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  1. Book ; Online: Thallium concentrations and isotope composition of MORB glasses and altered oceani crust from DSDP/ODP Hole 504B and DSDP Hole 52-417D, supplementary data to: Nielsen, Sune G; Rehk?mper, Mark; Teagle, Damon AH; Butterfield, David A; Alt, Jeffrey C; Halliday, Alex N (2006): Hydrothermal fluid fluxes calculated from the isotopic mass balance of thallium in the ocean crust. Earth and Planetary Science Letters, 251(1-2), 120-133

    Nielsen, Sune G / Alt, Jeffrey C / Butterfield, David A / Halliday, Alex N / Rehk?mper, Mark / Teagle, Damon AH

    2006  

    Abstract: Hydrothermal fluids expelled from the seafloor at high and low temperatures play pivotal roles in controlling seawater chemistry. However, the magnitude of the high temperature water flux of mid-ocean ridge axes remains widely disputed and the volume of ... ...

    Abstract Hydrothermal fluids expelled from the seafloor at high and low temperatures play pivotal roles in controlling seawater chemistry. However, the magnitude of the high temperature water flux of mid-ocean ridge axes remains widely disputed and the volume of low temperature vent fluids at ridge flanks is virtually unconstrained. Here, we determine both high and low temperature hydrothermal fluid fluxes using the chemical and isotopic mass balance of the element thallium (Tl) in the ocean crust. Thallium is a unique tracer of ocean floor hydrothermal exchange because of its contrasting behavior during seafloor alteration at low and high temperatures and the distinctive isotopic signatures of fresh and altered MORB and seawater. The calculated high temperature hydrothermal water flux is (0.17-2.93)*10**13 kg/yr with a best estimate of 0.72*10**13 kg/yr. This result suggests that only about 5 to 80% of the heat available at mid-ocean ridge axes from the crystallization and cooling of the freshly formed ocean crust, is released by high temperature black smoker fluids.The residual thermal energy ismost likely lost via conduction and/or through the circulation of intermediate temperature hydrothermal fluids that do not alter the chemical budgets of Tl in the ocean crust. The Tl-based calculations indicate that the low temperature hydrothermal water flux at ridge flanks is (0.2-5.4)*10**17 kg/yr. This implies that the fluids have an average temperature anomaly of only about 0.1 to 3.6 ?C relative to ambient seawater. If these low temperatures are correct then both Sr and Mg are expected to be relatively unreactive in ridge-flank hydrothermal systems and this may explain why the extent of basalt alteration that is observed for altered ocean crust appears insufficient to balance the oceanic budgets of 87Sr/86Sr and Mg.
    Language English
    Dates of publication 2006-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1016/j.epsl.2006.09.002
    DOI 10.1594/PANGAEA.723783
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Article ; Online: Isotopic evidence for the formation of the Moon in a canonical giant impact.

    Nielsen, Sune G / Bekaert, David V / Auro, Maureen

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 1817

    Abstract: Isotopic measurements of lunar and terrestrial rocks have revealed that, unlike any other body in the solar system, the Moon is indistinguishable from the Earth for nearly every isotopic system. This observation, however, contradicts predictions by the ... ...

    Abstract Isotopic measurements of lunar and terrestrial rocks have revealed that, unlike any other body in the solar system, the Moon is indistinguishable from the Earth for nearly every isotopic system. This observation, however, contradicts predictions by the standard model for the origin of the Moon, the canonical giant impact. Here we show that the vanadium isotopic composition of the Moon is offset from that of the bulk silicate Earth by 0.18 ± 0.04 parts per thousand towards the chondritic value. This offset most likely results from isotope fractionation on proto-Earth during the main stage of terrestrial core formation (pre-giant impact), followed by a canonical giant impact where ~80% of the Moon originates from the impactor of chondritic composition. Our data refute the possibility of post-giant impact equilibration between the Earth and Moon, and implies that the impactor and proto-Earth mainly accreted from a common isotopic reservoir in the inner solar system.
    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-22155-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (17582021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution.

    Nielsen, David H / Robbins, Richard G / Rueda, Leopoldo M

    Zootaxa

    2021  Volume 4967, Issue 1, Page(s) 1243

    Abstract: The superfamily Trombiculoidea is a large and diverse group of acarines that comprises six families; of these, the families Trombiculidae and Leeuwenhoekiidae are characterized by larvae commonly known as chiggers that are parasites of terrestrial ... ...

    Abstract The superfamily Trombiculoidea is a large and diverse group of acarines that comprises six families; of these, the families Trombiculidae and Leeuwenhoekiidae are characterized by larvae commonly known as chiggers that are parasites of terrestrial vertebrates, including humans, and some species are of medical importance as vectors of chigger-borne rickettsiosis (scrub typhus), caused by the rickettsia Orientia tsutsugamushi. This paper presents an annotated checklist of 3,013 generally accepted chigger species, together with their distribution by zoogeographic region, and a non-comprehensive list of synonyms. A total of 58 new combinations are proposed by transferring species to different genera, treating some subgenera as genera, or updating current generic names. The checklist updates earlier catalogs of the world chigger fauna, but because the literature on chigger taxonomy is voluminous and scattered, similar, regional monographs were utilized in constructing the classificatory foundation. This list may not contain every species, synonym or taxonomic rearrangement that has been published, but it reflects the most recent arrangement of chigger taxa. Distribution records are primarily drawn from collection sites listed in the original species descriptions, together with subsequently published geographical records.
    MeSH term(s) Animal Distribution ; Animals ; Trombiculidae/classification
    Language English
    Publishing date 2021-05-07
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.4967.1.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Isotopic evidence for the formation of the Moon in a canonical giant impact

    Sune G. Nielsen / David V. Bekaert / Maureen Auro

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 7

    Abstract: Here, the authors show that Earth and Moon are characterized by different vanadium isotope compositions, which is most likely resulting from vanadium isotope fractionation of the bulk silicate proto-Earth during the main stage of terrestrial core ... ...

    Abstract Here, the authors show that Earth and Moon are characterized by different vanadium isotope compositions, which is most likely resulting from vanadium isotope fractionation of the bulk silicate proto-Earth during the main stage of terrestrial core formation—followed by a canonical giant impact scenario, where 80% of the Moon originates from an impactor of chondritic composition.
    Keywords Science ; Q
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: NGS-determined molecular markers and disease burden metrics from ctDNA correlate with PFS in previously untreated DLBCL.

    Tabari, Ehsan / Lovejoy, Alexander F / Lin, Hai / Bolen, Christopher R / Lor Saelee, Seng / Lefkowitz, Joshua P / Kurtz, David M / Bottos, Alessia / Nielsen, Tina G / Parreira, Joana M / Luong, Khai T

    Leukemia & lymphoma

    2024  Volume 65, Issue 5, Page(s) 618–628

    Abstract: Personalized risk stratification and treatment may help improve outcomes among patients with diffuse large B-cell lymphoma (DLBCL). We developed a next-generation sequencing (NGS)-based method to assess a range of potential prognostic indicators, and ... ...

    Abstract Personalized risk stratification and treatment may help improve outcomes among patients with diffuse large B-cell lymphoma (DLBCL). We developed a next-generation sequencing (NGS)-based method to assess a range of potential prognostic indicators, and evaluated it using pretreatment plasma samples from 310 patients with previously untreated DLBCL from the GOYA trial (NCT01287741). Variant calls and DLBCL subtyping with the plasma-based method were concordant with corresponding tissue-based methods. Patients with a tumor burden greater than the median (
    MeSH term(s) Humans ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/blood ; Lymphoma, Large B-Cell, Diffuse/mortality ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Circulating Tumor DNA/blood ; Circulating Tumor DNA/genetics ; High-Throughput Nucleotide Sequencing ; Biomarkers, Tumor/blood ; Prognosis ; Male ; Female ; Middle Aged ; Aged ; Tumor Burden ; Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Mutation ; Aged, 80 and over
    Chemical Substances Circulating Tumor DNA ; Biomarkers, Tumor
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2024.2301924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: 'Dark' CO

    Godar, Amanda G / Chase, Timothy / Conway, Dalton / Ravichandran, Dharneedar / Woodson, Isaiah / Lai, Yen-Jung / Song, Kenan / Rittmann, Bruce E / Wang, Xuan / Nielsen, David R

    Bioprocess and biosystems engineering

    2023  Volume 47, Issue 2, Page(s) 223–233

    Abstract: Anaerobic succinate fermentations can achieve high-titer, high-yield performance while fixing ... ...

    Abstract Anaerobic succinate fermentations can achieve high-titer, high-yield performance while fixing CO
    MeSH term(s) Fermentation ; Succinic Acid ; Carbon Dioxide/pharmacology ; Salts ; Succinates ; Escherichia coli ; Carbonates/pharmacology
    Chemical Substances Succinic Acid (AB6MNQ6J6L) ; Carbon Dioxide (142M471B3J) ; Salts ; Succinates ; Carbonates
    Language English
    Publishing date 2023-12-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1476357-6
    ISSN 1615-7605 ; 1432-0797 ; 1615-7591
    ISSN (online) 1615-7605 ; 1432-0797
    ISSN 1615-7591
    DOI 10.1007/s00449-023-02957-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Vanadium Stable Isotopes in Biota of Terrestrial and Aquatic Food Chains.

    Chételat, John / Nielsen, Sune G / Auro, Maureen / Carpenter, David / Mundy, Lukas / Thomas, Philippe J

    Environmental science & technology

    2021  Volume 55, Issue 8, Page(s) 4813–4821

    Abstract: Vanadium, a potentially toxic metal, is enriched in the environment from anthropogenic releases, particularly during fossil fuel production and use and steel manufacturing. Metal stable isotopes are sophisticated tools to trace pollution; however, only ... ...

    Abstract Vanadium, a potentially toxic metal, is enriched in the environment from anthropogenic releases, particularly during fossil fuel production and use and steel manufacturing. Metal stable isotopes are sophisticated tools to trace pollution; however, only recent analytical advances have allowed for the accurate and precise measurement of vanadium isotope ratios (δ
    MeSH term(s) Alberta ; Animals ; Biota ; Carbon Isotopes ; Ecosystem ; Environmental Monitoring ; Food Chain ; Isotopes/analysis ; Northwest Territories ; Oil and Gas Fields ; Vanadium ; Water Pollutants, Chemical/analysis
    Chemical Substances Carbon Isotopes ; Isotopes ; Water Pollutants, Chemical ; Vanadium (00J9J9XKDE)
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.0c07509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Differential Diagnosis of Cartilaginous Lesions of Bone.

    Suster, David / Hung, Yin Pun / Nielsen, G Petur

    Archives of pathology & laboratory medicine

    2019  Volume 144, Issue 1, Page(s) 71–82

    Abstract: Context.—: Cartilaginous tumors represent one of the most common tumors of bone. Management of these tumors includes observation, curettage, and surgical excision or resection, depending on their locations and whether they are benign or malignant. They ... ...

    Abstract Context.—: Cartilaginous tumors represent one of the most common tumors of bone. Management of these tumors includes observation, curettage, and surgical excision or resection, depending on their locations and whether they are benign or malignant. They can be diagnostically challenging, particularly in small biopsies. In rare cases, benign tumors may undergo malignant transformation.
    Objective.—: To review common cartilaginous tumors, including in patients with multiple hereditary exostosis, Ollier disease, and Maffucci syndrome, and to discuss problems in the interpretation of well-differentiated cartilaginous neoplasms of bone. Additionally, the concept of atypical cartilaginous tumor/chondrosarcoma grade 1 will be discussed and its use clarified.
    Data sources.—: PubMed (US National Library of Medicine, Bethesda, Maryland) literature review, case review of archival cases at the Massachusetts General Hospital, and personal experience of the authors.
    Conclusions.—: This review has examined primary well-differentiated cartilaginous lesions of bone, including their differential diagnosis and approach to management. Because of the frequent overlap in histologic features, particularly between low-grade chondrosarcoma and enchondroma, evaluation of well-differentiated cartilaginous lesions should be undertaken in conjunction with thorough review of the imaging studies.
    MeSH term(s) Bone Neoplasms/diagnosis ; Chondroblastoma/diagnosis ; Chondroma/diagnosis ; Chondrosarcoma/diagnosis ; Diagnosis, Differential ; Humans
    Language English
    Publishing date 2019-12-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2019-0441-RA
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: De novo development of small cyclic peptides that are orally bioavailable.

    Merz, Manuel L / Habeshian, Sevan / Li, Bo / David, Jean-Alexandre G L / Nielsen, Alexander L / Ji, Xinjian / Il Khwildy, Khaled / Duany Benitez, Maury M / Phothirath, Phoukham / Heinis, Christian

    Nature chemical biology

    2023  Volume 20, Issue 5, Page(s) 624–633

    Abstract: Cyclic peptides can bind challenging disease targets with high affinity and specificity, offering enormous opportunities for addressing unmet medical needs. However, as with biological drugs, most cyclic peptides cannot be applied orally because they are ...

    Abstract Cyclic peptides can bind challenging disease targets with high affinity and specificity, offering enormous opportunities for addressing unmet medical needs. However, as with biological drugs, most cyclic peptides cannot be applied orally because they are rapidly digested and/or display low absorption in the gastrointestinal tract, hampering their development as therapeutics. In this study, we developed a combinatorial synthesis and screening approach based on sequential cyclization and one-pot peptide acylation and screening, with the possibility of simultaneously interrogating activity and permeability. In a proof of concept, we synthesized a library of 8,448 cyclic peptides and screened them against the disease target thrombin. Our workflow allowed multiple iterative cycles of library synthesis and yielded cyclic peptides with nanomolar affinities, high stabilities and an oral bioavailability (%F) as high as 18% in rats. This method for generating orally available peptides is general and provides a promising push toward unlocking the full potential of peptides as therapeutics.
    MeSH term(s) Peptides, Cyclic/chemistry ; Peptides, Cyclic/pharmacokinetics ; Peptides, Cyclic/administration & dosage ; Peptides, Cyclic/pharmacology ; Administration, Oral ; Biological Availability ; Animals ; Rats ; Humans ; Cyclization ; Peptide Library ; Thrombin/metabolism ; Thrombin/chemistry ; Male ; Combinatorial Chemistry Techniques ; Acylation
    Chemical Substances Peptides, Cyclic ; Peptide Library ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2202962-X
    ISSN 1552-4469 ; 1552-4450
    ISSN (online) 1552-4469
    ISSN 1552-4450
    DOI 10.1038/s41589-023-01496-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Characterizing Escherichia coli's transcriptional response to different styrene exposure modes reveals novel toxicity and tolerance insights.

    Machas, Michael / Kurgan, Gavin / Abed, Omar A / Shapiro, Alyssa / Wang, Xuan / Nielsen, David

    Journal of industrial microbiology & biotechnology

    2021  Volume 48, Issue 1-2

    Abstract: ... with phage shock protein response (e.g. pspABCDE/G), general stress regulators (e.g. marA, rpoH), and ...

    Abstract The global transcriptional response of Escherichia coli to styrene and potential influence of exposure source was determined by performing RNA sequencing (RNA-seq) analysis on both styrene-producing and styrene-exposed cells. In both cases, styrene exposure appears to cause both cell envelope and DNA damage, to which cells respond by down-regulating key genes/pathways involved in DNA replication, protein production, and cell wall biogenesis. Among the most significantly up-regulated genes were those involved with phage shock protein response (e.g. pspABCDE/G), general stress regulators (e.g. marA, rpoH), and membrane-altering genes (notably, bhsA, ompR, ldtC), whereas efflux transporters were, surprisingly, unaffected. Subsequent studies with styrene addition demonstrate how strains lacking ompR [involved in controlling outer membrane (OM) composition/osmoregulation] or any of tolQ, tolA, or tolR (involved in OM constriction) each displayed over 40% reduced growth relative to wild-type. Conversely, despite reducing basal fitness, overexpression of plsX (involved in phospholipid biosynthesis) led to 70% greater growth when styrene exposed. These collective differences point to the likely importance of OM properties in controlling native styrene tolerance. Overall, the collective behaviours suggest that, regardless of source, prolonged exposure to inhibitory styrene levels causes cells to shift from'growth mode' to 'survival mode', redistributing cellular resources to fuel native tolerance mechanisms.
    MeSH term(s) Escherichia coli/drug effects ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; RNA, Bacterial/genetics ; Styrene/toxicity ; Transcription, Genetic
    Chemical Substances Escherichia coli Proteins ; RNA, Bacterial ; Styrene (44LJ2U959V)
    Language English
    Publishing date 2021-03-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1482484-X
    ISSN 1476-5535 ; 1367-5435
    ISSN (online) 1476-5535
    ISSN 1367-5435
    DOI 10.1093/jimb/kuab019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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