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  1. Article ; Online: Bruton's Tyrosine Kinase Inhibition in Pemphigus: An Embattled Frontier.

    Payne, Aimee S / Manfredo Vieira, Silvio

    The Journal of investigative dermatology

    2024  

    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2024.03.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A precision counterstrike on central nervous system autoimmunity.

    Payne, Aimee S / Oh, Sangwook

    Cell research

    2023  Volume 34, Issue 4, Page(s) 275–276

    MeSH term(s) Autoimmunity ; Central Nervous System
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-023-00907-y
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  3. Article ; Online: T cell and bacterial microbiota interaction at intestinal and skin epithelial interfaces.

    Maseda, Damian / Manfredo-Vieira, Silvio / Payne, Aimee S

    Discovery immunology

    2023  Volume 2, Issue 1, Page(s) kyad024

    Abstract: Graphical Abstract. ...

    Abstract Graphical Abstract.
    Language English
    Publishing date 2023-11-25
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2754-2483
    ISSN (online) 2754-2483
    DOI 10.1093/discim/kyad024
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  4. Article: Engineering Cell Therapies for Autoimmune Diseases: From Preclinical to Clinical Proof of Concept.

    Oh, Sangwook / Payne, Aimee S

    Immune network

    2022  Volume 22, Issue 5, Page(s) e37

    Abstract: Autoimmune diseases are caused by a dysfunction of the acquired immune system. In a subset of autoimmune diseases, B cells escaping immune tolerance present autoantigen and produce cytokines and/or autoantibodies, resulting in systemic or organ-specific ... ...

    Abstract Autoimmune diseases are caused by a dysfunction of the acquired immune system. In a subset of autoimmune diseases, B cells escaping immune tolerance present autoantigen and produce cytokines and/or autoantibodies, resulting in systemic or organ-specific autoimmunity. Therefore, B cell depletion with monoclonal Abs targeting B cell lineage markers is standard care therapy for several B cell-mediated autoimmune disorders. In the last 5 years, genetically-engineered cellular immunotherapies targeting B cells have shown superior efficacy and long-term remission of B cell malignancies compared to historical clinical outcomes using B cell depletion with monoclonal Ab therapies. This has raised interest in understanding whether similar durable remission could be achieved with use of genetically-engineered cell therapies for autoimmunity. This review will focus on current human clinical trials using engineered cell therapies for B cell-associated autoimmune diseases.
    Language English
    Publishing date 2022-09-21
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2536191-0
    ISSN 2092-6685 ; 1598-2629
    ISSN (online) 2092-6685
    ISSN 1598-2629
    DOI 10.4110/in.2022.22.e37
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  5. Article ; Online: Pemphigus and Pemphigoid: From Disease Mechanisms to Druggable Pathways.

    Ellebrecht, Christoph T / Maseda, Damian / Payne, Aimee S

    The Journal of investigative dermatology

    2021  Volume 142, Issue 3 Pt B, Page(s) 907–914

    Abstract: Pemphigus and pemphigoid are paradigms for understanding the mechanisms of antibody-mediated autoimmune disease in humans. In pemphigus, IgG4-predominant autoantibodies cause intraepidermal blistering by direct interference with desmoglein interactions ... ...

    Abstract Pemphigus and pemphigoid are paradigms for understanding the mechanisms of antibody-mediated autoimmune disease in humans. In pemphigus, IgG4-predominant autoantibodies cause intraepidermal blistering by direct interference with desmoglein interactions and subsequent disruption of desmosomes and signaling pathways. In pemphigoid, IgG1, IgG4, and IgE autoantibodies against basement membrane zone antigens directly interfere with hemidesmosomal adhesion, activating complement and Fc receptor‒mediated effector pathways. Unraveling disease mechanisms in pemphigus and pemphigoid has identified numerous opportunities for clinical trials, which hold promise to identify safer and more effective therapies for these potentially life-threatening diseases.
    MeSH term(s) Autoantibodies ; Autoimmune Diseases ; Humans ; Immunoglobulin G ; Pemphigoid, Bullous/drug therapy ; Pemphigus/drug therapy
    Chemical Substances Autoantibodies ; Immunoglobulin G
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2021.04.040
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  6. Article ; Online: Clinical outcome and safety of rituximab therapy for pemphigoid diseases.

    Tovanabutra, Napatra / Payne, Aimee S

    Journal of the American Academy of Dermatology

    2019  Volume 82, Issue 5, Page(s) 1237–1239

    MeSH term(s) Dose-Response Relationship, Drug ; Follow-Up Studies ; Humans ; Immunologic Factors/administration & dosage ; Immunologic Factors/adverse effects ; Pemphigoid, Benign Mucous Membrane/drug therapy ; Pemphigoid, Benign Mucous Membrane/immunology ; Pemphigoid, Bullous/drug therapy ; Pemphigoid, Bullous/immunology ; Pennsylvania ; Recurrence ; Remission Induction/methods ; Rituximab/administration & dosage ; Rituximab/adverse effects ; Treatment Outcome
    Chemical Substances Immunologic Factors ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2019-11-16
    Publishing country United States
    Document type Letter
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2019.11.023
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  7. Article ; Online: B Cell-Directed Therapy in Autoimmunity.

    Abeles, Ilana / Palma, Chris / Meednu, Nida / Payne, Aimee S / Looney, R John / Anolik, Jennifer H

    Annual review of immunology

    2023  

    Abstract: Autoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the ... ...

    Abstract Autoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the efficacy of B cell depletion in these diverse autoimmune disorders, the rapidly expanding armamentarium of approved agents, and future approaches. The pathogenic roles for B cells include direct functions such as production of autoantibodies and proinflammatory cytokines and indirect functions via antigen presentation to T cells. The efficacy of B cell-depleting strategies varies across diseases and likely reflects the complexity of disease pathogenesis and relative contribution of B cell roles. Additionally, B cell-depleting therapies do not equally target all B cell subsets in all patients, and this likely explains some of the variability in responses. Recent reports of B cell depletion with novel chimeric antigen receptor (CAR) T cell approaches in an expanding number of autoimmune diseases highlight the potential role of B cell depletion in resetting immune tolerance. The relative importance of eliminating autoreactive B cells and plasma cells and approaches to doing so will also be discussed. Expected final online publication date for the
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-083122-044829
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  8. Article ; Online: The Importance of Patient-Focused Drug Development in Pemphigus and Pemphigoid.

    Yale, Marc / Dunn, Patrick / Strong, Rebecca / Davies, Isobel / Gallu, Laurence / Joly, Pascal / Murrell, Dedee F / Werth, Victoria P / Payne, Aimee S

    The Journal of investigative dermatology

    2023  Volume 143, Issue 10, Page(s) 1868–1871

    MeSH term(s) Humans ; Pemphigus/drug therapy ; Pemphigoid, Bullous/drug therapy
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.03.1673
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  9. Article ; Online: Increasing the Complement of Therapeutic Options in Bullous Pemphigoid.

    Kushner, Carolyn J / Payne, Aimee S

    The Journal of investigative dermatology

    2018  Volume 138, Issue 2, Page(s) 246–248

    Abstract: Bullous pemphigoid is a potentially life-threatening autoantibody-mediated dermatosis characterized by blister formation. Experimental mouse models of bullous pemphigoid feature complement-induced inflammation and tissue damage. Kasprick et al. now ... ...

    Abstract Bullous pemphigoid is a potentially life-threatening autoantibody-mediated dermatosis characterized by blister formation. Experimental mouse models of bullous pemphigoid feature complement-induced inflammation and tissue damage. Kasprick et al. now provide preclinical data that utilize ex vivo human skin assays and support testing of complement inhibition as a therapeutic strategy in human bullous pemphigoid.
    MeSH term(s) Animals ; Antibodies, Monoclonal ; Autoantibodies/immunology ; Complement Activation ; Humans ; Mice ; Pemphigoid, Bullous/immunology
    Chemical Substances Antibodies, Monoclonal ; Autoantibodies ; TNT003
    Language English
    Publishing date 2018-02-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2017.09.026
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  10. Article ; Online: B-cell targeted therapies in pemphigus.

    Maglie, Roberto / Antiga, Emiliano / Payne, Aimee S

    Italian journal of dermatology and venereology

    2020  Volume 156, Issue 2, Page(s) 161–173

    Abstract: Pemphigus is a rare autoimmune disease of the skin, characterized by autoantibodies targeting adhesion proteins of the epidermis, in particular desmoglein 3 and desmoglein 1, that cause the loss of cell-cell adhesion and the formation of intraepidermal ... ...

    Abstract Pemphigus is a rare autoimmune disease of the skin, characterized by autoantibodies targeting adhesion proteins of the epidermis, in particular desmoglein 3 and desmoglein 1, that cause the loss of cell-cell adhesion and the formation of intraepidermal blisters. Given that these autoantibodies are both necessary and sufficient for pemphigus to occur, the goal of pemphigus therapy is the elimination of autoreactive B-cells responsible for autoantibody production. Rituximab, an anti-CD20 monoclonal antibody, was the first targeted B-cell therapy approved for use in pemphigus and is now considered the frontline therapy for new onset disease. One limitation of this treatment is that it targets both autoreactive and non -autoreactive B-cells, which accounts for the increased risk of serious infections in treated patients. In addition, most rituximab-treated patients experience disease relapse, highlighting the need of new therapeutic options. This review provides a concise overview of rituximab use in pemphigus and discusses new B-cell and antibody-directed therapies undergoing investigation in clinical studies.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Autoantibodies ; B-Lymphocytes ; Humans ; Pemphigus/drug therapy ; Rituximab/therapeutic use
    Chemical Substances Antibodies, Monoclonal ; Autoantibodies ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2020-10-05
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.20.06694-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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