LIVIVO - Search results -

Search results

Result 1 - 10 of total 410

Search options

Article ; Online: Africa’s Resilience in the Face of COVID-19 Pandemic

Arakpogun, Emmanuel / El Sahn, Ziad / Prime, Karla / Gerli, Paolo / Olan, Femi

SSRN Electronic Journal ; ISSN 1556-5068

Let’s Talk about It!

2020

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.2139/ssrn.3640311
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.

Prime, Tracy A / Blaikie, Frances H / Evans, Cameron / Nadtochiy, Sergiy M / James, Andrew M / Dahm, Christina C / Vitturi, Dario A / Patel, Rakesh P / Hiley, C Robin / Abakumova, Irina / Requejo, Raquel / Chouchani, Edward T / Hurd, Thomas R / Garvey, John F / Taylor, Cormac T / Brookes, Paul S / Smith, Robin A J / Murphy, Michael P

Proceedings of the National Academy of Sciences of the United States of America

2009 Volume 106, Issue 26, Page(s) 10764–10769

Abstract: ... at cytochrome c oxidase and S-nitrosates thiol proteins. We developed mitochondria-targeted S-nitrosothiols (MitoSNOs ... an S-nitrosothiol to the lipophilic triphenylphosphonium cation, was rapidly and extensively ... accumulated within mitochondria, driven by the membrane potential, where it generated NO(*) and S-nitrosated ...

Abstract	Nitric oxide (NO()) competitively inhibits oxygen consumption by mitochondria at cytochrome c oxidase and S-nitrosates thiol proteins. We developed mitochondria-targeted S-nitrosothiols (MitoSNOs) that selectively modulate and protect mitochondrial function. The exemplar MitoSNO1, produced by covalently linking an S-nitrosothiol to the lipophilic triphenylphosphonium cation, was rapidly and extensively accumulated within mitochondria, driven by the membrane potential, where it generated NO() and S-nitrosated thiol proteins. MitoSNO1-induced NO() production reversibly inhibited respiration at cytochrome c oxidase and increased extracellular oxygen concentration under hypoxic conditions. MitoSNO1 also caused vasorelaxation due to its NO() generation. Infusion of MitoSNO1 during reperfusion was protective against heart ischemia-reperfusion injury, consistent with a functional modification of mitochondrial proteins, such as complex I, following S-nitrosation. These results support the idea that selectively targeting NO(*) donors to mitochondria is an effective strategy to reversibly modulate respiration and to protect mitochondria against ischemia-reperfusion injury.
MeSH term(s)	Animals ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/physiology ; Cell Line ; Electron Transport Complex I/metabolism ; HeLa Cells ; Heart/drug effects ; Heart/physiopathology ; Humans ; In Vitro Techniques ; Male ; Mass Spectrometry ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Mitochondria/physiology ; Mitochondria, Heart/metabolism ; Mitochondria, Heart/physiology ; Myoblasts/cytology ; Myoblasts/drug effects ; Myoblasts/metabolism ; Nitric Oxide/metabolism ; Nitrosation/drug effects ; Oxygen Consumption/drug effects ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/metabolism ; Reperfusion Injury/physiopathology ; Reperfusion Injury/prevention & control ; S-Nitrosothiols/chemical synthesis ; S-Nitrosothiols/metabolism ; S-Nitrosothiols/pharmacology ; Sulfhydryl Compounds/metabolism ; Vasodilation/drug effects
Chemical Substances	S-Nitrosothiols ; Sulfhydryl Compounds ; Nitric Oxide (31C4KY9ESH) ; Electron Transport Complex I (EC 7.1.1.2)
Language	English
Publishing date	2009-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.0903250106
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

Prime, Tracy A / Blaikie, Frances H / Evans, Cameron / Nadtochiy, Sergiy M / James, Andrew M / Dahm, Christina C / Vitturi, Dario A / Patel, Rakesh P / Hiley, C. Robin / Abakumova, Irina / Requejo, Raquel / Chouchani, Edward T / Hurd, Thomas R / Garvey, John F / Taylor, Cormac T / Brookes, Paul S / Smith, Robin A.J / Murphy, Michael P

Proceedings of the National Academy of Sciences of the United States of America. 2009 June 30, v. 106, no. 26

2009

Abstract	Nitric oxide (NO{bullet}) competitively inhibits oxygen consumption by mitochondria at cytochrome c oxidase and S-nitrosates thiol proteins. We developed mitochondria-targeted S-nitrosothiols (MitoSNOs) that selectively modulate and protect mitochondrial function. The exemplar MitoSNO1, produced by covalently linking an S-nitrosothiol to the lipophilic triphenylphosphonium cation, was rapidly and extensively accumulated within mitochondria, driven by the membrane potential, where it generated NO{bullet} and S-nitrosated thiol proteins. MitoSNO1-induced NO{bullet} production reversibly inhibited respiration at cytochrome c oxidase and increased extracellular oxygen concentration under hypoxic conditions. MitoSNO1 also caused vasorelaxation due to its NO{bullet} generation. Infusion of MitoSNO1 during reperfusion was protective against heart ischemia-reperfusion injury, consistent with a functional modification of mitochondrial proteins, such as complex I, following S-nitrosation. These results support the idea that selectively targeting NO{bullet} donors to mitochondria is an effective strategy to reversibly modulate respiration and to protect mitochondria against ischemia-reperfusion injury.
Keywords	anaerobic conditions ; cations ; cytochrome-c oxidase ; heart ; membrane potential ; mitochondria ; nitric oxide ; oxygen ; oxygen consumption ; proteins ; thiols ; vasodilation
Language	English
Dates of publication	2009-0630
Size	p. 10764-10769.
Publishing place	National Academy of Sciences
Document type	Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.0903250106
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4' 63/44: Show issues
87/25270: Show issues
Qa 4' 169/3: Show issues
Z 8.7: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: [Rezension von: Ho, Samuel P. S., Rural China in transition]

Prime, Penelope B / Ho, Samuel P. S

Journal of economic literature 34 ,2, S. 812-813

1996

Author's details	Penelope B. Prime
Keywords	40;49
Language	English
Publisher	Assoc
Publishing place	Nashville, Tenn
Document type	Article
ZDB-ID	3076-4 ; 2010159-4
ISSN	0022-0515
ISSN	0022-0515
Database	ECONomics Information System

Order via subito

Article ; Online: The role of digital transformation in addressing health inequalities in coastal communities: barriers and enablers.

Asthana, Sheena / Prime, Samantha

Frontiers in health services

2023 Volume 3, Page(s) 1225757

Abstract: Healthcare systems worldwide are striving for the "quadruple aim" of better population health and well-being, improved experience of care, healthcare team well-being (including that of carers) and lower system costs. By shifting the balance of care from ... ...

Abstract	Healthcare systems worldwide are striving for the "quadruple aim" of better population health and well-being, improved experience of care, healthcare team well-being (including that of carers) and lower system costs. By shifting the balance of care from reactive to preventive by facilitating the integration of data between patients and clinicians to support prevention, early diagnosis and care at home, many technological solutions exist to support this ambition. Yet few have been mainstreamed in the NHS. This is particularly the case in English coastal areas which, despite having a substantially higher burden of physical and mental health conditions and poorer health outcomes, also experience inequalities with respect to digital maturity. In this paper, we suggest ways in which digital health technologies (DHTs) can support a greater shift towards prevention; discuss barriers to digital transformation in coastal communities; and highlight ways in which central, regional and local bodes can enable transformation. Given a real risk that variations in digital maturity may be exacerbating coastal health inequalities, we call on health and care policy leaders and service managers to understands the potential benefits of a digital future and the risks of failing to address the digital divide.
Language	English
Publishing date	2023-08-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2813-0146
ISSN (online)	2813-0146
DOI	10.3389/frhs.2023.1225757
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Escape from Cellular Senescence Is Associated with Chromosomal Instability in Oral Pre-Malignancy.

Prime, Stephen S / Cirillo, Nicola / Parkinson, E Kenneth

Biology

2023 Volume 12, Issue 1

Abstract: An escape from cellular senescence through the development of unlimited growth potential is one of the hallmarks of cancer, which is thought to be an early event in carcinogenesis. In this review, we propose that the molecular effectors of senescence, ... ...

Abstract	An escape from cellular senescence through the development of unlimited growth potential is one of the hallmarks of cancer, which is thought to be an early event in carcinogenesis. In this review, we propose that the molecular effectors of senescence, particularly the inactivation of TP53 and CDKN2A, together with telomere attrition and telomerase activation, all lead to aneuploidy in the keratinocytes from oral potentially malignant disorders (OPMD). Premalignant keratinocytes, therefore, not only become immortal but also develop genotypic and phenotypic cellular diversity. As a result of these changes, certain clonal cell populations likely gain the capacity to invade the underlying connective tissue. We review the clinical implications of these changes and highlight a new PCR-based assay to identify aneuploid cell in fluids such as saliva, a technique that is extremely sensitive and could facilitate the regular monitoring of OPMD without the need for surgical biopsies and may avoid potential biopsy sampling errors. We also draw attention to recent studies designed to eliminate aneuploid tumour cell populations that, potentially, is a new therapeutic approach to prevent malignant transformations in OPMD.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12010103
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Escape from Cellular Senescence Is Associated with Chromosomal Instability in Oral Pre-Malignancy

Prime, Stephen S. / Cirillo, Nicola / Parkinson, E. Kenneth

Biology (Basel). 2023 Jan. 10, v. 12, no. 1

2023

Abstract	An escape from cellular senescence through the development of unlimited growth potential is one of the hallmarks of cancer, which is thought to be an early event in carcinogenesis. In this review, we propose that the molecular effectors of senescence, particularly the inactivation of TP53 and CDKN2A, together with telomere attrition and telomerase activation, all lead to aneuploidy in the keratinocytes from oral potentially malignant disorders (OPMD). Premalignant keratinocytes, therefore, not only become immortal but also develop genotypic and phenotypic cellular diversity. As a result of these changes, certain clonal cell populations likely gain the capacity to invade the underlying connective tissue. We review the clinical implications of these changes and highlight a new PCR-based assay to identify aneuploid cell in fluids such as saliva, a technique that is extremely sensitive and could facilitate the regular monitoring of OPMD without the need for surgical biopsies and may avoid potential biopsy sampling errors. We also draw attention to recent studies designed to eliminate aneuploid tumour cell populations that, potentially, is a new therapeutic approach to prevent malignant transformations in OPMD.
Keywords	aneuploidy ; biopsy ; carcinogenesis ; cell senescence ; chromosomal instability ; keratinocytes ; neoplasm cells ; phenotype ; polymerase chain reaction ; saliva ; telomerase ; telomeres
Language	English
Dates of publication	2023-0110
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12010103
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Cool Kids: Cognitive Behavioral Therapy in a Spanish Sample of Children and Adolescents with Anxiety Disorders.

Galí, Dafne / Forcadell, Eduard / Primé-Tous, Mireia / Puig, Olga / Lera-Miguel, Sara

Child psychiatry and human development

2023

Abstract: Anxiety disorders (ADs) negatively impact functioning and life quality. Studies on cognitive behavioral therapy (CBT) have demonstrated its short- and long-term efficacy. Cool Kids (CK) is a 10-session CBT-based group program administered to participants ...

Abstract	Anxiety disorders (ADs) negatively impact functioning and life quality. Studies on cognitive behavioral therapy (CBT) have demonstrated its short- and long-term efficacy. Cool Kids (CK) is a 10-session CBT-based group program administered to participants with ADs aged 7-17 years and their parents, and it has demonstrated efficacy compared with control groups. This study analyzes the effectiveness of CK in a clinical cohort of Spanish children and adolescents with ADs. CK was offered to 57 patients with AD and their caregivers at the Hospital Clínic, Barcelona. In all global registered measures, the results demonstrated a reduction of symptoms and their interference in daily functioning. Moreover, a significant improvement was observed in participants who completed more sessions. Thus, CK reduced the severity of anxiety and its interference over individual and family functioning.
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	223895-0
ISSN	1573-3327 ; 0009-398X
ISSN (online)	1573-3327
ISSN	0009-398X
DOI	10.1007/s10578-023-01579-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 772: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Change in the Concentration of Employment in Computer Services: Spatial Estimation at the U.S. Metro County Level

GRIMES, DONALD / PRIME, PENELOPE B / WALKER, MARY BETH

Growth and change. 2007 Mar., v. 38, no. 1

2007

Abstract: This article models the concentration of computer services activity across the U.S. with factors ...

Abstract	This article models the concentration of computer services activity across the U.S. with factors that incorporate spatial relationships. Specifically, we enhance the standard home-area study with an analysis that allows conditions in neighboring counties to affect the concentration of employment in the home county. We use county-level data for metropolitan areas between 1990 and 1997. To measure change in employment concentration, we use the change in location quotients for SIC 737, which captures employment concentration changes caused by both the number of firms and the scale of their activity relative to the national average. After controlling for local demand for computer services, our results support the importance of the presence of a qualified labor supply, interindustry linkages, proximity to a major airport, and spatial processes in explaining changes in computer services employment concentration, finding little support for the influence of cost factors. Our enhanced model reveals interjurisdictional relationships among these metro counties that could not be captured with standard estimates by state, metropolitan statistical area (MSA), or county. Using counties within MSAs, therefore, provides more general results than case studies but still allows measurement of local interactions.
Language	English
Dates of publication	2007-03
Size	p. 39-55.
Publisher	Blackwell Publishing Inc
Publishing place	Malden, USA
Document type	Article
ZDB-ID	1482672-0
ISSN	1468-2257 ; 0017-4815
ISSN (online)	1468-2257
ISSN	0017-4815
DOI	10.1111/j.1468-2257.2007.00352.x
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: A Scoping Review of the Role of Metalloproteinases in the Pathogenesis of Autoimmune Pemphigus and Pemphigoid.

Cirillo, Nicola / Prime, Stephen S

Biomolecules

2021 Volume 11, Issue 10

Abstract: Pemphigus and pemphigoid diseases are potentially life-threatening autoimmune blistering disorders that are characterized by intraepithelial and subepithelial blister formation, respectively. In both disease groups, skin and/or mucosal blistering develop ...

Abstract	Pemphigus and pemphigoid diseases are potentially life-threatening autoimmune blistering disorders that are characterized by intraepithelial and subepithelial blister formation, respectively. In both disease groups, skin and/or mucosal blistering develop as a result of a disruption of intercellular adhesion (pemphigus) and cell-extracellular matrix (ECM) adhesion (pemphigoid). Given that metalloproteinases can target cell adhesion molecules, the purpose of the present study was to investigate the role of these enzymes in the pathogenesis of these bullous dermatoses. Studies examining MMPs (matrix metalloproteinases) and the ADAM (a disintegrin and metalloproteinase) family of proteases in pemphigus and pemphigoid were selected from articles published in the repository of the National Library of Medicine (MEDLINE/PubMed) and bioRxiv. Multiple phases of screening were conducted, and relevant data were extracted and tabulated, with 29 articles included in the final qualitative analysis. The majority of the literature investigated the role of specific components of the MMP family primarily in bullous pemphigoid (BP) whereas studies that focused on pemphigus were rarer. The most commonly studied metalloproteinase was MMP-9 followed by MMP-2; other MMPs included MMP-1, MMP-3, MMP-8, MMP-12 and MMP-13. Molecules related to MMPs were also included, namely, ADAM5, 8, 10, 15, 17, together with TIMP-1 and TIMP-3. The results demonstrated that ADAM10 and MMP-9 activity is necessary for blister formation in experimental models of pemphigus vulgaris (PV) and BP, respectively. The data linking MMPs to the pathogenesis of experimental BP were relatively strong but the evidence for involvement of metalloproteinases in PV was more tentative. These molecules represent potential candidates for the development of mechanism-based treatments of these blistering diseases.
MeSH term(s)	ADAM Proteins/classification ; ADAM Proteins/genetics ; ADAM10 Protein/genetics ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Cell Adhesion/genetics ; Extracellular Matrix/genetics ; Humans ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinases/classification ; Matrix Metalloproteinases/genetics ; Pemphigoid, Bullous/genetics ; Pemphigoid, Bullous/immunology ; Pemphigoid, Bullous/pathology ; Pemphigus/genetics ; Pemphigus/immunology ; Pemphigus/pathology
Chemical Substances	ADAM Proteins (EC 3.4.24.-) ; Matrix Metalloproteinases (EC 3.4.24.-) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; ADAM10 Protein (EC 3.4.24.81)
Language	English
Publishing date	2021-10-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom11101506
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito