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Article ; Online: A Herbal Prescription of Insamyangyeongtang as a Therapeutic Agent for Frailty in Elderly: A Narrative Review.

Lee, Han-Gyul / Arai, Ichiro / Kwon, Seungwon

2024 Volume 16, Issue 5

Abstract: Frailty is a major geriatric syndrome with a multifactorial etiology that induces a decline in multiple physiological and psychological functions. In traditional East Asian medicine (TEAM), qi and blood deficiency clinically represent as fatigue, anemia, ...

Abstract	Frailty is a major geriatric syndrome with a multifactorial etiology that induces a decline in multiple physiological and psychological functions. In traditional East Asian medicine (TEAM), qi and blood deficiency clinically represent as fatigue, anemia, anorexia, decreased strength after illness, and weakness, commonly interpretated as frailty. An herbal prescription of Insamyangyeongtang (IYT, Ninjin'yoeito in Japanese, Ren-Shen-Yang-Rong-Tang in Chinese) tonifies qi and blood and has the potential to treat multiple targets caused by qi and blood deficiency. As the population ages and frailty increases, there is an increase in the potential effectiveness of IYT in frailty. This study reviewed relevant clinical trials to provide an updated view on the effect of IYT on frailty. IYT has therapeutic effects on frailty associated with chronic respiratory diseases (e.g., chronic obstructive pulmonary disease) and cognitive impairments (e.g., Alzheimer's disease) and improves respiratory symptoms and cognition. IYT also has therapeutic effects on weight gain, muscle mass, and strength, and improves nutritional status in frail elderly individuals who have decreased muscle mass and strength, loss of appetite, and weight loss. The same effect has been shown in frailty in elderly individuals with rehabilitation treatment and chronic diseases. IYT also improves frailty associated with symptoms such as intractable dizziness and genitourinary symptoms. The beneficial effects of IYT in several diseases could be important for medication replacement, reduction, and prevention of polypharmacy. Based on the results of this review, we suggest that IYT has the potential to be a therapeutic agent against frailty.
MeSH term(s)	Humans ; Aged ; Frailty ; Frail Elderly ; Pulmonary Disease, Chronic Obstructive ; Cognitive Dysfunction ; Cognition/physiology
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16050721
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Developing a sorptive material of cadmium from pyrolysis of hen manure.

Lee, Jae-In / Choi, Dongho / Kim, Seungwon / Kim, Jee Young / Park, Seong-Jik / Kwon, Eilhann E

Chemosphere

2024 Volume 351, Page(s) 141262

Abstract: A large amount of manure is generated from concentrated animal feeding operations (CAFOs), leading to serious environmental issues and hazardous risks from pathogens, such as methicillin-resistant Staphylococcus aureus. Therefore, developing an effective ...

Abstract	A large amount of manure is generated from concentrated animal feeding operations (CAFOs), leading to serious environmental issues and hazardous risks from pathogens, such as methicillin-resistant Staphylococcus aureus. Therefore, developing an effective method for manure disposal is essential. Thus, in this study, we suggest the use of CO
MeSH term(s)	Animals ; Female ; Cadmium ; Manure ; Pyrolysis ; Carbon Dioxide ; Chickens ; Methicillin-Resistant Staphylococcus aureus ; Charcoal
Chemical Substances	Cadmium (00BH33GNGH) ; Manure ; Carbon Dioxide (142M471B3J) ; Charcoal (16291-96-6)
Language	English
Publishing date	2024-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141262
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Article: National Health Insurance Data Analysis for the Second-Wave Development of Korean Medicine Clinical Practice Guidelines in South Korea.

Kwon, Chan-Young / Shin, Seungwon / Kwon, O-Jin / Moon, Wonkyung / Kim, Namkwen / Park, Minjung

Journal of pharmacopuncture

2023 Volume 26, Issue 2, Page(s) 198–209

Abstract: Objectives: After the evidence-based Korean medicine clinical practice guidelines (KM-CPGs) for 30 targeted diseases were developed in 2021, 34 diseases have been proposed for the second-wave development of the KM-CPGs. The purpose of this study was to ... ...

Abstract	Objectives: After the evidence-based Korean medicine clinical practice guidelines (KM-CPGs) for 30 targeted diseases were developed in 2021, 34 diseases have been proposed for the second-wave development of the KM-CPGs. The purpose of this study was to investigate the development priorities of the candidate diseases into the second-wave development of KM-CPGs in south Korea. Methods: In this study, we analyzed the Health Insurance Review and Assessment Service National Patient Sample data from 2017 to 2018 to determine the demand and economic importance of the candidates for the second-wave development of KM-CPGs in real-world clinical settings in Korea. Results: The annual number of visits and patients, annual healthcare expenditure per patient, and healthcare expenditure per institution were analyzed. Musculoskeletal disorders, including sciatica and adhesive capsulitis of the shoulder, were the most important topics regarding the number of visits and patients and annual healthcare expenditure per institution. Specifically, sciatica (52.05% of the total number of visits, 48.34% of the total number of patients, and 42.12% of the total treatment expenditure per institution) showed overwhelmingly high proportions. However, cerebral palsy (36.03% of the total number of inpatient visits and 24.55% of the total number of inpatient patients) was a more important topic in inpatient clinical settings than musculoskeletal conditions or cancer, and healthcare expenditure per patient in this topic had the highest ranking. Furthermore, fractures were found to be highly important in inpatient clinical settings. No patients had influenza A virus infection or posttraumatic stress disorders who visited the KM medical institution of interest. Conclusion: This study highlights the gap between the real-world clinical setting and the research field in some topics. The results of this study can provide guidance for the second-wave development of KM-CPGs in the future.
Language	English
Publishing date	2023-07-03
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2747301-6
ISSN	2234-6856 ; 2093-6966
ISSN (online)	2234-6856
ISSN	2093-6966
DOI	10.3831/KPI.2023.26.2.198
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Article ; Online: National Health Insurance Data Analysis for the Second-Wave Development of Korean Medicine Clinical Practice Guidelines in South Korea

Chan-Young Kwon / Seungwon Shin / O-Jin Kwon / Wonkyung Moon / Namkwen Kim / Minjung Park

Journal of Pharmacopuncture, Vol 26, Iss 2, Pp 198-

2023 Volume 209

Abstract: Objectives: After the evidence-based Korean medicine clinical practice guidelines (KMCPGs) for 30 targeted diseases were developed in 2021, 34 diseases have been proposed for the second-wave development of the KM-CPGs. The purpose of this study was to ... ...

Abstract	Objectives: After the evidence-based Korean medicine clinical practice guidelines (KMCPGs) for 30 targeted diseases were developed in 2021, 34 diseases have been proposed for the second-wave development of the KM-CPGs. The purpose of this study was to investigate the development priorities of the candidate diseases into the second-wave development of KM-CPGs in south Korea. Methods: In this study, we analyzed the Health Insurance Review and Assessment Service National Patient Sample data from 2017 to 2018 to determine the demand and economic importance of the candidates for the second-wave development of KM-CPGs in real-world clinical settings in Korea.Results: The annual number of visits and patients, annual healthcare expenditure per patient, and healthcare expenditure per institution were analyzed. Musculoskeletal disorders, including sciatica and adhesive capsulitis of the shoulder, were the most important topics regarding the number of visits and patients and annual healthcare expenditure per institution. Specifically, sciatica (52.05% of the total number of visits, 48.34% of the total number of patients, and 42.12% of the total treatment expenditure per institution) showed overwhelmingly high proportions. However, cerebral palsy (36.03% of the total number of inpatient visits and 24.55% of the total number of inpatient patients) was a more important topic in inpatient clinical settings than musculoskeletal conditions or cancer, and healthcare expenditure per patient in this topic had the highest ranking. Furthermore, fractures were found to be highly important in inpatient clinical settings. No patients had influenza A virus infection or posttraumatic stress disorders who visited the KM medical institution of interest.Conclusion: This study highlights the gap between the real-world clinical setting and the research field in some topics. The results of this study can provide guidance for the second- wave development of KM-CPGs in the future.
Keywords	korean medicine ; clinical practice guideline ; healthcare utilization ; national health insurance data ; Medicine ; R ; Miscellaneous systems and treatments ; RZ409.7-999 ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Korean Pharmacopuncture Institute
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gold thread acupuncture for hemifacial spasm.

Kwon, Seungwon / Kim, Gyeongmuk

Neurology

2018 Volume 91, Issue 4, Page(s) 185–186

MeSH term(s)	Acupuncture Therapy/methods ; Aged ; Female ; Gold ; Hemifacial Spasm/diagnostic imaging ; Hemifacial Spasm/therapy ; Humans
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2018-07-21
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000005868
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Ui II Zs.153: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: H

Shin, Hyeonbin / Jeong, Seungwon / Lee, Yeongjong / Jeon, Chanhee / Kwon, Gayoung / Kim, Sooyeon / Lee, Dongwon

Biomacromolecules

2022 Volume 23, Issue 9, Page(s) 3810–3821

Abstract: Renal ischemia-reperfusion (IR) injury is an inevitable complication in various clinical settings including kidney transplantation and major vascular surgeries. Renal IR injury is a major risk factor for acute kidney injury, which still remains a major ... ...

Abstract	Renal ischemia-reperfusion (IR) injury is an inevitable complication in various clinical settings including kidney transplantation and major vascular surgeries. Renal IR injury is a major risk factor for acute kidney injury, which still remains a major clinical challenge without effective therapy. The main cause of renal IR injury is the massive production of reactive oxygen species (ROS) including hydrogen peroxide (H
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Hydrogen Peroxide/metabolism ; Kidney/metabolism ; Mice ; Nanoparticles/therapeutic use ; Polymers/therapeutic use ; Prodrugs/pharmacology ; Reactive Oxygen Species/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Reperfusion Injury/prevention & control
Chemical Substances	Anti-Inflammatory Agents ; Antioxidants ; Polymers ; Prodrugs ; Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2022-08-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.2c00669
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of acupuncture on postoperative recovery and extubation time: A protocol for systematic review and meta analysis.

Kwon, Seungwon / Jin, Chul / Jeong, Aram / Yang, Seung-Bo

Medicine

2021 Volume 100, Issue 4, Page(s) e24502

Abstract: Background: This systematic review protocol aims to provide evidence of the efficacy and safety of acupuncture on postoperative recovery and extubation time.: Methods: The following 11 electronic databases will be searched from inception: The ... ...

Abstract	Background: This systematic review protocol aims to provide evidence of the efficacy and safety of acupuncture on postoperative recovery and extubation time. Methods: The following 11 electronic databases will be searched from inception: The Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, AMED, CINAHL, 1 Chinese database (CNKI), and 5 Korean databases (OASIS, DBpia, RISS, KISS, NDSL). Only randomized controlled trials of acupuncture treatment for postoperative recovery after surgery will be included for review. The selection of the studies, data extraction, and management will be performed independently by 3 researchers. Methodological quality, including the risk of bias, will be assessed using the Cochrane risk of bias assessment tool. Results and conclusions: Our systematic review will provide evidence of the efficacy of acupuncture on postoperative recovery and extubation time. This evidence will provide useful information to practitioners and patients in the field of surgery and complementary medicine. Prospero registration number: 2020 CRD42020168411.
MeSH term(s)	Acupuncture Therapy/methods ; Airway Extubation ; Humans ; Meta-Analysis as Topic ; Postoperative Care/methods ; Systematic Reviews as Topic
Language	English
Publishing date	2021-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000024502
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Article ; Online: Pyrrolinium-Substituted Persistent Zwitterionic Ferrocenate Derivative Enabling the Application of Ferrocene Anolyte.

Song, Hayoung / Kwon, Giyun / Citek, Cooper / Jeon, Seungwon / Kang, Kisuk / Lee, Eunsung

ACS applied materials & interfaces

2021 Volume 13, Issue 39, Page(s) 46558–46565

Abstract: Here, we report the imidazolium-/pyrrolinium-substituted persistent zwitterionic ferrocenate derivatives, which were characterized by electron paramagnetic resonance (EPR) ... ...

Abstract	Here, we report the imidazolium-/pyrrolinium-substituted persistent zwitterionic ferrocenate derivatives, which were characterized by electron paramagnetic resonance (EPR) and
Language	English
Publishing date	2021-09-24
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c11571
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years.

Cho, Seung-Yeon / Lee, Han-Gyul / Kwon, Seungwon / Park, Seong-Uk / Jung, Woo-Sang / Moon, Sang-Kwan / Park, Jung-Mi / Ko, Chang-Nam

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 3

Abstract: Background: The world's population is rapidly aging, and attention to and research on the increase in life expectancy and age-related diseases are needed. This study aimed to review the in vivo studies on the anti-aging effects of herbal medicines.: ... ...

Abstract	Background: The world's population is rapidly aging, and attention to and research on the increase in life expectancy and age-related diseases are needed. This study aimed to review the in vivo studies on the anti-aging effects of herbal medicines. Methods: In vivo studies of single or complex herbal medicines for anti-aging that were published in the last five years were included in this review. The following databases were used: PubMed, Scopus, ScienceDirect, Web of Science and EMBASE. Results: A total of 41 studies were considered eligible for the review. The articles were classified into body organs and functions, experimental country, herbal medicine, extraction method, administration route, dosage, duration, animal model, aging-induced method, sex, number of animals per group, and outcomes and mechanisms A single herbal extract was used in a total of 21 studies including Conclusions: Herbal medicine exhibited beneficial effects on anti-aging in various parts of the body and its function. Further investigation of the appropriate herbal medicine prescriptions and their components is recommended.
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16030448
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Magnetic Properties of Amorphous Ta/CoFeB/MgO/Ta Thin Films on Deformable Substrates with Magnetic Field Angle and Tensile Strain.

Jun, Ah Hyun / Hwang, Young Hyun / Kang, Byeongwoo / Lee, Seungwon / Seok, Jiwon / Lee, Jong Seong / Song, Seo Hyun / Ju, Byeong-Kwon

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 17

Abstract: Recently, the application of cobalt iron boron (CoFeB) thin films in magnetic sensors has been widely studied owing to their high magnetic moment, anisotropy, and stability. However, most of these studies were conducted on rigid silicon substrates. For ... ...

Abstract	Recently, the application of cobalt iron boron (CoFeB) thin films in magnetic sensors has been widely studied owing to their high magnetic moment, anisotropy, and stability. However, most of these studies were conducted on rigid silicon substrates. For diverse applications of magnetic and angle sensors, it is important to explore the properties of ferromagnetic thin films grown on nonrigid deformable substrates. In this study, representative deformable substrates (polyimide (PI), polyethylene naphthalate (PEN), and polydimethylsiloxane (PDMS)), which can be bent or stretched, were used to assess the in-plane magnetic field angle-dependent properties of amorphous Ta/CoFeB/MgO/Ta thin films grown on deformable substrates. The effects of substrate roughness, tensile stress, deformable substrate characteristics, and sputtering on magnetic properties, such as the coercive field (
Language	English
Publishing date	2023-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23177479
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