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Article: Therapeutic effects of probiotics and herbal medications on oxalate nephrolithiasis: a mini systematic review.

Taheri, Hamed / Feizabadi, Mohammad Mehdi / Keikha, Reza / Afkari, Rouhi

2024 Volume 16, Issue 1, Page(s) 4–18

Abstract: Background and objectives: The majority of all kidney stone cases are oxalate urolithiasis with a high risk of recurrence. Beside its widespread occurrence, kidney stones are characterized by severe complications and high treatment costs. Probiotics and ...

Abstract	Background and objectives: The majority of all kidney stone cases are oxalate urolithiasis with a high risk of recurrence. Beside its widespread occurrence, kidney stones are characterized by severe complications and high treatment costs. Probiotics and herbal medications could be forthcoming therapeutic interventions in the management of oxalate kidney stones. Materials and methods: The PubMed/MEDLINE database was searched for keywords " Results: Most of the oxalate-degrading probiotics belong to the Conclusion: Several strains of probiotics and herbal extracts confer protective effects against kidney stone/nephrolithiasis, indicating their promising nature for being considered as elements of preventive / adjuvant therapeutic strategies.
Language	English
Publishing date	2024-04-26
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2652849-6
ISSN	2008-4447 ; 2008-3289
ISSN (online)	2008-4447
ISSN	2008-3289
DOI	10.18502/ijm.v16i1.14866
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Use of Nanobiotechnology in Immunology and Vaccination.

Keikha, Reza / Daliri, Karim / Jebali, Ali

Vaccines

2021 Volume 9, Issue 2

Abstract: Nanotechnology uses the unique properties of nanostructures with a size of 1 to 200 nanometers. Different nanoparticles have shown great promise for the production of new vaccines and drugs. Nanostructures can be used to deliver immunological compounds ... ...

Abstract	Nanotechnology uses the unique properties of nanostructures with a size of 1 to 200 nanometers. Different nanoparticles have shown great promise for the production of new vaccines and drugs. Nanostructures can be used to deliver immunological compounds more effectively than microstructures to target sites. Different nanostructures can be applied to form a new generation of vaccines, adjuvants, and immune system drugs. The goal of nanotechnology is to better respond to a wide range of infectious and non-infectious diseases.
Language	English
Publishing date	2021-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines9020074
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Article ; Online: The evaluation of novel oral vaccines based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum to neutralize SARS-CoV-2 variants alpha and delta.

Keikha, Reza / Hashemi-Shahri, Seyed Mohammad / Jebali, Ali

Scientific reports

2021 Volume 11, Issue 1, Page(s) 21308

Abstract: The aim of this study was to present and evaluate novel oral vaccines, based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum, to neutralize severe acute ...

Abstract	The aim of this study was to present and evaluate novel oral vaccines, based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum, to neutralize severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) variants alpha and delta. After invitro evaluation of the oral vaccines on HEK293T/17 cells, we found that saRNA LNPs, saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum could express S-protein at both mRNA and protein levels. In the next step, BALB/c mice were orally vaccinated with saRNA LNPs, saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum at weeks 1 and 3. Importantly, a high titer of IgG and IgA was observed by all of them, sharply in week 6 (P < 0.05). In all study groups, their ratio of IgG2a/IgG1 was upper 1, indicating Th1-biased responses. Wild-type viral neutralization assay showed that the secreted antibodies in vaccinated mice and recovered COVID-19 patients could neutralize SARS-COV-2 variants alpha and delta. After oral administration of oral vaccines, biodistribution assay was done. It was found that all of them had the same biodistribution pattern. The highest concentration of S-protein was seen in the small intestine, followed by the large intestine and liver.
MeSH term(s)	Administration, Oral ; Adult ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/blood ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/pharmacokinetics ; Female ; HEK293 Cells ; Humans ; Immunoglobulin A/blood ; Immunoglobulin A/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Intestine, Small/metabolism ; Lactobacillus plantarum/genetics ; Lactobacillus plantarum/metabolism ; Lipids/chemistry ; Male ; Mice ; Mice, Inbred BALB C ; Middle Aged ; Models, Animal ; Nanoparticles/chemistry ; Neutralization Tests ; RNA, Messenger/genetics ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism ; Tissue Distribution ; Transfection/methods ; Vaccination/methods ; Vaccines, Synthetic/administration & dosage ; mRNA Vaccines
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin A ; Immunoglobulin G ; Lipids ; RNA, Messenger ; Spike Glycoprotein, Coronavirus ; Vaccines, Synthetic ; spike protein, SARS-CoV-2
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-00830-5
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Article ; Online: The relative expression of miR-31, miR-29, miR-126, and miR-17 and their mRNA targets in the serum of COVID-19 patients with different grades during hospitalization.

Keikha, Reza / Hashemi-Shahri, Seyed Mohammad / Jebali, Ali

European journal of medical research

2021 Volume 26, Issue 1, Page(s) 75

Abstract: Background: The aim of this study was to evaluate the expression of four up/down-regulated inflammatory miRNAs and their mRNA targets in the serum samples of COVID-19 patients with different grades. Also, we investigated the relative expression of these ...

Abstract	Background: The aim of this study was to evaluate the expression of four up/down-regulated inflammatory miRNAs and their mRNA targets in the serum samples of COVID-19 patients with different grades. Also, we investigated the relative expression of these miRNAs and mRNAs during hospitalization. Methods: In this cross-sectional study, 5 mL of blood sample were taken from COVID-19 patients with different grades and during hospitalization from several health centers of Yazd, Tehran, and Zahedan province of Iran from December 20, 2020 to March 2, 2021. The relative expression of miRNAs and mRNAs was evaluated by q-PCR. Results: We found that the relative expression of hsa-miR-31-3p, hsa-miR-29a-3p, and hsa-miR-126-3p was significantly decreased and the relative expression of their mRNA targets (ZMYM5, COL5A3, and CAMSAP1) was significantly increased with the increase of disease grade. Conversely, the relative expression of hsa-miR-17-3p was significantly increased and its mRNA target (DICER1) was significantly decreased with the increase of disease grade. This pattern was exactly seen during hospitalization of COVID-19 patients who did not respond to treatment. In COVID-19 patients who responded to treatment, the expression of selected miRNAs and their mRNA targets returned to the normal level. A negative significant correlation was seen between (1) the expression of hsa-miR-31-3p and ZMYM5, (2) hsa-miR-29a-3p and COL5A3, (3) hsa-miR-126-3p and CAMSAP1, and (4) hsa-miR-17-3p and DICER1 in COVID-19 patients with any grade (P < 0.05) and during hospitalization. Conclusions: In this study, we gained a more accurate understanding of the expression of up/down-regulated inflammatory miRNAs in the blood of COVID-19 patients. The obtained data may help us in the diagnosis and prognosis of COVID-19. Trial registration: The ethics committee of Zahedan University of Medical Sciences, Zahedan, Iran. (Ethical Code: IR.ZAUMS.REC.1399.316) was registered for this project.
MeSH term(s)	COVID-19/blood ; COVID-19/genetics ; COVID-19/virology ; Carrier Proteins/genetics ; Collagen/genetics ; Cross-Sectional Studies ; DEAD-box RNA Helicases/genetics ; Gene Expression Profiling ; Hospitalization/statistics & numerical data ; Humans ; Iran ; MicroRNAs/genetics ; Microtubule-Associated Proteins/genetics ; Nuclear Proteins/genetics ; RNA, Messenger/genetics ; Ribonuclease III/genetics ; SARS-CoV-2/physiology ; Severity of Illness Index
Chemical Substances	CAMSAP1 protein, human ; Carrier Proteins ; MIRN126 microRNA, human ; MIRN17 microRNA, human ; MIRN29a microRNA, human ; MIRN31 microRNA, human ; MicroRNAs ; Microtubule-Associated Proteins ; Nuclear Proteins ; RNA, Messenger ; ZMYM5 protein, human ; Collagen (9007-34-5) ; DICER1 protein, human (EC 3.1.26.3) ; Ribonuclease III (EC 3.1.26.3) ; DEAD-box RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2021-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-021-00544-4
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Zs.A 4636: Show issues

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Article ; Online: The Use of Nanobiotechnology in Immunology and Vaccination

Reza Keikha / Karim Daliri / Ali Jebali

Vaccines, Vol 9, Iss 2, p

2021 Volume 74

Abstract	Nanotechnology uses the unique properties of nanostructures with a size of 1 to 200 nanometers. Different nanoparticles have shown great promise for the production of new vaccines and drugs. Nanostructures can be used to deliver immunological compounds more effectively than microstructures to target sites. Different nanostructures can be applied to form a new generation of vaccines, adjuvants, and immune system drugs. The goal of nanotechnology is to better respond to a wide range of infectious and non-infectious diseases.
Keywords	nanotechnology ; nanostructures ; immunology ; vaccination ; Medicine ; R
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The evaluation of novel oral vaccines based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum to neutralize SARS-CoV-2 variants alpha and delta

Reza Keikha / Seyed Mohammad Hashemi-Shahri / Ali Jebali

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 9

Abstract: Abstract The aim of this study was to present and evaluate novel oral vaccines, based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum, to neutralize ... ...

Abstract	Abstract The aim of this study was to present and evaluate novel oral vaccines, based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum, to neutralize severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) variants alpha and delta. After invitro evaluation of the oral vaccines on HEK293T/17 cells, we found that saRNA LNPs, saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum could express S-protein at both mRNA and protein levels. In the next step, BALB/c mice were orally vaccinated with saRNA LNPs, saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum at weeks 1 and 3. Importantly, a high titer of IgG and IgA was observed by all of them, sharply in week 6 (P < 0.05). In all study groups, their ratio of IgG2a/IgG1 was upper 1, indicating Th1-biased responses. Wild-type viral neutralization assay showed that the secreted antibodies in vaccinated mice and recovered COVID-19 patients could neutralize SARS-COV-2 variants alpha and delta. After oral administration of oral vaccines, biodistribution assay was done. It was found that all of them had the same biodistribution pattern. The highest concentration of S-protein was seen in the small intestine, followed by the large intestine and liver.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The relative expression of miR-31, miR-29, miR-126, and miR-17 and their mRNA targets in the serum of COVID-19 patients with different grades during hospitalization

Reza Keikha / Seyed Mohammad Hashemi-Shahri / Ali Jebali

European Journal of Medical Research, Vol 26, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract Background The aim of this study was to evaluate the expression of four up/down-regulated inflammatory miRNAs and their mRNA targets in the serum samples of COVID-19 patients with different grades. Also, we investigated the relative expression ... ...

Abstract	Abstract Background The aim of this study was to evaluate the expression of four up/down-regulated inflammatory miRNAs and their mRNA targets in the serum samples of COVID-19 patients with different grades. Also, we investigated the relative expression of these miRNAs and mRNAs during hospitalization. Methods In this cross-sectional study, 5 mL of blood sample were taken from COVID-19 patients with different grades and during hospitalization from several health centers of Yazd, Tehran, and Zahedan province of Iran from December 20, 2020 to March 2, 2021. The relative expression of miRNAs and mRNAs was evaluated by q-PCR. Results We found that the relative expression of hsa-miR-31-3p, hsa-miR-29a-3p, and hsa-miR-126-3p was significantly decreased and the relative expression of their mRNA targets (ZMYM5, COL5A3, and CAMSAP1) was significantly increased with the increase of disease grade. Conversely, the relative expression of hsa-miR-17-3p was significantly increased and its mRNA target (DICER1) was significantly decreased with the increase of disease grade. This pattern was exactly seen during hospitalization of COVID-19 patients who did not respond to treatment. In COVID-19 patients who responded to treatment, the expression of selected miRNAs and their mRNA targets returned to the normal level. A negative significant correlation was seen between (1) the expression of hsa-miR-31-3p and ZMYM5, (2) hsa-miR-29a-3p and COL5A3, (3) hsa-miR-126-3p and CAMSAP1, and (4) hsa-miR-17-3p and DICER1 in COVID-19 patients with any grade (P < 0.05) and during hospitalization. Conclusions In this study, we gained a more accurate understanding of the expression of up/down-regulated inflammatory miRNAs in the blood of COVID-19 patients. The obtained data may help us in the diagnosis and prognosis of COVID-19. Trial registration: The ethics committee of Zahedan University of Medical Sciences, Zahedan, Iran. (Ethical Code: IR.ZAUMS.REC.1399.316) was registered for this project.
Keywords	miRNAs ; mRNA ; COVID-19 ; Hospitalization ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Late side effects of cancer treatment in childhood cancer survivors.

Keikhaei, Bijan / Bahadoram, Mohammad / Keikha, Amin / Bahadoram, Sara / Hassanzadeh, Shakiba / Mahmoudian-Sani, Mohammad-Reza

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2022 Volume 29, Issue 4, Page(s) 885–892

Abstract: Introduction: Childhood cancers are usually treated with chemotherapy and radiation. Therefore, understanding the late side effects of such treatments is important to improve the quality of life in childhood cancer survivors. The present study aimed to ... ...

Abstract	Introduction: Childhood cancers are usually treated with chemotherapy and radiation. Therefore, understanding the late side effects of such treatments is important to improve the quality of life in childhood cancer survivors. The present study aimed to investigate the late complications of treatments in childhood cancer survivors. Methods: This study is a retrospective descriptive study. A total number of 93 cases were enrolled in this study. These cases had a history of childhood cancer documented in their medical records at the Shafa Hospital, Ahvaz, Iran. The age range was 5.9-21.3 years and included 62 males and 31 female patients. Results: Many of the patients at this hospital with childhood cancer had experienced chemotherapy side effects as well as late effects of cancer therapy. Hypothyroidism is a late complication of therapy in thoracic cancers and head/neck tumors with relative frequencies of 23.1% and 12.5%, respectively. Scoliosis was observed in the patients undergoing the ABVD + COPP and 8/1 regimens with relative frequencies of 4% and 50%, respectively. Lower growth percentiles were also late side effects of cancer therapy. The highest relative frequency of growth retardation was observed in the <5 age group (46.7%). Restrictive lung changes had an overall relative frequency of 6.5% in male patients with all types of tumors. Sensorineural hearing loss was observed in patients with leukemia and Hodgkin lymphoma with relative frequencies of 8.7% and 24.0, respectively. Conclusion: The occurrence of most side effects could be decreased through early diagnosis, dose adjustment of some drugs, and preventative measures.
MeSH term(s)	Humans ; Child ; Male ; Female ; Child, Preschool ; Adolescent ; Young Adult ; Adult ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Cancer Survivors ; Retrospective Studies ; Quality of Life ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Hodgkin Disease/drug therapy ; Bleomycin/therapeutic use ; Dacarbazine ; Doxorubicin/therapeutic use ; Vinblastine
Chemical Substances	Bleomycin (11056-06-7) ; Dacarbazine (7GR28W0FJI) ; Doxorubicin (80168379AG) ; Vinblastine (5V9KLZ54CY)
Language	English
Publishing date	2022-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/10781552221087611
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Zs.A 4488: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Key security and privacy issues from implementing the National Electronic Health Record in the Islamic Republic of Iran.

Seiedfarajollah, Seyedesedigheh / Safdari, Reza / Ghazisaeedi, Marjan / Keikha, Leila

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

2019 Volume 25, Issue 9, Page(s) 656–659

Abstract: Background: In countries that have not implemented Electronic Health Records (EHR) comprehensively, international organizations are important steps in the development of EHR.: Aims: The objective of this study was to compare different dimensions of ... ...

Abstract	Background: In countries that have not implemented Electronic Health Records (EHR) comprehensively, international organizations are important steps in the development of EHR. Aims: The objective of this study was to compare different dimensions of privacy in the EHR systems in terms of the following standards organizations: ASTM, Health Level Seven (HL7), and International Organization for Standardization (ISO), in order to create a security and privacy model for EHR. Methods: This study was done in two steps: 1) survey of standards organizations, and 2) compare standards in comparative tables. Results: Standards 12, 1 and 5 were extracted from the ASTM, HL7 and ISO respectively. Conclusions: Evidence shows that the goal of standards was to create EHR systems that identified not only the access level of users, but taking consent for reveal information of people and also approved data by authorized persons in a secure framework. In this regard, ASTM looks comprehensive for privacy issues, while ISO18308 focuses on security issues and data interoperability simultaneously, while Hl7 has emphasized access.
MeSH term(s)	Computer Security/standards ; Confidentiality/standards ; Electronic Health Records/standards ; Health Level Seven/standards ; Humans ; Informed Consent/standards ; Iran
Language	English
Publishing date	2019-10-13
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1291071-5
ISSN	1687-1634 ; 1020-3397
ISSN (online)	1687-1634
ISSN	1020-3397
DOI	10.26719/emhj.19.006
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Zs.A 4388: Show issues

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Article ; Online: Parasite-based interventions in systemic lupus erythematosus (SLE): A systematic review.

Jafari, Amirhossein Azari / Keikha, Mojtaba / Mirmoeeni, Seyyedmohammadsadeq / Rahimi, Mohammad Taghi / Jafari, Reza

Autoimmunity reviews

2021 Volume 20, Issue 10, Page(s) 102896

Abstract: Background: The hygiene hypothesis proposed in 1989 expresses that allergic and infectious diseases are inversely related. Accordingly, it has been demonstrated that infection with some microorganisms such as parasites and helminths can provide a ... ...

Abstract	Background: The hygiene hypothesis proposed in 1989 expresses that allergic and infectious diseases are inversely related. Accordingly, it has been demonstrated that infection with some microorganisms such as parasites and helminths can provide a potential immunity and prevent the onset of some life-threatening autoimmune diseases like systemic lupus erythematosus (SLE). Therefore, in this comprehensive study, we systematically reviewed and discussed the use of live parasites or parasitic products in the treatment of mouse models of SLE. Methods: The present systematic review was performed using the following search terms: ("systemic lupus erythematosus" OR "SLE" OR "lupus") AND ("parasite" OR "protozoa" OR "helminths" OR "worms" OR "helminth" OR "worm") in PubMed, Scopus, and Web of Science online databases. We included studies reporting the effect of any intervention using parasites or parasitic-based products on animal models of SLE, which were published until January 20th, 2021 without any language or date restrictions. For each included study, we extracted the authors' names, publication year, type of animal, number of groups, types of intervention, sample size, changes in immunologic cells, auto-Abs, cytokines, and blood cells count, urine analysis, histological analysis of kidney/spleen/liver, outcome and survival. (PROSPERO CRD42020160460). Results: A total of 17 eligible articles were included in this systematic review. Sixteen out of the 17 studies reported immunomodulating changes in immunologic cells, cytokines, and/or auto-Abs in mouse models of SLE after using parasitic interventions compared to not-infected or control groups. Moreover, 14 studies reported decreased level of proteinuria and/or favorable kidney, liver, or spleen histological changes. Conclusion: In conclusion, we have demonstrated that parasites like Hymenolepis microstoma, TPC and ES-62 from Acanthocheilonema viteae, Plasmodium chabaudi, Schistosoma mansoni, and Toxoplasma gondii have favorable immunomodulating effects on SLE outcomes in lupus-prone mice.
MeSH term(s)	Animals ; Cytokines ; Humans ; Kidney ; Lupus Erythematosus, Systemic/therapy ; Mice ; Parasites ; Proteinuria
Chemical Substances	Cytokines
Language	English
Publishing date	2021-07-15
Publishing country	Netherlands
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2021.102896
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