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Article ; Online: Why sequence all eukaryotes?

Blaxter, Mark / Archibald, John M / Childers, Anna K / Coddington, Jonathan A / Crandall, Keith A / Di Palma, Federica / Durbin, Richard / Edwards, Scott V / Graves, Jennifer A M / Hackett, Kevin J / Hall, Neil / Jarvis, Erich D / Johnson, Rebecca N / Karlsson, Elinor K / Kress, W John / Kuraku, Shigehiro / Lawniczak, Mara K N / Lindblad-Toh, Kerstin / Lopez, Jose V /

Moran, Nancy A / Robinson, Gene E / Ryder, Oliver A / Shapiro, Beth / Soltis, Pamela S / Warnow, Tandy / Zhang, Guojie / Lewin, Harris A

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 4

Abstract: Life on Earth has evolved from initial simplicity to the astounding complexity we experience today. Bacteria and archaea have largely excelled in metabolic diversification, but eukaryotes additionally display abundant morphological innovation. How have ... ...

Abstract	Life on Earth has evolved from initial simplicity to the astounding complexity we experience today. Bacteria and archaea have largely excelled in metabolic diversification, but eukaryotes additionally display abundant morphological innovation. How have these innovations come about and what constraints are there on the origins of novelty and the continuing maintenance of biodiversity on Earth? The history of life and the code for the working parts of cells and systems are written in the genome. The Earth BioGenome Project has proposed that the genomes of all extant, named eukaryotes-about 2 million species-should be sequenced to high quality to produce a digital library of life on Earth, beginning with strategic phylogenetic, ecological, and high-impact priorities. Here we discuss why we should sequence all eukaryotic species, not just a representative few scattered across the many branches of the tree of life. We suggest that many questions of evolutionary and ecological significance will only be addressable when whole-genome data representing divergences at all of the branchings in the tree of life or all species in natural ecosystems are available. We envisage that a genomic tree of life will foster understanding of the ongoing processes of speciation, adaptation, and organismal dependencies within entire ecosystems. These explorations will resolve long-standing problems in phylogenetics, evolution, ecology, conservation, agriculture, bioindustry, and medicine.
MeSH term(s)	Animals ; Base Sequence/genetics ; Biodiversity ; Biological Evolution ; Ecology ; Ecosystem ; Eukaryota/genetics ; Genome ; Genomics/ethics ; Genomics/methods ; Humans ; Phylogeny
Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2115636118
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Article ; Online: Visual symptoms in Parkinson's disease and Parkinson's disease dementia.

Archibald, Neil K / Clarke, Mike P / Mosimann, Urs P / Burn, David J

Movement disorders : official journal of the Movement Disorder Society

2011 Volume 26, Issue 13, Page(s) 2387–2395

Abstract: Visual symptoms are common in PD and PD dementia and include difficulty reading, double vision, illusions, feelings of presence and passage, and complex visual hallucinations. Despite the established prognostic implications of complex visual ... ...

Abstract	Visual symptoms are common in PD and PD dementia and include difficulty reading, double vision, illusions, feelings of presence and passage, and complex visual hallucinations. Despite the established prognostic implications of complex visual hallucinations, the interaction between cognitive decline, visual impairment, and other visual symptoms remains poorly understood. Our aim was to characterize the spectrum of visual symptomatology in PD and examine clinical predictors for their occurrence. Sixty-four subjects with PD, 26 with PD dementia, and 32 age-matched controls were assessed for visual symptoms, cognitive impairment, and ocular pathology. Complex visual hallucinations were common in PD (17%) and PD dementia (89%). Dementia subjects reported illusions (65%) and presence (62%) more frequently than PD or control subjects, but the frequency of passage hallucinations in PD and PD dementia groups was equivalent (48% versus 69%, respectively; P = 0.102). Visual acuity and contrast sensitivity was impaired in parkinsonian subjects, with disease severity and age emerging as the key predictors. Regression analysis identified a variety of factors independently predictive of complex visual hallucinations (e.g., dementia, visual acuity, and depression), illusions (e.g., excessive daytime somnolence and disease severity), and presence (e.g., rapid eye movement sleep behavior disorder and excessive daytime somnolence). Our results demonstrate that different "hallucinatory" experiences in PD do not necessarily share common disease predictors and may, therefore, be driven by different pathophysiological mechanisms. If confirmed, such a finding will have important implications for future studies of visual symptoms and cognitive decline in PD and PD dementia.
MeSH term(s)	Aged ; Cognition Disorders/diagnosis ; Cognition Disorders/physiopathology ; Dementia/diagnosis ; Dementia/physiopathology ; Female ; Hallucinations/diagnosis ; Hallucinations/physiopathology ; Humans ; Male ; Neuropsychological Tests ; Parkinson Disease/diagnosis ; Parkinson Disease/physiopathology ; Psychiatric Status Rating Scales ; Severity of Illness Index ; Vision Disorders/diagnosis ; Vision Disorders/physiopathology
Language	English
Publishing date	2011-09-27
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.23891
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Article ; Online: Standards recommendations for the Earth BioGenome Project.

Lawniczak, Mara K N / Durbin, Richard / Flicek, Paul / Lindblad-Toh, Kerstin / Wei, Xiaofeng / Archibald, John M / Baker, William J / Belov, Katherine / Blaxter, Mark L / Marques Bonet, Tomas / Childers, Anna K / Coddington, Jonathan A / Crandall, Keith A / Crawford, Andrew J / Davey, Robert P / Di Palma, Federica / Fang, Qi / Haerty, Wilfried / Hall, Neil /

Hoff, Katharina J / Howe, Kerstin / Jarvis, Erich D / Johnson, Warren E / Johnson, Rebecca N / Kersey, Paul J / Liu, Xin / Lopez, Jose Victor / Myers, Eugene W / Pettersson, Olga Vinnere / Phillippy, Adam M / Poelchau, Monica F / Pruitt, Kim D / Rhie, Arang / Castilla-Rubio, Juan Carlos / Sahu, Sunil Kumar / Salmon, Nicholas A / Soltis, Pamela S / Swarbreck, David / Thibaud-Nissen, Françoise / Wang, Sibo / Wegrzyn, Jill L / Zhang, Guojie / Zhang, He / Lewin, Harris A / Richards, Stephen

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 4

Abstract: A global international initiative, such as the Earth BioGenome Project (EBP), requires both agreement and coordination on standards to ensure that the collective effort generates rapid progress toward its goals. To this end, the EBP initiated five ... ...

Abstract	A global international initiative, such as the Earth BioGenome Project (EBP), requires both agreement and coordination on standards to ensure that the collective effort generates rapid progress toward its goals. To this end, the EBP initiated five technical standards committees comprising volunteer members from the global genomics scientific community: Sample Collection and Processing, Sequencing and Assembly, Annotation, Analysis, and IT and Informatics. The current versions of the resulting standards documents are available on the EBP website, with the recognition that opportunities, technologies, and challenges may improve or change in the future, requiring flexibility for the EBP to meet its goals. Here, we describe some highlights from the proposed standards, and areas where additional challenges will need to be met.
MeSH term(s)	Animals ; Base Sequence/genetics ; Biodiversity ; Eukaryota/genetics ; Genomics/methods ; Genomics/standards ; Humans ; Reference Standards ; Reference Values ; Sequence Analysis, DNA/methods ; Sequence Analysis, DNA/standards
Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2115639118
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Article ; Online: Visual exploration in Parkinson's disease and Parkinson's disease dementia.

Archibald, Neil K / Hutton, Sam B / Clarke, Michael P / Mosimann, Urs P / Burn, David J

Brain : a journal of neurology

2013 Volume 136, Issue Pt 3, Page(s) 739–750

Abstract: Parkinson's disease, typically thought of as a movement disorder, is increasingly recognized as causing cognitive impairment and dementia. Eye movement abnormalities are also described, including impairment of rapid eye movements (saccades) and the ... ...

Abstract	Parkinson's disease, typically thought of as a movement disorder, is increasingly recognized as causing cognitive impairment and dementia. Eye movement abnormalities are also described, including impairment of rapid eye movements (saccades) and the fixations interspersed between them. Such movements are under the influence of cortical and subcortical networks commonly targeted by the neurodegeneration seen in Parkinson's disease and, as such, may provide a marker for cognitive decline. This study examined the error rates and visual exploration strategies of subjects with Parkinson's disease, with and without cognitive impairment, whilst performing a battery of visuo-cognitive tasks. Error rates were significantly higher in those Parkinson's disease groups with either mild cognitive impairment (P = 0.001) or dementia (P < 0.001), than in cognitively normal subjects with Parkinson's disease. When compared with cognitively normal subjects with Parkinson's disease, exploration strategy, as measured by a number of eye tracking variables, was least efficient in the dementia group but was also affected in those subjects with Parkinson's disease with mild cognitive impairment. When compared with control subjects and cognitively normal subjects with Parkinson's disease, saccade amplitudes were significantly reduced in the groups with mild cognitive impairment or dementia. Fixation duration was longer in all Parkinson's disease groups compared with healthy control subjects but was longest for cognitively impaired Parkinson's disease groups. The strongest predictor of average fixation duration was disease severity. Analysing only data from the most complex task, with the highest error rates, both cognitive impairment and disease severity contributed to a predictive model for fixation duration [F(2,76) = 12.52, P ≤ 0.001], but medication dose did not (r = 0.18, n = 78, P = 0.098, not significant). This study highlights the potential use of exploration strategy measures as a marker of cognitive decline in Parkinson's disease and reveals the efficiency by which fixations and saccades are deployed in the build-up to a cognitive response, rather than merely focusing on the outcome itself. The prolongation of fixation duration, present to a small but significant degree even in cognitively normal subjects with Parkinson's disease, suggests a disease-specific impact on the networks directing visual exploration, although the study also highlights the multi-factorial nature of changes in exploration and the significant impact of cognitive decline on efficiency of visual search.
MeSH term(s)	Aged ; Dementia/etiology ; Dementia/physiopathology ; Female ; Humans ; Male ; Parkinson Disease/etiology ; Parkinson Disease/physiopathology ; Saccades
Language	English
Publishing date	2013-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awt005
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Article ; Online: The 'Step by Step' Diabetic Foot Project in Tanzania: a model for improving patient outcomes in less-developed countries.

Abbas, Zulfiqarali G / Lutale, Janet K / Bakker, Karel / Baker, Neil / Archibald, Lennox K

International wound journal

2011 Volume 8, Issue 2, Page(s) 169–175

Abstract: Foot complications cause substantial morbidity in Tanzania, where 70% of leg amputations occur in diabetic patients. The Step by Step Foot Project was initiated to train healthcare personnel in diabetic foot management, facilitate transfer of knowledge ... ...

Abstract	Foot complications cause substantial morbidity in Tanzania, where 70% of leg amputations occur in diabetic patients. The Step by Step Foot Project was initiated to train healthcare personnel in diabetic foot management, facilitate transfer of knowledge and expertise, and improve patient education. The project comprised a 3-day basic course with an interim period 1-year of for screening, followed by an advanced course and evaluation of activities. Fifteen centres from across Tanzania participated during 2004-2006 and 12 during 2004-2007. Of 11,714 patients screened in 2005, 4335 (37%) had high-risk feet. Of 461 (11%) with ulcers, 45 (9·8%) underwent major amputation. Of 3860 patients screened during 2006-2007, there was a significant increase in the proportion with ulcers and amputations compared with 2005 (P < 0·001), likely a result of enhanced case finding. During 2005-2008, there was a fall in the incidence of foot ulcers in patient referrals to the main tertiary care centre in Dar es Salaam and a parallel fall in amputation among these referrals. In conclusion, the Step by Step Foot Project in Tanzania improved foot ulcer management for persons with diabetes and resulted in permanent, operational foot clinics across the country. This programme is an effective model for improving outcomes in other less-developed countries.
MeSH term(s)	Developing Countries ; Diabetic Foot/epidemiology ; Diabetic Foot/prevention & control ; Humans ; Incidence ; Mass Screening ; Patient Education as Topic ; Program Development/methods ; Retrospective Studies ; Tanzania/epidemiology ; Treatment Outcome
Language	English
Publishing date	2011-01-25
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/j.1742-481X.2010.00764.x
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Article ; Online: The retina in Parkinson's disease.

Archibald, Neil K / Clarke, Michael P / Mosimann, Urs P / Burn, David J

Brain : a journal of neurology

2009 Volume 132, Issue Pt 5, Page(s) 1128–1145

Abstract: As a more complete picture of the clinical phenotype of Parkinson's disease emerges, non-motor symptoms have become increasingly studied. Prominent among these non-motor phenomena are mood disturbance, cognitive decline and dementia, sleep disorders, ... ...

Abstract	As a more complete picture of the clinical phenotype of Parkinson's disease emerges, non-motor symptoms have become increasingly studied. Prominent among these non-motor phenomena are mood disturbance, cognitive decline and dementia, sleep disorders, hyposmia and autonomic failure. In addition, visual symptoms are common, ranging from complaints of dry eyes and reading difficulties, through to perceptual disturbances (feelings of presence and passage) and complex visual hallucinations. Such visual symptoms are a considerable cause of morbidity in Parkinson's disease and, with respect to visual hallucinations, are an important predictor of cognitive decline as well as institutional care and mortality. Evidence exists of visual dysfunction at several levels of the visual pathway in Parkinson's disease. This includes psychophysical, electrophysiological and morphological evidence of disruption of retinal structure and function, in addition to disorders of 'higher' (cortical) visual processing. In this review, we will draw together work from animal and human studies in an attempt to provide an insight into how Parkinson's disease affects the retina and how these changes might contribute to the visual symptoms experienced by patients.
MeSH term(s)	Aging/physiology ; Animals ; Dopamine/metabolism ; Electroretinography ; Evoked Potentials, Visual ; Hallucinations/pathology ; Hallucinations/physiopathology ; Hallucinations/psychology ; Humans ; Neurons/metabolism ; Neurons/pathology ; Neuropsychological Tests ; Parkinson Disease/pathology ; Parkinson Disease/physiopathology ; Parkinson Disease/psychology ; Retina/pathology ; Retina/physiopathology ; Visual Acuity ; Visual Pathways ; Visual Perception
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2009-03-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awp068
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Article ; Online: Standards recommendations for the earth biogenome project

Lawniczak, Mara K.N. / Durbin, Richard / Flicek, Paul / Lindblad-Toh, Kerstin / Wei, Xiaofeng / Archibald, John M. / Baker, William J. / Belov, Katherine / Blaxter, Mark L. / Bonet, Tomas Marques / Childers, Anna K. / Davey, Robert P. / Di Palma, Federica / Fang, Qi / Wilfried, Haerty / Hall, Neil / Hoff, Katharina J. / Howe, Kerstin / Jarvis, Erich D. /

Proceedings of the National Academy of Sciences of the United States of America. 2022 Jan. 25, v. 119, no. 4

2022

Abstract: A global international initiative such as the Earth BioGenome Project (EBP) requires both agreement and coordination on standards to ensure that the collective effort generates rapid progress towards its goals. Towards this end the EBP initiated five ... ...

Abstract	A global international initiative such as the Earth BioGenome Project (EBP) requires both agreement and coordination on standards to ensure that the collective effort generates rapid progress towards its goals. Towards this end the EBP initiated five technical standards committees comprising volunteer members from the global genomics scientific community: Sample Collection and Processing; Sequencing and Assembly; Annotation; Analysis; and IT and Informatics. The current versions of the resulting standards documents are available on the EBP website (earthbiogenome.org), with the recognition that opportunities, technologies and challenges may improve or change in the future requiring flexibility for the EBP to meet its goals. Here, we describe some highlights from the standards process, and areas where additional challenges will need to be met.
Keywords	Internet ; area ; committees ; metagenomics ; sampling ; volunteerism ; volunteers ; wills ; United States
Language	English
Dates of publication	2022-0125
Document type	Article ; Online
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2115639118
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Article ; Online: The Earth BioGenome Project 2020: Starting the clock.

Lewin, Harris A / Richards, Stephen / Lieberman Aiden, Erez / Allende, Miguel L / Archibald, John M / Bálint, Miklós / Barker, Katharine B / Baumgartner, Bridget / Belov, Katherine / Bertorelle, Giorgio / Blaxter, Mark L / Cai, Jing / Caperello, Nicolette D / Carlson, Keith / Castilla-Rubio, Juan Carlos / Chaw, Shu-Miaw / Chen, Lei / Childers, Anna K / Coddington, Jonathan A /

Conde, Dalia A / Corominas, Montserrat / Crandall, Keith A / Crawford, Andrew J / DiPalma, Federica / Durbin, Richard / Ebenezer, ThankGod E / Edwards, Scott V / Fedrigo, Olivier / Flicek, Paul / Formenti, Giulio / Gibbs, Richard A / Gilbert, M Thomas P / Goldstein, Melissa M / Graves, Jennifer Marshall / Greely, Henry T / Grigoriev, Igor V / Hackett, Kevin J / Hall, Neil / Haussler, David / Helgen, Kristofer M / Hogg, Carolyn J / Isobe, Sachiko / Jakobsen, Kjetill Sigurd / Janke, Axel / Jarvis, Erich D / Johnson, Warren E / Jones, Steven J M / Karlsson, Elinor K / Kersey, Paul J / Kim, Jin-Hyoung / Kress, W John / Kuraku, Shigehiro / Lawniczak, Mara K N / Leebens-Mack, James H / Li, Xueyan / Lindblad-Toh, Kerstin / Liu, Xin / Lopez, Jose V / Marques-Bonet, Tomas / Mazard, Sophie / Mazet, Jonna A K / Mazzoni, Camila J / Myers, Eugene W / O'Neill, Rachel J / Paez, Sadye / Park, Hyun / Robinson, Gene E / Roquet, Cristina / Ryder, Oliver A / Sabir, Jamal S M / Shaffer, H Bradley / Shank, Timothy M / Sherkow, Jacob S / Soltis, Pamela S / Tang, Boping / Tedersoo, Leho / Uliano-Silva, Marcela / Wang, Kun / Wei, Xiaofeng / Wetzer, Regina / Wilson, Julia L / Xu, Xun / Yang, Huanming / Yoder, Anne D / Zhang, Guojie

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 4

MeSH term(s)	Animals ; Base Sequence/genetics ; Biodiversity ; Eukaryota/genetics ; Genomics ; Humans
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Introductory Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2115635118
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Article ; Online: Improving Conversations about Parkinson's Dementia.

Dobreva, Ivelina / Thomas, Joanne / Marr, Anne / O'Connell, Ruairiadh / Roche, Moïse / Hannaway, Naomi / Dore, Charlotte / Rose, Sian / Liu, Ken / Bhome, Rohan / Baldwin-Jones, Sion / Roberts, Janet / Archibald, Neil / Alston, Duncan / Amar, Khaled / Edwards, Emma / Foley, Jennifer A / Haunton, Victoria J / Henderson, Emily J /

Jha, Ashwani / Lindop, Fiona / Magee, Cathy / Massey, Luke / Ruiz-Mendoza, Eladia / Mohamed, Biju / Patterson, Katherine / Ramaswamy, Bhanu / Schrag, Anette / Silverdale, Monty / Suárez-González, Aida / Subramanian, Indu / Foltynie, Tom / Williams-Gray, Caroline H / Yarnall, Alison J / Carroll, Camille / Bale, Claire / Hugill, Cassandra / Weil, Rimona S

Movement disorders clinical practice

2024

Abstract: Background: People with Parkinson's disease (PD) have an increased risk of dementia, yet patients and clinicians frequently avoid talking about it due to associated stigma, and the perception that "nothing can be done about it". However, open ... ...

Abstract	Background: People with Parkinson's disease (PD) have an increased risk of dementia, yet patients and clinicians frequently avoid talking about it due to associated stigma, and the perception that "nothing can be done about it". However, open conversations about PD dementia may allow people with the condition to access treatment and support, and may increase participation in research aimed at understanding PD dementia. Objectives: To co-produce information resources for patients and healthcare professionals to improve conversations about PD dementia. Methods: We worked with people with PD, engagement experts, artists, and a PD charity to open up these conversations. 34 participants (16 PD; 6 PD dementia; 1 Parkinsonism, 11 caregivers) attended creative workshops to examine fears about PD dementia and develop information resources. 25 PD experts contributed to the resources. Results: While most people with PD (70%) and caregivers (81%) shared worries about cognitive changes prior to the workshops, only 38% and 30%, respectively, had raised these concerns with a healthcare professional. 91% of people with PD and 73% of caregivers agreed that PD clinicians should ask about cognitive changes routinely through direct questions and perform cognitive tests at clinic appointments. We used insights from the creative workshops, and input from a network of PD experts to co-develop two open-access resources: one for people with PD and their families, and one for healthcare professionals. Conclusion: Using artistic and creative workshops, co-learning and striving for diverse voices, we co-produced relevant resources for a wider audience to improve conversations about PD dementia.
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article
ISSN	2330-1619
ISSN (online)	2330-1619
DOI	10.1002/mdc3.14054
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Article: Crystal structure of di-chlorido-(4,11-dimethyl-1,4,8,11-tetra-aza-bicyclo-[6.6.2]hexa-deca-ne)iron(III) hexa-fluorido-phosphate.

Funwie, Neil L / Cain, Amy N / Fanning, Brian Z / Hageman, Serena A / Mullens, Malorie / Roberts, Travis K / Turner, Daniel J / Valdez, Cammi N / Vaughan, Robert W / Ermias, Henok G / Silversides, Jon D / Archibald, Stephen J / Hubin, Timothy J / Prior, Timothy J

Acta crystallographica. Section E, Crystallographic communications

2015 Volume 71, Issue Pt 9, Page(s) 1073–1076

Abstract: The title compound, [FeCl2(C14H30N4)]PF6, contains Fe(3+) coordinated by the four nitro-gen atoms of an ethyl-ene cross-bridged cyclam macrocycle and two cis chloride ligands in a distorted octa-hedral environment. In contrast to other similar compounds ... ...

Abstract	The title compound, [FeCl2(C14H30N4)]PF6, contains Fe(3+) coordinated by the four nitro-gen atoms of an ethyl-ene cross-bridged cyclam macrocycle and two cis chloride ligands in a distorted octa-hedral environment. In contrast to other similar compounds this is a monomer. Inter-molecular C-H⋯Cl inter-actions exist in the structure between the complex ions. Comparison with the mononuclear Fe(2+) complex of the same ligand shows that the smaller Fe(3+) ion is more fully engulfed by the cavity of the bicyclic ligand. Comparison with the μ-oxido dinuclear complex of an unsubstituted ligand of the same size demonstrates that the methyl groups of 4,11-dimethyl-1,4,8,11-tetra-aza-bicyclo-[6.6.2]hexa-decane prevent dimerization upon oxidation.
Language	English
Publishing date	2015-08-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2041947-8
ISSN	2056-9890 ; 1600-5368
ISSN	2056-9890 ; 1600-5368
DOI	10.1107/S2056989015015340
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