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Article ; Online: Anticholinergics for asthma: a long history.

Rodrigo, Gustavo J

Current opinion in allergy and clinical immunology

2018 Volume 18, Issue 1, Page(s) 38–43

Abstract: Purpose of review: To provide a fast overview about the introduction and development of anticholinergic drugs in Western medicine to their current indications particularly in asthma.: Recent findings: Although short-acting muscarinic antagonists have ...

Abstract	Purpose of review: To provide a fast overview about the introduction and development of anticholinergic drugs in Western medicine to their current indications particularly in asthma. Recent findings: Although short-acting muscarinic antagonists have been positioned in the last 15 years for the treatment of adults and children with moderate-to-severe acute asthma in the emergency setting (reducing the risk of hospital admissions and improving lung function), a growing body of evidence has recently emerged that positions the long-acting muscarinic anticholinergic tiotropium bromide as add-on therapy to at least inhaled corticosteroids (ICS) maintenance therapy in adults, adolescents, and children with symptomatic asthma. Thus, the addition of tiotropium bromide to ICS alone or ICS and another controller was associated with significant improvements in spirometric measures and asthma control, and a significantly decrease in the rate of asthma exacerbations. Summary: Short-acting muscarinic antagonists and tiotropium bromide have a well established role in the treatment of different phases of asthma. Further data are needed to provide more evidence on other selective long-acting muscarinic antagonists in addition to tiotropium as potential treatment options.
MeSH term(s)	Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Animals ; Asthma/drug therapy ; Child ; Cholinergic Antagonists/therapeutic use ; Drug Therapy, Combination ; Evidence-Based Medicine ; Humans ; Muscarinic Antagonists/therapeutic use ; Tiotropium Bromide/therapeutic use
Chemical Substances	Adrenal Cortex Hormones ; Cholinergic Antagonists ; Muscarinic Antagonists ; Tiotropium Bromide (XX112XZP0J)
Language	English
Publishing date	2018-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2088710-3
ISSN	1473-6322 ; 1528-4050
ISSN (online)	1473-6322
ISSN	1528-4050
DOI	10.1097/ACI.0000000000000408
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Article ; Online: Long-term impacts of 48-h water and feed deprivation on blood and performance responses of grazing

Abreu, Mateus J I / Marques, Rodrigo S / Cidrini, Iorrano A / Batista, Luis H C / Ferreira, Igor M / Oliveira, Karla A / Cruz, Vinicius A / Limede, Arnaldo C / Sousa, Luciana M / França, Matheus Q S / Bísio, Gustavo H M / Siqueira, Gustavo R / Resende, Flávio D

Translational animal science

2024 Volume 8, Page(s) txae015

Abstract: The study investigated the effects of 48-h water and feed deprivation on blood and the performance of grazing Nellore ( ...

Abstract	The study investigated the effects of 48-h water and feed deprivation on blood and the performance of grazing Nellore (
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ISSN	2573-2102
ISSN (online)	2573-2102
DOI	10.1093/tas/txae015
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Article ; Online: Salivary cytokine expression after non-surgical periodontal therapy in smokers: 12-month follow-up.

Leite, Fábio R M / López, Rodrigo / Møller, Holger J / Nascimento, Gustavo G

Journal of periodontology

2023 Volume 94, Issue 7, Page(s) 823–834

Abstract: Background: Diverse smoking trajectories may influence cytokine expression after non-surgical periodontal therapy and supportive periodontal care. Thus, we aimed to describe cytokine profiles in periodontal healing after periodontal therapy in smokers.!# ...

Abstract	Background: Diverse smoking trajectories may influence cytokine expression after non-surgical periodontal therapy and supportive periodontal care. Thus, we aimed to describe cytokine profiles in periodontal healing after periodontal therapy in smokers. Methods: A smoking cessation program and non-surgical periodontal therapy were offered to 80 smokers with periodontitis. Smoking trajectories (quitters/light, moderate, heavy) were observed. The association of salivary interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α) with smoking trajectories and periodontal outcomes was determined using mixed-effects linear regression. Results: Among quitters/light smokers, IL-1β was associated with an increase in mean periodontal pocket depth (PPD) and mean clinical attachment level (CAL). IL-6 was associated with a decrease in mean PPD and CAL in heavy smokers, whereas IL-8 was associated with a decrease in PPD among moderate smokers. TNFα was associated with a reduction in mean PPD and CAL among quitters/light smokers, while among moderate smokers, TNFα was associated with an increase in mean PPD and CAL. IL-12 and IL-13 were associated with a decrease in mean PPD in moderate smokers. Conclusion: Our findings suggest that distinctive smoking exposures induce differential cytokine expression, which, in turn, seems to influence periodontal repair.
MeSH term(s)	Humans ; Cytokines ; Smokers ; Interleukin-6 ; Follow-Up Studies ; Interleukin-8 ; Tumor Necrosis Factor-alpha ; Interleukin-13
Chemical Substances	Cytokines ; Interleukin-6 ; Interleukin-8 ; Tumor Necrosis Factor-alpha ; Interleukin-13
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390921-9
ISSN	1943-3670 ; 0022-3492 ; 1049-8885 ; 0095-960X
ISSN (online)	1943-3670
ISSN	0022-3492 ; 1049-8885 ; 0095-960X
DOI	10.1002/JPER.22-0556
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Article: Wernicke-Korsakoff Syndrome as a Consequence of Hyperemesis Gravidarum: A Case Report.

Souza, Haniel B / Gonçalves, Rafaela F / Moreira, Monteiro J / Tavares, Rodrigo L / Isolan, Gustavo R

Cureus

2023 Volume 15, Issue 7, Page(s) e42766

Abstract: Wernicke-Korsakoff syndrome (WKS) is caused by severe thiamine (vitamin B1) deficiency and can lead to chronic deficits. In this case, a 22-year-old pregnant patient at 10 1/7 weeks of gestation presented to the emergency department with malaise, ... ...

Abstract	Wernicke-Korsakoff syndrome (WKS) is caused by severe thiamine (vitamin B1) deficiency and can lead to chronic deficits. In this case, a 22-year-old pregnant patient at 10 1/7 weeks of gestation presented to the emergency department with malaise, asthenia, headache, weakness, vomiting, and weight loss of 12 kg. Pancreatitis and hepatic steatosis were considered but ruled out, and cholecystolithiasis was confirmed by ultrasound. After significant neurological deterioration, the patient underwent a cranial MRI that revealed suggestive findings in the thalamus consistent with WKS. WKS is a rare complication of hyperemesis gravidarum and should be included in the differential diagnosis of persistent vomiting in order to initiate early and appropriate treatment.
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42766
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Article ; Online: Serum lactate increase during acute asthma treatment: a new piece of the puzzle.

Rodrigo, Gustavo J

Chest

2014 Volume 145, Issue 1, Page(s) 6–7

MeSH term(s)	Albuterol/blood ; Asthma/blood ; Bronchodilator Agents/blood ; Female ; Humans ; Lactic Acid/blood ; Male
Chemical Substances	Bronchodilator Agents ; Lactic Acid (33X04XA5AT) ; Albuterol (QF8SVZ843E)
Language	English
Publishing date	2014-01
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.13-2042
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Article ; Online: Advances in acute asthma.

Rodrigo, Gustavo J

Current opinion in pulmonary medicine

2015 Volume 21, Issue 1, Page(s) 22–26

Abstract: Purpose of review: The purpose of this study is to highlight some of the recent findings related with the management of acute exacerbations in the context of the emergency department setting.: Recent findings: β₂-agonist heliox-driven nebulization ... ...

Abstract	Purpose of review: The purpose of this study is to highlight some of the recent findings related with the management of acute exacerbations in the context of the emergency department setting. Recent findings: β₂-agonist heliox-driven nebulization significantly increased by 17% [95% confidence interval (CI) 5.2-29.4] peak expiratory flow, and decreased the rate of hospital admissions (risk ratio 0.77, 95% CI 0.62-0.98), compared with oxygen-driven nebulization. Other findings indicate that there is no robust evidence to support the use of intravenous or nebulized magnesium sulphate in adults with severe acute asthma, and that levalbuterol was not superior to albuterol regarding efficacy and safety in individuals with acute asthma. Finally, hyperlactatemia developed during the first hours of acute asthma treatment has a high prevalence, is related with the use of β₂-agonists and had no clinical consequences. Summary: After a comprehensive review of the best quality pieces of literature published in the last year, it is possible to conclude that the goals of acute asthma management remain almost unchanged.
MeSH term(s)	Acute Disease ; Adrenergic beta-1 Receptor Agonists/administration & dosage ; Adrenergic beta-1 Receptor Agonists/adverse effects ; Adult ; Albuterol/therapeutic use ; Asthma/drug therapy ; Asthma/physiopathology ; Bronchodilator Agents/therapeutic use ; Evidence-Based Emergency Medicine ; Helium/therapeutic use ; Hospitalization/statistics & numerical data ; Humans ; Hyperlactatemia/chemically induced ; Magnesium Sulfate/therapeutic use ; Nebulizers and Vaporizers ; Oxygen/therapeutic use ; Oxygen Inhalation Therapy/methods ; Treatment Outcome
Chemical Substances	Adrenergic beta-1 Receptor Agonists ; Bronchodilator Agents ; Helium (206GF3GB41) ; heliox (58933-55-4) ; Magnesium Sulfate (7487-88-9) ; Albuterol (QF8SVZ843E) ; Oxygen (S88TT14065)
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1285505-4
ISSN	1531-6971 ; 1070-5287 ; 1078-1641
ISSN (online)	1531-6971
ISSN	1070-5287 ; 1078-1641
DOI	10.1097/MCP.0000000000000123
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Article ; Online: Energy balance of dairy cows predicted by mid-infrared spectra data of milk using Bayesian approaches.

Rovere, Gabriel / de Los Campos, Gustavo / Gebreyesus, Grum / Savegnago, Rodrigo Pelicioni / Buitenhuis, Albert J

Journal of dairy science

2023 Volume 107, Issue 3, Page(s) 1561–1576

Abstract: Information on dry matter intake (DMI) and energy balance (EB) at the animal and herd level is important for management and breeding decisions. However, routine recording of these traits at commercial farms can be challenging and costly. Fourier- ... ...

Abstract	Information on dry matter intake (DMI) and energy balance (EB) at the animal and herd level is important for management and breeding decisions. However, routine recording of these traits at commercial farms can be challenging and costly. Fourier-transform mid-infrared (FT-MIR) spectroscopy is a noninvasive technique applicable to a large cohort of animals that is routinely used to analyze milk components and is convenient for predicting complex phenotypes that are typically difficult and expensive to obtain on a large scale. We aimed to develop prediction models for EB and use the predicted phenotypes for genetic analysis. First, we assessed prediction equations using 4,485 phenotypic records from 167 Holstein cows from an experimental station. The phenotypes available were body weight (BW), milk yield (MY) and milk components, weekly-averaged DMI, and FT-MIR data from all milk samples available. We implemented mixed models with Bayesian approaches and assessed them through 50 randomized replicates of a 5-fold cross-validation. Second, we used the best prediction models to obtain predicted phenotypes of EB (EBp) and DMI (DMIp) on 5 commercial farms with 2,365 phenotypic records of MY, milk components and FT-MIR data, and BW from 1,441 Holstein cows. Third, we performed a GWAS and estimated heritability and genetic correlations for energy content in milk (EnM), BW, DMIp, and EBp using the genomic information available on the cows from commercial farms. The highest correlation between the predicted and observed phenotype (r
MeSH term(s)	Humans ; Female ; Animals ; Cattle ; Milk ; Bayes Theorem ; Body Weight ; Breeding ; Farms
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2023-23772
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Article ; Online: Daily versus intermittent inhaled corticosteroid treatment for mild persistent asthma.

Rodrigo, Gustavo J

Current opinion in allergy and clinical immunology

2014 Volume 14, Issue 3, Page(s) 186–191

Abstract: Purpose of review: Guidelines recommend the use of daily inhaled corticosteroids as preferred treatment for preschoolers, children, adolescents, and adults with recurrent wheezing and mild persistent asthma. However, intermittent or as-needed inhaled ... ...

Abstract	Purpose of review: Guidelines recommend the use of daily inhaled corticosteroids as preferred treatment for preschoolers, children, adolescents, and adults with recurrent wheezing and mild persistent asthma. However, intermittent or as-needed inhaled corticosteroids treatment in response to symptoms is an emerging strategy. This review is focused on the analysis (clinical efficacy and safety) of this approach in comparison with the current daily-based therapy. Recent findings: Recently, some authors favored the use of inhaled corticosteroids based on symptoms. It has been suggested that a symptom-based approach could reduce the amount of drug used, minimize the risk of adverse events, and reduce healthcare costs. In contrast, physicians prescribing intermittent inhaled corticosteroids would give the wrong message to their patients about the chronicity of the disease. Currently, there is a significant body of high-quality clinical studies and systematic reviews that have addressed this important controversy, and whose analysis allows us to extract some important conclusions. Summary: Present evidence does not support a change in the direction of an intermittent or symptom-based use approach for recurrent wheezing and mild-to-moderate persistent asthma. At this point, there is no convincing basis to alter the current strategy to inhaled corticosteroids dosing, and more studies are needed comparing these two approaches.
MeSH term(s)	Administration, Inhalation ; Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Asthma/drug therapy ; Child ; Child, Preschool ; Costs and Cost Analysis ; Humans
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2088710-3
ISSN	1473-6322 ; 1528-4050
ISSN (online)	1473-6322
ISSN	1528-4050
DOI	10.1097/ACI.0000000000000061
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Article: Hypertension and Histopathology Severity of Non-Alcoholic Fatty Liver Disease Among Adults with Obesity: A Cross-Sectional Study.

Chambergo-Michilot, Diego / Rodrigo-Gallardo, Paola K / Huaman, Mariella R / Vasquez-Chavesta, Angie Z / Salinas-Sedo, Gustavo / Toro-Huamanchumo, Carlos J

Clinical and experimental gastroenterology

2023 Volume 16, Page(s) 129–136

Abstract: Background: Cardiovascular diseases are responsible for the majority of deaths resulting from non-alcoholic fatty liver disease (NAFLD). NAFLD is associated with hypertension and this is a key predictor of severe liver outcomes and an indicator of ... ...

Abstract	Background: Cardiovascular diseases are responsible for the majority of deaths resulting from non-alcoholic fatty liver disease (NAFLD). NAFLD is associated with hypertension and this is a key predictor of severe liver outcomes and an indicator of nonspecific portal fibrosis. Aim: To assess the association between hypertension and NAFLD severity. Methods: We conducted a secondary analysis of data from Peruvian adults with obesity and NAFLD who attended a Peruvian bariatric center. The severity of NAFLD was assessed using the Fatty Liver Inhibition of Progression algorithm / Steatosis, Activity and Fibrosis score. Hypertension was determined by either being recorded in the medical records or if the patient had a systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg. To evaluate the association of interest, we calculated crude and adjusted prevalence ratios (aPR) using Poisson generalized linear models with logarithmic link function and robust variances. For the multivariable models, we adjusted for age, sex, physical activity and smoking. Results: Our study included 234 participants. The prevalence of hypertension was 19.2%, while the prevalence of severe NAFLD was 46.2%. After adjusting for confounders, the prevalence of hypertension was found to be significantly higher in the severe NAFLD group compared to the non-severe group (aPR = 1.33; 95% CI: 1.03-1.74). When stratified by the presence of metabolic syndrome (MetS), the association remained significant only in the group without MetS (aPR = 1.80; 95% CI: 1.05-3.11). Conclusion: We found an association between hypertension and severe NAFLD in adults with obesity, particularly in those without MetS.
Language	English
Publishing date	2023-08-14
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2520690-4
ISSN	1178-7023
ISSN	1178-7023
DOI	10.2147/CEG.S402498
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Article ; Online: Efficacy and safety of tiotropium in school-age children with moderate-to-severe symptomatic asthma: A systematic review.

Rodrigo, Gustavo J / Neffen, Hugo

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2017 Volume 28, Issue 6, Page(s) 573–578

Abstract: Background: Recently published data support the benefits and safety of the once-daily (OD) long-acting anticholinergic tiotropium bromide bronchodilator for the treatment of uncontrolled moderate-to-severe asthma in adults and adolescents. However, its ... ...

Abstract	Background: Recently published data support the benefits and safety of the once-daily (OD) long-acting anticholinergic tiotropium bromide bronchodilator for the treatment of uncontrolled moderate-to-severe asthma in adults and adolescents. However, its role for the treatment of school-age asthmatics has not yet been clearly defined. The aim of this systematic review was to assess the efficacy and safety of tiotropium Respimat Methods: Randomized, placebo-controlled trials were included. Primary outcomes were peak forced expiratory volume in 1 s measured within 3 h post-dosing) [FEV Results: Three studies (more than 900 patients) were selected. Tiotropium was associated with significant improvements in FEV Conclusions: OD tiotropium Respimat
Language	English
Publishing date	2017-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.12759
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