by instrumental analysis. Consumers perceived GRS as more springy and less crumbly than TMR and PMR, while Texture Profile Analysis indicated that TMR was harder than GRS. Consumer segmentation was observed with two clear preference groups, one preferring GRS and one preferring TMR. For both groups, 'taste' seemed to be the main driver of liking, highlighting that consumer preference is most impacted by individual taste preferences.
MeSH term(s)	Female ; Animals ; Cattle ; Cheese ; Lactation ; Taste ; Taste Perception ; Milk
Language	English
Publishing date	2024-01-26
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2024.114046
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Article ; Online: Effect of bovine feeding system (pasture or concentrate) on the oxidative and sensory shelf life of whole milk powder.

Clarke, H J / Griffin, C / Hennessy, D / O'Callaghan, T F / O'Sullivan, M G / Kerry, J P / Kilcawley, K N

Journal of dairy science

2021 Volume 104, Issue 10, Page(s) 10654–10668

Abstract: Correlating volatile compounds with the sensory attributes of whole milk powder (WMP) is fundamental for appreciating the effect of lipid oxidation (LO) on sensory perception. LO compounds can adversely affect the sensory perception of WMP by imparting ... ...

Abstract	Correlating volatile compounds with the sensory attributes of whole milk powder (WMP) is fundamental for appreciating the effect of lipid oxidation (LO) on sensory perception. LO compounds can adversely affect the sensory perception of WMP by imparting rancid, metallic, and painty notes. Whole milk powders derived from milk produced by cows maintained on a pasture diet (grass and grass-clover mix) versus a nonpasture diet [total mixed ration (TMR); concentrates and silage] were stored at room temperature 21°C (ambient storage) and 37°C (accelerated storage) and analyzed for volatile compounds and sensory attributes every 2 mo for a total of 6 mo. Thirteen volatile compounds originating from LO were chosen to track the volatile profile of the WMP during storage. Color, composition, total fatty acid, and free fatty acid profiling were also carried out. Significant variations in the concentrations of 14 fatty acids were observed in WMP based on diet. Concentrations of free fatty acids increased in all sample types during storage. Similar trends in sensory attributes were observed with an increase in painty attributes, corresponding to an increase in hexanal. Buttery/toffee attributes were found to be more closely correlated with TMR WMP. Those WMP derived from pasture diets were found to be more susceptible to LO from a volatile perspective, particularly in relation to aldehyde development, which is likely due to increased concentrations of conjugated linoleic acid and α-linolenic acid found in these samples.
MeSH term(s)	Animal Feed/analysis ; Animals ; Cattle ; Diet/veterinary ; Fatty Acids ; Female ; Lactation ; Milk ; Oxidative Stress ; Powders ; Silage
Chemical Substances	Fatty Acids ; Powders
Language	English
Publishing date	2021-07-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2021-20299
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Article ; Online: Lentiviral expression of wild-type LAMA3A restores cell adhesion in airway basal cells from children with epidermolysis bullosa.

Molecular therapy : the journal of the American Society of Gene Therapy

2024

Abstract: The hallmark of epidermolysis bullosa (EB) is fragile attachment of epithelia due to genetic variants in cell adhesion genes. We describe 16 EB patients treated in the ear, nose, and throat department of a tertiary pediatric hospital linked to the United ...

Abstract	The hallmark of epidermolysis bullosa (EB) is fragile attachment of epithelia due to genetic variants in cell adhesion genes. We describe 16 EB patients treated in the ear, nose, and throat department of a tertiary pediatric hospital linked to the United Kingdom's national EB unit between 1992 and 2023. Patients suffered a high degree of morbidity and mortality from laryngotracheal stenosis. Variants in laminin subunit alpha-3 (LAMA3) were found in 10/15 patients where genotype was available. LAMA3 encodes a subunit of the laminin-332 heterotrimeric extracellular matrix protein complex and is expressed by airway epithelial basal stem cells. We investigated the benefit of restoring wild-type LAMA3 expression in primary EB patient-derived basal cell cultures. EB basal cells demonstrated weak adhesion to cell culture substrates, but could otherwise be expanded similarly to non-EB basal cells. In vitro lentiviral overexpression of LAMA3A in EB basal cells enabled them to differentiate in air-liquid interface cultures, producing cilia with normal ciliary beat frequency. Moreover, transduction restored cell adhesion to levels comparable to a non-EB donor culture. These data provide proof of concept for a combined cell and gene therapy approach to treat airway disease in LAMA3-affected EB.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2024.02.032
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Article ; Online: The Adelaide Score: An artificial intelligence measure of readiness for discharge after general surgery.

Kovoor, Joshua G / Bacchi, Stephen / Gupta, Aashray K / Stretton, Brandon / Malycha, James / Reddi, Benjamin A / Liew, Danny / O'Callaghan, Patrick G / Beltrame, John F / Zannettino, Andrew C / Jones, Karen L / Horowitz, Michael / Dobbins, Christopher / Hewett, Peter J / Trochsler, Markus I / Maddern, Guy J

ANZ journal of surgery

2023 Volume 93, Issue 9, Page(s) 2119–2124

Abstract: Background: This study aimed to examine the performance of machine learning algorithms for the prediction of discharge within 12 and 24 h to produce a measure of readiness for discharge after general surgery.: Methods: Consecutive general surgery ... ...

Abstract	Background: This study aimed to examine the performance of machine learning algorithms for the prediction of discharge within 12 and 24 h to produce a measure of readiness for discharge after general surgery. Methods: Consecutive general surgery patients at two tertiary hospitals, over a 2-year period, were included. Observation and laboratory parameter data were stratified into training, testing and validation datasets. Random forest, XGBoost and logistic regression models were evaluated. Each ward round note time was taken as a different event. Primary outcome was classification accuracy of the algorithmic model able to predict discharge within the next 12 h on the validation data set. Results: 42 572 ward round note timings were included from 8826 general surgery patients. Discharge occurred within 12 h for 8800 times (20.7%), and within 24 h for 9885 (23.2%). For predicting discharge within 12 h, model classification accuracies for derivation and validation data sets were: 0.84 and 0.85 random forest, 0.84 and 0.83 XGBoost, 0.80 and 0.81 logistic regression. For predicting discharge within 24 h, model classification accuracies for derivation and validation data sets were: 0.83 and 0.84 random forest, 0.82 and 0.81 XGBoost, 0.78 and 0.79 logistic regression. Algorithms generated a continuous number between 0 and 1 (or 0 and 100), representing readiness for discharge after general surgery. Conclusions: A derived artificial intelligence measure (the Adelaide Score) successfully predicts discharge within the next 12 and 24 h in general surgery patients. This may be useful for both treating teams and allied health staff within surgical systems.
MeSH term(s)	Humans ; Artificial Intelligence ; Patient Discharge ; Algorithms ; Machine Learning ; Logistic Models
Language	English
Publishing date	2023-06-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.18546
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Article ; Online: Acute kidney injury with combination vancomycin and piperacillin-tazobactam therapy in the ICU: A retrospective cohort study.

O'Callaghan, Kevin / Hay, Karen / Lavana, Jayshree / McNamara, John F

International journal of antimicrobial agents

2020 Volume 56, Issue 1, Page(s) 106010

Abstract: Vancomycin and piperacillin-tazobactam are commonly used antibiotics. There is increasing evidence to indicate that these therapies in combination predispose patients to acute kidney injury (AKI). However, studies of intensive care unit (ICU) patients ... ...

Abstract	Vancomycin and piperacillin-tazobactam are commonly used antibiotics. There is increasing evidence to indicate that these therapies in combination predispose patients to acute kidney injury (AKI). However, studies of intensive care unit (ICU) patients with these antibiotics have produced conflicting results. In this single-centre, retrospective cohort study, data was collected on ICU patients prescribed combination vancomycin and piperacillin-tazobactam (VPT) for at least 48 h, compared with patients prescribed vancomycin with either cefepime or meropenem (VMC) for the same time period. Primary outcome was incidence of AKI; secondary outcomes included a desirability of outcome ranking (DOOR) scale, and association between antibiotic duration and kidney injury. A total of 260 patients were included. AKI was observed in 27% of cases overall. Incidence of AKI was higher with VPT compared with VMC on bivariate (relative risk reduction [RRR] 1.9, 95% confidence interval [CI] 0.9-4.1, P = 0.08) and multivariate (RRR 2.2, 95% CI 1.0-4.9, P = 0.05) analyses. Longer duration of antibiotic therapy was associated with increased rates of AKI independent of which antibiotics were prescribed: RRR 4.9, 95% CI 2.1-11.1, P = <0.001 for 5-6 days compared with <5 days, and RRR 2.3, 95% CI 1.0-5.5, P = 0.05 for >7 days compared with <5 days. This study demonstrated an association between increased risk of nephrotoxicity and combination VPT therapy in ICU patients. The concept remains controversial, with recent suggestions that VPT does not truly cause nephrotoxicity. Given our findings and the weight of previous studies, there is a strong mandate to undertake prospective trials to resolve the issue.
MeSH term(s)	Acute Kidney Injury/chemically induced ; Aged ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Cefepime/adverse effects ; Cefepime/therapeutic use ; Critical Care/methods ; Duration of Therapy ; Female ; Humans ; Intensive Care Units/statistics & numerical data ; Kidney/drug effects ; Kidney/pathology ; Male ; Meropenem/adverse effects ; Meropenem/therapeutic use ; Middle Aged ; Piperacillin, Tazobactam Drug Combination/adverse effects ; Piperacillin, Tazobactam Drug Combination/therapeutic use ; Retrospective Studies ; Vancomycin/adverse effects ; Vancomycin/therapeutic use ; beta-Lactamase Inhibitors/adverse effects ; beta-Lactamase Inhibitors/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; beta-Lactamase Inhibitors ; Piperacillin, Tazobactam Drug Combination (157044-21-8) ; Vancomycin (6Q205EH1VU) ; Cefepime (807PW4VQE3) ; Meropenem (FV9J3JU8B1)
Language	English
Publishing date	2020-05-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2020.106010
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Analysis of tissue lipidomics and computed tomography pulmonary fat attenuation volume (CT

O'Callaghan, Marissa / Duignan, John / Tarling, Elizabeth J / Waters, Darragh K / McStay, Megan / O'Carroll, Orla / Bridges, James P / Redente, Elizabeth F / Franciosi, Alessandro N / McGrath, Emmet E / Butler, Marcus W / Dodd, Jonathan D / Fabre, Aurelie / Murphy, David J / Keane, Michael P / McCarthy, Cormac

Respirology (Carlton, Vic.)

2023 Volume 28, Issue 11, Page(s) 1043–1052

Abstract: Background and objective: There is increasing interest in the role of lipids in processes that modulate lung fibrosis with evidence of lipid deposition in idiopathic pulmonary fibrosis (IPF) histological specimens. The aim of this study was to identify ... ...

Abstract	Background and objective: There is increasing interest in the role of lipids in processes that modulate lung fibrosis with evidence of lipid deposition in idiopathic pulmonary fibrosis (IPF) histological specimens. The aim of this study was to identify measurable markers of pulmonary lipid that may have utility as IPF biomarkers. Study design and methods: IPF and control lung biopsy specimens were analysed using a unbiased lipidomic approach. Pulmonary fat attenuation volume (PFAV) was assessed on chest CT images (CT Results: There was a significant increase in total lipid content on histological analysis of IPF lung tissue (23.16 nmol/mg) compared to controls (18.66 mol/mg, p = 0.0317). The median CT Conclusion: CT
MeSH term(s)	Humans ; Lipidomics ; Pilot Projects ; Lung ; Idiopathic Pulmonary Fibrosis ; Tomography, X-Ray Computed/methods ; Biomarkers ; Lipids ; Fibrosis ; Retrospective Studies
Chemical Substances	Biomarkers ; Lipids
Language	English
Publishing date	2023-08-29
Publishing country	Australia
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14582
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Article ; Online: Vital Signs: Missed Opportunities for Preventing Congenital Syphilis - United States, 2022.

McDonald, Robert / O'Callaghan, Kevin / Torrone, Elizabeth / Barbee, Lindley / Grey, Jeremy / Jackson, David / Woodworth, Kate / Olsen, Emily / Ludovic, Jennifer / Mayes, Nikki / Chen, Sherry / Wingard, Rachel / Johnson Jones, Michelle / Drame, Fanta / Bachmann, Laura / Romaguera, Raul / Mena, Leandro

MMWR. Morbidity and mortality weekly report

2023 Volume 72, Issue 46, Page(s) 1269–1274

Abstract: Introduction: Congenital syphilis cases in the United States increased 755% during 2012-2021. Syphilis during pregnancy can lead to stillbirth, miscarriage, infant death, and maternal and infant morbidity; these outcomes can be prevented through ... ...

Abstract	Introduction: Congenital syphilis cases in the United States increased 755% during 2012-2021. Syphilis during pregnancy can lead to stillbirth, miscarriage, infant death, and maternal and infant morbidity; these outcomes can be prevented through appropriate screening and treatment. Methods: A cascading framework was used to identify and classify missed opportunities to prevent congenital syphilis among cases reported to CDC in 2022 through the National Notifiable Diseases Surveillance System. Data on testing and treatment during pregnancy and clinical manifestations present in the newborn were used to identify missed opportunities to prevent congenital syphilis. Results: In 2022, a total of 3,761 cases of congenital syphilis in the United States were reported to CDC, including 231 (6%) stillbirths and 51 (1%) infant deaths. Lack of timely testing and adequate treatment during pregnancy contributed to 88% of cases of congenital syphilis. Testing and treatment gaps were present in the majority of cases across all races, ethnicities, and U.S. Census Bureau regions. Conclusions and implications for public health practice: Addressing missed opportunities for prevention, primarily timely testing and appropriate treatment of syphilis during pregnancy, is important for reversing congenital syphilis trends in the United States. Implementing tailored strategies addressing missed opportunities at the local and national levels could substantially reduce congenital syphilis.
MeSH term(s)	Infant ; Infant, Newborn ; Pregnancy ; Female ; Humans ; United States/epidemiology ; Syphilis, Congenital/epidemiology ; Syphilis, Congenital/prevention & control ; Syphilis/diagnosis ; Syphilis/epidemiology ; Syphilis/prevention & control ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/prevention & control ; Population Surveillance ; Stillbirth ; Vital Signs
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm7246e1
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Article ; Online: Estimation of skeletal muscle mass in 4-year-old children using the D

Sidiqi, Aysha / Fariha, Farzana / Shanta, Shaila S / Dasiewicz, Alison / Mahmud, Abdullah Al / Moore, Daniel R / Shankaran, Mahalakshmi / Hellerstein, Marc K / Evans, William J / Gernand, Alison D / Islam, M Munirul / Abrams, Steven A / Harrington, Jennifer / Nyangau, Edna / Roth, Daniel E / O'Callaghan, Karen M

Pediatric research

2023 Volume 94, Issue 3, Page(s) 1195–1202

Abstract: Background: Given limited experience in applying the creatine-(methyl-D: Methods: Following D: Results: SMM was measured successfully in 91% of participants, and there were no adverse events. Mean ± SD SMM was greater than ALM (4.5 ± 0.4 and 3.2 ± ...

Abstract	Background: Given limited experience in applying the creatine-(methyl-D Methods: Following D Results: SMM was measured successfully in 91% of participants, and there were no adverse events. Mean ± SD SMM was greater than ALM (4.5 ± 0.4 and 3.2 ± 0.6 kg, respectively). Precision of SMM was low (intraclass correlation = 0.20; 95% CI: 0.02, 0.75; n = 10). Grip strength was not associated with SMM in multivariable analysis (0.004 kg per 100 g of SMM; 95% CI: -0.031, 0.038; n = 91). Conclusions: The D Impact: The D3-creatine (D3Cr) stable isotope dilution method was considered a feasible method for the estimation of skeletal muscle mass (SMM) in young children in a community setting and was well accepted among participants. SMM was weakly associated with both dual-energy x-ray absorptiometry-derived values of appendicular lean mass and grip strength. High within-child variability in estimated values of SMM suggests that further optimization of the D3Cr stable isotope dilution method is required prior to implementation in community research settings.
MeSH term(s)	Humans ; Child, Preschool ; Creatine/metabolism ; Creatinine/metabolism ; Muscle, Skeletal/metabolism ; Body Composition/physiology ; Bangladesh ; Absorptiometry, Photon/methods ; Isotopes/metabolism
Chemical Substances	Creatine (MU72812GK0) ; Creatinine (AYI8EX34EU) ; Isotopes
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-023-02587-1
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