LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1641

Search options

  1. Book: The origins of schizophrenia

    Brown, Alan S.

    2012  

    Author's details ed. by Alan S. Brown
    Language English
    Size XII, 428 S. : Ill., graph. Darst.
    Publisher Columbia Univ. Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT017438068
    ISBN 978-0-231-15124-5 ; 0-231-15124-1
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 3183 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Advancing our standards: Do we need to standardize the use of nonstandard donor organs in patients with low MELD?

    Hutchison, Alan L / Brown, Robert S

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2024  Volume 30, Issue 5, Page(s) 451–453

    MeSH term(s) Humans ; Liver Transplantation ; Tissue Donors ; Tissue and Organ Procurement ; Retrospective Studies ; Severity of Illness Index ; End Stage Liver Disease/diagnosis ; End Stage Liver Disease/surgery ; Living Donors
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1097/LVT.0000000000000345
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4702: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: The déjà vu experience

    Brown, Alan S.

    (Essays in cognitive psychology)

    2004  

    Author's details Alan S. Brown
    Series title Essays in cognitive psychology
    Keywords Deja Vu ; Déjà-vu-Erlebnis
    Subject Déjà vu
    Language English
    Size XII, 231 S. : Ill., graph. Darst.
    Publisher Psychology Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014081110
    ISBN 1-84169-075-9 ; 978-1-84169-075-9
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 3942 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book ; Conference proceedings: A Symposium: Impending Epidemic of Obesity, Metabolic Syndrome and Diabetes Mellitus - the Role of Prevention

    Brown, Alan S.

    based on a symposium held September 30 through October 2, 2004 in Tucson, Arizona

    (The American journal of cardiology ; 96,4A = Suppl.)

    2005  

    Title variant Impending epidemic of obesity, metabolic syndrome and diabetes mellitus - the role of prevention
    Event/congress Symposium Impending Epidemic of Obesity, Metabolic Syndrome and Diabetes Mellitus - The Role of Prevention (2004, TucsonAriz.)
    Author's details guest. ed.: Alan S. Brown
    Series title The American journal of cardiology ; 96,4A = Suppl.
    Collection
    Language English
    Size 69E S. : Ill., graph. Darst.
    Publisher Excerpta Medica
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014498140
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui IV Zs 73 -96,4A- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Quantitative versus qualitative emotion regulation goals: Differential effects on emotional responses.

    Kreibig, Sylvia D / Brown, Alan S / Gross, James J

    Psychophysiology

    2023  Volume 60, Issue 12, Page(s) e14387

    Abstract: Emotion regulation (ER) involves both a goal (e.g., to feel less emotion) and a strategy (e.g., reappraisal). To clarify the impact of ER goals on emotional responding, we conducted a within-participant study (N = 156) in which we held the strategy ... ...

    Abstract Emotion regulation (ER) involves both a goal (e.g., to feel less emotion) and a strategy (e.g., reappraisal). To clarify the impact of ER goals on emotional responding, we conducted a within-participant study (N = 156) in which we held the strategy constant (reappraisal) to isolate the impact of regulation goals. We compared the impact of a quantitative goal (changing emotion quantity/intensity) with that of a qualitative goal (changing emotion quality/type) on emotional responses to negative and positive pictures. We manipulated ER goals by cuing participants to continue viewing the picture (unregulated/no ER goal) or to reappraise it to decrease its predominant affective impact (quantitative goal) or increase its opposite-valence impact (qualitative goal). We assessed emotional responses through self-reported feelings and facial expressions (corrugator supercilii and zygomaticus major electromyography). Our findings suggest that the type of regulation goal has a differential effect on emotional responses, with qualitative goals being more effective in modulating both negative and positive emotions. For negative stimuli, attempts to use a quantitative goal decreased negative but not positive emotional responses (uncoupled negative deactivation). Conversely, attempts to use a qualitative goal decreased negative and increased positive emotional responses (reciprocal positive activation). For positive stimuli, the quantitative goal generated uncoupled positive deactivation, while the qualitative goal produced reciprocal negative activation. Results highlight the importance of considering specific regulation goals in shaping emotional responses. Future research in the field of ER may benefit from identifying and manipulating different goals and strategies to understand how to effectively regulate emotions.
    MeSH term(s) Humans ; Emotional Regulation ; Cognition/physiology ; Emotions/physiology ; Motivation ; Self Report ; Goals
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209486-1
    ISSN 1540-5958 ; 0048-5772
    ISSN (online) 1540-5958
    ISSN 0048-5772
    DOI 10.1111/psyp.14387
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 502: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Wild ungulates and shrub control interact to restore herbaceous vegetation in shrub-encroached mesic grassland of South Africa

    Mthunzi Mndela / Alan S. Barrett / Leslie R. Brown

    Frontiers in Ecology and Evolution, Vol

    2023  Volume 11

    Abstract: ... potential for management of S. plumosum-encroached grasslands. ...

    Abstract Shrub encroachment threatens grassland ecosystem services including herbaceous plant diversity, productivity, and overall grazing capacity. Hence, various shrub control methods including mechanical removal and herbicides are applied to restore herbaceous vegetation. However, the knowledge regarding the outcomes of integrated shrub management on herbaceous vegetation is limited. We investigated herbaceous vegetation responses after 7 years following the integration of shrub control and herbivory at Telperion Nature Reserve, Mpumalanga Province, South Africa. In a split-plot experiment using four enclosures and non-enclosures as main plots, we randomly assigned each of the following treatments in four 4 × 4-m subplots in each main plot: 1) foliar metsulfuron-methyl herbicide, 2) 50% mechanical shrub removal, 3) 100% removal, and 4) no removal (untreated controls). A one-off Seriphium plumosum removal and the application of species-specific herbicide were conducted in 2015. Shrub control by herbivory interaction was significant (p < 0.05) for herbaceous canopy cover, basal cover, density, and species richness. The effects of herbivory were significant (p < 0.05) in the 50% removal treatment, increasing herbaceous plant diversity, density, and richness to the same level as 100% removal and herbicide treatments. In enclosures, however, the 50% shrub removal treatment attained relatively low herbaceous plant cover, density, species diversity, and richness compared to the herbicide treatment. Overall, this study revealed that herbivory and shrub control interact to facilitate herbaceous vegetation restoration, with 50% shrub removal by herbivory combination showing potential for management of S. plumosum-encroached grasslands.
    Keywords enclosures ; grassland ecosystem services ; herbicide ; herbivory ; mechanical shrub removal ; Seriphium plumosum ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
    Subject code 580
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Impact of

    Graham, Susannah C / Barrett, Alan S / Brown, Leslie R

    Royal Society open science

    2020  Volume 7, Issue 4, Page(s) 192025

    Abstract: Mesic Highveld Grassland is important for biodiversity conservation, but is threatened by bush densification ... ...

    Abstract Mesic Highveld Grassland is important for biodiversity conservation, but is threatened by bush densification from
    Language English
    Publishing date 2020-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.192025
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays.

    Brown, Alan P / Friedrichs, Gregory S / Tang, Hai-Ming / Traebert, Martin / Weber, Valerie / Yao, Nancy / Yan, Gan-Xin

    International journal of toxicology

    2024  , Page(s) 10915818241230900

    Abstract: During drug discovery, small molecules are typically assayed in vitro for secondary pharmacology effects, which include ion channels relevant to cardiac electrophysiology. Compound A was an irreversible inhibitor of myeloperoxidase investigated for the ... ...

    Abstract During drug discovery, small molecules are typically assayed in vitro for secondary pharmacology effects, which include ion channels relevant to cardiac electrophysiology. Compound A was an irreversible inhibitor of myeloperoxidase investigated for the treatment of peripheral artery disease. Oral doses in dogs at ≥5 mg/kg resulted in cardiac arrhythmias in a dose-dependent manner (at Cmax, free ≥1.53 μM) that progressed in severity with time. Nevertheless, a panel of 13 different cardiac ion channel (K, Na, and Ca) assays, including hERG, failed to identify pharmacologic risks of the molecule. Compound A and a related Compound B were evaluated for electrophysiological effects in the isolated rabbit ventricular wedge assay. Compounds A and B prolonged QT and Tp-e intervals at ≥1 and ≥.3 μM, respectively, and both prolonged QRS at ≥5 μM. Compound A produced early after depolarizations and premature ventricular complexes at ≥5 μM. These data indicate both compounds may be modulating hERG (I
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1379845-5
    ISSN 1092-874X ; 1091-5818
    ISSN (online) 1092-874X
    ISSN 1091-5818
    DOI 10.1177/10915818241230900
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1870: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Maternal Immune Activation and Related Factors in the Risk of Offspring Psychiatric Disorders.

    Conway, Fiona / Brown, Alan S

    Frontiers in psychiatry

    2019  Volume 10, Page(s) 430

    Abstract: Maternal immune activation (MIA) at the time of gestation has been linked to increased risk of neurodevelopmental psychiatric disorders. Animal and human models have been used to evaluate the relationship between MIA and these outcomes. Given that each ... ...

    Abstract Maternal immune activation (MIA) at the time of gestation has been linked to increased risk of neurodevelopmental psychiatric disorders. Animal and human models have been used to evaluate the relationship between MIA and these outcomes. Given that each of these two disciplines of study have their benefits and limitations, a translational perspective is expected to illuminate more than by the use of any single approach. In this article, we discuss this translational framework and explore how it may be enhanced by the utilization of epigenetic studies and by investigating the microbiome. In this perspectives piece, we focus on the impact of epidemiologic studies, animal models, and preclinical studies in the literature on MIA as well as the potential for greater integration between fields.
    Language English
    Publishing date 2019-06-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2019.00430
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Species-specific Bioactivation of Morpholines as a Causative of Drug Induced Liver Injury Observed in Monkeys

    Gunduz, Mithat / Argikar, Upendra A / Cirello, Amanda L / Brown, Alan P / Bonazzi, Simone / Walles, Markus

    Drug metabolism and bioanalysis letters

    2023  

    Abstract: ... in this manuscript [(S)-3-methyl-4-(7-((R)-3-methylmorpholino)-2-(thiazol-4-yl)-3H-imidazo[4,5-b]pyridin-5-yl ...

    Abstract Background: Everolimus, an allosteric mechanistic target of rapamycin (mTOR) inhibitor, recently demonstrated the therapeutic value of mTOR inhibitors for Central Nervous System (CNS) indications driven by hyperactivation of mTOR. A newer, potent brain-penetrant analog of everolimus, referred to as (1) in this manuscript [(S)-3-methyl-4-(7-((R)-3-methylmorpholino)-2-(thiazol-4-yl)-3H-imidazo[4,5-b]pyridin-5-yl)morpholine,(1)] catalytically inhibits mTOR function in the brain and increases the lifespan of mice with neuronal mTOR hyperactivation.
    Introduction: Early evaluation of the safety of 1 was conducted in cynomolgus monkeys in which oral doses were administered to three animals in a rising-dose fashion (from 2 to 30 mg/kg/day). 1 produced severe toxicity including the evidence of hepatic toxicity, along with non-dose proportional increases in drug exposure. Investigations of cross-species hepatic bioactivation of 1 were conducted to assess whether the formation of reactive drug metabolites was associated with the mechanism of liver toxicity.
    Method: 1 contained two morpholine rings known as structural alerts and can potentially form reactive intermediates through oxidative metabolism. Bioactivation of 1 was investigated in rat, human and monkey liver microsomes fortified with trapping agents such as methoxylamine or potassium cyanide.
    Results: Our results suggest that bioactivation of the morpholine moieties to reactive intermediates may have been involved in the mechanism of liver toxicity observed with 1. Aldehyde intermediates trappable by methoxylamine were identified in rat and monkey liver microsomal studies. In addition, a total of four cyano conjugates arising from the formation of iminium ion intermediates were observed and identified. These findings may potentially explain the observed monkey toxicity. Interestingly, methoxylamine or cyano adducts of 1 were not observed in human liver microsomes.
    Conclusion: The bioactivation of 1 appears to be species-specific. Circumstantial evidence for the toxicity derived from 1 point to the formation of iminium ion intermediates trappable by cyanide in monkey liver microsomes. The cyano conjugates were only observed in monkey liver microsomes, potentially pointing to cause at least the hepatotoxicity observed in monkeys. In contrast, methoxylamine conjugates were detected in both rat and monkey liver microsomes, with only a trace amount in human liver microsomes. Cyano conjugates were not observed in human liver microsomes, challenging the team on the drugability and progressivity of 1 through drug development. The mechanisms for drug-induced liver toxicity are multifactorial. These results are highly suggestive that the iminium ion may be an important component in the mechanism of liver toxicity 1 observed in the monkey.
    Language English
    Publishing date 2023-12-01
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 2949-6829
    ISSN (online) 2949-6829
    DOI 10.2174/0118723128260455231104180653
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top