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Article ; Online: Impact of Pharmacy-Related Memes on Students' Professional Identity Formation.

Doctor, Nathan / G Elder, Kimberly / Hafling, Brooke / F Leslie, Katie

American journal of pharmaceutical education

2024 Volume 88, Issue 3, Page(s) 100657

Abstract: Objective: Professional identity formation (PIF) is the process which one internalizes the values and norms of a profession, ultimately becoming a member of that profession. The objective of this study was to determine the perceived professional ... ...

Abstract	Objective: Professional identity formation (PIF) is the process which one internalizes the values and norms of a profession, ultimately becoming a member of that profession. The objective of this study was to determine the perceived professional identities of pharmacists in memes and how pharmacy-related memes affect students' PIF. Methods: Student pharmacists from a single academic institution participated in focus groups to discuss the concept of professional identity, view self-submitted pharmacy-related memes, and reflect on the memes' impact on their PIF. An inductive, thematic content analysis was performed, and a theoretical model was developed to illustrate the themes observed. Results: Twenty-six student pharmacists participated in the study. Before exposure to the self-submitted memes, the participants described the professional identity of a pharmacist in a more idealistic way, noting pharmacist roles such as medication expert, educator, and patient care provider. After exposure to the memes, the participants' responses reflected a pharmacist identity based on feelings of being antagonized, overwhelmed, and misperceived. Despite these challenges, the participants noted the importance of remaining professional. Conclusion: When exposed to pharmacy-related memes, the students' perceptions of the pharmacist identity changed from one based on idealistic roles to an identity based on negative feelings and interactions. Owing to memes' ability to reflect one's experiences, it is important to recognize the impact memes may have on PIF. Further research is needed to determine how pharmacy educators can help students navigate identity dissonances that arise from the students' pharmacy experiences.
MeSH term(s)	Humans ; Social Identification ; Education, Pharmacy ; Pharmacy ; Students ; Pharmaceutical Services ; Students, Pharmacy
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	603807-4
ISSN	1553-6467 ; 0002-9459
ISSN (online)	1553-6467
ISSN	0002-9459
DOI	10.1016/j.ajpe.2024.100657
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Article: The novel two-component system AmsSR governs alternative metabolic pathway usage in

Casella, Leila G / Torres, Nathanial J / Tomlinson, Brooke R / Shepherd, Mark / Shaw, Lindsey N

Frontiers in microbiology

2023 Volume 14, Page(s) 1139253

Abstract: In this study, we identify a novel two-component system ... ...

Abstract	In this study, we identify a novel two-component system in
Language	English
Publishing date	2023-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1139253
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Article ; Online: Reactivity of [(PNP)Mn(CO)

Livesay, Brooke N / Schmidt, Jurgen G / Williams, Robert F / Billow, Brennan S / Tondreau, Aaron M

ACS organic & inorganic Au

2023 Volume 3, Issue 4, Page(s) 199–208

Abstract: Organophosphorus nerve agents (OPAs) are a toxic class of synthetic compounds that cause adverse effects with many biological systems. Development of methods for environmental remediation and passivation has been ongoing for years. However, little ... ...

Abstract	Organophosphorus nerve agents (OPAs) are a toxic class of synthetic compounds that cause adverse effects with many biological systems. Development of methods for environmental remediation and passivation has been ongoing for years. However, little progress has been made in therapeutic development for exposure victims. Given the postexposure behavior of OPA materials in enzymes such as acetylcholinesterase (AChE), development of electrophilic compounds as therapeutics may be more beneficial than the currently employed nucleophilic countermeasures. In this report, we present our studies with an electrophilic, 16-electron manganese complex (
Language	English
Publishing date	2023-05-25
Publishing country	United States
Document type	Journal Article
ISSN	2694-247X
ISSN (online)	2694-247X
DOI	10.1021/acsorginorgau.3c00003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparative Effectiveness of Clinician- Versus Peer-Supported Problem-Solving Therapy for Rural Older Adults With Depression.

Hollister, Brooke / Crabb, Rebecca / Areán, Patricia

Psychiatric services (Washington, D.C.)

2024 , Page(s) appips20230027

Abstract: ... among older adults in rural California.: Methods: Older adults with depression (N=105) received ... an introductory PST session with a clinician, followed by 11 sessions of CM-PST with a clinician (N=85) or SG-PST ... with a peer counselor (N=20).: Results: Both interventions resulted in clinically significant improvement ...

Abstract	Objective: Self-guided and peer-supported treatments for depression among rural older adults may address some common barriers to treatment. This pilot study compared the effect on depression of peer-supported, self-guided problem-solving therapy (SG-PST) with case management problem-solving therapy (CM-PST) among older adults in rural California. Methods: Older adults with depression (N=105) received an introductory PST session with a clinician, followed by 11 sessions of CM-PST with a clinician (N=85) or SG-PST with a peer counselor (N=20). Results: Both interventions resulted in clinically significant improvement in depression by week 12. Depression scores in the CM-PST group dropped by 4.1 points more than in the SG-PST group between baseline and week 12 (95% CI=0.99-7.22, p<0.001, Hedges's g=1.08). Conclusions: The results suggest that peer-supported SG-PST is a viable, acceptable option for rural older adults with depression as a second-line treatment if access to clinicians is limited.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1220173-x
ISSN	1557-9700 ; 1075-2730
ISSN (online)	1557-9700
ISSN	1075-2730
DOI	10.1176/appi.ps.20230027
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Article: A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan.

Jayne, Lorna / Lavin-Peter, Aurora / Roessler, Julian / Tyshkovskiy, Alexander / Antoszewski, Mateusz / Ren, Erika / Markovski, Aleksandar / Sun, Senmiao / Yao, Hanqi / Sankaran, Vijay G / Gladyshev, Vadim N / Brooke, Robert T / Horvath, Steve / Griffith, Eric C / Hrvatin, Sinisa

bioRxiv : the preprint server for biology

2024

Abstract: Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the underlying mechanisms of how torpor affects aging, and whether hypothermic and hypometabolic states can be induced to slow aging ... ...

Abstract	Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the underlying mechanisms of how torpor affects aging, and whether hypothermic and hypometabolic states can be induced to slow aging and increase health span, remain unknown. We demonstrate that the activity of a spatially defined neuronal population in the avMLPA, which has previously been identified as a torpor-regulating brain region, is sufficient to induce a torpor like state (TLS) in mice. Prolonged induction of TLS slows epigenetic aging across multiple tissues and improves health span. We isolate the effects of decreased metabolic rate, long-term caloric restriction, and decreased core body temperature (T
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.20.585828
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Article ; Online: Family Anesthesia Experience

Susan M. Martinelli / Thanh N. Tran / Brooke A. Chidgey / Robert S. Isaak / Emily G. Teeter / Fei Chen

MedEdPORTAL, Vol

Improving Social Support of Residents Through Education of Their Family and Friends

2023 Volume 19

Abstract: Introduction The prevalence of burnout among anesthesiology residents is 41%–51%. Burnout is associated with medical errors, physician turnover, and substance use disorder. Social support and wellness may reduce burnout, but a barrier is support persons’ ...

Abstract	Introduction The prevalence of burnout among anesthesiology residents is 41%–51%. Burnout is associated with medical errors, physician turnover, and substance use disorder. Social support and wellness may reduce burnout, but a barrier is support persons’ lack of understanding of an anesthesiologist's work demands. We developed the Family Anesthesia Experience (FAX) to help support persons best support their resident. Methods FAX consisted of a 4-hour event with hands-on experience, didactics portion, and panel discussion. Participants learned about a typical day in the life of an anesthesiology resident, wellness, burnout, substance use disorder, and available support resources, and had hands-on experience with procedures. The panel discussion offered logistical information about anesthesiology residency and allowed support persons to ask panel members questions. A postevent survey collected feedback on the event. Results Fifty-one participants (first-year anesthesiology residents and their support persons) attended the event. Eight of 11 residents (73%) and 32 of 40 support persons (80%) completed the survey. All enjoyed the event, would recommend it to other anesthesiology resident support persons, and felt the event would improve communication and support. Most learned a moderate (35%) to large amount (50%) from the event. Qualitative feedback suggested most support persons found the event helpful in improving their understanding of anesthesiology residents’ work demands. Discussion The FAX was well liked by participants. Although we did not assess specific knowledge gained and long-term effects of the 2022 event, evaluations of previous years’ events suggest that the event improved participants’ understanding of anesthesiology residents’ work and stressors.
Keywords	Social Support ; Wellness ; Anesthesiology ; Simulation ; Well-Being/Mental Health ; Medicine (General) ; R5-920 ; Education ; L
Subject code	300
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Association of American Medical Colleges
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome.

Ranum, Jordan N / Ledwith, Mitchell P / Alnaji, Fadi G / Diefenbacher, Meghan / Orton, Richard / Sloan, Elisabeth / Guereca, Melissa / Feltman, Elizabeth M / Smollett, Katherine / da Silva Filipe, Ana / Conley, Michaela / Russell, Alistair B / Brooke, Christopher B / Hutchinson, Edward / Mehle, Andrew

bioRxiv : the preprint server for biology

2024

Abstract: Productive infections by RNA viruses require faithful replication of the entire genome. Yet many RNA viruses also produce deletion-containing viral genomes (DelVGs), aberrant replication products with large internal deletions. DelVGs interfere with the ... ...

Abstract	Productive infections by RNA viruses require faithful replication of the entire genome. Yet many RNA viruses also produce deletion-containing viral genomes (DelVGs), aberrant replication products with large internal deletions. DelVGs interfere with the replication of wild-type virus and their presence in patients is associated with better clinical outcomes as they. The DelVG RNA itself is hypothesized to confer this interfering activity. DelVGs antagonize replication by out-competing the full-length genome and triggering innate immune responses. Here, we identify an additionally inhibitory mechanism mediated by a new class of viral proteins encoded by DelVGs. We identified hundreds of cryptic viral proteins translated from DelVGs. These DelVG-encoded proteins (DPRs) include canonical viral proteins with large internal deletions, as well as proteins with novel C-termini translated from alternative reading frames. Many DPRs retain functional domains shared with their full-length counterparts, suggesting they may have activity during infection. Mechanistic studies of DPRs derived from the influenza virus protein PB2 showed that they poison replication of wild-type virus by acting as dominant-negative inhibitors of the viral polymerase. These findings reveal that DelVGs have a dual inhibitory mechanism, acting at both the RNA and protein level. They further show that DPRs have the potential to dramatically expand the functional proteomes of diverse RNA viruses.
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.12.570638
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Article ; Online: Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome.

Ranum, Jordan N / Ledwith, Mitchell P / Alnaji, Fadi G / Diefenbacher, Meghan / Orton, Richard / Sloan, Elizabeth / Güereca, Melissa / Feltman, Elizabeth M / Smollett, Katherine / da Silva Filipe, Ana / Conley, Michaela / Russell, Alistair B / Brooke, Christopher B / Hutchinson, Edward / Mehle, Andrew

Nucleic acids research

2024 Volume 52, Issue 6, Page(s) 3199–3212

Abstract	Productive infections by RNA viruses require faithful replication of the entire genome. Yet many RNA viruses also produce deletion-containing viral genomes (DelVGs), aberrant replication products with large internal deletions. DelVGs interfere with the replication of wild-type virus and their presence in patients is associated with better clinical outcomes. The DelVG RNA itself is hypothesized to confer this interfering activity. DelVGs antagonize replication by out-competing the full-length genome and triggering innate immune responses. Here, we identify an additionally inhibitory mechanism mediated by a new class of viral proteins encoded by DelVGs. We identified hundreds of cryptic viral proteins translated from DelVGs. These DelVG-encoded proteins (DPRs) include canonical viral proteins with large internal deletions, as well as proteins with novel C-termini translated from alternative reading frames. Many DPRs retain functional domains shared with their full-length counterparts, suggesting they may have activity during infection. Mechanistic studies of DPRs derived from the influenza virus protein PB2 showed that they poison replication of wild-type virus by acting as dominant-negative inhibitors of the viral polymerase. These findings reveal that DelVGs have a dual inhibitory mechanism, acting at both the RNA and protein level. They further show that DPRs have the potential to dramatically expand the functional proteomes of diverse RNA viruses.
MeSH term(s)	Humans ; Genome, Viral/genetics ; Influenza A virus/genetics ; Proteome/genetics ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication/genetics ; Sequence Deletion/genetics ; Animals ; Dogs ; Cell Line
Chemical Substances	Proteome ; RNA, Viral ; Viral Proteins
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkae133
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Article ; Online: Nontoxic Initiator Alternatives to TEMED for Redox Hydrogel Polymerization.

Pumford, Elizabeth A / Jackson Hoffman, Brooke A / Kasko, Andrea M

ACS applied bio materials

2024 Volume 7, Issue 4, Page(s) 2264–2271

Abstract: ... tetramethylethylenediamine (TEMED), which hinders hydrogel utility in direct contact with cells (e.g., wound dressings ...

Abstract	Polymeric hydrogels are versatile biomaterials, offering unique advantages in tunability and biocompatibility that make them well-suited to a range of applications. Cross-linking, a fundamental step in hydrogel fabrication, is often initiated using a toxic redox system, ammonium persulfate (APS), and tetramethylethylenediamine (TEMED), which hinders hydrogel utility in direct contact with cells (e.g., wound dressings). To overcome this limitation, we developed alternative redox gelation systems that serve as nontoxic replacements for TEMED. The alternate initiators were either synthetic or bioinspired amine-containing polymers, Glycofect and polyethylenimine (PEI). Used with APS, these initiator candidates produced hydrogels with short gelation time and comparable moduli to TEMED-based gels and underwent further mechanical testing and biocompatibility characterization. While achieving mechanical properties similar to those of the control, the gels based on Glycofect and PEI outperformed TEMED-based gels in two cell viability studies, with Glycofect-initiated gels displaying significantly higher cytocompatibility. Taken together, these results indicate that Glycofect may serve as a drop-in replacement for TEMED to fabricate hydrogels with improved biocompatibility.
MeSH term(s)	Hydrogels/pharmacology ; Polymerization ; Ethylenediamines ; Polymers/pharmacology ; Oxidation-Reduction
Chemical Substances	Hydrogels ; N,N,N',N'-tetramethylethylenediamine (110-18-9) ; Ethylenediamines ; Polymers
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.3c01264
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Article ; Online: Skepticism of and critical thinking about media messages: Conflicting relationships with body dissatisfaction.

Bennett, Brooke L / Martin-Wagar, Caitlin A / Boswell, Rebecca G / Forrest, Lauren N / Perelman, Hayley / Latner, Janet D

Eating behaviors

2023 Volume 51, Page(s) 101820

Abstract: ... dissatisfaction using recommended measures of media literacy. Racially diverse female undergraduate students (N ...

Abstract	Despite the theoretical connection between media literacy and body dissatisfaction, empirical findings about their relationship are decidedly mixed. There is not a clear explanation for these discrepancies. The present study aimed to 1) compare the attitudes young adult women with those of a reference group of adolescents to examine whether similar values were observed despite differences in age group and racial/ethnic identity, 2) to examine the relationships between media literacy and body dissatisfaction using recommended measures of media literacy. Racially diverse female undergraduate students (N = 152, M
MeSH term(s)	Adolescent ; Young Adult ; Humans ; Female ; Adult ; Body Dissatisfaction ; Body Image ; Thinking ; Emotions ; Attitude
Language	English
Publishing date	2023-09-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2073366-5
ISSN	1873-7358 ; 1471-0153
ISSN (online)	1873-7358
ISSN	1471-0153
DOI	10.1016/j.eatbeh.2023.101820
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