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Article ; Online: A tRF nucleator for Nucleolin in cancer metastasis.

Xu, Yichen / Ruggero, Davide

2022 Volume 82, Issue 14, Page(s) 2536–2538

Abstract: In this issue of Molecular Cell, Liu et al. (2022) report that 5'- ... ...

Abstract	In this issue of Molecular Cell, Liu et al. (2022) report that 5'-tRF
MeSH term(s)	Breast Neoplasms/genetics ; Female ; Humans ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Nucleolin
Chemical Substances	Phosphoproteins ; RNA-Binding Proteins ; RNA, Transfer (9014-25-9)
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2022.06.025
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Article ; Online: Releasing the brake on protein synthesis in hematopoietic stem cells.

Forester, Craig M / Ruggero, Davide

Cell stem cell

2021 Volume 28, Issue 7, Page(s) 1183–1185

Abstract: Protein synthesis regulation constitutes a key node in directing decisions between hematopoietic stemness and differentiation. In this issue of Cell Stem Cell, Lv et al. (2021) describe a mechanism by which HSCs fine-tune translation rates by controlling ...

Abstract	Protein synthesis regulation constitutes a key node in directing decisions between hematopoietic stemness and differentiation. In this issue of Cell Stem Cell, Lv et al. (2021) describe a mechanism by which HSCs fine-tune translation rates by controlling 60S and 40S ribosomal subunit joining through targeted degradation of ZNF622 in response to stress.
MeSH term(s)	Cell Differentiation ; Hematopoietic Stem Cells
Language	English
Publishing date	2021-07-02
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2375354-7
ISSN	1875-9777 ; 1934-5909
ISSN (online)	1875-9777
ISSN	1934-5909
DOI	10.1016/j.stem.2021.06.003
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Zs.A 6589: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: miR-217 Regulates Normal and Tumor Cell Fate Following Induction of Endoplasmic Reticulum Stress.

Dey, Neekkan / Koumenis, Costas / Ruggero, Davide / Fuchs, Serge Y / Diehl, J Alan

Molecular cancer research : MCR

2024 Volume 22, Issue 4, Page(s) 360–372

Abstract: Rapidly proliferating cancer cells require a microenvironment where essential metabolic nutrients like glucose, oxygen, and growth factors become scarce as the tumor volume surpasses the established vascular capacity of the tissue. Limits in nutrient ... ...

Abstract	Rapidly proliferating cancer cells require a microenvironment where essential metabolic nutrients like glucose, oxygen, and growth factors become scarce as the tumor volume surpasses the established vascular capacity of the tissue. Limits in nutrient availability typically trigger growth arrest and/or apoptosis to prevent cellular expansion. However, tumor cells frequently co-opt cellular survival pathways thereby favoring cell survival under this environmental stress. The unfolded protein response (UPR) pathway is typically engaged by tumor cells to favor adaptation to stress. PERK, an endoplasmic reticulum (ER) protein kinase and UPR effector is activated in tumor cells and contributes tumor cell adaptation by limiting protein translation and balancing redox stress. PERK also induces miRNAs that contribute to tumor adaptation. miR-211 and miR-216b were previously identified as PERK-ATF4-regulated miRNAs that regulate cell survival. We have identified another PERK-responsive miRNA, miR-217, with increased expression under prolonged ER stress. Key targets of miR-217 are identified as TRPM1, the host gene for miR-211 and EZH2. Evidence is provided that miR-217 expression is essential for the rapid loss of miR-211 in prolonged ER stress and provides a functional link for determining whether cells adapt to stress or commit to apoptosis. Implications: PERK-dependent induction of miR-217 limits accumulation and function of the prosurvival miRNA, miR-211, to establish cell fate and promote cell commitment to apoptosis.
MeSH term(s)	Humans ; eIF-2 Kinase/genetics ; eIF-2 Kinase/metabolism ; Endoplasmic Reticulum Stress/genetics ; Unfolded Protein Response ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Apoptosis/physiology ; Neoplasms/genetics ; Tumor Microenvironment ; TRPM Cation Channels/genetics
Chemical Substances	eIF-2 Kinase (EC 2.7.11.1) ; MicroRNAs ; TRPM1 protein, human ; TRPM Cation Channels ; MIRN217 microRNA, human
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2098788-2
ISSN	1557-3125 ; 1541-7786
ISSN (online)	1557-3125
ISSN	1541-7786
DOI	10.1158/1541-7786.MCR-23-0676
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Article: A tRF nucleator for Nucleolin in cancer metastasis

Xu, Yichen / Ruggero, Davide

Molecular cell. 2022 July 21, v. 82, no. 14

2022

Abstract: In this issue of Molecular Cell, Liu et al. (2022) report that 5′-tRFCʸˢ, a stress-induced transfer RNA-derived RNA fragment (tRF) derived from the 5′ halves of cysteine tRNAs, regulates post-transcriptional gene expression, enabling the survival and ... ...

Abstract	In this issue of Molecular Cell, Liu et al. (2022) report that 5′-tRFCʸˢ, a stress-induced transfer RNA-derived RNA fragment (tRF) derived from the 5′ halves of cysteine tRNAs, regulates post-transcriptional gene expression, enabling the survival and lung metastasis formation of breast cancers.
Keywords	breasts ; cysteine ; gene expression ; lungs ; metastasis
Language	English
Dates of publication	2022-0721
Size	p. 2536-2538.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2022.06.025
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Protein synthesis control in cancer: selectivity and therapeutic targeting.

Kovalski, Joanna R / Kuzuoglu-Ozturk, Duygu / Ruggero, Davide

The EMBO journal

2022 Volume 41, Issue 8, Page(s) e109823

Abstract: Translational control of mRNAs is a point of convergence for many oncogenic signals through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on translational control to appropriately adapt to limited resources while ... ...

Abstract	Translational control of mRNAs is a point of convergence for many oncogenic signals through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on translational control to appropriately adapt to limited resources while maintaining cell growth and survival, which creates a selective therapeutic window compared to non-transformed cells. In this review, we first discuss how cancer cells modulate the translational machinery to rapidly and selectively synthesize proteins in response to internal oncogenic demands and external factors in the tumor microenvironment. We highlight the clinical potential of compounds that target different translation factors as anti-cancer therapies. Next, we detail how RNA sequence and structural elements interface with the translational machinery and RNA-binding proteins to coordinate the translation of specific pro-survival and pro-growth programs. Finally, we provide an overview of the current and emerging technologies that can be used to illuminate the mechanisms of selective translational control in cancer cells as well as within the microenvironment.
MeSH term(s)	Carcinogenesis ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Protein Biosynthesis ; RNA, Messenger/metabolism ; Tumor Microenvironment
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2022-03-22
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.2021109823
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Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Examining Myc-Dependent Translation Changes in Cellular Homeostasis and Cancer.

Kovalski, Joanna R / Xu, Yichen / Ruggero, Davide

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2318, Page(s) 255–266

Abstract: A central component of Myc's role as a master coordinator of energy metabolism and biomass accumulation is its ability to increase the rate of protein synthesis, driving cell cycle progression, and proliferation. Importantly, Myc-induced alterations in ... ...

Abstract	A central component of Myc's role as a master coordinator of energy metabolism and biomass accumulation is its ability to increase the rate of protein synthesis, driving cell cycle progression, and proliferation. Importantly, Myc-induced alterations in both global and specific mRNA translation is a key determinant of Myc's oncogenic function. Herein, we provide five assays to enable researchers to measure global protein synthesis changes, to identify the translatome uniquely regulated by Myc and to investigate the mechanisms generating the tailored Myc translation network. Metabolic labeling of cells with
MeSH term(s)	Cell Transformation, Neoplastic/metabolism ; DNA/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Genes, myc/genetics ; Genes, myc/physiology ; Homeostasis/genetics ; Homeostasis/physiology ; Humans ; Metabolomics/methods ; Neoplasms/genetics ; Neoplasms/metabolism ; Protein Biosynthesis/genetics ; Protein Biosynthesis/physiology ; Proteins/genetics ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; RNA, Messenger/metabolism ; Ribosomes/metabolism
Chemical Substances	Proteins ; Proto-Oncogene Proteins c-myc ; RNA, Messenger ; DNA (9007-49-2)
Language	English
Publishing date	2021-05-21
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1476-1_13
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Article ; Online: Translational control in cancer etiology.

Ruggero, Davide

Cold Spring Harbor perspectives in biology

2013 Volume 5, Issue 2

Abstract: The link between perturbations in translational control and cancer etiology is becoming a primary focus in cancer research. It has now been established that genetic alterations in several components of the translational apparatus underlie spontaneous ... ...

Abstract	The link between perturbations in translational control and cancer etiology is becoming a primary focus in cancer research. It has now been established that genetic alterations in several components of the translational apparatus underlie spontaneous cancers as well as an entire class of inherited syndromes known as "ribosomopathies" associated with increased cancer susceptibility. These discoveries have illuminated the importance of deregulations in translational control to very specific cellular processes that contribute to cancer etiology. In addition, a growing body of evidence supports the view that deregulation of translational control is a common mechanism by which diverse oncogenic pathways promote cellular transformation and tumor development. Indeed, activation of these key oncogenic pathways induces rapid and dramatic translational reprogramming both by increasing overall protein synthesis and by modulating specific mRNA networks. These translational changes promote cellular transformation, impacting almost every phase of tumor development. This paradigm represents a new frontier in the multihit model of cancer formation and offers significant promise for innovative cancer therapies. Current research, in conjunction with cutting edge technologies, will further enable us to explore novel mechanisms of translational control, functionally identify translationally controlled mRNA groups, and unravel their impact on cellular transformation and tumorigenesis.
MeSH term(s)	Cell Transformation, Neoplastic/genetics ; Genetic Predisposition to Disease ; Humans ; Models, Genetic ; Mutation ; Neoplasm Metastasis/genetics ; Neoplasms/genetics ; Peptide Initiation Factors/genetics ; Peptide Initiation Factors/physiology ; Protein Biosynthesis/physiology ; Ribosomes/genetics ; Ribosomes/physiology
Chemical Substances	Peptide Initiation Factors
Language	English
Publishing date	2013-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	1943-0264
ISSN (online)	1943-0264
DOI	10.1101/cshperspect.a012336
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A wobbly road to drug resistance in melanoma: tRNA-modifying enzymes in translation reprogramming.

McMahon, Mary / Ruggero, Davide

The EMBO journal

2018 Volume 37, Issue 15

MeSH term(s)	Codon ; Drug Resistance ; Humans ; Melanoma ; RNA, Transfer
Chemical Substances	Codon ; RNA, Transfer (9014-25-9)
Language	English
Publishing date	2018-07-02
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.201899978
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Article ; Online: New frontiers in translational control of the cancer genome.

Truitt, Morgan L / Ruggero, Davide

Nature reviews. Cancer

2017 Volume 17, Issue 5, Page(s) 332

Language	English
Publishing date	2017-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2062767-1
ISSN	1474-1768 ; 1474-175X
ISSN (online)	1474-1768
ISSN	1474-175X
DOI	10.1038/nrc.2017.30
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Zs.A 5563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Use of Tens in the Diagnosis of Functional Mandibular Lateral Deviation

Eleonora Ortu / Sara Di Nicolantonio / Alessandra Mummolo / Ruggero Cattaneo / Davide Pietropaoli / Annalisa Monaco

Applied Sciences, Vol 13, Iss 24, p

2023 Volume 13258

Abstract: Introduction: The traditional diagnosis of functional lateral deviation is based on a clinical evaluation and dental casts, supported by an instrumental analysis through X-rays; however, these diagnostic techniques do not provide any information about ... ...

Abstract	Introduction: The traditional diagnosis of functional lateral deviation is based on a clinical evaluation and dental casts, supported by an instrumental analysis through X-rays; however, these diagnostic techniques do not provide any information about the neuromuscular system. Several years ago, some authors stressed the importance of the mandibular rest position and its reproducibility as a diagnostic reference, and this became possible with the development of the Myomonitor, TENS. Aim: The aim of this study was to compare mandible position before and after the use of ultra-low-frequency transcutaneous electric nervous stimulation (ULFTENS) in children with diagnosed functional mandibular lateral deviation. Methods: This study was performed on 60 children, aged between 8 and 13 years, with a mean age of 10.1 years (SD 0.81), and with functional mandibular lateral deviation diagnosed clinically, who were referred to the dental clinic for pediatric dental care. Diagnostic neuromuscular registrations were made for all children, and their casts were mounted on a Galetti articulator at the myocentric position. These casts were then compared to those provided by a wax bite registration in the intercuspidal position. Results: Compared with the existing intercuspidal position, neuromuscular registration showed improvement in 30 (50%) patients, 18 patients (30%) showed no changes, and worsening of the tooth midline discrepancy was assessed in the remaining 12 (20%). The molar relationship did not follow the same trend of the midline because of the three-dimensional changes in the maxillo–mandibular relationship induced by TENS. After TENS, there was a significant correlation between the midline and right side deviation (r > 0.65); there was no correlation between the midline and the left side (r < 0.65). Furthermore, the right molar movement showed no correlation with the contralateral molar (r < 0.65). The posterior areas of the arch moved in a very unpredictable way, resulting in the diagnosis and prognosis ...
Keywords	TENS ; lateral deviation ; myocentric position ; growing patients ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	796
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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