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Article: Optimization of Protein Quality of Plant-Based Foods Through Digitalized Product Development.

Rojas Conzuelo, Zaray / Robyr, Roger / Kopf-Bolanz, Katrin A

2022 Volume 9, Page(s) 902565

Abstract: With the increasing availability of plant-based protein products that should serve as alternatives to animal-based protein products, it is necessary to develop not only environmentally friendly but also nutritious foods. Especially the protein content ... ...

Abstract	With the increasing availability of plant-based protein products that should serve as alternatives to animal-based protein products, it is necessary to develop not only environmentally friendly but also nutritious foods. Especially the protein content and quality are of concern in these products. The algorithm of NutriOpt was developed using linear programming to support the development of food products with a balanced amino acid profile while considering digestibility. The current version contains a database with 84 plant protein sources from different food groups (legumes, cereals, nuts, seeds) and with different grades of purification (flours, concentrates, isolates) from which NutriOpt can create mixtures with high protein quality while complying with constraints such as protein content, number of ingredients, and weight of the mixture. The program was tested through different case studies based on commercial plant-based drinks. It was possible to obtain formulations with a Protein Digestibility Corrected Amino Acid Score (PDCAAS) over 100 with ingredients and quantities potentially suitable for plant-based analogs. Our model can help to develop the second generation of plant-based product alternatives that can really be used as an alternative on long-term consumption. Further, there is still a great potential of expansion of the program for example to use press cakes or even to model whole menus or diets in the future.
Language	English
Publishing date	2022-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.902565
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Protein Quality Changes of Vegan Day Menus with Different Plant Protein Source Compositions.

Rojas Conzuelo, Zaray / Bez, Natalie S / Theobald, Steffen / Kopf-Bolanz, Katrin A

Nutrients

2022 Volume 14, Issue 5

Abstract: To underline the importance of protein quality in plant-based diets, we estimated the protein quality of different exclusively plant-protein-based day menus that are based on the "planetary health diet" developed by the EAT-Lancet Commission. PDCAAS and ... ...

Abstract	To underline the importance of protein quality in plant-based diets, we estimated the protein quality of different exclusively plant-protein-based day menus that are based on the "planetary health diet" developed by the EAT-Lancet Commission. PDCAAS and DIAAS were used to estimate the protein quality (PQ) and fulfilling of the amino acid recommendation for adults in vegan daily menus based on the planetary health diet: 2 days with only low-quality (LQ) protein sources and 2 days with low + high-quality (HQ) protein sources. The protein quality of Day 1LQ (DIAAS 76, PDCAAS 88) was increased by the addition of high-quality protein sources (HQPS): Day 1HQ (DIAAS 94, PDCAAS 98). Day 2LQ had a low PQ (DIAAS 71, PDCAAS 74), but when HQPS were used (Day 2HQ), the PQ increased (DIAAS 83, PDCAAS 88). Scenarios (day 1HQ, day 1LQ, and day 2 HQ) were classified as of good PQ. However, day 1LQ had a low protein quality. Consuming HQPS in a vegan diet can help to fulfil the recommendation of essential amino acids. This work served to understand and apply methods to estimate protein quality that can be applied to optimize protein mixtures to fulfil amino acid requirements in the future.
MeSH term(s)	Diet, Vegan ; Dietary Proteins/metabolism ; Digestion ; Humans ; Plant Proteins/metabolism ; Vegans
Chemical Substances	Dietary Proteins ; Plant Proteins
Language	English
Publishing date	2022-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051088
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Article: Protein Quality Changes of Vegan Day Menus with Different Plant Protein Source Compositions

Rojas Conzuelo, Zaray / Bez, Natalie S. / Theobald, Steffen / Kopf-Bolanz, Katrin A.

Nutrients. 2022 Mar. 04, v. 14, no. 5

2022

Abstract: To underline the importance of protein quality in plant-based diets, we estimated the protein quality of different exclusively plant-protein-based day menus that are based on the “planetary health diet” developed by the EAT-Lancet Commission. PDCAAS and ... ...

Abstract	To underline the importance of protein quality in plant-based diets, we estimated the protein quality of different exclusively plant-protein-based day menus that are based on the “planetary health diet” developed by the EAT-Lancet Commission. PDCAAS and DIAAS were used to estimate the protein quality (PQ) and fulfilling of the amino acid recommendation for adults in vegan daily menus based on the planetary health diet: 2 days with only low-quality (LQ) protein sources and 2 days with low + high-quality (HQ) protein sources. The protein quality of Day 1LQ (DIAAS 76, PDCAAS 88) was increased by the addition of high-quality protein sources (HQPS): Day 1HQ (DIAAS 94, PDCAAS 98). Day 2LQ had a low PQ (DIAAS 71, PDCAAS 74), but when HQPS were used (Day 2HQ), the PQ increased (DIAAS 83, PDCAAS 88). Scenarios (day 1HQ, day 1LQ, and day 2 HQ) were classified as of good PQ. However, day 1LQ had a low protein quality. Consuming HQPS in a vegan diet can help to fulfil the recommendation of essential amino acids. This work served to understand and apply methods to estimate protein quality that can be applied to optimize protein mixtures to fulfil amino acid requirements in the future.
Keywords	plant proteins ; protein sources ; protein value ; vegan diet
Language	English
Dates of publication	2022-0304
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051088
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Article ; Online: Aroma of peas, its constituents and reduction strategies - Effects from breeding to processing.

Trindler, Christian / Annika Kopf-Bolanz, Katrin / Denkel, Christoph

Food chemistry

2021 Volume 376, Page(s) 131892

Abstract: Peas as an alternative protein source have attracted a great deal of interest from the food industry and consumers in recent years. However, pea proteins usually do not taste neutral and exhibit a distinct flavor, often characterized as "beany". This is ... ...

Abstract	Peas as an alternative protein source have attracted a great deal of interest from the food industry and consumers in recent years. However, pea proteins usually do not taste neutral and exhibit a distinct flavor, often characterized as "beany". This is usually contrasted by the food industry's desire for sensory neutral protein sources. In this review, we highlight the current state of knowledge about the aroma of peas and its changes along the pea value chain. Possible causes and origins, and approaches to reduce or eliminate the aroma constituents are presented. Fermentative methods were identified as interesting to mitigate undesirable off-flavors. Major potential has also been discussed for breeding, as there appears to be a considerable leverage at this point in the value chain: a reduction of plant-derived flavors, precursors, or substrates involved in off-flavor evolution could prevent the need for expensive removal later.
Language	English
Publishing date	2021-12-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.131892
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Article: Aroma of peas, its constituents and reduction strategies – Effects from breeding to processing

Trindler, Christian / Annika Kopf-Bolanz, Katrin / Denkel, Christoph

Food chemistry. 2022 May 15, v. 376

2022

Abstract	Peas as an alternative protein source have attracted a great deal of interest from the food industry and consumers in recent years. However, pea proteins usually do not taste neutral and exhibit a distinct flavor, often characterized as “beany”. This is usually contrasted by the food industry's desire for sensory neutral protein sources. In this review, we highlight the current state of knowledge about the aroma of peas and its changes along the pea value chain. Possible causes and origins, and approaches to reduce or eliminate the aroma constituents are presented. Fermentative methods were identified as interesting to mitigate undesirable off-flavors. Major potential has also been discussed for breeding, as there appears to be a considerable leverage at this point in the value chain: a reduction of plant-derived flavors, precursors, or substrates involved in off-flavor evolution could prevent the need for expensive removal later.
Keywords	evolution ; food chemistry ; food industry ; odors ; off flavors ; peas ; protein sources ; supply chain
Language	English
Dates of publication	2022-0515
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.131892
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Article: Serum Metabolites Responding in a Dose-Dependent Manner to the Intake of a High-Fat Meal in Normal Weight Healthy Men Are Associated with Obesity.

Bütikofer, Ueli / Burnand, David / Portmann, Reto / Blaser, Carola / Schwander, Flurina / Kopf-Bolanz, Katrin A / Laederach, Kurt / Badertscher, René / Walther, Barbara / Vergères, Guy

Metabolites

2021 Volume 11, Issue 6

Abstract: Although the composition of the human blood metabolome is influenced both by the health status of the organism and its dietary behavior, the interaction between these two factors has been poorly characterized. This study makes use of a previously ... ...

Abstract	Although the composition of the human blood metabolome is influenced both by the health status of the organism and its dietary behavior, the interaction between these two factors has been poorly characterized. This study makes use of a previously published randomized controlled crossover acute intervention to investigate whether the blood metabolome of 15 healthy normal weight (NW) and 17 obese (OB) men having ingested three doses (500, 1000, 1500 kcal) of a high-fat (HF) meal can be used to identify metabolites differentiating these two groups. Among the 1024 features showing a postprandial response, measured between 0 h and 6 h, in the NW group, 135 were dose-dependent. Among these 135 features, 52 had fasting values that were significantly different between NW and OB men, and, strikingly, they were all significantly higher in OB men. A subset of the 52 features was identified as amino acids (e.g., branched-chain amino acids) and amino acid derivatives. As the fasting concentration of most of these metabolites has already been associated with metabolic dysfunction, we propose that challenging normal weight healthy subjects with increasing caloric doses of test meals might allow for the identification of new fasting markers associated with obesity.
Language	English
Publishing date	2021-06-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11060392
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Article: Lebensmittel. Quantitatives Potenzial zur Verwertung von Molke in Lebensmitteln in der Schweiz

Kopf-Bolanz, Katrin

Agrarforschung Schweiz

2015 Volume 6, Issue 6, Page(s) 270

Language	German
Document type	Article
ZDB-ID	2534391-9
ISSN	1663-7852
Database	Current Contents Nutrition, Environment, Agriculture

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Article: Comparison of nutritional composition between plant-based drinks and cow's milk.

Walther, Barbara / Guggisberg, Dominik / Badertscher, René / Egger, Lotti / Portmann, Reto / Dubois, Sébastien / Haldimann, Max / Kopf-Bolanz, Katrin / Rhyn, Peter / Zoller, Otmar / Veraguth, Rosmarie / Rezzi, Serge

Frontiers in nutrition

2022 Volume 9, Page(s) 988707

Abstract: The high decline in liquid milk consumption in Western countries has been compensated by the increased consumption of processed dairy products and the rapidly increasing number of new plant-based beverages constantly introduced in the market, advertised ... ...

Abstract	The high decline in liquid milk consumption in Western countries has been compensated by the increased consumption of processed dairy products and the rapidly increasing number of new plant-based beverages constantly introduced in the market, advertised as milk substitutes and placed on shelves near milk products. To provide better understanding about the nutritional value of these drinks compared with cow's milk, 27 plant-based drinks of 8 different species and two milk samples were purchased from two big retailers in Switzerland, and their composition regarding protein, carbohydrate, fat, vitamin, and mineral contents and residue load [glyphosate, aminomethylphosphonic acid (AMPA), and arsenic] was analyzed quantitatively and qualitatively. Energy and nutrient intakes were calculated and compared with the dietary reference values for Germany, Austria and Switzerland (D-A-CH). In addition, the digestible indispensable amino acid score (DIAAS) was calculated to estimate the quality of the proteins. Milk contained more energy; fat; carbohydrate; vitamins C, B
Language	English
Publishing date	2022-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.988707
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Article: The role of TRPV6 in breast carcinogenesis.

Bolanz, Katrin A / Hediger, Matthias A / Landowski, Christopher P

Molecular cancer therapeutics

2008 Volume 7, Issue 2, Page(s) 271–279

Abstract: TRPV6 is an endothelial calcium entry channel that is strongly expressed in breast adenocarcinoma tissue. In this study, we further confirmed this observation by analysis of breast cancer tissues, which indicated that TRPV6 mRNA expression was up- ... ...

Abstract	TRPV6 is an endothelial calcium entry channel that is strongly expressed in breast adenocarcinoma tissue. In this study, we further confirmed this observation by analysis of breast cancer tissues, which indicated that TRPV6 mRNA expression was up-regulated between 2-fold and 15-fold compared with the average in normal breast tissue. Whereas TRPV6 is expressed in the cancer tissue, its role as a calcium channel in breast carcinogenesis is poorly understood. Therefore, we investigated how TRPV6 affects the viability, apoptosis, and calcium transport in the breast cancer cell line T47D. Hormones can also affect the tumor development; hence, we determined the effects of estradiol, progesterone, and 1,25-vitamin D on TRPV6 transcription. Interestingly, the estrogen receptor antagonist tamoxifen reduced expression of TRPV6 and is able to inhibit its calcium transport activity (IC(50), 7.5 micromol/L). The in vitro model showed that TRPV6 can be regulated by estrogen, progesterone, tamoxifen, and 1,25-vitamin D and has a large influence on breast cancer cell proliferation. Moreover, the effect of tamoxifen on cell viability was enhanced when TRPV6 expression was silenced with small interfering RNA. TRPV6 may be a novel target for the development of calcium channel inhibitors to treat breast adenocarcinoma expressing TRPV6.
MeSH term(s)	Adenocarcinoma/etiology ; Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Antineoplastic Agents, Hormonal/pharmacology ; Breast Neoplasms/etiology ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Calcium/metabolism ; Calcium Channel Blockers/pharmacology ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Calcium Channels/physiology ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; RNA, Messenger/metabolism ; RNA, Small Interfering/pharmacology ; TRPV Cation Channels/antagonists & inhibitors ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; TRPV Cation Channels/physiology ; Tamoxifen/pharmacology ; Tumor Cells, Cultured
Chemical Substances	Antineoplastic Agents, Hormonal ; Calcium Channel Blockers ; Calcium Channels ; RNA, Messenger ; RNA, Small Interfering ; TRPV Cation Channels ; TRPV6 protein, human ; Tamoxifen (094ZI81Y45) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2008-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-07-0478
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chemical inhibitors of the calcium entry channel TRPV6.

Landowski, Christopher P / Bolanz, Katrin A / Suzuki, Yoshiro / Hediger, Matthias A

Pharmaceutical research

2010 Volume 28, Issue 2, Page(s) 322–330

Abstract: Purpose: Calcium entry channels in the plasma membrane are thought to play a major role in maintaining cellular Ca(2+) levels, crucial for growth and survival of normal and cancer cells. The calcium-selective channel TRPV6 is expressed in prostate, ... ...

Abstract	Purpose: Calcium entry channels in the plasma membrane are thought to play a major role in maintaining cellular Ca(2+) levels, crucial for growth and survival of normal and cancer cells. The calcium-selective channel TRPV6 is expressed in prostate, breast, and other cancer cells. Its expression coincides with cancer progression, suggesting that it drives cancer cell growth. However, no specific inhibitors for TRPV6 have been identified thus far. Methods: To develop specific TRPV6 inhibitors, we synthesized molecules based on the lead compound TH-1177, reported to inhibit calcium entry channels in prostate cancer cells in vitro and in vivo. Results: We found that one of our compounds (#03) selectively inhibited TRPV6 over five times better than TRPV5, whereas TH-1177 and the other synthesized compounds preferentially inhibited TRPV5. The IC(50) value for growth inhibition by blocking endogenous Ca(2+) entry channels in the LNCaP human prostate cancer cell line was 0.44 ± 0.07 μM compared to TH-1177 (50 ± 0.4 μM). Conclusions: These results suggest that compound #03 is a relatively selective and potent inhibitor for TRPV6 and that it is an interesting lead compound for the treatment of prostate cancer and other cancers of epithelial origin.
MeSH term(s)	Animals ; Breast Neoplasms/metabolism ; Calcium/metabolism ; Calcium Channel Blockers/chemical synthesis ; Calcium Channel Blockers/pharmacology ; Calcium Channels ; Cell Proliferation/drug effects ; Cells, Cultured ; Econazole/analogs & derivatives ; Female ; Humans ; Inhibitory Concentration 50 ; Male ; Miconazole/analogs & derivatives ; Prostatic Neoplasms/metabolism ; Pyrrolidines/chemical synthesis ; Pyrrolidines/chemistry ; Pyrrolidines/pharmacology ; RNA, Small Interfering/pharmacology ; TRPV Cation Channels/antagonists & inhibitors
Chemical Substances	Calcium Channel Blockers ; Calcium Channels ; Pyrrolidines ; RNA, Small Interfering ; TH 1177 ; TRPV Cation Channels ; TRPV5 protein, human ; TRPV6 protein, human ; Econazole (6Z1Y2V4A7M) ; Miconazole (7NNO0D7S5M) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2010-11-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	843063-9
ISSN	1573-904X ; 0724-8741 ; 0739-0742
ISSN (online)	1573-904X
ISSN	0724-8741 ; 0739-0742
DOI	10.1007/s11095-010-0249-9
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