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  1. Book ; Online ; Thesis: Untersuchung der Hyaluronsäure-reichen Matrix im Fettgewebe des Knochenmarks während der Entwicklung und Progression von Typ 2 Diabetes Mellitus

    Heller, Katja [Verfasser] / Grandoch, Maria [Gutachter]

    2024  

    Author's details Katja Heller ; Gutachter: Maria Grandoch
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Book ; Online ; Thesis: Klonale Hämatopoese in experimentell-induzierter Kolitis

    Rolauer, Luca Stephan [Verfasser] / Grandoch, Maria [Gutachter] / Breitkreutz, Jörg [Gutachter]

    2024  

    Author's details Luca Stephan Rolauer ; Gutachter: Maria Grandoch, Jörg Breitkreutz
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: Trained Innate Immunity in Animal Models of Cardiovascular Diseases.

    Kleimann, Patricia / Irschfeld, Lisa-Marie / Grandoch, Maria / Flögel, Ulrich / Temme, Sebastian

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Acquisition of immunological memory is an important evolutionary strategy that evolved to protect the host from repetitive challenges from infectious agents. It was believed for a long time that memory formation exclusively occurs in the adaptive part of ...

    Abstract Acquisition of immunological memory is an important evolutionary strategy that evolved to protect the host from repetitive challenges from infectious agents. It was believed for a long time that memory formation exclusively occurs in the adaptive part of the immune system with the formation of highly specific memory T cells and B cells. In the past 10-15 years, it has become clear that innate immune cells, such as monocytes, natural killer cells, or neutrophil granulocytes, also have the ability to generate some kind of memory. After the exposure of innate immune cells to certain stimuli, these cells develop an enhanced secondary response with increased cytokine secretion even after an encounter with an unrelated stimulus. This phenomenon has been termed trained innate immunity (TI) and is associated with epigenetic modifications (histone methylation, acetylation) and metabolic alterations (elevated glycolysis, lactate production). TI has been observed in tissue-resident or circulating immune cells but also in bone marrow progenitors. Risk-factors for cardiovascular diseases (CVDs) which are associated with low-grade inflammation, such as hyperglycemia, obesity, or high salt, can also induce TI with a profound impact on the development and progression of CVDs. In this review, we briefly describe basic mechanisms of TI and summarize animal studies which specifically focus on TI in the context of CVDs.
    MeSH term(s) Animals ; Immunity, Innate ; Adaptive Immunity ; Trained Immunity ; Cardiovascular Diseases ; Monocytes ; Models, Animal
    Language English
    Publishing date 2024-02-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Noninvasive assessment of metabolic turnover during inflammation by

    Flocke, Vera / Temme, Sebastian / Bouvain, Pascal / Grandoch, Maria / Flögel, Ulrich

    Frontiers in immunology

    2023  Volume 14, Page(s) 1258027

    Abstract: Background: Inflammation and metabolism exhibit a complex interplay, where inflammation influences metabolic pathways, and in turn, metabolism shapes the quality of immune responses. Here, glucose turnover is of special interest, as proinflammatory ... ...

    Abstract Background: Inflammation and metabolism exhibit a complex interplay, where inflammation influences metabolic pathways, and in turn, metabolism shapes the quality of immune responses. Here, glucose turnover is of special interest, as proinflammatory immune cells mainly utilize glycolysis to meet their energy needs. Noninvasive approaches to monitor both processes would help elucidate this interwoven relationship to identify new therapeutic targets and diagnostic opportunities.
    Methods: For induction of defined inflammatory hotspots, LPS-doped Matrigel plugs were implanted into the neck of C57BL/6J mice. Subsequently,
    Results: After plug implantation and intravenous administration of the
    Conclusion: 1
    MeSH term(s) Humans ; Mice ; Animals ; Deuterium ; Lipopolysaccharides ; Mice, Inbred C57BL ; Magnetic Resonance Spectroscopy/methods ; Inflammation ; Glucose/metabolism
    Chemical Substances Deuterium (AR09D82C7G) ; Lipopolysaccharides ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1258027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Extrazelluläre Matrix nach akuter kardialer Ischämie - Untersuchungen zur Bedeutung der zirkulierenden Hyaluronsäure

    Schmitz, Friederike [Verfasser] / Grandoch, Maria [Gutachter]

    2022  

    Author's details Friederike Schmitz ; Gutachter: Maria Grandoch
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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    Inter-library loan at ZB MED

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  6. Book ; Online ; Thesis: Extrazelluläre Matrix nach akuter kardialer Ischämie - Untersuchungen zur Bedeutung der zirkulierenden Hyaluronsäure

    Schmitz, Friederike [Verfasser] / Grandoch, Maria [Gutachter]

    2022  

    Author's details Friederike Schmitz ; Gutachter: Maria Grandoch
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: The thrombin receptor PAR4 supports visceral adipose tissue inflammation.

    Kleeschulte, Sonja / Fischinger, Vivien / Öhlke, Lisa / Bode, Johannes / Kamler, Markus / Dobrev, Dobromir / Grandoch, Maria / Fender, Anke C

    Naunyn-Schmiedeberg's archives of pharmacology

    2024  

    Abstract: Thrombin inhibition suppresses adiposity, WAT inflammation and metabolic dysfunction in mice. Protease-activated receptor (PAR)1 does not account for thrombin-driven obesity, so we explored the culprit role of PAR4 in this context. Male WT and PAR- ... ...

    Abstract Thrombin inhibition suppresses adiposity, WAT inflammation and metabolic dysfunction in mice. Protease-activated receptor (PAR)1 does not account for thrombin-driven obesity, so we explored the culprit role of PAR4 in this context. Male WT and PAR-4
    Language English
    Publishing date 2024-04-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-024-03097-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book ; Online ; Thesis: Auswirkungen einer Myokardischämie auf das Sarkomerprotein Titin im Skelettmuskel

    Kollenbroich, Alexander [Verfasser] / Krüger, Martina [Gutachter] / Grandoch, Maria [Gutachter]

    2023  

    Author's details Alexander Kollenbroich ; Gutachter: Martina Krüger, Maria Grandoch
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Book ; Online ; Thesis: Die Bedeutung des braunen Fettgewebes im murinen Modell der kardialen Ischämie und Reperfusion

    Beran, Arne [Verfasser] / Grandoch, Maria [Gutachter] / Altschmied, Joachim [Gutachter]

    2023  

    Author's details Arne Beran ; Gutachter: Maria Grandoch, Joachim Altschmied
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  10. Book ; Online ; Thesis: Analyse der Titinmodifikationen im rechten Ventrikel diabetischer Mäuse nach kardialer Ischämie-Reperfusion

    Röhrig, Julia Leonie [Verfasser] / Krüger, Martina [Gutachter] / Grandoch, Maria [Gutachter]

    2023  

    Author's details Julia Leonie Röhrig ; Gutachter: Martina Krüger, Maria Grandoch
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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    Inter-library loan at ZB MED

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