LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1277

Search options

  1. Book ; Online: Convolutional Neural Network Ensemble Learning for Hyperspectral Imaging-based Blackberry Fruit Ripeness Detection in Uncontrolled Farm Environment

    Olisah, Chollette C. / Trewhella, Ben / Li, Bo / Smith, Melvyn L. / Winstone, Benjamin / Whitfield, E. Charles / Fernández, Felicidad Fernández / Duncalfe, Harriet

    2024  

    Abstract: Fruit ripeness estimation models have for decades depended on spectral index features or colour-based features, such as mean, standard deviation, skewness, colour moments, and/or histograms for learning traits of fruit ripeness. Recently, few studies ... ...

    Abstract Fruit ripeness estimation models have for decades depended on spectral index features or colour-based features, such as mean, standard deviation, skewness, colour moments, and/or histograms for learning traits of fruit ripeness. Recently, few studies have explored the use of deep learning techniques to extract features from images of fruits with visible ripeness cues. However, the blackberry (Rubus fruticosus) fruit does not show obvious and reliable visible traits of ripeness when mature and therefore poses great difficulty to fruit pickers. The mature blackberry, to the human eye, is black before, during, and post-ripening. To address this engineering application challenge, this paper proposes a novel multi-input convolutional neural network (CNN) ensemble classifier for detecting subtle traits of ripeness in blackberry fruits. The multi-input CNN was created from a pre-trained visual geometry group 16-layer deep convolutional network (VGG16) model trained on the ImageNet dataset. The fully connected layers were optimized for learning traits of ripeness of mature blackberry fruits. The resulting model served as the base for building homogeneous ensemble learners that were ensemble using the stack generalization ensemble (SGE) framework. The input to the network is images acquired with a stereo sensor using visible and near-infrared (VIS-NIR) spectral filters at wavelengths of 700 nm and 770 nm. Through experiments, the proposed model achieved 95.1% accuracy on unseen sets and 90.2% accuracy with in-field conditions. Further experiments reveal that machine sensory is highly and positively correlated to human sensory over blackberry fruit skin texture.

    Comment: 25 pages, 10 figures, 6 tables; submited to EAAI
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning
    Subject code 006
    Publishing date 2024-01-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  2. Article ; Online: Using Implementation Mapping to develop and test an implementation strategy for active learning to promote physical activity in children: a feasibility study using a hybrid type 2 design.

    Walker, Timothy J / Kohl, Harold W / Bartholomew, John B / Green, Charles / Fernández, Maria E

    Implementation science communications

    2022  Volume 3, Issue 1, Page(s) 26

    Abstract: Background: Incorporating physical movement in the teaching of academic content (active learning) is a promising approach to improve children's health and academic performance. Despite documented benefits, implementation of active learning remains ... ...

    Abstract Background: Incorporating physical movement in the teaching of academic content (active learning) is a promising approach to improve children's health and academic performance. Despite documented benefits, implementation of active learning remains challenging for schools. The aims of this study are to develop an implementation strategy to support the delivery of active learning in elementary schools and examine the impact of the developed implementation strategy on the implementation and effectiveness of active learning.
    Methods: Aim 1 will use Implementation Mapping, which is a multi-step approach that guides the use of theory, stakeholder input, and existing literature to develop a scientifically based implementation strategy for active learning in elementary schools. Aim 2 will feature a feasibility study to examine the impact of the implementation strategy on both implementation and effectiveness outcomes, consistent with a Hybrid Type 2 design. Acceptability and implementation fidelity will be the primary implementation outcomes, and student physical activity levels will be the primary effectiveness outcome. We will recruit two elementary schools within our partner district, and one will be randomly assigned to receive usual support while the other will receive the newly developed implementation strategy. Participants from each school will complete baseline, 6-, and 12-month assessments. Bayesian statistical approaches will quantitatively examine preliminary effectiveness outcomes. We will also use an embedded mixed methods approach to triangulate findings.
    Discussion: This study's innovative overarching conceptual framework (centered on Implementation Mapping) will inform the development and testing of the implementation strategy. This study also uses methodological approaches optimal for feasibility studies, including mixed methods and Bayesian statistics. As a result, we will be able to gain a thorough understanding about the feasibility and preliminary effectiveness of the implementation strategy, which will inform subsequent research and practice for implementing active learning in schools.
    Trial registration: ClinicalTrials.gov, NCT05048433 , registered on September 8, 2021.
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article
    ISSN 2662-2211
    ISSN (online) 2662-2211
    DOI 10.1186/s43058-022-00271-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Androgen receptors immunoreactivity in the rat brain of males with same-sex preference.

    Fernández-Guasti, Alonso / Quintanar, Blanca Gómez / Reyes, Rebeca / Hernández, Alejandra / Chavira, Roberto / Roselli, Charles E

    Hormones and behavior

    2022  Volume 146, Page(s) 105279

    Abstract: Androgen receptors (AR) are crucial in the control of male sexual behavior and sex preference. AR are particularly concentrated in areas related with the neuroendocrine control of sex preference including the medial amygdala (MeA), the ventromedial ... ...

    Abstract Androgen receptors (AR) are crucial in the control of male sexual behavior and sex preference. AR are particularly concentrated in areas related with the neuroendocrine control of sex preference including the medial amygdala (MeA), the ventromedial nucleus of the hypothalamus (VMH), the bed nucleus of the stria terminalis (BNST), the medial preoptic area (MPOA), the nucleus accumbens (Acb), the suprachiasmatic (SCh) and supraoptic (SO) nuclei, but also seem to be important for the control of reproductive processes in the hippocampus (CA1-CA4 and dentate gyrus, DG). In the present study we analyzed the density of AR in these brain areas of adult male rats with sexual preference (established in a three-compartment box). Same-sex preference was produced in male rats by the prenatal administration of the aromatase inhibitor, letrozole (0.56 μg/kg/ml s.c. G10-22) that usually produces 1-2 animals per litter with same sex preference, while the others retain a female sex preference. We also included a group of proestrus females that had a clear preference for a sexually active male. AR were analyzed by immunocytochemistry using PG21 as primary antibody. We also measured total plasma testosterone concentrations by radioimmunoassay. In males with same sex preference there was a specific AR overexpression in CA3 and CA4 that suggests a feminized pattern because females in proestrus trend to show a higher density of AR in these hippocampal areas. Sex differences in AR density were found in the anterior cingulate cortex (ACg) and frontoparietal cortex (FrPa). Serum levels of testosterone did not differ between groups. Data are discussed based on the role of AR in the hippocampus.
    MeSH term(s) Animals ; Female ; Male ; Rats ; Receptors, Androgen/metabolism ; Septal Nuclei/metabolism ; Brain/metabolism ; Testosterone ; Sexual Behavior
    Chemical Substances Receptors, Androgen ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 214409-8
    ISSN 1095-6867 ; 0018-506X
    ISSN (online) 1095-6867
    ISSN 0018-506X
    DOI 10.1016/j.yhbeh.2022.105279
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: metabCombiner 2.0: Disparate Multi-Dataset Feature Alignment for LC-MS Metabolomics.

    Habra, Hani / Meijer, Jennifer L / Shen, Tong / Fiehn, Oliver / Gaul, David A / Fernández, Facundo M / Rempfert, Kaitlin R / Metz, Thomas O / Peterson, Karen E / Evans, Charles R / Karnovsky, Alla

    Metabolites

    2024  Volume 14, Issue 2

    Abstract: Liquid chromatography-high-resolution mass spectrometry (LC-HRMS), as applied to untargeted metabolomics, enables the simultaneous detection of thousands of small molecules, generating complex datasets. Alignment is a crucial step in data processing ... ...

    Abstract Liquid chromatography-high-resolution mass spectrometry (LC-HRMS), as applied to untargeted metabolomics, enables the simultaneous detection of thousands of small molecules, generating complex datasets. Alignment is a crucial step in data processing pipelines, whereby LC-MS features derived from common ions are assembled into a unified matrix amenable to further analysis. Variability in the analytical factors that influence liquid chromatography separations complicates data alignment. This is prominent when aligning data acquired in different laboratories, generated using non-identical instruments, or between batches from large-scale studies. Previously, we developed metabCombiner for aligning disparately acquired LC-MS metabolomics datasets. Here, we report significant upgrades to metabCombiner that enable the stepwise alignment of multiple untargeted LC-MS metabolomics datasets, facilitating inter-laboratory reproducibility studies. To accomplish this, a "primary" feature list is used as a template for matching compounds in "target" feature lists. We demonstrate this workflow by aligning four lipidomics datasets from core laboratories generated using each institution's in-house LC-MS instrumentation and methods. We also introduce batchCombine, an application of the metabCombiner framework for aligning experiments composed of multiple batches. metabCombiner is available as an R package on Github and Bioconductor, along with a new online version implemented as an R Shiny App.
    Language English
    Publishing date 2024-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo14020125
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Patient-Reported Outcomes After Vestibular Implantation for Bilateral Vestibular Hypofunction.

    Ayiotis, Andrianna I / Schoo, Desi P / Fernandez Brillet, Celia / Lane, Kelly E / Carey, John P / Della Santina, Charles C

    JAMA otolaryngology-- head & neck surgery

    2024  Volume 150, Issue 3, Page(s) 240–248

    Abstract: Importance: Standard-of-care treatment proves inadequate for many patients with bilateral vestibular hypofunction (BVH). Vestibular implantation is an emerging alternative.: Objective: To examine patient-reported outcomes from prosthetic vestibular ... ...

    Abstract Importance: Standard-of-care treatment proves inadequate for many patients with bilateral vestibular hypofunction (BVH). Vestibular implantation is an emerging alternative.
    Objective: To examine patient-reported outcomes from prosthetic vestibular stimulation.
    Design, setting, and participants: The Multichannel Vestibular Implant (MVI) Early Feasibility Study is an ongoing prospective, nonrandomized, single-group, single-center cohort study conducted at Johns Hopkins Hospital that has been active since 2016 in which participants serve as their own controls. The study includes adults with severe or profound adult-onset BVH for at least 1 year and inadequate compensation despite standard-of-care treatment. As of March 2023, 12 candidates completed the eligibility screening process.
    Intervention: The MVI system electrically stimulates semicircular canal branches of the vestibular nerve to convey head rotation.
    Main outcomes and measures: Patient-reported outcome instruments assessing dizziness (Dizziness Handicap Inventory [DHI]) and vestibular-related disability (Vestibular Disorders-Activities of Daily Living [VADL]). Health-related quality of life (HRQOL) assessed using the Short Form-36 Utility (SF36U) and Health Utilities Index Mark 3 (HUI3), from which quality-adjusted life-years were computed.
    Results: Ten individuals (5 female [50%]; mean [SD] age, 58.5 [5.0] years; range, 51-66 years) underwent unilateral implantation. A control group of 10 trial applicants (5 female [50%]; mean [SD] age, 55.1 [8.5] years; range, 42-73 years) completed 6-month follow-up surveys after the initial application. After 0.5 years of continuous MVI use, a pooled mean (95% CI) of within-participant changes showed improvements in dizziness (DHI, -36; 95% CI, -55 to -18), vestibular disability (VADL, -1.7; 95% CI, -2.6 to -0.7), and HRQOL by SF36U (0.12; 95% CI, 0.07-0.17) but not HUI3 (0.02; 95% CI, -0.22 to 0.27). Improvements exceeded minimally important differences in the direction of benefit (exceeding 18, 0.65, and 0.03, respectively, for DHI, VADL, and SF36U). The control group reported no mean change in dizziness (DHI, -4; 95% CI, -10 to 2), vestibular disability (VADL, 0.1; 95% CI, -0.9 to 1.1) or HRQOL per SF36U (0; 95% CI, -0.06 to 0.05) but an increase in HRQOL per HUI3 (0.10; 95% CI, 0.04-0.16). Lifetime HRQOL gain for MVI users was estimated to be 1.7 quality-adjusted life-years (95% CI, 0.6-2.8) using SF36U and 1.4 (95% CI, -1.2 to 4.0) using HUI3.
    Conclusions and relevance: This cohort study found that vestibular implant recipients report vestibular symptom improvements not reported by a control group. These patient-reported benefits support the use of vestibular implantation as a treatment for bilateral vestibular hypofunction.
    MeSH term(s) Adult ; Humans ; Female ; Middle Aged ; Dizziness/etiology ; Quality of Life ; Activities of Daily Living ; Cohort Studies ; Prospective Studies ; Vertigo/diagnosis ; Vestibular Diseases/diagnosis
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2023.4475
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Nonhuman Primate Paternal Care: Species and Individual Differences in Behavior and Mechanisms.

    Ziegler, Toni E / Tecot, Stacey R / Fernandez-Duque, Eduardo / Savage, Anne / Snowdon, Charles T

    Advances in neurobiology

    2022  Volume 27, Page(s) 213–238

    Abstract: Direct care of offspring by the father (sire) is relatively rare in primates. Besides humans, there are a number of species where the male is essential for the survival of offspring: marmosets, tamarins, titis and owl monkeys, some lemurs, and siamangs. ... ...

    Abstract Direct care of offspring by the father (sire) is relatively rare in primates. Besides humans, there are a number of species where the male is essential for the survival of offspring: marmosets, tamarins, titis and owl monkeys, some lemurs, and siamangs. All these species show reduced sexual dimorphism, territoriality, and biparental care. However, timing and levels of direct care may vary among these species. Here, relying on both lab and field data, we address the variability found in father's involvement with his infants, the behavioral, neuroendocrine and sensory systems that are a cause and consequence of paternal care, and social bonds between the breeding pair. We integrate studies of laboratory animals (where detailed observations and experimentation are possible) with field studies (which illuminate the ecological and evolutionary functions of paternal care) and discuss the future directions for examining the proximate and ultimate mechanisms of paternal care in nonhuman primates.
    MeSH term(s) Animals ; Fathers ; Humans ; Individuality ; Male ; Primates ; Social Behavior
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article
    ISSN 2190-5215
    ISSN 2190-5215
    DOI 10.1007/978-3-030-97762-7_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Using Implementation Mapping to develop and test an implementation strategy for active learning to promote physical activity in children

    Timothy J. Walker / Harold W. Kohl / John B. Bartholomew / Charles Green / Maria E. Fernández

    Implementation Science Communications, Vol 3, Iss 1, Pp 1-

    a feasibility study using a hybrid type 2 design

    2022  Volume 9

    Abstract: Abstract Background Incorporating physical movement in the teaching of academic content (active learning) is a promising approach to improve children’s health and academic performance. Despite documented benefits, implementation of active learning ... ...

    Abstract Abstract Background Incorporating physical movement in the teaching of academic content (active learning) is a promising approach to improve children’s health and academic performance. Despite documented benefits, implementation of active learning remains challenging for schools. The aims of this study are to develop an implementation strategy to support the delivery of active learning in elementary schools and examine the impact of the developed implementation strategy on the implementation and effectiveness of active learning. Methods Aim 1 will use Implementation Mapping, which is a multi-step approach that guides the use of theory, stakeholder input, and existing literature to develop a scientifically based implementation strategy for active learning in elementary schools. Aim 2 will feature a feasibility study to examine the impact of the implementation strategy on both implementation and effectiveness outcomes, consistent with a Hybrid Type 2 design. Acceptability and implementation fidelity will be the primary implementation outcomes, and student physical activity levels will be the primary effectiveness outcome. We will recruit two elementary schools within our partner district, and one will be randomly assigned to receive usual support while the other will receive the newly developed implementation strategy. Participants from each school will complete baseline, 6-, and 12-month assessments. Bayesian statistical approaches will quantitatively examine preliminary effectiveness outcomes. We will also use an embedded mixed methods approach to triangulate findings. Discussion This study’s innovative overarching conceptual framework (centered on Implementation Mapping) will inform the development and testing of the implementation strategy. This study also uses methodological approaches optimal for feasibility studies, including mixed methods and Bayesian statistics. As a result, we will be able to gain a thorough understanding about the feasibility and preliminary effectiveness of the implementation strategy, ...
    Keywords Implementation strategies ; Active learning ; Physical activity ; Implementation science ; Implementation Mapping ; Medicine (General) ; R5-920
    Subject code 380
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  8. Article ; Online: Publisher Correction: Using survey data to estimate the impact of the omicron variant on vaccine efficacy against COVID‑19 infection.

    Rufino, Jesús / Baquero, Carlos / Frey, Davide / Glorioso, Christin A / Ortega, Antonio / Reščič, Nina / Roberts, Julian Charles / Lillo, Rosa E / Menezes, Raquel / Champati, Jaya Prakash / Anta, Antonio Fernández

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 1776

    Language English
    Publishing date 2023-01-31
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-28948-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Publisher Correction

    Jesús Rufino / Carlos Baquero / Davide Frey / Christin A. Glorioso / Antonio Ortega / Nina Reščič / Julian Charles Roberts / Rosa E. Lillo / Raquel Menezes / Jaya Prakash Champati / Antonio Fernández Anta

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    Using survey data to estimate the impact of the omicron variant on vaccine efficacy against COVID‑19 infection

    2023  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  10. Article ; Online: Vestibular Implant Surgery.

    Schoo, Desi P / Ward, Bryan K / Chow, Margaret R / Ayiotis, Andrianna I / Fernández Brillet, Celia / Boutros, Peter J / Lane, Kelly E / Lee, Claudia N / Morris, Brian J / Carey, John P / Della Santina, Charles C

    The Laryngoscope

    2023  Volume 134, Issue 4, Page(s) 1842–1846

    MeSH term(s) Humans ; Vestibule, Labyrinth/surgery ; Bilateral Vestibulopathy ; Prostheses and Implants
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top