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  1. Article ; Online: Low plasma glucose results in non-diabetic adults referred from primary care are not associated with morbidity, mortality, or underlying endogenous hypoglycemic disorders.

    Linton, Kathryn / Seckl, Jonathan R / Gibb, Fraser W

    Endocrine

    2023  Volume 80, Issue 3, Page(s) 503–504

    MeSH term(s) Adult ; Humans ; Blood Glucose ; Hypoglycemia/epidemiology ; Hypoglycemic Agents ; Morbidity ; Primary Health Care ; Insulin
    Chemical Substances Blood Glucose ; Hypoglycemic Agents ; Insulin
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-023-03314-w
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  2. Article: Growth of

    Padovan, Anna C / Turnbull, Alison R / Nowland, Samantha J / Osborne, Matthew W J / Kaestli, Mirjam / Seymour, Justin R / Gibb, Karen S

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: The opportunistic ... ...

    Abstract The opportunistic pathogen
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12060834
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  3. Article ; Online: COVID-19 vaccine-associated subacute thyroiditis: an unusual suspect for de Quervain's thyroiditis.

    Jeeyavudeen, Mohammad Sadiq / Patrick, Alan W / Gibb, Fraser W / Dover, Anna R

    BMJ case reports

    2021  Volume 14, Issue 11

    Abstract: Subacute thyroiditis following vaccination is an uncommon presentation of thyrotoxicosis. As the world undertakes its largest immunisation campaign to date in an attempt to protect the population from COVID-19 infections, an increasing number of rare ... ...

    Abstract Subacute thyroiditis following vaccination is an uncommon presentation of thyrotoxicosis. As the world undertakes its largest immunisation campaign to date in an attempt to protect the population from COVID-19 infections, an increasing number of rare post vaccine side effects are being observed. We report a case of a middle-aged woman who presented with painful thyroid swelling following the second dose of the COVID-19 mRNA vaccine BNT162b2 (Pfizer-BioNTech) with clinical, biochemical and imaging features consistent with destructive thyrotoxicosis. Symptomatic management only was required for the self-limiting episode. Thyroiditis typically has a mild and self-limiting course and thus this observation should not deter people from vaccination, as COVID-19 infection has a far greater morbidity and mortality risk than thyroiditis.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Female ; Humans ; Middle Aged ; SARS-CoV-2 ; Thyroiditis/chemically induced ; Thyroiditis/diagnosis ; Thyroiditis, Subacute/chemically induced ; Thyroiditis, Subacute/diagnosis
    Chemical Substances COVID-19 Vaccines ; BNT162 vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-11-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-246425
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  4. Article ; Online: Associations between glucagon prescribing, hospital admissions for hypoglycaemia and continuous glucose monitoring metrics in adults with type 1 diabetes.

    Stimson, Roland H / Dover, Anna R / Strachan, Mark W J / Wright, Rohana J / Lyall, Marcus J / Jeeyavudeen, Mohammad S / Forbes, Shareen / Gibb, Fraser W

    Journal of diabetes and its complications

    2023  Volume 37, Issue 9, Page(s) 108561

    Abstract: Aims: To assess features associated with glucagon prescribing and hospital admissions with hypoglycaemia in type one diabetes.: Methods: Observational study of 4462 adults. Outcome measures were features associated with glucagon prescriptions and ... ...

    Abstract Aims: To assess features associated with glucagon prescribing and hospital admissions with hypoglycaemia in type one diabetes.
    Methods: Observational study of 4462 adults. Outcome measures were features associated with glucagon prescriptions and predictors of hospital admissions with hypoglycaemia and high levels of glucagon prescribing.
    Results: 74 % did not collect any glucagon prescriptions and 2.7 % collected >6 over 3.5 years. Hospital admission with hypoglycaemia (P = 0.032), impaired awareness (P = 0.049) and female sex (P < 0.001) were associated with glucagon collection. More frequent prescribing of glucagon was associated with diabetes duration (P < 0.001) and socioeconomic deprivation (P < 0.001). Higher average glucose (P = 0.047), higher time above 13.9 mM (P = 0.008) and higher SD (P = 0.002) were associated with glucagon prescribing. Diabetes duration (P < 0.001) and HbA1c (P < 0.001) were higher in people with hospitalised hypoglycaemia. Higher time above 13.9 mM (P = 0.004) and SD glucose (P < 0.001) were most clearly associated with hospitalised hypoglycaemia.
    Conclusions: A minority of people with type 1 diabetes have access to glucagon suggesting more could be done to better target this treatment. Individuals with risk factors and those with frequent glucagon prescriptions should be identified for interventions known to reduce hypoglycaemia.
    MeSH term(s) Adult ; Humans ; Female ; Glucagon ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/epidemiology ; Blood Glucose ; Blood Glucose Self-Monitoring/adverse effects ; Benchmarking ; Hypoglycemia/chemically induced ; Hypoglycemia/epidemiology ; Hypoglycemia/prevention & control ; Glucose ; Hospitals ; Hypoglycemic Agents/adverse effects
    Chemical Substances Glucagon (9007-92-5) ; Blood Glucose ; Glucose (IY9XDZ35W2) ; Hypoglycemic Agents
    Language English
    Publishing date 2023-07-22
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2023.108561
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    Zs.A 2225: Show issues Location:
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  5. Article ; Online: Changes in continuous glucose monitoring metrics and predictors of improvement 12 months after conversion from Freestyle Libre to Freestyle Libre 2.

    Stimson, Roland H / Dover, Anna R / Strachan, Mark W J / Wright, Rohana J / Forbes, Shareen / Gibb, Fraser W

    Diabetic medicine : a journal of the British Diabetic Association

    2023  Volume 40, Issue 11, Page(s) e15130

    Abstract: Aims: We sought to assess whether conversion from Freestyle Libre to Freestyle Libre 2 (with low and high glucose alert functions) was associated with improved glucose metrics.: Research design and methods: A prospective observational study to assess ...

    Abstract Aims: We sought to assess whether conversion from Freestyle Libre to Freestyle Libre 2 (with low and high glucose alert functions) was associated with improved glucose metrics.
    Research design and methods: A prospective observational study to assess changes in CGM metrics in 672 adults with type 1 diabetes when converting to Freestyle Libre 2. Secondary outcomes included predictors of reduction in time below range (TBR) and increase in time in range (TIR).
    Results: TBR fell by a median of 1.0% (IQR -2.7 to 0.3, p < 0.001) after 12 months and TIR decreased by 1.0% (-8.7 to 6.0, p = 0.004). TIR did not fall in people using high glucose alerts (p = 0.353). Average duration of low glucose events (<3.9 mmoL/L) fell by 10 min (-46 to 18, p < 0.001). Significant improvements in TIR (p = 0.029) and time above 13.9 mM (p = 0.002) were observed in those using high glucose alerts. Alert threshold settings were not associated with glycaemic response; however, low alert use was independently associated with a fall in TBR of ≥0.5% (HR 1.9 [95% CI 1.2-3.1], p = 0.009) and high alert use was independently associated with a rise in TIR of ≥5% (HR 1.6 [95% CI 1.0-2.5], p = 0.043) at 12 months.
    Conclusions: Conversion to Freestyle Libre 2 was associated with significant improvements in low glucose metrics. Alert function users were more likely to see improvements across all CGM metrics. Challenges remain in encouraging alert use, helping users set optimal alert thresholds and optimizing response to alerts.
    MeSH term(s) Adult ; Humans ; Blood Glucose ; Blood Glucose Self-Monitoring ; Diabetes Mellitus, Type 1 ; Prospective Studies
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2023-05-14
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 605769-x
    ISSN 1464-5491 ; 0742-3071 ; 1466-5468
    ISSN (online) 1464-5491
    ISSN 0742-3071 ; 1466-5468
    DOI 10.1111/dme.15130
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    Zs.A 1954: Show issues Location:
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  6. Article ; Online: Direct Evidence of Plasticity within Human Primary Motor and Somatosensory Cortices of Patients with Glioblastoma.

    Gibb, William R / Kong, Nathan W / Tate, Matthew C

    Neural plasticity

    2020  Volume 2020, Page(s) 8893708

    Abstract: Glioblastoma multiforme (GBM) is a devastating disease without cure. It is also the most common primary brain tumor in adults. Although aggressive surgical resection is standard of care, these operations are limited by tumor infiltration of critical ... ...

    Abstract Glioblastoma multiforme (GBM) is a devastating disease without cure. It is also the most common primary brain tumor in adults. Although aggressive surgical resection is standard of care, these operations are limited by tumor infiltration of critical cortical and subcortical regions. A better understanding of how the brain can recover and reorganize function in response to GBM would provide valuable clinical data. This ability, termed neuroplasticity, is not well understood in the adult human brain. A better understanding of neuroplasticity in GBM could allow for improved extent of resection, even in areas classically thought to have critical, static function. The best evidence to date has demonstrated neuroplasticity only in slower growing tumors or through indirect measures such as functional MRI or transcranial magnetic stimulation. In this novel study, we utilize a unique experimental paradigm to show direct evidence of plasticity via serial direct electrocortical stimulation (DES) within primary motor (M1) and somatosensory (S1) cortices in GBM patients. Six patients with glioblastoma multiforme in or near the primary motor or somatosensory cortex were included in this retrospective observational study. These patients had two awake craniotomies with DES to map cortical motor and sensory sites in M1 and S1. Five of six patients exhibited at least one site of neuroplasticity within M1 or S1. Out of the 51 total sites stimulated, 32 (62.7%) demonstrated plasticity. Of these sites, 14 (43.7%) were in M1 and 18 (56.3%) were in S1. These data suggest that even in patients with GBM in or near primary brain regions, significant functional reorganization is possible. This is a new finding which may lead to a better understanding of the fundamental factors promoting or inhibiting plasticity. Further exploration may aid in treatment of patients with brain tumors and other neurologic disorders.
    MeSH term(s) Adult ; Electric Stimulation ; Female ; Glioblastoma/physiopathology ; Humans ; Male ; Middle Aged ; Motor Cortex/physiopathology ; Neuronal Plasticity ; Retrospective Studies ; Somatosensory Cortex/physiopathology ; Young Adult
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1454938-4
    ISSN 1687-5443 ; 2090-5904 ; 0792-8483
    ISSN (online) 1687-5443
    ISSN 2090-5904 ; 0792-8483
    DOI 10.1155/2020/8893708
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    Zs.A 3305: Show issues Location:
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  7. Article ; Online: Children's lead exposure in the U.S.: Application of a national-scale, probabilistic aggregate model with a focus on residential soil and dust lead (Pb) scenarios.

    Zartarian, V G / Xue, J / Gibb-Snyder, E / Frank, J J / Tornero-Velez, R / Stanek, L W

    The Science of the total environment

    2023  Volume 905, Page(s) 167132

    Abstract: Lead (Pb) exposures from soil and dust ingestion contribute to children's blood lead levels (BLLs) in the United States. The U.S. Environmental Protection Agency (EPA)'s Strategy to Reduce Lead Exposures and Disparities in U.S. Communities and the ... ...

    Abstract Lead (Pb) exposures from soil and dust ingestion contribute to children's blood lead levels (BLLs) in the United States. The U.S. Environmental Protection Agency (EPA)'s Strategy to Reduce Lead Exposures and Disparities in U.S. Communities and the Federal Action Plan to Reduce Childhood Lead Exposure describe multi-pronged collaborative approaches. These include reducing multi-media lead exposures nationally using analytical tools such as EPA's Stochastic Human Exposure and Dose Simulation model for lead [SHEDS-Pb; formerly known as SHEDS-IEUBK (Integrated Exposure Uptake Biokinetic model)], which was initially developed and applied with a focus on children's drinking water exposures. In this study we applied SHEDS-Pb to determine what residential soil Pb and dust Pb concentrations (individually and their sum) can keep BLLs of potentially exposed young children in the general U.S. population below specified values, considering aggregate exposures from water, soil, dust, food, and air. We considered two age groups (1 to <2 years and 2 to <6 years), two BLL values (5 μg/dL and 3.5 μg/dL), and two population percentiles (95
    MeSH term(s) Child ; Humans ; United States ; Child, Preschool ; Lead/analysis ; Environmental Exposure/analysis ; Dust/analysis ; Soil ; Nutrition Surveys ; Drinking Water/analysis
    Chemical Substances Lead (2P299V784P) ; Dust ; Soil ; Drinking Water
    Language English
    Publishing date 2023-09-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.167132
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  8. Article: The Future of Biomarkers in Veterinary Medicine: Emerging Approaches and Associated Challenges.

    Perera, Tharangani R W / Skerrett-Byrne, David A / Gibb, Zamira / Nixon, Brett / Swegen, Aleona

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 17

    Abstract: New biomarkers promise to transform veterinary practice through rapid diagnosis of diseases, effective monitoring of animal health and improved welfare and production efficiency. However, the road from biomarker discovery to translation is not always ... ...

    Abstract New biomarkers promise to transform veterinary practice through rapid diagnosis of diseases, effective monitoring of animal health and improved welfare and production efficiency. However, the road from biomarker discovery to translation is not always straightforward. This review focuses on molecular biomarkers under development in the veterinary field, introduces the emerging technological approaches transforming this space and the role of 'omics platforms in novel biomarker discovery. The vast majority of veterinary biomarkers are at preliminary stages of development and not yet ready to be deployed into clinical translation. Hence, we examine the major challenges encountered in the process of biomarker development from discovery, through validation and translation to clinical practice, including the hurdles specific to veterinary practice and to each of the 'omics platforms-transcriptomics, proteomics, lipidomics and metabolomics. Finally, recommendations are made for the planning and execution of biomarker studies with a view to assisting the success of novel biomarkers in reaching their full potential.
    Language English
    Publishing date 2022-08-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12172194
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  9. Article ; Online: Alternative oxidase promotes high iron tolerance in

    Sharma, Rishabh / Gibb, Andrew A / Barnts, Kelcie / Elrod, John W / Puri, Sumant

    Microbiology spectrum

    2023  Volume 11, Issue 6, Page(s) e0215723

    Abstract: Importance: The ... ...

    Abstract Importance: The yeast
    MeSH term(s) Humans ; Animals ; Mice ; Candida albicans/genetics ; Candida albicans/metabolism ; Reactive Oxygen Species/metabolism ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Iron/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism
    Chemical Substances alternative oxidase (EC 1.-) ; Reactive Oxygen Species ; Oxidoreductases (EC 1.-) ; Iron (E1UOL152H7) ; Fungal Proteins
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02157-23
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  10. Article ; Online: Comparison of two carbonaceous supported Fe-rich adsorbents for arsenate removal: A functionalisation and mechanistic study with applicability to groundwater treatment.

    Pap, Sabolc / Turk Sekulic, Maja / Tran, Hai Nguyen / Chao, Huan-Ping / Gilbert, Peter J / Gibb, Stuart W / Taggart, Mark A

    Chemosphere

    2024  , Page(s) 142205

    Abstract: ... model best described the experimental results with high correlation coefficients (R ...

    Abstract The presence of arsenic in groundwater, and through this in drinking water, has been shown to present a serious risk to public health in many regions of the world. In this study, two iron-rich carbonous adsorbents were compared for the removal of arsenate (As(V)) from groundwater. Biochars (FeO-biochar and FeO-pyrochar) derived from biomass waste were functionalised in two different ways with iron chloride for comparation. Batch and dynamic parameters were optimised to achieve >99% As(V) removal efficiency. Experimental data best described by the pseudo-second order kinetic model, while multi-stage diffusion appeared to limit mass transfer of As(V). Among the isotherm models evaluated, the Freundlich model best described the experimental results with high correlation coefficients (R
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.142205
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