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Article: Continuous Improvement of Antiplatelet Therapy in Cardiovascular Disease

Verheugt, Freek W.A. / Huber, Kurt

2023 Volume 123, Issue 02, Page(s) 133–134

Language	English
Publishing date	2023-01-05
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0042-1760129
Database	Thieme publisher's database

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Article: The need for new oral anticoagulants in clinical practice: an introduction.

Bode, Christoph / Verheugt, Freek Wa

Journal of cardiovascular medicine (Hagerstown, Md.)

2009 Volume 10, Issue 8, Page(s) 593–594

MeSH term(s)	Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/drug therapy ; Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Humans
Chemical Substances	Anticoagulants
Language	English
Publishing date	2009-08
Publishing country	United States
Document type	Introductory Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0b013e32832e48f8
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Article ; Online: The role of aspirin in women's health.

Verheugt, Freek Wa / Bolte, Antoinette C

International journal of women's health

2011 Volume 3, Page(s) 151–166

Abstract: Background: The aim of this review is to discuss the role of aspirin for various conditions in women.: Methods: A nonsystematic review of articles published on PubMed(®) that examines the role of aspirin in women.: Results: Aspirin is associated ... ...

Abstract	Background: The aim of this review is to discuss the role of aspirin for various conditions in women. Methods: A nonsystematic review of articles published on PubMed(®) that examines the role of aspirin in women. Results: Aspirin is associated with a significant reduction of stroke risk in women, which may be linked to age. However, despite this evidence, underutilization of aspirin in eligible women is reported. In women of reproductive age, it may also have a role to play in reducing early-onset preeclampsia and intrauterine growth restriction, and in the prevention of recurrent miscarriage in women with antiphospholipid antibodies; it may also reduce cardiovascular risk in associated systemic conditions such as lupus. Aspirin may reduce colorectal cancer risk in women, but its role in breast cancer warrants further data from controlled trials. Conclusions: The risk-benefit threshold for aspirin use in women has been established for several conditions. Reasons why women are less likely to be prescribed aspirin have not been established, but the overall underuse of aspirin in women needs to be addressed.
Language	English
Publishing date	2011-06-30
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508161-5
ISSN	1179-1411 ; 1179-1411
ISSN (online)	1179-1411
ISSN	1179-1411
DOI	10.2147/IJWH.S18033
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Article ; Online: Incidence, clinical impact and risk of bleeding during oral anticoagulation therapy.

Rubboli, Andrea / Becattini, Cecilia / Verheugt, Freek Wa

World journal of cardiology

2011 Volume 3, Issue 11, Page(s) 351–358

Abstract: Bleeding is the most important complication of oral anticoagulation (OAC) with vitamin K-antagonists. Whilst bleeding is unavoidably related to OAC, it may have a great impact on the prognosis of treated subjects by leading to discontinuation of ... ...

Abstract	Bleeding is the most important complication of oral anticoagulation (OAC) with vitamin K-antagonists. Whilst bleeding is unavoidably related to OAC, it may have a great impact on the prognosis of treated subjects by leading to discontinuation of treatment, permanent disability or death. The yearly incidence of bleeding during OAC is 2%-5% for major bleeding, 0.5%-1% for fatal bleeding, and 0.2%-0.4% for intracranial bleeding. While OAC interruption and/or antagonism, as well as administration of coagulation factors, represent the necessary measures for the management of bleeding, proper stratification of the individual risk of bleeding prior to start OAC is of paramount importance. Several factors, including advanced age, female gender, poor control and higher intensity of OAC, associated diseases and medications, as well as genetic factors, have been proven to be associated with an increased risk of bleeding. Most of these factors have been included in the development of bleeding prediction scores, which should now be used by clinicians when prescribing and monitoring OAC. Owing to the many limitations of OAC, including a narrow therapeutic window, cumbersome management, and wide inter- and intra-individual variability, novel oral anticoagulants, such as factor Xa inhibitors and direct thrombin inhibitors, have been recently developed. These agents can be given in fixed doses, have little interaction with foods and drugs, and do not require regular monitoring of anticoagulation. While the novel oral anticoagulants show promise for effective thromboprophylaxis in atrial fibrillation and venous thromboembolism, definitive data on their safety and efficacy are awaited.
Language	English
Publishing date	2011-11-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573665-6
ISSN	1949-8462 ; 1949-8462
ISSN (online)	1949-8462
ISSN	1949-8462
DOI	10.4330/wjc.v3.i11.351
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Article ; Online: Incidence, clinical impact and risk of bleeding during oral anticoagulation therapy

Andrea Rubboli / Cecilia Becattini / Freek WA Verheugt

World Journal of Cardiology, Vol 3, Iss 11, Pp 351-

2011 Volume 358

Abstract	Bleeding is the most important complication of oral anticoagulation (OAC) with vitamin K-antagonists. Whilst bleeding is unavoidably related to OAC, it may have a great impact on the prognosis of treated subjects by leading to discontinuation of treatment, permanent disability or death. The yearly incidence of bleeding during OAC is 2%-5% for major bleeding, 0.5%-1% for fatal bleeding, and 0.2%-0.4% for intracranial bleeding. While OAC interruption and/or antagonism, as well as administration of coagulation factors, represent the necessary measures for the management of bleeding, proper stratification of the individual risk of bleeding prior to start OAC is of paramount importance. Several factors, including advanced age, female gender, poor control and higher intensity of OAC, associated diseases and medications, as well as genetic factors, have been proven to be associated with an increased risk of bleeding. Most of these factors have been included in the development of bleeding prediction scores, which should now be used by clinicians when prescribing and monitoring OAC. Owing to the many limitations of OAC, including a narrow therapeutic window, cumbersome management, and wide inter- and intra-individual variability, novel oral anticoagulants, such as factor Xa inhibitors and direct thrombin inhibitors, have been recently developed. These agents can be given in fixed doses, have little interaction with foods and drugs, and do not require regular monitoring of anticoagulation. While the novel oral anticoagulants show promise for effective thromboprophylaxis in atrial fibrillation and venous thromboembolism, definitive data on their safety and efficacy are awaited.
Keywords	Bleeding ; Oral anticoagulation ; Vitamin K antagonists ; Dabigatran ; Apixaban ; Rivaroxaban ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Baishideng Publishing Group Co., Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: GARFIELD-AF: a worldwide prospective registry of patients with atrial fibrillation at risk of stroke.

Bassand, Jean-Pierre / Apenteng, Patricia N / Atar, Dan / Camm, A John / Cools, Frank / Corbalan, Ramon / Fitzmaurice, David A / Fox, Keith Aa / Goto, Shinya / Haas, Sylvia / Hacke, Werner / Jerjes-Sanchez, Carlos / Koretsune, Yukihiro / Heuzey, Jean-Yves Le / Sawhney, Jitendra Ps / Oh, Seil / Stępińska, Janina / Cate, Vincent Ten / Verheugt, Freek Wa /

Kayani, Gloria / Pieper, Karen S / Kakkar, Ajay K / Garfield-Af Investigators, For The

Future cardiology

2020 Volume 17, Issue 1, Page(s) 19–38

Abstract: The Global Anticoagulant Registry in the Field-Atrial Fibrillation (GARFIELD-AF) examined real-world practice in a total of 57,149 (5069 retrospective, 52,080 prospective) patients with newly diagnosed AF at risk of stroke/systemic embolism, enrolled at ... ...

Abstract	The Global Anticoagulant Registry in the Field-Atrial Fibrillation (GARFIELD-AF) examined real-world practice in a total of 57,149 (5069 retrospective, 52,080 prospective) patients with newly diagnosed AF at risk of stroke/systemic embolism, enrolled at over 1000 centers in 35 countries. It aimed to capture data on AF burden, patients' clinical profile, patterns of clinical practice and antithrombotic management, focusing on stroke/systemic embolism prevention, uptake of new oral anticoagulants, impact on death and bleeding. GARFIELD-AF set new standards for quality of data collection and analysis. A total of 36 peer-reviewed articles were already published and 73 abstracts presented at international congresses, covering treatment strategies, geographical variations in baseline risk and therapies, adverse outcomes and common comorbidities such as heart failure. A risk prediction tool as well as innovative observational studies and artificial intelligence methodologies are currently being developed by GARFIELD-AF researchers.
MeSH term(s)	Anticoagulants/therapeutic use ; Artificial Intelligence ; Atrial Fibrillation/complications ; Atrial Fibrillation/epidemiology ; Humans ; Prospective Studies ; Registries ; Retrospective Studies ; Risk Factors ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control
Chemical Substances	Anticoagulants
Language	English
Publishing date	2020-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2274267-0
ISSN	1744-8298 ; 1479-6678
ISSN (online)	1744-8298
ISSN	1479-6678
DOI	10.2217/fca-2020-0014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prior stroke and transient ischemic attack as risk factors for subsequent stroke in atrial fibrillation patients: A report from the GARFIELD-AF registry.

Hacke, Werner / Bassand, Jean-Pierre / Virdone, Saverio / Camm, A John / Fitzmaurice, David A / Fox, Keith Aa / Goldhaber, Samuel Z / Goto, Shinya / Haas, Sylvia / Kayani, Gloria / Mantovani, Lorenzo G / Misselwitz, Frank / Pieper, Karen S / Turpie, Alexander Gg / van Eickels, Martin / Verheugt, Freek Wa / Kakkar, Ajay K

International journal of stroke : official journal of the International Stroke Society

2019 Volume 15, Issue 3, Page(s) 308–317

Abstract: Background: It is not always possible to verify whether a patient complaining of symptoms consistent with transient ischemic attack has had an actual cerebrovascular event.: Research question: To characterize the risk of cardiovascular events ... ...

Abstract	Background: It is not always possible to verify whether a patient complaining of symptoms consistent with transient ischemic attack has had an actual cerebrovascular event. Research question: To characterize the risk of cardiovascular events associated with a history of stroke/transient ischemic attack in patients with atrial fibrillation. Study design and methods: This study investigated the clinical characteristics and outcomes of patients with a history of stroke/transient ischemic attack among 52,014 patients enrolled prospectively in GARFIELD-AF registry. The diagnosis of stroke or transient ischemic attack was not protocol defined but based on physicians' assessment. Patients' one-year risk of death, stroke/systemic embolism, and major bleeding was assessed by multivariable Cox regression. Results: At enrollment, 5617 (10.9%) patients were reported to have a history of stroke or transient ischemic attack. Patients with stroke or transient ischemic attack were older and had a greater burden of diabetes, moderate-to-severe kidney disease, and atherothrombosis and higher median CHA Interpretation: A history of prior stroke or transient ischemic attack is a strong independent risk factor for mortality and stroke/systemic embolism. This excess risk is mainly attributed to a history of stroke (with or without transient ischemic attack), whereas history of transient ischemic attack is a weaker predictor.
MeSH term(s)	Aged ; Aged, 80 and over ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Female ; Follow-Up Studies ; Humans ; Ischemic Attack, Transient/diagnosis ; Ischemic Attack, Transient/epidemiology ; Male ; Middle Aged ; Prospective Studies ; Registries ; Research Report/trends ; Risk Factors ; Stroke/diagnosis ; Stroke/epidemiology
Language	English
Publishing date	2019-12-17
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2303728-3
ISSN	1747-4949 ; 1747-4930
ISSN (online)	1747-4949
ISSN	1747-4930
DOI	10.1177/1747493019891516
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Article: Risk Evaluation Tools for Prediction and Possible Guidance of DAPT: Is Scoring a Hit in East Asians Patients undergoing PCI?

Hein, Ralph / Verheugt, Freek W.A. / Sibbing, Dirk

Thrombosis and Haemostasis

2019 Volume 119, Issue 07, Page(s) 1033–1035

Language	English
Publishing date	2019-06-10
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0039-1692169
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Article ; Online: High T2-weighted signal intensity is associated with elevated troponin T in hypertrophic cardiomyopathy.

Gommans, Dh Frank / Cramer, G Etienne / Bakker, Jeannette / Michels, Michelle / Dieker, Hendrik-Jan / Timmermans, Janneke / Fouraux, Michael A / Marcelis, Carlo Lm / Verheugt, Freek Wa / Brouwer, Marc A / Kofflard, Marcel Jm

Heart (British Cardiac Society)

2017 Volume 103, Issue 4, Page(s) 293–299

Abstract: Objective: Areas of high signal intensity (HighT2) on T2-weighted cardiovascular magnetic resonance (CMR) imaging have been demonstrated in hypertrophic cardiomyopathy (HCM). It has been hypothesised that HighT2 may indicate active tissue injury in HCM. ...

Abstract	Objective: Areas of high signal intensity (HighT2) on T2-weighted cardiovascular magnetic resonance (CMR) imaging have been demonstrated in hypertrophic cardiomyopathy (HCM). It has been hypothesised that HighT2 may indicate active tissue injury in HCM. In this context, we studied HighT2 in relation to cardiac troponin. Methods: Outpatient HCM patients without a history of coronary artery disease underwent CMR imaging at 1.5 T using T2-weighted, cine and late gadolinium enhancement (LGE) imaging to assess HighT2, left ventricular (LV) function, LV mass and the presence and extent of LGE. Highly sensitive cardiac troponin T (hs-cTnT) was assessed as a marker of injury, with hs-cTnT ≥14 and >3 ng/L defined as an elevated and detectable troponin. Results: HighT2 was present in 28% of patients (28/101). An elevated hs-cTnT was present in 54% of patients with HighT2 (15/28) compared with 14% of patients without HighT2 (10/73) (p<0.001). Hs-cTnT was detectable in 96% of patients with HighT2 (27/28) compared with 66% of patients without HighT2 (48/73) (p=0.002). In case of an undetectable hs-cTnT, HighT2 was only seen in 4% (1/26). In addition, the extent of HighT2 was related with increasing hs-cTnT concentrations (Spearman's ρ: 0.42, p<0.001). Conclusions: In this CMR study of patients with HCM, we observed HighT2 in a quarter of patients, and demonstrated that HighT2 was associated with an elevated hs-cTnT. This observation, combined with the very high negative predictive value of an undetectable hs-cTnT for HighT2, provides supportive evidence for the hypothesis that HighT2 is indicative of recently sustained myocyte injury.
MeSH term(s)	Adult ; Aged ; Ambulatory Care ; Biomarkers/blood ; Cardiomyopathy, Hypertrophic/blood ; Cardiomyopathy, Hypertrophic/diagnostic imaging ; Cardiomyopathy, Hypertrophic/physiopathology ; Contrast Media/administration & dosage ; Female ; Humans ; Magnetic Resonance Imaging, Cine ; Male ; Meglumine/administration & dosage ; Middle Aged ; Netherlands ; Organometallic Compounds/administration & dosage ; Pilot Projects ; Predictive Value of Tests ; Prognosis ; Troponin T/blood ; Up-Regulation ; Ventricular Function, Left
Chemical Substances	Biomarkers ; Contrast Media ; Organometallic Compounds ; Troponin T ; Meglumine (6HG8UB2MUY) ; gadoterate meglumine (L0ND3981AG)
Language	English
Publishing date	2017-02-15
Publishing country	England
Document type	Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2016-309900
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Article ; Online: Effectiveness of two intensive treatment methods for smoking cessation and relapse prevention in patients with coronary heart disease

Berndt Nadine / Bolman Catherine / Lechner Lilian / Mudde Aart / Verheugt Freek WA / de Vries Hein

BMC Cardiovascular Disorders, Vol 12, Iss 1, p

study protocol and baseline description

2012 Volume 33

Abstract: Abstract Background There is no more effective intervention for secondary prevention of coronary heart disease than smoking cessation. Yet, evidence about the (cost-)effectiveness of smoking cessation treatment methods for cardiac inpatients that also ... ...

Abstract	Abstract Background There is no more effective intervention for secondary prevention of coronary heart disease than smoking cessation. Yet, evidence about the (cost-)effectiveness of smoking cessation treatment methods for cardiac inpatients that also suit nursing practice is scarce. This protocol describes the design of a study on the (cost-)effectiveness of two intensive smoking cessation interventions for hospitalised cardiac patients as well as first results on the inclusion rates and the characteristics of the study population. Methods/design An experimental study design is used in eight cardiac wards of hospitals throughout the Netherlands to assess the (cost-)effectiveness of two intensive smoking cessation counselling methods both combined with nicotine replacement therapy. Randomization is conducted at the ward level (cross-over). Baseline and follow-up measurements after six and 12 months are obtained. Upon admission to the cardiac ward, nurses assess patients’ smoking behaviour, ensure a quit advice and subsequently refer patients for either telephone counselling or face-to-face counselling. The counselling interventions have a comparable structure and content but differ in provider and delivery method, and in duration. Both counselling interventions are compared with a control group receiving no additional treatment beyond the usual care. Between December 2009 and June 2011, 245 cardiac patients who smoked prior to hospitalisation were included in the usual care group, 223 in the telephone counselling group and 157 in the face-to-face counselling group. Patients are predominantly male and have a mean age of 57 years. Acute coronary syndrome is the most frequently reported admission diagnosis. The ultimate goal of the study is to assess the effects of the interventions on smoking abstinence and their cost-effectiveness. Telephone counselling is expected to be more (cost-)effective in highly motivated patients and patients with high SES, whereas face-to-face counselling is expected to be more (cost-)effective in less motivated patients and patients with low SES. Discussion This study examines two intensive smoking cessation interventions for cardiac patients using a multi-centre trial with eight cardiac wards. Although not all eligible patients could be included and the distribution of patients is skewed in the different groups, the results will be able to provide valuable insight into effects and costs of counselling interventions varying in delivery mode and intensity, also concerning subgroups. Trial registration Dutch Trial Register NTR2144
Keywords	Coronary heart disease ; Smoking cessation ; Face-to-face counselling ; Telephone counselling ; Nicotine replacement therapy ; Cost-effectiveness study ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2012-05-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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