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Book ; Thesis: Therapie des metastasierten kolorektalen Karzinoms mit 5-Fluorouracil als 2-Stunden-Infusion oder intravenöse Bolusinjektion in Kombination mit Folinsäure und Interferon Alpha 2 B

Dinger, Urda

Ergebnisse einer klinischen Phase-II-Studie

1994

Author's details	vorgelegt von Urda Dinger, geb. Schmutzler
Language	German
Size	102 Bl. : graph. Darst.
Edition	[Mikrofiche-Ausg.]
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Münster (Westfalen), Univ., Diss., 1994
Note	2 Mikrofiches
HBZ-ID	HT006503180
Database	Catalogue ZB MED Medicine, Health

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Article ; Conference proceedings: Late onset B-Streptokokkeninfektion durch infizierte Muttermilch

Fiebig, B / Pargac, N / Dinger, J

Zeitschrift für Geburtshilfe und Neonatologie

2008

Abstract: ... von B-Streptokkoken durch vertikale Infektion unter der Geburt aus. Durch das Stillen ... Eine weitere Hypothese beinhaltet die Besiedlung der Muttermilch einer im Vaginalabstrich B-Streptokokken ... positiven Mutter über die Hände. Wir berichten von zwei Kasuistiken bei denen eine B-Streptokokkensepsis und ...

Event/congress	34. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin, Zürich, 2008
Abstract	Neben den häufiger auftretenden Frühformen von Infektionen mit ß-hämolysierenden Streptokokken in der Neu- und Frühgeborenenperiode finden sich seltener auch Fälle von späten Infektionen mit Auftreten nach der ersten Lebenswoche. Der Infektions- bzw. Übertragungsweg dieser späten Infektion ist letztendlich nicht geklärt. Diskutiert werden eine verzögerte Manifestation, Reinfektionen wie auch horizontale, nosokomiale Infektionen. Einzelfallberichte zu einem weiteren Infektionsweg über infizierte Muttermilch stillender Mütter sind berichtet worden. Hypothesen gehen hier von entweder einer primären Besiedlung der oropharyngealen Mukosa von B-Streptokkoken durch vertikale Infektion unter der Geburt aus. Durch das Stillen wird eine Übertragung in die Milchgänge durch Unterdruck am Ende der Stillmahlzeit ermöglicht. Eine erneute Infektion des Neugeborenen nach Vermehrung der Keime in der Muttermilch kann dann zu dieser schwer verlaufenden Sepsis führen. Eine weitere Hypothese beinhaltet die Besiedlung der Muttermilch einer im Vaginalabstrich B-Streptokokken positiven Mutter über die Hände. Wir berichten von zwei Kasuistiken bei denen eine B-Streptokokkensepsis und –Meningitis über infizierte Muttermilch aufgetreten war. Die erste Kasuistik beschreibt ein reifes Neugeborenes mit unauffälliger Schwangerschaftsanamnese und guter postnataler Adaptation, welches nach Entlassung aus der Klinik nach der U2 am siebzehnten Lebenstag mit schwerer Sepsis und Meningitis vorgestellt wurde. In der Blutkultur und im Liquor konnten ß-hämolysierende Streptokokken nachgewiesen werden. In der Muttermilch ließen sich entsprechende Keime nachweisen. Aufgrund rezidivierender Krampfanfälle und tiefer Apnoen wurde die Intubation und Beatmung notwendig. Trotz unverzüglich begonnener antibiotischer Dreifachtherapie kam es im Verlauf zu schweren Folgeerscheinungen mit großen cerebralen Infarzierungen bifrontal und okkzipital. Die zweite Kasuistik berichtet von einem reifen Neugeborenen, unauffälliger Schwangerschaftsanamnese mit negativen mütterlichen Abstrichen bezüglich ß-hämolysierender Streptokokken und unauffälliger postnataler Adaptation. Am zwölften Lebenstag wurde das Neugeborenen mit schlechtem Trinkverhalten, Hyperexzitabilität und Berührungsempfindlichkeit vorgestellt. Bei deutlicher Nackensteifigkeit bestand der Verdacht auf eine Meningitis. In der Blutkultur und Magensekret konnten ß-hämolysierende Streptokokken nachgewiesen werden. Gleichermaßen zeigte sich eine hohe Keimzahl der Erreger in der Muttermilch. Bei late onset Infektionen eines gestillten Neugeborenen sollte neben rezidivierenden Infektionen auch an eine Übertragung durch infizierte Muttermilch gedacht werden und bei Verdacht eine sofortige Beendigung der Muttermilchzufuhr zur Folge haben. Interessanterweise sind einige Fälle infizierter Muttermilch ohne klinische Hinweise auf eine Mastitis beschrieben.
Language	German
Publishing date	2008-05-15
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	1226748-x
ISSN	1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
ISSN (online)	1439-1651
ISSN	0948-2393 ; 0300-967X ; 1615-5300
DOI	10.1055/s-2008-1078940
Database	Thieme publisher's database

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Article ; Online: CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.

Suan, Dan / Kräutler, Nike J / Maag, Jesper L V / Butt, Danyal / Bourne, Katherine / Hermes, Jana R / Avery, Danielle T / Young, Clara / Statham, Aaron / Elliott, Michael / Dinger, Marcel E / Basten, Antony / Tangye, Stuart G / Brink, Robert

Immunity

2017 Volume 47, Issue 6, Page(s) 1142–1153.e4

Abstract: Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center ...

Abstract	Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to the MBC lineage. Here, we report that the chemokine receptor CCR6 uniquely marks MBC precursors in both mouse and human GCs. CCR6
MeSH term(s)	Animals ; B7-2 Antigen/genetics ; B7-2 Antigen/immunology ; Cell Differentiation ; Cell Lineage/immunology ; Gene Expression Profiling ; Gene Expression Regulation ; Germinal Center/cytology ; Germinal Center/immunology ; Humans ; Immunity, Humoral ; Immunologic Memory ; Immunophenotyping ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Phenotype ; Plasma Cells/cytology ; Plasma Cells/immunology ; Positive Regulatory Domain I-Binding Factor 1/genetics ; Positive Regulatory Domain I-Binding Factor 1/immunology ; Precursor Cells, B-Lymphoid/cytology ; Precursor Cells, B-Lymphoid/immunology ; Receptors, CCR6/genetics ; Receptors, CCR6/immunology ; Receptors, CXCR4/genetics ; Receptors, CXCR4/immunology ; Signal Transduction
Chemical Substances	B7-2 Antigen ; CCR6 protein, mouse ; CXCR4 protein, mouse ; Cd86 protein, mouse ; Prdm1 protein, mouse ; Receptors, CCR6 ; Receptors, CXCR4 ; Positive Regulatory Domain I-Binding Factor 1 (EC 2.1.1.-)
Language	English
Publishing date	2017--19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2017.11.022
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Breast milk transmission of group B streptococcal infection.

Dinger, Jürgen / Müller, Diane / Pargac, Nils / Schwarze, Roland

The Pediatric infectious disease journal

2002 Volume 21, Issue 6, Page(s) 567–568

Abstract: A term female infant developed late onset group B streptococcal disease on Day 12 of life ... Asymptomatic excretion of group B Streptococcus in breast milk may be an underrecognized cause of neonatal ...

Abstract	A term female infant developed late onset group B streptococcal disease on Day 12 of life. The source of the organism appeared to be expressed maternal breast milk in the absence of clinical mastitis. Asymptomatic excretion of group B Streptococcus in breast milk may be an underrecognized cause of neonatal infection.
MeSH term(s)	Amikacin/pharmacology ; Amikacin/therapeutic use ; Ampicillin/pharmacology ; Ampicillin/therapeutic use ; Breast Feeding ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Milk, Human/microbiology ; Penicillins/pharmacology ; Penicillins/therapeutic use ; Pregnancy ; Streptococcal Infections/drug therapy ; Streptococcal Infections/transmission ; Streptococcus agalactiae/growth & development
Chemical Substances	Penicillins ; Ampicillin (7C782967RD) ; Amikacin (84319SGC3C)
Language	English
Publishing date	2002-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/00006454-200206000-00017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Synthesis, crystal structure, property research, and DFT calculation of 2,3-diphenylfuro[3,2-b]quinoxaline

Yao, Qi-Chao / Wu, Ding-Er / Xia, Min

Journal of molecular structure. 2013 June 24, v. 1042

2013

Abstract: The title compound is obtained via the intramolecular condensation of 3-(2-oxo-1,2-diphenylethyl)quinoxalin-2(1H)-one in the presence of excessive boron trifluoride etherate and characterized by ¹HNMR, ¹³CNMR, IR, and EI-MS. The solution-based and solid- ... ...

Abstract	The title compound is obtained via the intramolecular condensation of 3-(2-oxo-1,2-diphenylethyl)quinoxalin-2(1H)-one in the presence of excessive boron trifluoride etherate and characterized by ¹HNMR, ¹³CNMR, IR, and EI-MS. The solution-based and solid-state fluorescence along with the electrochemical property are studied in detail. The unique herring-bone arrangement which is revealed by the X-ray crystallography should account for the intense solid-state fluorescence. The theoretic calculations are employed to clarify the origin of the large Stokes shift and the positive solvatochromism in view of the geometric relaxation and the transition feature.
Keywords	X-ray diffraction ; boron ; condensation ; crystal structure ; electrochemistry ; fluorescence
Language	English
Dates of publication	2013-0624
Size	p. 78-85.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	194476-9
ISSN	0022-2860 ; 0377-046X
ISSN	0022-2860 ; 0377-046X
DOI	10.1016/j.molstruc.2013.03.044
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Shaping outcomes of Reciproc Blue and Rotate in roots canals with band-shaped isthmuses: micro-CT study.

Keskin, Cangül / Pirimoğlu, Burcu / Çiftçioğlu, Elif / Dinger, Esma / Kömeç, Onur / Keleş, Ali

Clinical oral investigations

2023 Volume 27, Issue 12, Page(s) 7337–7344

Abstract: Objective: This study assessed the outcome of shaping the mesial roots of mandibular first molars containing band-shaped isthmuses with an isthmus floor located at the apical third with Reciproc Blue and Rotate instruments in terms of canal ... ...

Abstract	Objective: This study assessed the outcome of shaping the mesial roots of mandibular first molars containing band-shaped isthmuses with an isthmus floor located at the apical third with Reciproc Blue and Rotate instruments in terms of canal transportation, canal aberrations and unprepared apical canals. Materials and methods: Pair-matched mesial roots of mandibular first molars according to their isthmus location (distance from apical foramina) and size were constructed based on quantitative measurements (length, major and minor diameter at isthmus roof and floor) on preoperative micro-CT scanning (n = 10). The pair-matched specimens were prepared either using Reciproc Blue R25 (25.08v) or Rotate (15.04, 20.05, 25.06) instruments and then subjected to a second micro-CT scanning. Micro-CT scans were analysed to evaluate the canal transportation at the apical foramen and isthmus floor levels and the frequency of procedural errors (separated instruments, artificial canal preparation, cross shaping and unprepared apical canals). Canal transportation values were compared using Mann-Whitney U, and the distribution of procedural errors was compared with chi-square tests with a 5% significance threshold. Results: Greater transportation values were detected in the apical foramen level compared to the isthmus floor in both groups. No significant difference was detected between Rotate and Reciproc Blue groups in terms of absolute transportation values and the incidence of procedural errors (p > .05). Conclusion: Preparation of mesial root canals containing a band-shaped isthmus at the apical portion with Reciproc Blue and Rotate instruments caused transportation of the original canal position at the isthmus floor and the apical foramen levels and resulted in procedural errors. Clinical relevance: This ex vivo micro-CT study using controlled pair-matched specimens showed that presence of a band-shaped isthmus complicates canal preparation procedure irrespective of the preparation systems.
MeSH term(s)	X-Ray Microtomography ; Root Canal Preparation ; Dental Pulp Cavity/diagnostic imaging ; Tooth Apex ; Molar/diagnostic imaging ; Molar/surgery ; Equipment Design
Language	English
Publishing date	2023-10-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-023-05324-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Protocol for the production and purification of an i-Motif-specific nanobody.

Zeraati, Mahdi / Ross, Samuel E / Aghaei, Behnaz / Rajal, Alvaro González / King, Cecile / Dinger, Marcel E

STAR protocols

2023 Volume 4, Issue 4, Page(s) 102729

Abstract: Intercalated motifs or i-Motifs (iMs) are nucleic acid structures formed by cytosine-rich sequences, which may regulate cellular processes and have broad applications in nanotechnology due to their pH-dependent nature. We have developed an iM-specific ... ...

Abstract	Intercalated motifs or i-Motifs (iMs) are nucleic acid structures formed by cytosine-rich sequences, which may regulate cellular processes and have broad applications in nanotechnology due to their pH-dependent nature. We have developed an iM-specific nanobody (iMbody) that can recognize iM DNA structures regardless of their sequences, making it a versatile research tool for studying iMs in various contexts. Here, we provide a protocol for the bacterial expression and His-tag purification of iMbody. We then describe procedures for performing ELISA and immunostaining using iMbody.
MeSH term(s)	Nucleotide Motifs ; Nanotechnology/methods ; DNA/metabolism
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Journal Article
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2023.102729
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Article: Zinc, vitamin B-6, and nutrients.

Cavdar, A O / Uçkan, D / Dinger, N

The American journal of clinical nutrition

1988 Volume 48, Issue 2, Page(s) 380–381

MeSH term(s)	Adult ; Female ; Humans ; Nutritional Status ; Pregnancy/blood ; Pyridoxine/blood ; Zinc/blood
Chemical Substances	Zinc (J41CSQ7QDS) ; Pyridoxine (KV2JZ1BI6Z)
Language	English
Publishing date	1988-08
Publishing country	United States
Document type	Letter
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Olivocochlear efferent contributions to speech-in-noise recognition across signal-to-noise ratios.

Mertes, Ian B / Johnson, Kristin M / Dinger, Zoë A

The Journal of the Acoustical Society of America

2019 Volume 145, Issue 3, Page(s) 1529

Abstract: The medial olivocochlear (MOC) efferent system modifies cochlear output to aid signal detection in noise, but the precise role of efferents in speech-in-noise understanding remains unclear. The current study examined the contribution of the MOC reflex ... ...

Abstract	The medial olivocochlear (MOC) efferent system modifies cochlear output to aid signal detection in noise, but the precise role of efferents in speech-in-noise understanding remains unclear. The current study examined the contribution of the MOC reflex for speech recognition in noise in 30 normal-hearing young adults (27 females, mean age = 22.7 yr). The MOC reflex was assessed using contralateral inhibition of transient-evoked otoacoustic emissions. Speech-in-noise perception was evaluated using the coordinate response measure presented in ipsilateral speech-shaped noise at signal-to-noise ratios (SNRs) ranging from -12 to 0 dB. Performance was assessed without and with the presence of contralateral noise to activate the MOC reflex. Performance was significantly better with contralateral noise only at the lowest SNR. There was a trend of better performance with increasing contralateral inhibition at the lowest SNR. Threshold of the psychometric function was significantly correlated with contralateral inhibition. Response time on the speech task was not significantly correlated with contralateral inhibition. Results suggest that the MOC reflex contributes to listening in low SNRs and the relationship between the MOC reflex and perception is highly dependent upon the task characteristics.
Language	English
Publishing date	2019-05-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/1.5094766
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Article: Measuring personality functioning with the 12-item version of the OPD-Structure Questionnaire (OPD-SQS): reliability, factor structure, validity, and measurement invariance in the general population.

Ehrenthal, Johannes C / Kruse, Johannes / Schmalbach, Bjarne / Dinger, Ulrike / Werner, Samuel / Schauenburg, Henning / Brähler, Elmar / Kampling, Hanna

Frontiers in psychology

2023 Volume 14, Page(s) 1248992

Abstract: Background: The assessment of personality functioning is at the core of current dimensional models of personality disorders. A variety of measures from different clinical and research traditions aim to assess basic psychological capacities regarding the ...

Abstract	Background: The assessment of personality functioning is at the core of current dimensional models of personality disorders. A variety of measures from different clinical and research traditions aim to assess basic psychological capacities regarding the self and others. While some instruments have shown reliability and validity in clinical or other selected samples, much less is known about their performance in the general population. Methods: In three samples representative of the German adult population with a total of 7,256 participants, levels of personality functioning were measured with the short 12-item version of the Operationalized Psychodynamic Diagnosis - Structure Questionnaire (OPD-SQS). We addressed questions of factor structure, reliability, validity, factorial invariance, and provide norm values. Results: Confirmatory factor analysis indicated a satisfactory to good model fit. OPD-SQS models were mostly unaffected by variables such as gender, age, or measurement time. As expected, personality functioning was associated with general psychopathology as well as indices of occupational functioning. Conclusion: The OPD-SQS is a viable measure to assess personality functioning in the general population.
Language	English
Publishing date	2023-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1248992
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