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Article ; Online: Response to Ski CF & Thompson DR (2011) Commentary on Yohannes AM, Doherty P, Bundy C & Yalfani A (2010) The long-term benefits of cardiac rehabilitation on depression, anxiety, physical activity and quality of life. Journal of Clinical Nursing 19, 2806-2813.

Yohannes, Abebaw M / Doherty, Patrick / Bundy, Christine / Yalfani, Ali

2011 Volume 20, Issue 23-24, Page(s) 3587–3588

MeSH term(s)	Anxiety ; Depression ; Heart Diseases/rehabilitation ; Humans ; Motor Activity ; Quality of Life
Language	English
Publishing date	2011-12
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	1159483-4
ISSN	1365-2702 ; 0962-1067 ; 1752-9816
ISSN (online)	1365-2702
ISSN	0962-1067 ; 1752-9816
DOI	10.1111/j.1365-2702.2011.03980.x
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Zs.A 3764: Show issues

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Article ; Online: Roles of arginine and lysine residues in the translocation of a cell-penetrating peptide from (13)C, (31)P, and (19)F solid-state NMR.

Su, Yongchao / Doherty, Tim / Waring, Alan J / Ruchala, Piotr / Hong, Mei

Biochemistry

2009 Volume 48, Issue 21, Page(s) 4587–4595

Abstract: ... Low-temperature (13)C-(31)P distances between the peptide and the lipid phosphates indicate that both the Arg(10 ... of two cationic residues, Arg(10) and Lys(13), in the CPP penetratin. (13)C chemical shifts indicate ... guanidinium Czeta atom and the Lys(13) Cepsilon atom are close to the lipid (31)P (4.0-4.2 A), proving ...

Abstract	Cell-penetrating peptides (CPPs) are small cationic peptides that cross the cell membrane while carrying macromolecular cargoes. We use solid-state NMR to investigate the structure and lipid interaction of two cationic residues, Arg(10) and Lys(13), in the CPP penetratin. (13)C chemical shifts indicate that Arg(10) adopts a rigid beta-strand conformation in the liquid-crystalline state of anionic lipid membranes. This behavior contrasts with all other residues observed so far in this peptide, which adopt a dynamic beta-turn conformation with coil-like chemical shifts at physiological temperature. Low-temperature (13)C-(31)P distances between the peptide and the lipid phosphates indicate that both the Arg(10) guanidinium Czeta atom and the Lys(13) Cepsilon atom are close to the lipid (31)P (4.0-4.2 A), proving the existence of charge-charge interaction for both Arg(10) and Lys(13) in the gel-phase membrane. However, since lysine substitution in CPPs is known to weaken their translocation ability, we propose that the low temperature stabilizes interactions of both lysine and arginine with the phosphates, whereas at high temperatures, the lysine-phosphate interaction is much weaker than the arginine-phosphate interaction. This is supported by the unusually high rigidity of the Arg(10) side chain and its beta-strand conformation at high temperatures. The latter is proposed to be important for ion pair formation by allowing close approach of the lipid headgroups to guanidinium side chains. (19)F and (13)C spin diffusion experiments indicate that penetratin is oligomerized into beta-sheets in gel-phase membranes. These solid-state NMR data indicate that guanidinium-phosphate interactions exist in penetratin, and guanidinium groups play a stronger structural role than ammonium groups in the lipid-assisted translocation of CPPs across liquid-crystalline cell membranes.
MeSH term(s)	Amino Acid Sequence ; Arginine ; Carrier Proteins/chemistry ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Membrane/metabolism ; Cell-Penetrating Peptides ; Hydrophobic and Hydrophilic Interactions ; Lipid Metabolism ; Lipids/chemistry ; Lysine ; Magnetic Resonance Spectroscopy ; Molecular Sequence Data ; Mutation ; Protein Multimerization ; Protein Structure, Quaternary ; Protein Transport ; Temperature
Chemical Substances	Carrier Proteins ; Cell-Penetrating Peptides ; Lipids ; Arginine (94ZLA3W45F) ; penetratin (A2AQZ20TEK) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2009-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/bi900080d
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Zs.A 217: Show issues

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Article: CoVID Tracker Ireland: What is its Function?

Banks, J / Doherty, C P

Irish medical journal

2022 Volume 115, Issue 1, Page(s) 513

MeSH term(s)	COVID-19 ; Humans ; Ireland/epidemiology ; SARS-CoV-2
Language	English
Publishing date	2022-01-20
Publishing country	Ireland
Document type	Editorial
ZDB-ID	193134-9
ISSN	0332-3102 ; 0021-129X
ISSN	0332-3102 ; 0021-129X
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Zs.B 148: Show issues

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Article ; Online: Use of 5-alpha reductase inhibitors and risk of gastrointestinal cancers in men with benign prostatic hyperplasia: A population-based cohort study.

Doherty, Niamh / Cardwell, Chris / Murchie, Peter / Hill, Christopher / Azoulay, Laurent / Hicks, Blánaid

International journal of cancer

2024

Abstract: Pre-clinical evidence suggests that 5-alpha reductase inhibitors (5ARi's), prescribed in the treatment of benign prostatic hyperplasia, reduce colorectal and gastro-oesophageal cancer incidence via action on the male hormonal pathway. However, few ... ...

Abstract	Pre-clinical evidence suggests that 5-alpha reductase inhibitors (5ARi's), prescribed in the treatment of benign prostatic hyperplasia, reduce colorectal and gastro-oesophageal cancer incidence via action on the male hormonal pathway. However, few studies to date have investigated this association at the population level. Our study aimed to investigate the risk of colorectal and gastro-oesophageal cancers with the use of 5ARi's. We conducted a retrospective cohort study of new users of 5ARi's and alpha-blockers among patients with benign prostatic hyperplasia in the UK Clinical Practice Research Datalink. Patients were followed until a first ever diagnosis of colorectal or gastro-oesophageal cancer, death from any cause or end of registration with the general practice or 31st of December 2017. Cox proportional hazards models with inverse probability of treatment weights were used to calculate weighted hazard ratios (HR) and 95% confidence intervals (CIs) of incident colorectal cancer or gastro-oesophageal cancer associated with the use of 5ARi's compared to alpha-blockers. During a mean follow-up of 6.6 years, we found no association between the use of 5ARi's and colorectal (HR: 1.13, 95% CI 0.91-1.41) or gastro-oesophageal (HR 1.14, 95% CI 0.76-1.63) cancer risk compared to alpha-blockers. Sensitivity analysis showed largely consistent results when varying lag periods, using multiple imputations, and accounting for competing risk of death. Our study found no association between the use of 5ARi's and risk of colorectal or gastro-oesophageal cancer in men with benign prostatic hyperplasia.
Language	English
Publishing date	2024-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34937
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article ; Online: Mitigating Illumination-, Leaf-, and View-Angle Dependencies in Hyperspectral Imaging Using Polarimetry.

Krafft, Daniel / Scarboro, Clifton G / Hsieh, William / Doherty, Colleen / Balint-Kurti, Peter / Kudenov, Michael

Plant phenomics (Washington, D.C.)

2024 Volume 6, Page(s) 157

Abstract: Automation of plant phenotyping using data from high-dimensional imaging sensors is on the forefront of agricultural research for its potential to improve seasonal yield by monitoring crop health and accelerating breeding programs. A common challenge ... ...

Abstract	Automation of plant phenotyping using data from high-dimensional imaging sensors is on the forefront of agricultural research for its potential to improve seasonal yield by monitoring crop health and accelerating breeding programs. A common challenge when capturing images in the field relates to the spectral reflection of sunlight (glare) from crop leaves that, at certain solar incidences and sensor viewing angles, presents unwanted signals. The research presented here involves the convergence of 2 parallel projects to develop a facile algorithm that can use polarization data to decouple light reflected from the surface of the leaves and light scattered from the leaf's tissue. The first project is a mast-mounted hyperspectral imaging polarimeter (HIP) that can image a maize field across multiple diurnal cycles throughout a growing season. The second project is a multistatic fiber-based Mueller matrix bidirectional reflectance distribution function (mmBRDF) instrument which measures the polarized light-scattering behavior of individual maize leaves. The mmBRDF data was fitted to an existing model, which outputs parameters that were used to run simulations. The simulated data were then used to train a shallow neural network which works by comparing unpolarized 2-band vegetation index (VI) with linearly polarized data from the low-reflectivity bands of the VI. Using GNDVI and red-edge reflection ratio we saw an improvement of an order of magnitude or more in the mean error (
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ISSN	2643-6515
ISSN (online)	2643-6515
DOI	10.34133/plantphenomics.0157
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Article ; Online: Trauma Surgeons Experience Compassion Fatigue - A Major Metropolitan Area Survey.

Hoefer, Lea / Tatebe, Leah C / Patel, Purvi / Tyson, Anna / Kingsley, Samuel / Chang, Grace / Kaminsky, Matt / Doherty, James / Hampton, David

The journal of trauma and acute care surgery

2024

Abstract: ... and CS. Significance was p ≤ 0.05.: Results: There were 57 TS (response rate:75.4% (n = 43 ... p < 0.01). Night shifts were associated with higher BO (Coef: 1.55, 95% CI: 0.07-3.03, p = 0.05 ... conversely day shifts were associated with higher STS (Coef: 1.94, 95% CI: 0.32-3.56, p = 0.03). Higher TEQ ...

Abstract	Introduction: Compassion Fatigue (CF), the physical, emotional, and psychological impact of helping others, is composed of three domains: Compassion Satisfaction (CS), Secondary Traumatic Stress (STS), and Burnout (BO). Trauma surgeons (TS) experience work-related stress resulting in high rates of CF which can manifest as physical and psychological disorders. We hypothesized that TS experience CF and there are potentially modifiable systemic factors to mitigate its symptoms. Methods: All TS in a major metropolitan area were eligible. Personal and professional demographic information was obtained. Each participant completed six validated surveys: 1) Professional Quality of Life Scale (Pro-QOL), 2) Perceived Stress Scale (PSS), 3) Multidimensional Scale of Perceived Social Support (MSPSS), 4) Adverse Childhood Events (ACE) Questionnaire, 5) Brief Coping Inventory (BCI), and 6) Toronto Empathy Questionnaire (TEQ). CF subscale risk scores (low:<23, moderate:23-41, high:>41) were recorded. Linear regression analysis assessed the demographic and environmental factors association with BO, STS, and CS. Variables significant on univariate analysis were included in multivariate models to determine the independent influence on BO, STS, and CS. Significance was p ≤ 0.05. Results: There were 57 TS (response rate:75.4% (n = 43); Caucasian: 65% (n = 28), male:67% (n = 29)). TS experienced CF (BO:26 (IQR: 21-32), STS:23 (IQR: 19-32), CS:39 (IQR: 34-45)). The PSS score was significantly associated with increased BO (Coef: 0.52, 95% CI: 0.28-0.77) and STS (Coef: 0.44. 95% CI: 0.15-0.73), and decreased CS (Coef: -0.51, 95% CI: -0.80- -0.23) (p < 0.01). Night shifts were associated with higher BO (Coef: 1.55, 95% CI: 0.07-3.03, p = 0.05), conversely day shifts were associated with higher STS (Coef: 1.94, 95% CI: 0.32-3.56, p = 0.03). Higher TEQ scores were associated with greater CS (Coef: 0.33, 95% CI: 0.12-0.55, p < 0.01). Conclusion: TS experience moderate BO and STS associated with modifiable system- and work-related stressors. Efforts to reduce CF should focus on addressing sources of workplace stress and promoting empathic care. Level of evidence: III, Prognostic and Epidemiological.
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000004223
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Zs.A 127: Show issues

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Article ; Online: Benefits of routine probiotic supplementation in preterm infants.

Rath, C P / Athalye-Jape, G / Nathan, E / Doherty, D / Rao, S / Patole, S

Acta paediatrica (Oslo, Norway : 1992)

2023 Volume 112, Issue 11, Page(s) 2352–2358

Abstract: Aim: We introduced routine probiotic supplementation (RPS) of preterm infants in June 2012. We previously reported that RPS reduced the incidence of necrotising enterocolitis (NEC) and mortality in such infants. In this study, we assessed if the ... ...

Abstract	Aim: We introduced routine probiotic supplementation (RPS) of preterm infants in June 2012. We previously reported that RPS reduced the incidence of necrotising enterocolitis (NEC) and mortality in such infants. In this study, we assessed if the benefits of RPS were sustained for infants in the current era. Method: We compared the outcomes of preterm infants in recent epoch 3 (RPS, 1st June 2014 to 31st December 2019) versus epoch 2 (RPS, 1st June 2012 to 31st May 2014) and epoch 1 (no RPS, 1st December 2008 to 30th November 2010). Multiple logistic and Cox regression models were used to compare the outcomes. Results: There were 645 infants in epoch 1, 712 in epoch 2 and 1715 in epoch 3. Age at full feeds was significantly lower in epoch 3 vs. 2 and epoch 3 vs. 1 in infants <28 weeks of gestation. NEC and late-onset sepsis (LOS) were significantly lower in epoch 3 vs. 1 in infants <28 weeks. LOS and age at full feeds were significantly lower in epoch 3 vs. 2 and epoch 3 vs. 1 in infants with gestation 28 to 32 weeks. Conclusion: The benefits associated with RPS were sustained during epoch 3.
MeSH term(s)	Infant ; Infant, Newborn ; Humans ; Infant, Premature ; Probiotics/therapeutic use ; Incidence ; Sepsis ; Infant, Premature, Diseases/epidemiology ; Enterocolitis, Necrotizing/epidemiology ; Enterocolitis, Necrotizing/prevention & control ; Infant, Very Low Birth Weight
Language	English
Publishing date	2023-08-02
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.16924
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Article: [Progress and practice of objective measurement of physical behaviors in large-scale cohort research].

Chen, Y Y / Ke, Y L / Lyu, J / Sun, D J Y / Pan, L / Pei, P / Du, H D / Chen, J S / Chen, Z M / Li, L M / Doherty, D O H E R T Y / Yu, C Q

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2024 Volume 45, Issue 1, Page(s) 35–40

Abstract: Due to the limited reliability of traditional self-completed questionnaire, the accuracy of measurement of physical behaviors (physical activity, sedentary behavior and sleep) is not high. With the development of technology, wearable devices (e.g. ... ...

Abstract	Due to the limited reliability of traditional self-completed questionnaire, the accuracy of measurement of physical behaviors (physical activity, sedentary behavior and sleep) is not high. With the development of technology, wearable devices (e.g. accelerometer) can be used for more accurate measurement of physical behaviors and have great application potential in large-scale research. However, the data of objective measurement of physical behaviors from large-scale cohort research in Asian populations is still limited. Between August 2020 and December 2021, the 3
MeSH term(s)	Humans ; Female ; Aged ; Middle Aged ; Male ; Reproducibility of Results ; Accelerometry ; Exercise ; Surveys and Questionnaires ; Sleep
Language	Chinese
Publishing date	2024-01-17
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.cn112338-20230724-00036
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Zs.B 3276: Show issues

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Article ; Online: The UK government's 2022 food strategy a year later.

Doherty, Bob / Jackson, Peter / Wagstaff, Carol / White, Martin / Duncombe, Tracey

Nature food

2023 Volume 4, Issue 10, Page(s) 824–825

Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Letter
ISSN	2662-1355
ISSN (online)	2662-1355
DOI	10.1038/s43016-023-00859-x
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Article ; Online: Physical Telerehabilitation interventions for Gait and balance in Multiple sclerosis: A Scoping review.

Doherty, Fiona / Powell, Paul / McBride, Ciara / Monaghan, Kenneth

Journal of the neurological sciences

2023 Volume 456, Page(s) 122827

Abstract: Background: Gait and balance impairments affects approximately a quarter of people with multiple sclerosis (pwMS) at onset and increases to almost half by five years. Physical rehabilitation has been recognised as the gold standard method to restore ... ...

Abstract	Background: Gait and balance impairments affects approximately a quarter of people with multiple sclerosis (pwMS) at onset and increases to almost half by five years. Physical rehabilitation has been recognised as the gold standard method to restore physical function in multiple sclerosis (MS). Emerging evidence in the literature is suggesting that a remote therapy rehabilitation platform (Telerehabilitation) is cost-effective, beneficial, and satisfying for patients and health care practitioners. The overarching aim of this review is to identify and summarise the evidence on the different types of telerehabilitation interventions available to manage gait and balance. Methods: This review followed a methodological framework for conducting scoping reviews. PubMed, Science Direct and Web of Science were searched in April 2023 for relevant published literature. The inclusion criteria were peer-reviewed journal articles written in English which included telerehabilitation interventions for pwMS. Search keywords included multiple sclerosis and telerehabilitation. A reviewer screened titles and abstracts and eligible articles were fully reviewed. The included studies were categorised based on the type of intervention. Results: Eight studies were included in this review. The participants (n = 355) had an average age of 48 years (SD = 9.9) with 50% who had relapsing remitting multiple sclerosis who were living with MS for 12 years on average. Study designs included randomised control trials (n = 3), pilot studies and feasibility studies (n = 4). Two types of interventions were identified: Exergaming (n = 5) and Web-Based Physical Therapy (n = 2) of which exergaming appeared to be optimal in improving gait and balance. Conclusion: This scoping review identified and summarised the evidence on telerehabilitation interventions used for gait and balance in MS. The evidence is showing that telerehabilitation could be used as an alternative to conventional rehabilitation methods for improving gait and balance. More robust trials with larger sample sizes are needed to build on the current evidence to enable telerehabilitation to be integrated into care pathways in the future.
MeSH term(s)	Humans ; Middle Aged ; Telerehabilitation/methods ; Multiple Sclerosis/complications ; Multiple Sclerosis/rehabilitation ; Gait ; Multiple Sclerosis, Relapsing-Remitting ; Physical Therapy Modalities
Language	English
Publishing date	2023-12-07
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2023.122827
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