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  1. Article: There can be smoke without fire: warranted caution in promoting electronic cigarettes and heat not burn devices as a safer alternative to cigarette smoking.

    McAlinden, Kielan Darcy / Sohal, Sukhwinder Singh / Sharma, Pawan

    ERJ open research

    2019  Volume 5, Issue 3

    Abstract: The tobacco industry is now shifting its focus from combustible cigarettes to promoting the "safer" electronic nicotine delivery alternatives. This editorial presents emerging challenges these devices pose to human health. ...

    Abstract The tobacco industry is now shifting its focus from combustible cigarettes to promoting the "safer" electronic nicotine delivery alternatives. This editorial presents emerging challenges these devices pose to human health.
    Language English
    Publishing date 2019-08-12
    Publishing country England
    Document type Editorial
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00114-2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Electronic cigarettes: Modern instruments for toxic lung delivery and posing risk for the development of chronic disease

    McAlinden, Kielan Darcy / Lu, Wenying / Eapen, Mathew Suji / Sohal, Sukhwinder Singh

    international journal of biochemistry & cell biology. 2021 Aug., v. 137

    2021  

    Abstract: Following the emergence of electronic cigarette, or vaping product use associated lung injury (EVALI) in 2019 in the US, regulation of e-cigarettes has become globally tighter and the collective evidence of the detrimental effects of vaping has grown. ... ...

    Abstract Following the emergence of electronic cigarette, or vaping product use associated lung injury (EVALI) in 2019 in the US, regulation of e-cigarettes has become globally tighter and the collective evidence of the detrimental effects of vaping has grown. The danger of cellular distress and altered homeostasis is heavily associated with the modifiable nature of electronic cigarette devices. An array of harmful chemicals and elevated concentrations of metals have been detected in e-cigarette aerosols which have been linked to various pathogeneses. Vaping is linked to increased inflammation, altered lipid homeostasis and mitochondrial dysfunction whilst also increasing microbial susceptibility whilst the long-term damage is yet to be observed. The scientific evidence is mounting and highlighting that, along with traditional tobacco cigarette smoking, electronic cigarette vaping is not a safe practice.
    Keywords chronic diseases ; cigarettes ; distress ; electronic equipment ; homeostasis ; inflammation ; lipids ; lungs ; mitochondria ; risk ; toxicity
    Language English
    Dates of publication 2021-08
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2021.106039
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: There can be smoke without fire

    Kielan Darcy McAlinden / Sukhwinder Singh Sohal / Pawan Sharma

    ERJ Open Research, Vol 5, Iss

    warranted caution in promoting electronic cigarettes and heat not burn devices as a safer alternative to cigarette smoking

    2019  Volume 3

    Keywords Medicine ; R
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Cochrane review update leaves big questions unanswered regarding vaping: implications for medical practitioners.

    McAlinden, Kielan Darcy / Barnsley, Kathryn / Weber, Heinrich C / Haug, Greg / Chia, Collin / Eapen, Mathew Suji / Sohal, Sukhwinder Singh

    The European respiratory journal

    2021  Volume 57, Issue 5

    Language English
    Publishing date 2021-05-13
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00022-2021
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  5. Article ; Online: Electronic cigarettes: Modern instruments for toxic lung delivery and posing risk for the development of chronic disease.

    McAlinden, Kielan Darcy / Lu, Wenying / Eapen, Mathew Suji / Sohal, Sukhwinder Singh

    The international journal of biochemistry & cell biology

    2021  Volume 137, Page(s) 106039

    Abstract: Following the emergence of electronic cigarette, or vaping product use associated lung injury (EVALI) in 2019 in the US, regulation of e-cigarettes has become globally tighter and the collective evidence of the detrimental effects of vaping has grown. ... ...

    Abstract Following the emergence of electronic cigarette, or vaping product use associated lung injury (EVALI) in 2019 in the US, regulation of e-cigarettes has become globally tighter and the collective evidence of the detrimental effects of vaping has grown. The danger of cellular distress and altered homeostasis is heavily associated with the modifiable nature of electronic cigarette devices. An array of harmful chemicals and elevated concentrations of metals have been detected in e-cigarette aerosols which have been linked to various pathogeneses. Vaping is linked to increased inflammation, altered lipid homeostasis and mitochondrial dysfunction whilst also increasing microbial susceptibility whilst the long-term damage is yet to be observed. The scientific evidence is mounting and highlighting that, along with traditional tobacco cigarette smoking, electronic cigarette vaping is not a safe practice.
    MeSH term(s) Chronic Disease ; Electronic Nicotine Delivery Systems/statistics & numerical data ; Humans ; Lung Injury/etiology ; Lung Injury/pathology ; Vaping/adverse effects
    Language English
    Publishing date 2021-07-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2021.106039
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  6. Article ; Online: In utero Exposure to Nicotine Containing Electronic Cigarettes Increases the Risk of Allergic Asthma in Female Offspring.

    McAlinden, Kielan Darcy / Naidu, Vgm / Sohal, Sukhwinder Singh / Sharma, Pawan

    publication RETRACTED

    American journal of physiology. Lung cellular and molecular physiology

    2020  

    Abstract: E-cigarettes (eCig) are being considered as an alternative to quit cigarette smoking while their long-term effect on lung pathophysiology are unknown. Maternal eCig-vaping may be promoted and considered as a safer cigarette smoking-replacement during ... ...

    Abstract E-cigarettes (eCig) are being considered as an alternative to quit cigarette smoking while their long-term effect on lung pathophysiology are unknown. Maternal eCig-vaping may be promoted and considered as a safer cigarette smoking-replacement during pregnancy thus needing further assessment. Using murine models of in utero vaping and allergic asthma with complementary in vitro experiments we tested whether maternal eCig vaping enhances features of allergic asthma in offspring. Female BALB/c mice were exposed to either eCig vapor (± nicotine) or room air. Female offspring from these mothers were subjected to an ovalbumin (OVA)-induced allergic asthma model. Lung function and airway inflammation was assessed. Tissues were histologically assessed with H&E, Periodic Acid-Schiff and Masson's trichrome. Mitochondrial homeostasis protein expression was measured using immunohistochemistry while human airway smooth muscle (ASM) and Beas-2B cells were used to further measure cellular function and mitochondrial respiration. Allergen-challenge in mice lead to significant increase in airway inflammation, development of airway hyperresponsiveness (AHR) and increase in mucus and airway wall thickening (hallmark features of allergic asthma). Allergic asthma features were significantly enhanced in offspring from eCig (+Nicotine)-exposed mothers and were mainly reliant upon Th2-dependent inflammation with complementary changes in mitochondrial homeostasis. Further, in vitro data demonstrated that eCig (±Nicotine)-exposure impaired airway cell homeostasis and perturbed mitochondrial function. Collectively, maternal eCig vaping enhanced and worsened features of allergic asthma and this could partly be attributed to aberrant mitochondrial function.
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00230.2019
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  7. Article ; Online: The Ill Effects of IQOS on Airway Cells: Let's Not Get Burned All Over Again.

    McAlinden, Kielan Darcy / Eapen, Mathew Suji / Lu, Wenying / Sharma, Pawan / Sohal, Sukhwinder Singh

    American journal of respiratory cell and molecular biology

    2020  Volume 63, Issue 2, Page(s) 269–270

    MeSH term(s) Electronic Nicotine Delivery Systems ; Humans ; Lung Injury ; Respiratory System ; Vaping
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2020-0094LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2851: Show issues Location:
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  8. Article ; Online: The rise of electronic nicotine delivery systems and the emergence of electronic-cigarette-driven disease.

    McAlinden, Kielan Darcy / Eapen, Mathew Suji / Lu, Wenying / Sharma, Pawan / Sohal, Sukhwinder Singh

    American journal of physiology. Lung cellular and molecular physiology

    2020  Volume 319, Issue 4, Page(s) L585–L595

    Abstract: In 2019, the United States experienced the emergence of the vaping-associated lung injury (VALI) epidemic. Vaping is now known to result in the development and progression of severe lung disease in the young and healthy. Lack of regulation on electronic ... ...

    Abstract In 2019, the United States experienced the emergence of the vaping-associated lung injury (VALI) epidemic. Vaping is now known to result in the development and progression of severe lung disease in the young and healthy. Lack of regulation on electronic cigarettes in the United States has resulted in over 2,000 patients and 68 deaths. We examine the clinical representation of VALI and the delve into the scientific evidence of how deadly exposure to electronic cigarettes can be. E-cigarette vapor is shown to affect numerous cellular processes, cellular metabolism, and cause DNA damage (which has implications for cancer). E-cigarette use is associated with a higher risk of developing crippling lung conditions such as chronic obstructive pulmonary disease (COPD), which would develop several years from now, increasing the already existent smoking-related burden. The role of vaping and virus susceptibility is yet to be determined; however, vaping can increase the virulence and inflammatory potential of several lung pathogens and is also linked to an increased risk of pneumonia. As it has emerged for cigarette smoking, great caution should also be given to vaping in relation to SARS-CoV-2 infection and the COVID-19 pandemic. Sadly, e-cigarettes are continually promoted and perceived as a safer alternative to cigarette smoking. E-cigarettes and their modifiable nature are harmful, as the lungs are not designed for the chronic inhalation of e-cigarette vapor. It is of interest that e-cigarettes have been shown to be of no help with smoking cessation. A true danger lies in vaping, which, if ignored, will lead to disastrous future costs.
    MeSH term(s) Adolescent ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/pathology ; Disease Susceptibility/chemically induced ; E-Cigarette Vapor/toxicity ; Electronic Nicotine Delivery Systems/statistics & numerical data ; Female ; Humans ; Lung Diseases, Interstitial/chemically induced ; Lung Diseases, Interstitial/epidemiology ; Lung Injury/chemically induced ; Lung Injury/epidemiology ; Lung Injury/mortality ; Male ; Middle Aged ; Pandemics ; Pneumonia/epidemiology ; Pneumonia, Viral/pathology ; Pulmonary Disease, Chronic Obstructive/chemically induced ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/mortality ; SARS-CoV-2 ; Smoking Cessation/methods ; United States/epidemiology ; Vaping/adverse effects ; Vaping/epidemiology ; Vaping/mortality
    Chemical Substances E-Cigarette Vapor
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00160.2020
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  9. Article ; Online: COVID-19 and vaping: risk for increased susceptibility to SARS-CoV-2 infection?

    McAlinden, Kielan Darcy / Eapen, Mathew Suji / Lu, Wenying / Chia, Collin / Haug, Greg / Sohal, Sukhwinder Singh

    The European respiratory journal

    2020  Volume 56, Issue 1

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pulmonary Disease, Chronic Obstructive ; SARS-CoV-2 ; Smokers ; Vaping
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01645-2020
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  10. Article ; Online: microRNAs Are Key Regulators in Chronic Lung Disease

    Mathew Suji Eapen / Kielan Darcy McAlinden / Stephen Myers / Wenying Lu / Sukhwinder Singh Sohal

    Journal of Clinical Medicine, Vol 8, Iss 11, p

    Exploring the Vital Link between Disease Progression and Lung Cancer

    2019  Volume 1986

    Abstract: microRNAs (miRNAs) bind to mRNAs and inhibit their expression through post-transcriptionally regulating gene expression. Here, we elaborate upon the concise summary of the role of miRNAs in carcinogenesis with specific attention to precursor respiratory ... ...

    Abstract microRNAs (miRNAs) bind to mRNAs and inhibit their expression through post-transcriptionally regulating gene expression. Here, we elaborate upon the concise summary of the role of miRNAs in carcinogenesis with specific attention to precursor respiratory pathogenesis caused by cigarette smoke modulation of these miRNAs. We review how miRNAs are implicated in cigarette-smoke-driven mechanisms, such as epithelial to mesenchymal transition, autophagy modulation, and lung ageing, which are important in the development of chronic obstructive pulmonary disease and potential progression to lung cancer. Extracellular vesicles are key to inter-cellular communication and sharing of miRNAs. A deeper understanding of the role of miRNAs in chronic respiratory disease and their use as clinical biomarkers has great potential. Therapeutic targeting of miRNAs may significantly benefit the prevention of cancer progression.
    Keywords microrna ; copd ; lung cancer ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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