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  1. Book ; Online ; E-Book: Unaging

    Friedland, Robert

    the four factors that impact how you age

    2022  

    Abstract: Aging is a subject of concern to everyone, but is widely misunderstood. If we view it as inevitable, we miss the fact that not everyone is able to grow to an old age. Realization of this reality helps us to understand that aging presents a wonderful ... ...

    Author's details Robert P. Friedland
    Abstract Aging is a subject of concern to everyone, but is widely misunderstood. If we view it as inevitable, we miss the fact that not everyone is able to grow to an old age. Realization of this reality helps us to understand that aging presents a wonderful opportunity - an opportunity to make choices about how we live which can enhance the aging process and offer a chance to live to our potential. This book clearly presents the four, multiple reserve, factors (cognitive, physical, psychological and social) which impact our ability to have healthy responses to the stresses of aging. By giving the biological basis for the advice given, you will learn the steps to take in your activities, diet and mental outlook to grasp the opportunity that aging offers. Everyone must know that what we do makes a difference
    Keywords Aging / Prevention ; Older people / Health and hygiene ; Longevity ; Quality of life
    Subject code 613.2
    Language English
    Size 1 Online-Ressource (xvii, 327 Seiten), Illustrationen, Diagramme
    Publisher Cambridge University Press
    Publishing place Cambridge, United Kingdom ; New York, NY
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030723794
    ISBN 978-1-00-908364-5 ; 9781009087742 ; 1-00-908364-3 ; 1009087746
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Neurodegenerative diseases: from gut-brain axis to brain microbiome.

    Friedland, Robert P / Haribabu, Bodduluri

    Frontiers in aging neuroscience

    2023  Volume 15, Page(s) 1171955

    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1171955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cognitive and social activities and long-term dementia risk.

    Friedland, Robert P

    The Lancet. Public health

    2021  Volume 6, Issue 5, Page(s) e269

    MeSH term(s) Cognition ; Dementia/epidemiology ; Female ; Humans ; Prospective Studies ; United Kingdom
    Language English
    Publishing date 2021-04-29
    Publishing country England
    Document type Letter ; Comment
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(21)00071-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Alzheimer's disease and low-dose radiation therapy: A new hope.

    Dunlap, Neal E / Friedland, Robert P / Cai, Lu

    Radiation medicine and protection

    2024  Volume 5, Issue 1, Page(s) 1–6

    Abstract: The concept of low-dose radiation (LDR)-induced hormetic responses was initially observed approximately 70 years ago and systematically reviewed along with the discovery of LDR-induced adaptive responses in a ... ...

    Abstract The concept of low-dose radiation (LDR)-induced hormetic responses was initially observed approximately 70 years ago and systematically reviewed along with the discovery of LDR-induced adaptive responses in a cytogenetic
    Language English
    Publishing date 2024-02-07
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-5557
    ISSN (online) 2666-5557
    DOI 10.1016/j.radmp.2024.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cognitive and social activities and long-term dementia risk

    Robert P Friedland

    The Lancet Public Health, Vol 6, Iss 5, Pp e269- (2021)

    2021  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The role for the metagenome in the pathogenesis of COVID-19.

    Friedland, Robert P / Haribabu, Bodduluri

    EBioMedicine

    2020  Volume 61, Page(s) 103019

    MeSH term(s) COVID-19/etiology ; COVID-19/microbiology ; Humans ; Inflammation ; Metagenome ; Metagenomics
    Keywords covid19
    Language English
    Publishing date 2020-10-07
    Publishing country Netherlands
    Document type Letter ; Review
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.103019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The role for the metagenome in the pathogenesis of COVID-19

    Robert P Friedland / Bodduluri Haribabu

    EBioMedicine, Vol 61, Iss , Pp 103019- (2020)

    2020  

    Keywords Medicine ; R ; Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Mechanisms of molecular mimicry involving the microbiota in neurodegeneration.

    Friedland, Robert P

    Journal of Alzheimer's disease : JAD

    2015  Volume 45, Issue 2, Page(s) 349–362

    Abstract: The concept of molecular mimicry was established to explain commonalities of structure which developed in response to evolutionary pressures. Most examples of molecular mimicry in medicine have involved homologies of primary protein structure which cause ...

    Abstract The concept of molecular mimicry was established to explain commonalities of structure which developed in response to evolutionary pressures. Most examples of molecular mimicry in medicine have involved homologies of primary protein structure which cause disease. Molecular mimicry can be expanded beyond amino acid sequence to include microRNA and proteomic effects which are either pathogenic or salutogenic (beneficial) in regard to Parkinson's disease, Alzheimer's disease, and related disorders. Viruses of animal or plant origin may mimic nucleotide sequences of microRNAs and influence protein expression. Both Parkinson's and Alzheimer's diseases involve the formation of transmissible self-propagating prion-like proteins. However, the initiating factors responsible for creation of these misfolded nucleating factors are unknown. Amyloid patterns of protein folding are highly conserved through evolution and are widely distributed in the world. Similarities of tertiary protein structure may be involved in the creation of these prion-like agents through molecular mimicry. Cross-seeding of amyloid misfolding, altered proteostasis, and oxidative stress may be induced by amyloid proteins residing in bacteria in our microbiota in the gut and in the diet. Pathways of molecular mimicry induced processes induced by bacterial amyloid in neurodegeneration may involve TLR 2/1, CD14, and NFκB, among others. Furthermore, priming of the innate immune system by the microbiota may enhance the inflammatory response to cerebral amyloids (such as amyloid-β and α-synuclein). This paper describes the specific molecular pathways of these cross-seeding and neuroinflammatory processes. Evolutionary conservation of proteins provides the opportunity for conserved sequences and structures to influence neurological disease through molecular mimicry.
    MeSH term(s) Animals ; Cytokines/metabolism ; Humans ; Microbiota ; Molecular Mimicry ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/physiopathology
    Chemical Substances Cytokines
    Language English
    Publishing date 2015
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-142841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article ; Online: The role for the metagenome in the pathogenesis of COVID-19

    Friedland, Robert P / Haribabu, Bodduluri

    EBioMedicine

    2020  Volume 61, Page(s) 103019

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.103019
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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