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Article ; Online: Giant hollow M(n)L(2n) spherical complexes: structure, functionalisation and applications.

Harris, Kate / Fujita, Daishi / Fujita, Makoto

Chemical communications (Cambridge, England)

2013 Volume 49, Issue 60, Page(s) 6703–6712

Abstract: Drawing inspiration from the self-assembly of hollow spherical virus capsids and protein cages found in nature, a family of roughly spherical coordination polyhedra with general formula MnL2n was designed and several members of the series have been ... ...

Abstract	Drawing inspiration from the self-assembly of hollow spherical virus capsids and protein cages found in nature, a family of roughly spherical coordination polyhedra with general formula MnL2n was designed and several members of the series have been synthesised. These spherical complexes are self-assembled upon reaction of bent bis(pyridine) ligands with Pd(2+) ions. The introduction of functional side chains into the ligands is straightforward, making the synthesis of both exo- and endohedrally functionalised spherical complexes possible. Accumulation of a high density of functional groups at the periphery of the spherical framework results in an enhancement of the weak interactions used in biomolecular recognition processes and the strong and selective interaction of the complex with a variety of substrates. Discrete and well-defined environments are generated within the spherical framework by functionalisation of the interior of the complex. These environments can be used for the selective encapsulation of guest molecules, including species as diverse as simple metal ions, fluoroalkanes and fullerenes. The well-defined cavity of the spherical complexes can also be exploited for the synthesis of precisely size-controlled nanoparticles and polymers. Most recently, a protein was successfully enclosed within a hollow self-assembled spherical complex, with a long-term view towards the control of protein functions for the development of new applications.
MeSH term(s)	Coordination Complexes/chemistry ; Ions/chemistry ; Ligands ; Models, Molecular ; Palladium/chemistry ; Pyridines/chemistry ; Ubiquitin/administration & dosage
Chemical Substances	Coordination Complexes ; Ions ; Ligands ; Pyridines ; Ubiquitin ; Palladium (5TWQ1V240M)
Language	English
Publishing date	2013-08-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c3cc43191f
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Article ; Online: DEET (N,N-diethyl-meta-toluamide) induced delay of blowfly landing and oviposition rates on treated pig carrion (Sus scrofa L.).

Shelomi, Matan / Matern, Leia M / Dinstell, Jenna M / Harris, Daren W / Kimsey, Robert B

Journal of forensic sciences

2012 Volume 57, Issue 6, Page(s) 1507–1511

Abstract: The question of whether the insect repellent N,N-Diethyl-meta-toluamide (DEET) affected fly ...

Abstract	The question of whether the insect repellent N,N-Diethyl-meta-toluamide (DEET) affected fly attraction, oviposition, and larval development was investigated; in part, to determine whether the common habit of wearing DEET as a repellent could affect the rate of human decomposition. Experiments using pig surrogates of human decedents were carried out in a rural environment. Dead piglets were sprayed with DEET, and fly behavior, colonization levels, and maggot development were compared with those in nonsprayed controls. Piglets treated with DEET experienced significant delays in fly visitation and oviposition and delayed appearance of each larval instar, as well as reduced total larval numbers (p < 0.01 for all variables), with subsequently reduced decomposition (p < 0.05). Such changes in fly behavior and larval population development would significantly impact the estimation of the period following the death from entomological evidence in decedents wearing DEET at the time of their death.
MeSH term(s)	Animals ; DEET/chemistry ; Diptera/physiology ; Entomology ; Feeding Behavior/physiology ; Forensic Pathology ; Insect Repellents/chemistry ; Larva ; Oviposition ; Postmortem Changes ; Swine ; Temperature
Chemical Substances	Insect Repellents ; DEET (134-62-3)
Language	English
Publishing date	2012-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	219216-0
ISSN	1556-4029 ; 0022-1198
ISSN (online)	1556-4029
ISSN	0022-1198
DOI	10.1111/j.1556-4029.2012.02159.x
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Article ; Online: Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.

Thomas, James B / Giddings, Angela M / Olepu, Srinivas / Wiethe, Robert W / Harris, Danni L / Narayanan, Sanju / Warner, Keith R / Sarret, Philippe / Longpre, Jean-Michel / Runyon, Scott P / Gilmour, Brian P

Bioorganic & medicinal chemistry letters

2015 Volume 25, Issue 2, Page(s) 292–296

Abstract: ... to the identification of the novel NTS2 selective nonpeptide, N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl ... carbonyl}-l-leucine (9). This compound is a potent partial agonist in the FLIPR assay with a profile ...

Abstract	Compounds acting via the GPCR neurotensin receptor type 2 (NTS2) display analgesic effects in relevant animal models. Using a pharmacophore model based on known NT receptor nonpeptide compounds, we screened commercial databases to identify compounds that might possess activity at NTS2 receptor sites. Modification of our screening hit to include structural features known to be recognized by NTS1 and NTS2, led to the identification of the novel NTS2 selective nonpeptide, N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (9). This compound is a potent partial agonist in the FLIPR assay with a profile of activity similar to that of the reference NTS2 analgesic nonpeptide levocabastine (5).
MeSH term(s)	Calcium/metabolism ; Drug Partial Agonism ; Humans ; Leucine/analogs & derivatives ; Leucine/chemistry ; Leucine/pharmacology ; Models, Molecular ; Molecular Structure ; Quinazolines/chemistry ; Quinazolines/pharmacology ; Radioligand Assay ; Receptors, Neurotensin/agonists ; Structure-Activity Relationship
Chemical Substances	NTRC-808 ; NTSR2 protein, human ; Quinazolines ; Receptors, Neurotensin ; Leucine (GMW67QNF9C) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2015-01-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2014.11.047
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Article ; Online: Reduction of protein adsorption and macrophage and astrocyte adhesion on ventricular catheters by polyethylene glycol and N-acetyl-L-cysteine.

Harris, Carolyn A / Resau, James H / Hudson, Eric A / West, Richard A / Moon, Candice / Black, Andrew D / McAllister, James P

Journal of biomedical materials research. Part A

2011 Volume 98, Issue 3, Page(s) 425–433

Abstract: ... functional polyethylene glycol (PEG604 and PEG5K, respectively) and N-acetyl-L-cysteine via adsorption and ...

Abstract	Cellular obstruction of poly(dimethyl)siloxane (PDMS) catheters is one of the most prevalent causes of shunt failure in the treatment of hydrocephalus. By modifying PDMS using short- and long-chain mono-functional polyethylene glycol (PEG604 and PEG5K, respectively) and N-acetyl-L-cysteine via adsorption and covalent binding (NAC and NAC/EDC/NHS, respectively), we increased surface wettability. We hypothesized that these surface modifications would inhibit protein adsorption and decrease host macrophage and astrocyte adhesion. Tested in a bioreactor set to mimic physiological flow, all modified surfaces significantly decreased albumin adsorption compared with PDMS (p < 0.05) except for PEG604-modified PDMS (p = 0.14). All four modification strategies significantly reduced (p < 0.01) fibronectin adsorption. PEG604, PEG5K, NAC, and NAC/EDC/NHS reduced the average level of macrophage adhesion by 53%, 63%, 40%, and 58% (p <.0.05 except when comparing PDMS with NAC) and astrocyte adhesion by 47%, 83%, 91%, and 72% (p < 0.05 except when comparing PDMS with PEG604), respectively. Combined with saline soak results which suggest that the surface wettability is stable over 30 days for each modification, our results are consistent with the hypothesis that these modifications decrease cell adhesion on catheters in vitro for the treatment of hydrocephalus.
MeSH term(s)	Acetylcysteine/chemistry ; Acetylcysteine/metabolism ; Adsorption ; Animals ; Astrocytes/cytology ; Catheters ; Cell Adhesion ; Cell Line ; Cells, Cultured ; Coated Materials, Biocompatible/chemistry ; Coated Materials, Biocompatible/metabolism ; Dimethylpolysiloxanes/chemistry ; Dimethylpolysiloxanes/metabolism ; Fibronectins/metabolism ; Macrophages/cytology ; Mice ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/metabolism ; Proteins/metabolism ; Rats ; Serum Albumin/metabolism ; Wettability
Chemical Substances	Coated Materials, Biocompatible ; Dimethylpolysiloxanes ; Fibronectins ; Proteins ; Serum Albumin ; Polyethylene Glycols (30IQX730WE) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2011-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2099989-6
ISSN	1552-4965 ; 1549-3296 ; 0021-9304
ISSN (online)	1552-4965
ISSN	1549-3296 ; 0021-9304
DOI	10.1002/jbm.a.33130
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Article ; Online: [((H)L)2Fe6(NCMe)m]n+ (m = 0, 2, 4, 6; n = -1, 0, 1, 2, 3, 4, 6): an electron-transfer series featuring octahedral Fe6 clusters supported by a hexaamide ligand platform.

Zhao, Qinliang / Harris, T David / Betley, Theodore A

Journal of the American Chemical Society

2011 Volume 133, Issue 21, Page(s) 8293–8306

Abstract: ... L)(2)Fe(6)](n+), where n=-1→4) within a 1.3 V potential range. Accordingly, each of these species is ... readily accessed chemically to provide the electron-transfer series [((H)L)(2)Fe(6)(NCMe)(m)][PF(6)](n) (m ... delocalized electronic structure. The cyclic voltammogram of [((H)L)(2)Fe(6)](n+) in acetonitrile reveals ...

Abstract	Using a trinucleating hexaamide ligand platform, the all-ferrous hexanuclear cluster ((H)L)(2)Fe(6) (1) is obtained from reaction of 3 equiv of Fe(2)(Mes)(4) (Mes = 2,4,6-Me(3)C(6)H(2)) with 2 equiv of the ligand ((H)L)H(6). Compound 1 was characterized by X-ray diffraction analysis, (57)Fe Mössbauer, SQUID magnetometry, mass spectrometry, and combustion analysis, providing evidence for an S=6 ground state and delocalized electronic structure. The cyclic voltammogram of [((H)L)(2)Fe(6)](n+) in acetonitrile reveals a rich redox chemistry, featuring five fully reversible redox events that span six oxidation states ([((H)L)(2)Fe(6)](n+), where n=-1→4) within a 1.3 V potential range. Accordingly, each of these species is readily accessed chemically to provide the electron-transfer series [((H)L)(2)Fe(6)(NCMe)(m)][PF(6)](n) (m=0, n=-1 (2); m=2, n=1 (3); m=4, n=2 (4); m=6, n=3 (5); m=6, n=4 (6)). Compounds 2-6 were isolated and characterized by X-ray diffraction, (57)Fe Mössbauer and multinuclear NMR spectroscopy, and combustion analysis. Two-electron oxidation of the tetracationic cluster in 6 by 2 equiv of [NO](+) generates the thermally unstable hexacationic cluster [((H)L)(2)Fe(6)(NCMe)(m)](6+), which is characterized by NMR and (57)Fe Mössbauer spectroscopy. Importantly, several stepwise systematic metrical changes accompany oxidation state changes to the [Fe(6)] core, namely trans ligation of solvent molecules and variation in Mössbauer spectra, spin ground state, and intracluster Fe-Fe separation. The observed metrical changes are rationalized by considering a qualitative, delocalized molecular orbital description, which provides a set of frontier orbitals populated by Fe 3d electrons.
Language	English
Publishing date	2011-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/ja2015845
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Article: A nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester, attenuates lipoprivic feeding in mice.

Czech, Donald A / Kazel, Melanie R / Harris, John

Physiology & behavior

2003 Volume 80, Issue 1, Page(s) 75–79

Abstract: ... synthase (NOS) inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), reaching statistical significance ... at 10 mg/kg of L-NAME at h1 when compared to vehicle control condition. The inactive isomer, D-NAME, was ... measured general locomotor activity (grid crossings and rears) in an open arena under 10-50 mg/kg of L-NAME ...

Abstract	Possible involvement of nitric oxide (NO) in lipoprivic feeding was investigated in nondeprived male ICR mice adapted to a high-fat diet in a within-subjects design. Lipoprivation was induced by blocking fatty acid oxidation with Na-mercaptoacetate (MA), which produces a short-term increase in feeding in mice and rats. Food intake, measured at 1, 2, and 4 h following injection of 70 mg/kg of MA, was attenuated in a dose related manner with increasing pretreatment dose (1,10, 25 and 50 mg/kg sc) of the NO-synthase (NOS) inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), reaching statistical significance at 10 mg/kg of L-NAME at h1 when compared to vehicle control condition. The inactive isomer, D-NAME, was ineffective, thereby supporting stereospecific drug action and directly implicating NO. A control experiment measured general locomotor activity (grid crossings and rears) in an open arena under 10-50 mg/kg of L-NAME in the same mice; both measures were significantly different from vehicle condition only at the highest dose. These findings support involvement of NO in lipoprivic hyperphagia; they are consistent with and extend research linking NO and ingestive behaviors through use of NOS inhibitors. Possible influences of confounds were discussed.
MeSH term(s)	Animals ; Dietary Fats/metabolism ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; Feeding Behavior/drug effects ; Feeding Behavior/physiology ; Food Deprivation/physiology ; Lipids/physiology ; Male ; Mice ; Mice, Inbred ICR ; Motor Activity/drug effects ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide/physiology
Chemical Substances	Dietary Fats ; Enzyme Inhibitors ; Lipids ; Nitric Oxide (31C4KY9ESH) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
Language	English
Publishing date	2003-10
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/s0031-9384(03)00220-8
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Article: Effect of antioxidants on L-glutamate and N-methyl-4-phenylpyridinium ion induced-neurotoxicity in PC12 cells.

Mazzio, E / Huber, J / Darling, S / Harris, N / Soliman, K F

Neurotoxicology

2001 Volume 22, Issue 2, Page(s) 283–288

Abstract: ... cell death, were coenzyme Q-0, coenzyme Q-10, L-deprenyl and N-acetyl-L-cysteine. Compounds, which provided ... protection against MPP+-HCl toxicity, were allopurinol, coenzyme Q-10, L-deprenyl, N-acetyl-L-cysteine and ... and N-acetyl-L-cysteine. These results indicate that the mechanism of cell death ...

Abstract	The neuropathology associated with Parkinson's disease within and around the substantia nigra is thought to involve excessive production of free radicals, dopamine autoxidation, defects in the expression of glutathione peroxidase, attenuated levels of reduced glutathione, altered calcium homeostasis, excitotoxicity and genetic defects in mitochondrial complex I activity. While the neurotoxic mechanisms are vastly different for excitotoxins and N-methyl-4-phenylpyridinium ion (MPP+), both are thought to involve free radical production, compromised mitochondrial activity and excessive lipid peroxidation. In the present study, several dietary antioxidant compounds, monoamine oxidase inhibitors and ergogenic compounds were examined for protective action against neurotoxicity induced by L-glutamate (15 mM) or MPP+-HCl (5 mM) in a plastic adhering variant of murine pheochromocytoma cells. The results show no significant protective effects exhibited by azulene, (+)-catechin, curcrumin, (-)-epigallocatechin gallate, green tea, morin, pygnogenol, silymarin, clove oil, garlic oil or rosemary, extract. Compounds, which were effective in providing protection against L-glutamate-induced cell death, were coenzyme Q-0, coenzyme Q-10, L-deprenyl and N-acetyl-L-cysteine. Compounds, which provided protection against MPP+-HCl toxicity, were allopurinol, coenzyme Q-10, L-deprenyl, N-acetyl-L-cysteine and sesame oil. In both models, significant protection was achieved in the presence of coenzyme Q-10, L-deprenyl and N-acetyl-L-cysteine. These results indicate that the mechanism of cell death in both of these toxicity models is most likely not related to the destructive effects of free radicals.
MeSH term(s)	1-Methyl-4-phenylpyridinium/antagonists & inhibitors ; 1-Methyl-4-phenylpyridinium/toxicity ; Animals ; Antioxidants/pharmacology ; Cell Survival/drug effects ; Excitatory Amino Acid Agonists/toxicity ; Excitatory Amino Acid Antagonists/toxicity ; Excitatory Amino Acids/toxicity ; Glutamic Acid/toxicity ; Kinetics ; N-Methylaspartate/toxicity ; PC12 Cells ; Rats ; Receptors, N-Methyl-D-Aspartate/drug effects ; Receptors, N-Methyl-D-Aspartate/metabolism
Chemical Substances	Antioxidants ; Excitatory Amino Acid Agonists ; Excitatory Amino Acid Antagonists ; Excitatory Amino Acids ; Receptors, N-Methyl-D-Aspartate ; Glutamic Acid (3KX376GY7L) ; N-Methylaspartate (6384-92-5) ; 1-Methyl-4-phenylpyridinium (R865A5OY8J)
Language	English
Publishing date	2001-06-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	800820-6
ISSN	0161-813X
ISSN	0161-813X
DOI	10.1016/s0161-813x(01)00017-1
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Article ; Online: Host response signature trends in bacteraemia - authors' response.

Peri, Anna Maria / Harris, Patrick N A / Paterson, David L

Infectious diseases (London, England)

2024 Volume 56, Issue 5, Page(s) 418–420

MeSH term(s)	Humans ; Bacteremia
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2839775-7
ISSN	2374-4243 ; 2374-4235
ISSN (online)	2374-4243
ISSN	2374-4235
DOI	10.1080/23744235.2024.2326591
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Article ; Online: Scoping review of risk-scoring tools for early prediction of bloodstream infections caused by carbapenem-resistant Enterobacterales: do we really have a reliable risk-scoring tool?

Aslan, Abdullah Tarik / Ezure, Yukiko / Harris, Patrick N A / Paterson, David L

JAC-antimicrobial resistance

2024 Volume 6, Issue 1, Page(s) dlae032

Abstract: Background: Bloodstream infections (BSIs) caused by carbapenem-resistant Enterobacterales (CRE) are a global health concern. Rapid identification of CRE may improve patient outcomes and reduce inappropriate antibiotic prescription. The use of risk- ... ...

Abstract	Background: Bloodstream infections (BSIs) caused by carbapenem-resistant Enterobacterales (CRE) are a global health concern. Rapid identification of CRE may improve patient outcomes and reduce inappropriate antibiotic prescription. The use of risk-scoring tools (RSTs) can be valuable for optimizing the decision-making process for empirical antibiotic therapy of suspected CRE bacteraemia. These tools can also be used to triage use of expensive rapid diagnostic methods. Methods: We systematically reviewed the relevant literature in PubMed/MEDLINE, CINAHL, Cochrane, Web of Science, Embase and Scopus up to 1 November 2022 to identify RSTs that predict CRE BSIs. The literature review and analysis of the articles were performed by two researchers; any inconsistencies were resolved through discussion. Results: We identified 9 RSTs developed for early prediction of CRE BSIs and only logistic regression was used for most studies. These RSTs were quite different from each other in terms of their performance and the variables they included. They also had notable limitations and very few of them were externally validated. Conclusions: RSTs for early prediction of CRE BSIs have limitations and lack of external validity outside the local setting in which they were developed. Future studies to identify optimal RSTs in high and low CRE-endemic settings are warranted. Approaches based on rapid diagnostics and RSTs should be compared with a treatment approach using both methods in a randomized controlled trial.
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article ; Review
ISSN	2632-1823
ISSN (online)	2632-1823
DOI	10.1093/jacamr/dlae032
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Article ; Online: Effectiveness of Interventions Promoting Dietary Intake, Physical Activity, and Healthy Weight Status of Children in Family Child Care: A Systematic Review.

Vorage, Lieke / Vincze, Lisa / Tudehope, Lucy / Harris, Neil

Journal of nutrition education and behavior

2024 Volume 56, Issue 4, Page(s) 242–255

Abstract: Introduction: This systematic review examines the effectiveness of interventions in family child care (FCC) on (1) children's dietary intake, physical activity levels and weight, and (2) FCC health-promoting environments, policies, and practices. Quasi- ... ...

Abstract	Introduction: This systematic review examines the effectiveness of interventions in family child care (FCC) on (1) children's dietary intake, physical activity levels and weight, and (2) FCC health-promoting environments, policies, and practices. Quasi-experimental studies measuring these outcomes were included. Methods: All available articles up to July 2023 were searched using MEDLINE, ERIC, CINAHL, Embase, Scopus, and A+ Education, and 15 interventions were included. Methodological quality was assessed with the Effective Public Health Practice Project Assessment tool. Results: Thirteen studies were weak, and 2 strong in quality. Four interventions included children's dietary intake as an outcome measure, 2 included physical activity, and 3 weight status. Twelve interventions assessed nutrition and 7 physical activity environmental outcomes. Discussion: Interventions in FCC improved children's dietary intake, but their impact on physical activity and weight status was inconclusive. Furthermore, positive impacts were observed in environmental outcomes related to nutrition, whereas research on physical activity environmental outcomes was limited. Implications for research and practice: Future research could replicate interventions to validate effectiveness and understand positive outcome mechanisms. Future interventions might use FCC stakeholders' input, incorporate innovative physical activity components, enhance FCC providers' position as role models, involve parents, and target those groups that are at a high risk of being obese.
MeSH term(s)	Humans ; Child ; Pediatric Obesity/prevention & control ; Child Care ; Exercise ; Eating ; Educational Status
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Systematic Review ; Journal Article
ISSN	1878-2620
ISSN (online)	1878-2620
DOI	10.1016/j.jneb.2023.12.011
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