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Article ; Online: Composite coating of chitosan with salicylic acid retards pear fruit softening under cold and supermarket storage.

Sinha, Aeshna / Gill, P P S / Jawandha, S K / Grewal, S K

Food research international (Ottawa, Ont.)

2022 Volume 160, Page(s) 111724

Abstract: Fruit softening is enzyme mediated degradation process determined by the action of cell wall modifying enzymes. Present study evaluated the combined effects of chitosan (CH) and salicylic acid (SA) coatings in modulation of fruit softening enzymes in ... ...

Abstract	Fruit softening is enzyme mediated degradation process determined by the action of cell wall modifying enzymes. Present study evaluated the combined effects of chitosan (CH) and salicylic acid (SA) coatings in modulation of fruit softening enzymes in Punjab Beauty pear (Pyrus pyrifolia × Pyrus communis) fruit stored under cold (0-1 °C and 90-95 % RH) and supermarket (20-22 °C and 80-85 % RH) conditions. Composite CH + SA coatings reduced mass loss and retained fruit firmness throughout the 67 and 20 days storage period. In addition, CH + SA prevented membrane damage by suppressing the electrolyte leakage and malondialdehyde (MDA) accumulation as compared to CH or SA alone. CH 2.0 % + SA 2.0 mM coating efficiently delayed the cell wall degrading enzymatic activities including pectin methylesterase (PME), polygalacturonase (PG) and cellulase associated with fruit softening up to 60 and 15 days storage period in cold and supermarket conditions, respectively.
MeSH term(s)	Chitosan/metabolism ; Fruit/metabolism ; Pyrus/metabolism ; Salicylic Acid ; Supermarkets
Chemical Substances	Chitosan (9012-76-4) ; Salicylic Acid (O414PZ4LPZ)
Language	English
Publishing date	2022-07-21
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.111724
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Article ; Online: Pitfalls and Opportunities for the Growing Role of AI in Heart Failure.

Grewal, Jagpreet S / Sengupta, Partho P

Journal of cardiac failure

2024

Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1281194-4
ISSN	1532-8414 ; 1071-9164
ISSN (online)	1532-8414
ISSN	1071-9164
DOI	10.1016/j.cardfail.2024.03.001
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Zs.A 4340: Show issues

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Article ; Online: The molecular basis of heterochromatin assembly and epigenetic inheritance.

Grewal, Shiv I S

Molecular cell

2023 Volume 83, Issue 11, Page(s) 1767–1785

Abstract: Heterochromatin plays a fundamental role in gene regulation, genome integrity, and silencing of repetitive DNA elements. Histone modifications are essential for the establishment of heterochromatin domains, which is initiated by the recruitment of ... ...

Abstract	Heterochromatin plays a fundamental role in gene regulation, genome integrity, and silencing of repetitive DNA elements. Histone modifications are essential for the establishment of heterochromatin domains, which is initiated by the recruitment of histone-modifying enzymes to nucleation sites. This leads to the deposition of histone H3 lysine-9 methylation (H3K9me), which provides the foundation for building high-concentration territories of heterochromatin proteins and the spread of heterochromatin across extended domains. Moreover, heterochromatin can be epigenetically inherited during cell division in a self-templating manner. This involves a "read-write" mechanism where pre-existing modified histones, such as tri-methylated H3K9 (H3K9me3), support chromatin association of the histone methyltransferase to promote further deposition of H3K9me. Recent studies suggest that a critical density of H3K9me3 and its associated factors is necessary for the propagation of heterochromatin domains across multiple generations. In this review, I discuss the key experiments that have highlighted the importance of modified histones for epigenetic inheritance.
MeSH term(s)	Histones/genetics ; Histones/metabolism ; Heterochromatin/genetics ; Heterochromatin/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Schizosaccharomyces/genetics ; Epigenesis, Genetic
Chemical Substances	Histones ; Heterochromatin ; Schizosaccharomyces pombe Proteins ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43)
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Intramural
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2023.04.020
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Zs.A 5055: Show issues

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Article ; Online: Abortion-related crowdfunding post-Dobbs.

Snyder, Jeremy / Grewal, Ashmita

Perspectives on sexual and reproductive health

2024

Abstract: ... of the Supreme Court decision in Dobbs. V. Jackson Women's Health Organization, a time period that saw increased ...

Abstract	Previous research on abortion-related crowdfunding campaigns found that they are impacted by stigma around abortion and rarely successful. This paper analyzes crowdfunding activity in the US following a leak of the Supreme Court decision in Dobbs. V. Jackson Women's Health Organization, a time period that saw increased financial support of abortion access funds. Crowdfunding campaigns that included "abort" or "abortion" and were created between May 2 and November 8, 2022 were recorded from the GoFundMe and GiveSendGo crowdfunding platforms. These campaigns were reviewed for whether they were US based and sought funding where abortion was used as a justification for support. Included campaigns were assigned a campaign recipient type: (1) Organizations providing abortion access; (2) Organizations seeking legal protection for abortion; (3) Individuals seeking abortion access; (4) Organizations seeking to reduce abortion access; and (5) Individuals with needs resulting from choosing not to access abortion. The authors also identified four types of rationale for supporting these campaigns. Following a leak of the Dobbs decision, 398 abortion-related crowdfunding campaigns in the US raised over $3.8 million from over 50,000 donations. Campaigns supporting abortion access organizations raised higher median amounts than organizations seeking to reduce abortion access. Individuals seeking abortion access raised higher median amounts than individuals who chose not to terminate a pregnancy. In a reversal from pre-Dobbs crowdfunding, abortion access campaigns tended to outperform other abortion-related campaigns. It is not clear how long-lived this change in support will be and campaigners remain vulnerable to changes in platforms' content moderation policies.
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075205-2
ISSN	1931-2393 ; 1538-6341
ISSN (online)	1931-2393
ISSN	1538-6341
DOI	10.1111/psrh.12249
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Zs.A 943: Show issues

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Article ; Online: An interview with Scott Fraser.

Grewal, Seema

Development (Cambridge, England)

2021 Volume 148, Issue 24

Abstract: ... awarded the SDB's 2021 Edwin G. Conklin Medal, which aims to recognize 'a developmental biologist who has ...

Abstract	Scott Fraser is a Provost Professor, and the Director of Science Initiatives, at the University of Southern California, USA. Scott has had a long-standing interest in applying the tools of chemistry, engineering and physics to problems in biology and medicine. Amongst other things, Scott is best known for his contributions to developing microscopes and tools to image developing embryos. Earlier this year, Scott was awarded the SDB's 2021 Edwin G. Conklin Medal, which aims to recognize 'a developmental biologist who has made and is continuing to make extraordinary research contributions to the field, and is an excellent mentor who has helped train the next generation of outstanding scientists'. We caught up with Scott to find out more about his interdisciplinary research and his approach to mentoring.
MeSH term(s)	Awards and Prizes ; Developmental Biology/history ; Embryonic Development/genetics ; History, 20th Century ; History, 21st Century ; Humans
Language	English
Publishing date	2021-12-23
Publishing country	England
Document type	Biography ; Historical Article ; Interview
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.200393
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Article ; Online: Obstetric anaesthesiology: manpower and service provision issues in India.

Gupta, S / Grewal, A / Jain, K

International journal of obstetric anesthesia

2023 Volume 57, Page(s) 103928

Abstract: Obstetric anaesthesiologists play a pivotal role as peripartum physicians steering the team of obstetric healthcare providers towards a continuum of medical education, enhanced training and safer patient care. However, in resource-limited countries, ... ...

Abstract	Obstetric anaesthesiologists play a pivotal role as peripartum physicians steering the team of obstetric healthcare providers towards a continuum of medical education, enhanced training and safer patient care. However, in resource-limited countries, deficiency of human resources and hence services available poses challenges to those attempting to reduce maternal mortality rates. Measures to fill the gap include creating a cadre of uniformly well-trained and certified non-physician anaesthesia providers (NPAPs) supervised by a physician obstetric anaesthesiologist and well-equipped rural and urban health care facilities. The Association of Obstetric Anaesthesiologists of India needs to upscale their outreach programs with regular knowledge updates and practical skill training to the NPAPs, medical graduates and postgraduate doctors in these regions. A combination of strong local administrative will, legislation for the provision of essential supplies and a global collaborative effort using checklists and protocols may help to stem gaps in the provision of safe maternal care.
MeSH term(s)	Pregnancy ; Female ; Humans ; Anesthesiology ; Maternal Health Services ; Workforce ; Maternal Mortality ; India
Language	English
Publishing date	2023-09-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1086024-1
ISSN	1532-3374 ; 0959-289X
ISSN (online)	1532-3374
ISSN	0959-289X
DOI	10.1016/j.ijoa.2023.103928
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Article: Graphene oxide coated aluminium as an efficient antibacterial surface

Mandal, P. / Ghosh, S.K. / Grewal, H.S.

Environmental technology & innovation. 2022 Nov., v. 28

2022

Abstract: Antimicrobial coatings on metallic surfaces are rapidly emerging to combat bacterial pathogens. The excess use of conventional antibiotics increases the number of resistant strains at an alarming rate, which in turn leads to detrimental implications in ... ...

Abstract	Antimicrobial coatings on metallic surfaces are rapidly emerging to combat bacterial pathogens. The excess use of conventional antibiotics increases the number of resistant strains at an alarming rate, which in turn leads to detrimental implications in the healthcare sector. Hence, it is of great importance in developing a new class of material with inherent bactericidal activity and good biocompatibility. In the present study, we have modified the aluminium surfaces by a coating of graphene oxide (GO) due to its excellent physicochemical properties, water dispersity and low cytotoxicity. Coatings were developed through facile and enviornment-friendly transfer method. The antimicrobial properties of GO coated aluminium are investigated against Gram-negative strain E. coli through agar plate counting and ‘Live/Dead’ fluorescence staining. Further, to shed light into the mechanism of antibacterial activity of GO at the molecular level, we have performed X-ray reflectivity (XRR) study considering a phospholipid multilayer as a model system to mimic bacteria cell membrane. Results show a significant bactericidal activity of the GO coatings compared to uncoated aluminium with lower concentration showing slightly better antibacterial property due to higher roughness. The obtained results may pave the way for engineering graphene-based antimicrobial coatings on a material surface using an easy, environment-friendly, cost-effective and straight forward processing route.
Keywords	Escherichia coli ; X-ray reflectivity ; agar ; aluminum ; antibacterial properties ; biocompatibility ; cell membranes ; cost effectiveness ; cytotoxicity ; environmental technology ; fluorescence ; graphene ; graphene oxide ; health services ; phospholipids
Language	English
Dates of publication	2022-11
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2352-1864
DOI	10.1016/j.eti.2022.102591
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Composite coating of chitosan with salicylic acid retards pear fruit softening under cold and supermarket storage

Sinha, Aeshna / Gill, P.P.S / Jawandha, S.K. / Grewal, S.K.

Food Research International. 2022 Oct., v. 160 p.111724-

2022

Abstract	Fruit softening is enzyme mediated degradation process determined by the action of cell wall modifying enzymes. Present study evaluated the combined effects of chitosan (CH) and salicylic acid (SA) coatings in modulation of fruit softening enzymes in Punjab Beauty pear (Pyrus pyrifolia × Pyrus communis) fruit stored under cold (0–1 °C and 90–95 % RH) and supermarket (20–22 °C and 80–85 % RH) conditions. Composite CH + SA coatings reduced mass loss and retained fruit firmness throughout the 67 and 20 days storage period. In addition, CH + SA prevented membrane damage by suppressing the electrolyte leakage and malondialdehyde (MDA) accumulation as compared to CH or SA alone. CH 2.0 % + SA 2.0 mM coating efficiently delayed the cell wall degrading enzymatic activities including pectin methylesterase (PME), polygalacturonase (PG) and cellulase associated with fruit softening up to 60 and 15 days storage period in cold and supermarket conditions, respectively.
Keywords	Pyrus communis ; Pyrus pyrifolia ; cell walls ; chitosan ; cold ; electrolyte leakage ; endo-1,4-beta-glucanase ; food research ; fruit quality ; fruits ; malondialdehyde ; pears ; pectinesterase ; polygalacturonase ; salicylic acid ; storage time ; supermarkets ; Cellulase ; Fruit softening ; Storage condition ; Cell wall hydrolysing enzymes ; Pyrus pyrifolia x Pyrus communis
Language	English
Dates of publication	2022-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.111724
Database	NAL-Catalogue (AGRICOLA)

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Article: Salicylic acid enriched beeswax coatings suppress fruit softening in pears by modulation of cell wall degrading enzymes under different storage conditions

Sinha, Aeshna / Gill, P.P.S. / Jawandha, S.K. / Kaur, Preetinder / Grewal, S.K.

Food packaging and shelf life. 2022 June, v. 32

2022

Abstract: Pear fruits are highly perishable and experiences excessive softening during postharvest storage. The aim of the present study was to evaluate the effect of salicylic acid (SA) enriched beeswax (BW) coatings in retardation of pear fruit softening related ...

Abstract	Pear fruits are highly perishable and experiences excessive softening during postharvest storage. The aim of the present study was to evaluate the effect of salicylic acid (SA) enriched beeswax (BW) coatings in retardation of pear fruit softening related changes during 67 d of cold storage and 20 d of supermarket storage conditions. Results revealed that BW + SA coatings effectively reduced the mass loss and maintained fruit firmness as compared to control and BW or SA alone. The composite coatings delayed the respiratory peak, decreased the membrane permeability and malondialdehyde (MDA) accumulation in stored pears. Furthermore, these coatings efficiently restrained the rise in the activities of cell wall degrading enzymes notably pectin methylesterase (PME), polygalacturonase (PG) and cellulase in fruits. Among all the treatments, BW 2.0% + SA 2.0 mM efficiently regulated the cell wall metabolism and maintained structural integrity of fruits. Results suggest that composite BW + SA coatings can serve as a facile and eco-friendly postharvest approach to prevent fruit softening by regulation of cell wall solubilising enzymes of stored pears.
Keywords	beeswax ; cell walls ; cold storage ; endo-1,4-beta-glucanase ; fruit quality ; fruits ; malondialdehyde ; membrane permeability ; metabolism ; pears ; pectinesterase ; polygalacturonase ; postharvest storage ; salicylic acid ; shelf life ; solubilization ; supermarkets
Language	English
Dates of publication	2022-06
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2214-2894
DOI	10.1016/j.fpsl.2022.100821
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: An interview with Sally Lowell.

Grewal, Seema

Development (Cambridge, England)

2020 Volume 147, Issue 5

Abstract: ... more about her career and her research, and why she's excited about her role at the Company. ...

Abstract	Sally Lowell is a Wellcome Trust Senior Research Fellow at the University of Edinburgh, UK. Her research group, which is based in the Centre for Regenerative Medicine, studies cell fate decisions in stem cells, focussing on how communication and interactions between cells can influence these decisions. Sally, who has been a long-serving committee member of the British Society for Developmental Biology, recently joined the Board of Directors at The Company of Biologists. We caught up with Sally to find out more about her career and her research, and why she's excited about her role at the Company.
MeSH term(s)	Developmental Biology ; History, 21st Century ; Humans ; Neural Stem Cells/cytology ; Pluripotent Stem Cells/cytology ; Publishing ; Regenerative Medicine
Language	English
Publishing date	2020-03-02
Publishing country	England
Document type	Biography ; Historical Article ; Interview
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.188565
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