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  1. Article: Convalescent Plasma for the Treatment of Severe COVID-19.

    Franchini, Massimo / Liumbruno, Giancarlo Maria

    Biologics : targets & therapy

    2021  Volume 15, Page(s) 31–38

    Abstract: The COVID-19 pandemic in 2020 is one of the worst catastrophic events in human history. Several non-specific antiviral drugs have been tried to defeat the SARS-CoV-2, with mixed results. Convalescent plasma from patients who have recovered from COVID-19 ... ...

    Abstract The COVID-19 pandemic in 2020 is one of the worst catastrophic events in human history. Several non-specific antiviral drugs have been tried to defeat the SARS-CoV-2, with mixed results. Convalescent plasma from patients who have recovered from COVID-19 is one of the specific biologic therapies being considered to treat SARS-CoV-2 infection. Preliminary studies have shown that convalescent plasma, containing antibodies able to neutralize SARS-CoV-2, is promising in blocking viral replication and improving patients' clinical symptoms. The results of several ongoing randomized controlled trials are, however, keenly awaited to definitively elucidate the safety and efficacy of this blood component in COVID-19. In this narrative review, we summarize the current evidence from the literature on the treatment of severe COVID-19 with convalescent plasma. A concise overview of the hypothesized mechanisms of action is also presented.
    Language English
    Publishing date 2021-02-04
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2415708-9
    ISSN 1177-5491 ; 1177-5475
    ISSN (online) 1177-5491
    ISSN 1177-5475
    DOI 10.2147/BTT.S272063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hemostatic therapy as a management strategy for acquired hemophilia: what does the future hold?

    Franchini, Massimo / Schiavulli, Michele / Liumbruno, Giancarlo Maria

    Expert review of hematology

    2021  Volume 14, Issue 3, Page(s) 263–270

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Autoantibodies ; Autoimmune Diseases ; Factor VIII ; Hemophilia A/diagnosis ; Hemophilia A/drug therapy ; Hemorrhage ; Hemostatics/therapeutic use ; Humans
    Chemical Substances Autoantibodies ; Hemostatics ; Factor VIII (9001-27-8)
    Language English
    Publishing date 2021-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2021.1892483
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    Zs.A 6943: Show issues Location:
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  3. Article ; Online: Potential mechanisms of action of convalescent plasma in COVID-19.

    Franchini, Massimo / Glingani, Claudia / Liumbruno, Giancarlo Maria

    Diagnosis (Berlin, Germany)

    2021  Volume 8, Issue 4, Page(s) 413–420

    Abstract: The COVID-19 pandemic will be remembered as one of the worst catastrophic events in human history. Unfortunately, no universally recognized effective therapeutic agents are currently available for the treatment of severe SARS-CoV-2 infection. In this ... ...

    Abstract The COVID-19 pandemic will be remembered as one of the worst catastrophic events in human history. Unfortunately, no universally recognized effective therapeutic agents are currently available for the treatment of severe SARS-CoV-2 infection. In this context, the use of convalescent plasma from recovered COVID-19 patients has gained increasing interest thanks to the initially positive clinical reports. A number of mechanisms of action have been proposed for convalescent plasma, including direct neutralization and suppression of viremia, anti-inflammatory and immunomodulation effects and mitigation of the COVID-19-associated hypercoagulable state. These immune and non-immune mechanisms will be critically discussed in this narrative review.
    MeSH term(s) COVID-19/therapy ; Humans ; Immunization, Passive ; Pandemics
    Language English
    Publishing date 2021-03-01
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2194-802X
    ISSN (online) 2194-802X
    DOI 10.1515/dx-2020-0161
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  4. Article ; Online: COVID-19 vaccine-associated immune thrombosis and thrombocytopenia (VITT): Diagnostic and therapeutic recommendations for a new syndrome.

    Franchini, Massimo / Liumbruno, Giancarlo Maria / Pezzo, Mario

    European journal of haematology

    2021  Volume 107, Issue 2, Page(s) 173–180

    Abstract: Very rare cases of thrombosis associated with thrombocytopenia have occurred following the vaccination with AstraZeneca COVID-19 vaccine. The aim of this concise review is to summarize the current knowledge on the epidemiologic and pathogenic mechanisms ... ...

    Abstract Very rare cases of thrombosis associated with thrombocytopenia have occurred following the vaccination with AstraZeneca COVID-19 vaccine. The aim of this concise review is to summarize the current knowledge on the epidemiologic and pathogenic mechanisms of this syndrome named vaccine-associated immune thrombosis and thrombocytopenia (VITT). A practical patient management section will also be dealt with using information available from national and international scientific societies as well as expert panels. A literature search on the VITT syndrome was carried out in PubMed using appropriate MeSH headings. Overall, 40 VITT cases have been reported. Continuous pharmacovigilance monitoring is needed to collect more data on the real incidence and the pathogenesis of VITT syndrome. Such information will also help us to optimize the management this rare but often clinically severe thrombotic condition associated with COVID-19 vaccination.
    MeSH term(s) Biomarkers ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; Cost of Illness ; Disease Management ; Disease Susceptibility ; Humans ; Patient Outcome Assessment ; Risk Assessment ; Risk Factors ; SARS-CoV-2/immunology ; Severity of Illness Index ; Syndrome ; Thrombocytopenia/diagnosis ; Thrombocytopenia/epidemiology ; Thrombocytopenia/etiology ; Thrombocytopenia/therapy ; Thrombosis/diagnosis ; Thrombosis/epidemiology ; Thrombosis/etiology ; Thrombosis/therapy
    Chemical Substances Biomarkers ; COVID-19 Vaccines
    Language English
    Publishing date 2021-06-09
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.13665
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 323: Show issues Location:
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  5. Article: Dynamics of anti-SARS-CoV-2 antibodies in repeat convalescent plasma donors.

    Franchini, Massimo / Glingani, Claudia / Liumbruno, Giancarlo Maria / Mengoli, Carlo

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2021  Volume 60, Issue 6, Page(s) 103216

    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/therapy ; Humans ; Immunization, Passive ; SARS-CoV-2
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2021-07-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2021.103216
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    Zs.A 1739: Show issues Location:
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  6. Article ; Online: Superwarfarin poisoning: a challenging diagnosis.

    Pezzo, Mario / Orioli, Marica / Pagani, Mauro / Caiola, Simone / Liumbruno, Giancarlo Maria / Franchini, Massimo

    Diagnosis (Berlin, Germany)

    2021  

    Language English
    Publishing date 2021-07-02
    Publishing country Germany
    Document type Letter
    ISSN 2194-802X
    ISSN (online) 2194-802X
    DOI 10.1515/dx-2021-0064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Operational protocol for donation of anti-COVID-19 convalescent plasma in Italy.

    Franchini, Massimo / Marano, Giuseppe / Velati, Claudio / Pati, Ilaria / Pupella, Simonetta / Maria Liumbruno, Giancarlo

    Vox sanguinis

    2020  Volume 116, Issue 1, Page(s) 136–137

    Keywords covid19
    Language English
    Publishing date 2020-05-17
    Publishing country England
    Document type Letter
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12940
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    Zs.A 74: Show issues Location:
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  8. Article: The Three Pillars of COVID-19 Convalescent Plasma Therapy.

    Franchini, Massimo / Liumbruno, Giancarlo Maria / Piacentini, Giorgio / Glingani, Claudia / Zaffanello, Marco

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 4

    Abstract: The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread rapidly around the world in the last year causing the coronavirus disease 2019 (COVID-19), which still is a severe threat for public health. The therapeutic ... ...

    Abstract The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread rapidly around the world in the last year causing the coronavirus disease 2019 (COVID-19), which still is a severe threat for public health. The therapeutic management of COVID-19 is challenging as, up until now, no specific and efficient pharmacological therapy has been validated. Translating the experience from previous viral epidemics, passive immunotherapy by means of plasma from individuals recovered from COVID-19 has been intensively investigated since the beginning of the pandemic. In this narrative review, we critically analyze the three factors, named "pillars", that play a key role in determining the clinical effectiveness of this biologic therapy: the convalescent plasma, the disease (COVID-19), and the patients.
    Language English
    Publishing date 2021-04-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11040354
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  9. Article ; Online: Regarding International Forum on Hospital Transfusion Services' Response to COVID-19.

    Franchini, Massimo / Marano, Giuseppe / Velati, Claudio / Pati, Ilaria / Pupella, Simonetta / Liumbruno, Giancarlo Maria

    Vox sanguinis

    2020  Volume 115, Issue 8, Page(s) 827

    MeSH term(s) Blood Transfusion ; COVID-19 ; Hospitals ; Humans ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12967
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  10. Article ; Online: Impact of pathogen reduction technology on neutralizing antibody titer in COVID-19 convalescent plasma.

    Franchini, Massimo / Baldanti, Fausto / Percivalle, Elena / Ferrari, Alessandro / Biasi, Pietro / Liumbruno, Giancarlo Maria / Glingani, Claudia

    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

    2021  Volume 29, Issue 1, Page(s) 101–102

    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/therapy ; Humans ; Immunization, Passive ; SARS-CoV-2 ; Technology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2021-07-29
    Publishing country France
    Document type Letter ; Comment
    ZDB-ID 1204698-x
    ISSN 1953-8022 ; 1246-7820
    ISSN (online) 1953-8022
    ISSN 1246-7820
    DOI 10.1016/j.tracli.2021.07.006
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