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  1. Article ; Online: 24 h Rest/Activity Rhythms in Older Adults with Memory Impairment: Associations with Cognitive Performance and Depressive Symptomatology.

    Antonsdottir, Inga M / Low, Dominique V / Chen, Diefei / Rabinowitz, Jill A / Yue, Yiwei / Urbanek, Jacek / Wu, Mark N / Zeitzer, Jamie M / Rosenberg, Paul B / Friedman, Leah F / Sheikh, Javaid I / Yesavage, Jerome A / Zipunnikov, Vadim / Spira, Adam P

    Advanced biology

    2023  Volume 7, Issue 11, Page(s) e2300138

    Abstract: Little is known about links of circadian rhythm alterations with neuropsychiatric symptoms and cognition in memory impaired older adults. Associations of actigraphic rest/activity rhythms (RAR) with depressive symptoms and cognition are examined using ... ...

    Abstract Little is known about links of circadian rhythm alterations with neuropsychiatric symptoms and cognition in memory impaired older adults. Associations of actigraphic rest/activity rhythms (RAR) with depressive symptoms and cognition are examined using function-on-scalar regression (FOSR). Forty-four older adults with memory impairment (mean: 76.84 ± 8.15 years; 40.9% female) completed 6.37 ± 0.93 days of actigraphy, the Beck depression inventory-II (BDI-II), mini-mental state examination (MMSE) and consortium to establish a registry for Alzheimer's disease (CERAD) delayed word recall. FOSR models with BDI-II, MMSE, or CERAD as individual predictors adjusted for demographics (Models A1-A3) and all three predictors and demographics (Model B). In Model B, higher BDI-II scores are associated with greater activity from 12:00-11:50 a.m., 2:10-5:50 p.m., 8:40-9:40 p.m., 11:20-12:00 a.m., higher CERAD scores with greater activity from 9:20-10:00 p.m., and higher MMSE scores with greater activity from 5:50-10:50 a.m. and 12:40-5:00 p.m. Greater depressive symptomatology is associated with greater activity in midafternoon, evening, and overnight into midday; better delayed recall with greater late evening activity; and higher global cognitive performance with greater morning and afternoon activity (Model B). Time-of-day specific RAR alterations may affect mood and cognitive performance in this population.
    MeSH term(s) Humans ; Female ; Male ; Aged ; Neuropsychological Tests ; Cognition ; Circadian Rhythm ; Alzheimer Disease ; Memory Disorders/diagnosis
    Language English
    Publishing date 2023-07-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2701-0198
    ISSN (online) 2701-0198
    DOI 10.1002/adbi.202300138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: An updated h-index measures both the primary and total scientific output of a researcher.

    Bucur, Octavian / Almasan, Alex / Zubarev, Roman / Friedman, Mark / Nicolson, Garth L / Sumazin, Pavel / Leabu, Mircea / Nikolajczyk, Barbara S / Avram, Dorina / Kunej, Tanja / Calin, George A / Godwin, Andrew K / Adami, Hans-Olov / Zaphiropoulos, Peter G / Richardson, Des R / Schmitt-Ulms, Gerold / Westerblad, Håkan / Keniry, Megan / Grau, Georges E R /
    Carbonetto, Salvatore / Stan, Radu V / Popa-Wagner, Aurel / Takhar, Kasumov / Baron, Beverly W / Galardy, Paul J / Yang, Feng / Data, Dipak / Fadare, Oluwole / Yeo, Kt Jerry / Gabreanu, Georgiana R / Andrei, Stefan / Soare, Georgiana R / Nelson, Mark A / Liehn, Elisa A

    Discoveries (Craiova, Romania)

    2015  Volume 3, Issue 3

    Abstract: ... in the field he/she works in. A scientist's Hirsch-index (h-index) quantifies their total effective published ... output, but h-index summarizes the total value of their published work without regard ... the same weight as articles where the author played a minor role. Thus, we propose an updated h-index named ...

    Abstract The growing interest in scientometry stems from ethical concerns related to the proper evaluation of scientific contributions of an author working in a hard science. In the absence of a consensus, institutions may use arbitrary methods for evaluating scientists for employment and promotion. There are several indices in use that attempt to establish the most appropriate and suggestive position of any scientist in the field he/she works in. A scientist's Hirsch-index (h-index) quantifies their total effective published output, but h-index summarizes the total value of their published work without regard to their contribution to each publication. Consequently, articles where the author was a primary contributor carry the same weight as articles where the author played a minor role. Thus, we propose an updated h-index named Hirsch(p,t)-index that informs about both total scientific output and output where the author played a primary role. Our measure, h(p,t) = h(p),h(t), is composed of the h-index h(t) and the h-index calculated for articles where the author was a key contributor; i.e. first/shared first or senior or corresponding author. Thus, a h(p,t) = 5,10 would mean that the author has 5 articles as first, shared first, senior or corresponding author with at least 5 citations each, and 10 total articles with at least 10 citations each. This index can be applied in biomedical disciplines and in all areas where the first and last position on an article are the most important. Although other indexes, such as r- and w-indexes, were proposed for measuring the authors output based on the position of researchers within the published articles, our simpler strategy uses the already established algorithms for h-index calculation and may be more practical to implement.
    Language English
    Publishing date 2015-09-30
    Publishing country Romania
    Document type Journal Article
    ISSN 2359-7232
    ISSN 2359-7232
    DOI 10.15190/d.2015.42
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In Memoriam: Robert H. Wilkins, MD, 1934 to 2017.

    Ewend, Matthew G / Friedman, Allan H / Sampson, John H

    Neurosurgery

    2017  Volume 81, Issue 1, Page(s) 6–8

    Language English
    Publishing date 2017-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyx283
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  4. Article ; Online: Obituary. Robert H. Wilkins, MD, 1934-2017.

    Sampson, John H / Haglund, Michael M / Friedman, Allan H / Ewend, Matthew G

    Journal of neurosurgery

    2017  Volume 127, Issue 6, Page(s) 1457–1458

    Language English
    Publishing date 2017-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2017.6.JNS171416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Korea, M*A*S*H, and the accidental pioneers of vascular surgery.

    Friedman, Steven G

    Journal of vascular surgery

    2017  Volume 66, Issue 2, Page(s) 666–670

    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2017.01.055
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  6. Book: Sleisenger & Fordtran's gastrointestinal and liver disease / 1 / Mark Feldman ; Lawrence S. Friedman ; Marvin H. Sleisenger

    Feldman, Mark / Sleisenger, Marvin H. / Fordtran, John S. / Friedman, Lawrence S.

    pathophysiology, diagnosis, management

    2002  

    Collection Sleisenger & Fordtran's gastrointestinal and liver disease
    Language English
    Size XLI, 1192, I-98 S. : Ill., graph. Darst.
    Edition 7. ed., 1. print.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013427661
    ISBN 0-7216-8973-6 ; 978-0-7216-8973-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 A 4078 order for loan Magazin

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  7. Book: Sleisenger & Fordtran's gastrointestinal and liver disease / 2 / Mark Feldman ; Lawrence S. Friedman ; Marvin H. Sleisenger

    Feldman, Mark / Sleisenger, Marvin H. / Fordtran, John S. / Friedman, Lawrence S.

    pathophysiology, diagnosis, management

    2002  

    Collection Sleisenger & Fordtran's gastrointestinal and liver disease
    Language English
    Size XLI S., S. 1195 - 2385, I-98 S. : Ill., graph. Darst.
    Edition 7. ed., 1. print.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013427678
    ISBN 0-7216-8973-6 ; 978-0-7216-8973-9
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: The dimerization equilibrium of a ClC Cl(-)/H(+) antiporter in lipid bilayers.

    Chadda, Rahul / Krishnamani, Venkatramanan / Mersch, Kacey / Wong, Jason / Brimberry, Marley / Chadda, Ankita / Kolmakova-Partensky, Ludmila / Friedman, Larry J / Gelles, Jeff / Robertson, Janice L

    eLife

    2016  Volume 5

    Abstract: Interactions between membrane protein interfaces in lipid bilayers play an important role in membrane protein folding but quantification of the strength of these interactions has been challenging. Studying dimerization of ClC-type transporters offers a ... ...

    Abstract Interactions between membrane protein interfaces in lipid bilayers play an important role in membrane protein folding but quantification of the strength of these interactions has been challenging. Studying dimerization of ClC-type transporters offers a new approach to the problem, as individual subunits adopt a stable and functionally verifiable fold that constrains the system to two states - monomer or dimer. Here, we use single-molecule photobleaching analysis to measure the probability of ClC-ec1 subunit capture into liposomes during extrusion of large, multilamellar membranes. The capture statistics describe a monomer to dimer transition that is dependent on the subunit/lipid mole fraction density and follows an equilibrium dimerization isotherm. This allows for the measurement of the free energy of ClC-ec1 dimerization in lipid bilayers, revealing that it is one of the strongest membrane protein complexes measured so far, and introduces it as new type of dimerization model to investigate the physical forces that drive membrane protein association in membranes.
    MeSH term(s) Chloride Channels/metabolism ; Lipid Bilayers ; Protein Multimerization ; Single Molecule Imaging
    Chemical Substances CLC-1 channel ; Chloride Channels ; Lipid Bilayers
    Language English
    Publishing date 2016-08-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.17438
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  9. Article: "Triple-H" therapy for cerebral vasospasm following subarachnoid hemorrhage.

    Lee, Kendall H / Lukovits, Timothy / Friedman, Jonathan A

    Neurocritical care

    2006  Volume 4, Issue 1, Page(s) 68–76

    Abstract: The combination of induced hypertension, hypervolemia, and hemodilution (triple-H therapy) is often ... Although this paradigm has gained widespread acceptance over the past 20 years, the efficacy of triple-H therapy and ... its precise role in the management of the acute phase of SAH remains uncertain. In addition, triple-H therapy ...

    Abstract The combination of induced hypertension, hypervolemia, and hemodilution (triple-H therapy) is often utilized to prevent and treat cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). Although this paradigm has gained widespread acceptance over the past 20 years, the efficacy of triple-H therapy and its precise role in the management of the acute phase of SAH remains uncertain. In addition, triple-H therapy may carry significant medical morbidity, including pulmonary edema, myocardial ischemia, hyponatremia, renal medullary washout, indwelling catheter-related complications, cerebral hemorrhage, and cerebral edema. This review examines the evidence underlying the implementation of triple-H therapy, and makes practical recommendations for the use of this therapy in patients with aneurysmal SAH.
    MeSH term(s) Blood Volume ; Cerebrovascular Circulation/physiology ; Hemodilution ; Humans ; Hypertension ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/physiopathology ; Subarachnoid Hemorrhage/therapy ; Vasospasm, Intracranial/etiology ; Vasospasm, Intracranial/physiopathology ; Vasospasm, Intracranial/prevention & control
    Language English
    Publishing date 2006
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1385/NCC:4:1:068
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  10. Article ; Online: H-ras localizes to cell nuclei and varies with the cell cycle.

    Contente, Sara / Yeh, Tze-Jou Annie / Friedman, Robert M

    Genes & cancer

    2013  Volume 2, Issue 2, Page(s) 166–172

    Abstract: H-Ras functions as a signal switch molecule in numerous signaling pathways in the cytoplasm ... requiring H-Ras localization to the inner surface of the cytoplasmic membrane, and H-Ras is considered to be ... a cytoplasmic protein. Immunoblot studies of cells transformed by overexpression of c-H-ras indicated that H ...

    Abstract H-Ras functions as a signal switch molecule in numerous signaling pathways in the cytoplasm, requiring H-Ras localization to the inner surface of the cytoplasmic membrane, and H-Ras is considered to be a cytoplasmic protein. Immunoblot studies of cells transformed by overexpression of c-H-ras indicated that H-Ras protein was present in both cytoplasmic and nuclear extracts, suggesting a possible correlation of nuclear H-Ras and cellular transformation. Unexpectedly, additional studies revealed that H-Ras protein was also present in the nuclei of nontransformed and primary mouse cells, which do not overexpress H-Ras. Mouse fibroblast NIH 3T3 cells, L cells, and a primary fibroblast line all had H-Ras present in both cytoplasmic and nuclear extracts. Nuclear extracts of cells synchronized by growth without serum displayed an increasing amount of H-Ras and cyclin D1 as cells grew after serum addition. Treatment with farnesyltransferase inhibitor caused loss of H-Ras from the nucleus. Immunofluorescence in situ studies of nuclei from synchronized cultures showed that H-Ras protein appeared in and disappeared from the nuclei as the cells moved through the growth cycle. This cycling occurred in both nontransformed and ras-transformed cells. Flow cytometry measurements on parallel cultures revealed that the time point at which the greatest percentage of cells were in S phase, for each line, corresponded to appearance of a noticeably stronger in situ signal for H-Ras. H-Ras may participate in nuclear signaling pathways associated with replication in addition to its cytoplasmic signaling functions.
    Language English
    Publishing date 2013-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2538519-7
    ISSN 1947-6027 ; 1947-6019
    ISSN (online) 1947-6027
    ISSN 1947-6019
    DOI 10.1177/1947601911405042
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