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  1. Article: Involvement of α

    Alsufyani, Hadeel A / Docherty, James R

    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

    2023  Volume 27, Issue 4, Page(s) 325–331

    Abstract: ... ...

    Abstract α
    Language English
    Publishing date 2023-06-29
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 1387595-4
    ISSN 2093-3827 ; 1226-4512
    ISSN (online) 2093-3827
    ISSN 1226-4512
    DOI 10.4196/kjpp.2023.27.4.325
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    Zs.A 4872: Show issues Location:
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  2. Article ; Online: Effects of RS17053 on α

    Alsufyani, Hadeel A / Docherty, James R

    Fundamental & clinical pharmacology

    2023  Volume 37, Issue 6, Page(s) 1170–1178

    Abstract: Background: RS17053 is classed as an α: Objectives: We have examined its profile of action at all subtypes of α: Methods: Noradrenaline (NA) evoked contractions of rat vas deferens involve α: Results: RS17053 (10: Conclusion: Results in rat ... ...

    Abstract Background: RS17053 is classed as an α
    Objectives: We have examined its profile of action at all subtypes of α
    Methods: Noradrenaline (NA) evoked contractions of rat vas deferens involve α
    Results: RS17053 (10
    Conclusion: Results in rat vas deferens demonstrate low potency of RS17053 at α
    MeSH term(s) Male ; Rats ; Animals ; Prazosin/pharmacology ; Vas Deferens/physiology ; Receptors, Adrenergic, alpha-1/physiology ; Norepinephrine/pharmacology ; Aorta
    Chemical Substances Prazosin (XM03YJ541D) ; Receptors, Adrenergic, alpha-1 ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2023-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 639134-5
    ISSN 1472-8206 ; 0767-3981
    ISSN (online) 1472-8206
    ISSN 0767-3981
    DOI 10.1111/fcp.12930
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    Zs.A 2247: Show issues Location:
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  3. Article: Transition Readiness Into Adult Health Care in Children With Inflammatory Bowel Disease.

    Alsufyani, Hadeel A / Jar, Sondos / Jambi, Wehad S / Meer, Nuha / Bajunaid, Weam / Albaradei, Hadeel A / Alharbi, Nadin A / Aziz, Haneen / Mosli, Mahmoud / Saadah, Omar I

    Cureus

    2023  Volume 15, Issue 10, Page(s) e46825

    Abstract: Background and aim Approximately 25% of inflammatory bowel disease (IBD) cases are diagnosed before the age of 18 years. Compared to adults, pediatric IBD is more aggressive and progresses rapidly. It is important to have a well-structured transition ... ...

    Abstract Background and aim Approximately 25% of inflammatory bowel disease (IBD) cases are diagnosed before the age of 18 years. Compared to adults, pediatric IBD is more aggressive and progresses rapidly. It is important to have a well-structured transition process in place when patients are transferred from pediatric to adult care. We aimed to evaluate the readiness of Saudi adolescents with IBD to be transitioned from pediatric to adult care using the Transition Readiness Assessment Questionnaire (TRAQ). Materials and methods This cross-sectional study was carried out at King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia, between January and December 2021. Pediatric patients aged between 12-18 with confirmed IBD were recruited. The mean TRAQ component and the overall scores were calculated and analyzed. Results A total of 54 patients with IBD were included. The overall mean TRAQ scores were moderately high (3.60±0.78), including high mean values for individual domains of the TRAQ. In terms of components of TRAQ, no significant differences between males and females were encountered; however, there was a trend for males having higher scores than females in tracking health issues (P=0.07). Patients older than 15 years had higher overall scores than younger patients (P=0.04). The level of child education was found to be the only independent variable that correlated with higher overall scores (P=0.005). Conclusions In this cohort of Saudi adolescents with IBD, patients showed moderately high overall mean TRAQ scores reflecting high readiness for transitioning. While males demonstrated a trend for higher scores compared to females in tracking health issues, patients older than 15 had higher total scores relative to younger patients. More studies are needed to examine the impact of better transition readiness on the long-term outcome of IBD.
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46825
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  4. Article: Roles for α

    Alsufyani, Hadeel A / Docherty, James R

    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

    2021  Volume 25, Issue 6, Page(s) 525–532

    Abstract: We have investigated the relative roles of ... ...

    Abstract We have investigated the relative roles of α
    Language English
    Publishing date 2021-10-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 1387595-4
    ISSN 2093-3827 ; 1226-4512
    ISSN (online) 2093-3827
    ISSN 1226-4512
    DOI 10.4196/kjpp.2021.25.6.525
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    Zs.A 4872: Show issues Location:
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  5. Article ; Online: Pharmacology of Drugs Used as Stimulants.

    Docherty, James R / Alsufyani, Hadeel A

    Journal of clinical pharmacology

    2021  Volume 61 Suppl 2, Page(s) S53–S69

    Abstract: Psychostimulant, cardiovascular, and temperature actions of stimulants involve adrenergic (norepinephrine), dopaminergic (dopamine), and serotonergic (serotonin) pathways. Stimulants such as amphetamine, 3,4-methylenedioxymethamphetamine (MDMA), or ... ...

    Abstract Psychostimulant, cardiovascular, and temperature actions of stimulants involve adrenergic (norepinephrine), dopaminergic (dopamine), and serotonergic (serotonin) pathways. Stimulants such as amphetamine, 3,4-methylenedioxymethamphetamine (MDMA), or mephedrone can act on the neuronal membrane monoamine transporters NET, DAT, and SERT and/or the vesicular monoamine transporter 2 to inhibit reuptake of neurotransmitter or cause release by reverse transport. Stimulants may have additional effects involving pre- and postsynaptic/junctional receptors for norepinephrine, dopamine, and serotonin and other receptors. As a result, stimulants may have a wide range of possible actions. Agents with cocaine or MDMA-like actions can induce serious and potentially fatal adverse events via thermodysregulatory, cardiovascular, or other mechanisms. MDMA-like stimulants may cause hyperthermia that can be life threathening. Recreational users of stimulants should be aware of the dangers of hyperthermia in a rave/club environment.
    MeSH term(s) Central Nervous System Stimulants/pharmacology ; Dopamine/metabolism ; Humans ; Neurotransmitter Transport Proteins/metabolism ; Norepinephrine/metabolism ; Serotonin/metabolism ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/pathology
    Chemical Substances Central Nervous System Stimulants ; Neurotransmitter Transport Proteins ; Serotonin (333DO1RDJY) ; Dopamine (VTD58H1Z2X) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2021-08-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 188980-1
    ISSN 1552-4604 ; 0091-2700 ; 0021-9754
    ISSN (online) 1552-4604
    ISSN 0091-2700 ; 0021-9754
    DOI 10.1002/jcph.1918
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  6. Article ; Online: Cardiovascular and temperature adverse actions of stimulants.

    Docherty, James R / Alsufyani, Hadeel A

    British journal of pharmacology

    2021  Volume 178, Issue 13, Page(s) 2551–2568

    Abstract: The vast majority of illicit stimulants act at monoaminergic systems, causing both psychostimulant and adverse effects. Stimulants can interact as substrates or antagonists at the nerve terminal monoamine transporter that mediates the reuptake of ... ...

    Abstract The vast majority of illicit stimulants act at monoaminergic systems, causing both psychostimulant and adverse effects. Stimulants can interact as substrates or antagonists at the nerve terminal monoamine transporter that mediates the reuptake of monoamines across the nerve synaptic membrane and at the vesicular monoamine transporter (VMAT-2) that mediates storage of monoamines in vesicles. Stimulants can act directly at presynaptic or postsynaptic receptors for monoamines or have indirect monoamine-mimetic actions due to the release of monoamines. Cocaine and other stimulants can acutely increase the risk of sudden cardiac death. Stimulants, particularly MDMA, in hot conditions, such as that occurring at a "rave," have caused fatalities from the consequences of hyperthermia, often compounding cardiac adverse actions. This review examines the pharmacology of the cardiovascular and temperature adverse actions of stimulants.
    MeSH term(s) Biological Transport ; Central Nervous System Stimulants/adverse effects ; Cocaine/adverse effects ; Temperature ; Vesicular Monoamine Transport Proteins/metabolism
    Chemical Substances Central Nervous System Stimulants ; Vesicular Monoamine Transport Proteins ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2021-05-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15465
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  7. Article: The renin angiotensin aldosterone system and COVID-19.

    Alsufyani, Hadeel A / Docherty, James R

    Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

    2020  Volume 28, Issue 8, Page(s) 977–984

    Abstract: The ongoing pandemic has stimulated study of the Renin Angiotensin Aldosterone System (RAAS), and how it can be manipulated to treat COVID-19. Studies are examining whether drugs that act on the RAAS system might be useful to treat COVID-19. COVID-19 and ...

    Abstract The ongoing pandemic has stimulated study of the Renin Angiotensin Aldosterone System (RAAS), and how it can be manipulated to treat COVID-19. Studies are examining whether drugs that act on the RAAS system might be useful to treat COVID-19. COVID-19 and the RAAS are closely linked both in infection and in possible post-infection inflammatory cascades. We detail the Physiology and
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country Saudi Arabia
    Document type Journal Article ; Review
    ZDB-ID 1378024-4
    ISSN 1319-0164
    ISSN 1319-0164
    DOI 10.1016/j.jsps.2020.06.019
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    Zs.A 4758: Show issues Location:
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  8. Article ; Online: Involvement of G proteins and Rho kinase in α

    Alsufyani, Hadeel A / Docherty, James R

    Canadian journal of physiology and pharmacology

    2020  Volume 99, Issue 6, Page(s) 654–659

    Abstract: Contractions of the rat portal vein in response to the ... ...

    Abstract Contractions of the rat portal vein in response to the α
    MeSH term(s) Animals ; Male ; Portal Vein ; Rats ; Receptors, Adrenergic, alpha-1 ; rho-Associated Kinases
    Chemical Substances Receptors, Adrenergic, alpha-1 ; ROCK1 protein, human (EC 2.7.11.1) ; rho-Associated Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2020-10-23
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 127527-6
    ISSN 1205-7541 ; 0008-4212
    ISSN (online) 1205-7541
    ISSN 0008-4212
    DOI 10.1139/cjpp-2020-0347
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    Zs.A 589: Show issues Location:
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  9. Article ; Online: Renin-Angiotensin System Implications to COVID-19 Comorbidities.

    Alsufyani, Hadeel A / Alrefaie, Zienab

    Journal of microscopy and ultrastructure

    2020  Volume 8, Issue 4, Page(s) 148–151

    Abstract: The role of the renin-angiotensin system (RAS) and its pharmacological modulators in the susceptibility and outcomes of SARS CoV-2 pandemic (COVID-19) has been much discussed recently. Angiotensin-converting enzyme type 2 (ACE2) has attracted much ... ...

    Abstract The role of the renin-angiotensin system (RAS) and its pharmacological modulators in the susceptibility and outcomes of SARS CoV-2 pandemic (COVID-19) has been much discussed recently. Angiotensin-converting enzyme type 2 (ACE2) has attracted much attention and debate in relevance to COVID-19. It not only acts as the receptor to which the SARS CoV-2 virus binds to be introduced into cells but also balances the effects of angiotensin II offering anti-inflammatory and antifibrotic protective actions to different organs. This mini-review aims to shed some light on the possible involvement of ACE2 and RAS alternate pathways in the comorbidities and clinical findings observed in COVID-19 patients.
    Language English
    Publishing date 2020-12-10
    Publishing country India
    Document type Journal Article ; Review
    ISSN 2213-8803
    ISSN (online) 2213-8803
    DOI 10.4103/jmau.jmau_105_20
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  10. Article ; Online: Body composition profile of children and adolescent patients with inflammatory bowel disease.

    Alsufyani, Hadeel A / Mosli, Mahmoud M / Saadah, Omar I

    International journal of clinical practice

    2021  Volume 75, Issue 5, Page(s) e14023

    Abstract: Background and aims: Children with inflammatory bowel disease (IBD) generally show an alteration in their fat and soft tissue mass contents. These alterations may influence disease severity and increase the risk of post-operative complications.: ... ...

    Abstract Background and aims: Children with inflammatory bowel disease (IBD) generally show an alteration in their fat and soft tissue mass contents. These alterations may influence disease severity and increase the risk of post-operative complications.
    Methods: This is a retrospective cross-sectional study of patients with IBD, diagnosed and followed up between 2013 and 2018, in Jeddah, Saudi Arabia, who had dual-energy x-ray absorptiometry (DXA) scans for bone density evaluation. Obesity was defined based on fat mass index (FMI) and myopenia based on appendicular skeletal muscle mass (SMMa).
    Results: This study incorporated 95 child and adolescent patients (52% female) with IBD: 59 with Crohn's disease (CD) and 36 with ulcerative colitis (UC), mean age 11.8 ± 3.3 years and mean duration of illness 1.8 ± 1.9 years. The most common disease phenotype and behaviour for CD patients were ileocolonic (57.6%) and non-stricturing and non-penetrating (76.3%). Of UC patients, 75% had extensive disease (pancolitis). Body composition profile in the total IBD cohort was classified as normal in 49.5%, obese in 26.3%, myopenic in 23.2% and myopenic-obese in 1.1%. The use of biological therapy was identified as a negative predictor for both obesity (OR = 7.0, 95% CI: 1.3-37.9, P = .02) and myopenia (OR = 0.11, 95% CI:0.02-0.47, P = .003), and female gender was shown to predict myopenia (OR = 3.5, 95% CI: 1.0-11.8, P = .04).
    Conclusions: Saudi Arabian children with IBD showed comparable body composition profiles to adult patients with IBD. Biological therapy was associated with a decreased incidence of both obesity and myopenia, and female gender was found to predict myopenia.
    MeSH term(s) Adolescent ; Adult ; Body Composition ; Child ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/drug therapy ; Cross-Sectional Studies ; Female ; Humans ; Inflammatory Bowel Diseases/complications ; Male ; Retrospective Studies ; Saudi Arabia/epidemiology
    Language English
    Publishing date 2021-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.14023
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